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Cortical thickness abnormalities in patients with first episode psychosis:a meta-analysis of psychoradiologic studies and replication in an independent sample

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Psychoradiology 2021年第4期1卷 185-198页

作者： Keren Wen Youjin Zhao Qiyong Gong Ziyu Zhu Qian Li Nanfang Pan Shiqin Fu joaquim radua Eduard Vieta Poornima Kumar Graham j.Kemp Bharat B.Biswal Huaxi Mr research Center(HMrrC) Department of RadiologyWest China Hospital of Sichuan UniversityChengdu 610041SichuanChina research Unit of Psychoradiology Chinese Academy of Medical SciencesChengdu 610041SichuanChina Functional and Molecular Imaging Key Laboratory of Sichuan Province Chengdu 610041SichuanChina Institut d’Investigacions Biom`ediques August Pi i Sunyer(IDIBAPS) Mental Health Research Networking Center(CIBERSAM)Barcelona 08036CataloniaSpain Centre for Psychiatric research and Education Department of Clinical NeuroscienceKarolinska InstitutetSolna 171-77StockholmSweden Department of Psychosis Studies Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK Barcelona Bipolar Disorders and Depressive Unit Hospital ClinicInstitute of NeurosciencesUniversity of BarcelonaBarcelona 08036CataloniaSpain Center for Depression Anxiety and Stress ResearchMcLean HospitalBelmont 02478MAUSA Department of Psychiatry Harvard Medical SchoolBoston 02115MAUSA Liverpool Magnetic resonance Imaging Centre(LiMrIC)and Institute of Life Course and Medical Sciences University of LiverpoolLiverpool L693GEUK Department of Biomedical Engineering New Jersey Institute of TechnologyNewark 07102NJUSA The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for NeuroinformationUniversity of Electronic Science and Technology of ChinaChengdu 610054SichuanChina

Background:Abnormalities of cortical thickness(CTh)in patients with their first episode psychosis(FEP)have been frequently reported,but findings are ***:To define the most consistent CTh changes in patients with FEP by meta-analysis of publishedwholebrain ***:The meta-analysis used seed-based dmapping(SDM)software to obtain the most prominent regional CTh changes in FEP,and meta-regression analyses to explore the effects of demographics and clinical *** meta-analysis results were verified in an independent sample of 142 FEP patients and 142 age-and sex-matched healthy controls(HCs),using both a vertex-wise and a region of interest analysis,with multiple comparisons ***:The meta-analysis identified lower CTh in the rightmiddle temporal cortex(MTC)extending to superior temporal cortex(STC),insula,and anterior cingulate cortex(ACC)in FEP compared with *** significant correlations were identified between CTh alterations and demographic or clinical *** results were replicated in the independent dataset ***:This study identifies a robust pattern of cortical abnormalities in FEP and extends understanding of gray matter abnormalities and pathological mechanisms in FEP.

关键词： psychoradiology first episode psychosis early psychosis cortical thickness meta-analysis seed-based d mapping

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美国以及世界范围内的放射学及核医学调查:1950年—2007年间,应用频率、辐射剂量并与其他放射源做比较

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国际医学放射学杂志 2010年第1期 76-76页

作者： F.A.Mettler M.Bhargavan K.Faulkner D.B.Gilley j.E.gray G.S.Ibbott 李志明 radiology and Nuclear Medicine Service New Mexico VA Health Care System1501 San Pedro Blvd SEAlbuquerqueNM 87108USA

美国国家放射防护及测量委员会和联合国原子辐射效应科学委员会分别对美国和世界范围内的所有放射源进行评估。本文目的是对两个开放的、可利用的调查结果进行总结,并与以往的数据进行对比。2006年美国大约有3亿7千7百万项诊断性和介入... 详细信息

美国国家放射防护及测量委员会和联合国原子辐射效应科学委员会分别对美国和世界范围内的所有放射源进行评估。本文目的是对两个开放的、可利用的调查结果进行总结,并与以往的数据进行对比。2006年美国大约有3亿7千7百万项诊断性和介入放射学检查,以及1800万项核医学检查。美国的放射学操

关键词：应用频率核医学原子医学年有效剂量美国美利坚合众国北美洲放射源粒子源放射学

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Technical Note: Identification of CT Texture Features robust to Tumor Size Variations for Normal Lung Texture Analysis

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International journal of Medical Physics, Clinical Engineering and radiation Oncology 2018年第3期7卷 330-338页

作者： Wookjin Choi Sadegh riyahi Seth j. Kligerman Chia-ju Liu james G. Mechalakos Wei Lu Department of Medical Physics Memorial Sloan Kettering Cancer Center New York USA Department of radiology University of California at San Diego San Diego USA Department of radiology Memorial Sloan Kettering Cancer Center New York USA

Normal lung CT texture features have been used for the prediction of radiation-induced lung disease (rILD). For these features to be clinically useful, they should be robust to tumor size variations and not correlated with the normal lung volume of interest, i.e., the volume of the peri-tumoral region (PTr). CT images of 14 lung cancer patients were studied. Different sizes of gross tumor volumes (GTVs) were simulated and placed in the lung contralateral to the tumor. 27 texture features [nine from intensity histogram, eight from the gray-level co-occurrence matrix (GLCM) and ten from the gray-level run-length matrix (GLrM)] were extracted from the PTr. The Bland-Altman analysis was applied to measure the normalized range of agreement (nroA) for each feature when GTV size varied. A feature was considered as robust when its nroA was less than the threshold (100%). Sixteen texture features were identified as robust. None of the robust features was correlated with the volume of the PTr. No feature showed statistically significant differences (P 0.05) on GTV locations. We identified 16 robust normal lung CT texture features that can be further examined for the prediction of rILD.

关键词： radiation-Induced Lung Disease Normal Lung Texture radiomics CT Stereotactic Body radiotherapy

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The use of dielectrophoresis in oral cancer

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中国口腔颌面外科杂志 2008年第B5期6卷 151-152页

作者： Hayley j. Mulhall Fatima H. Labeed Michael P. Hughes Mark P. Lewis School of Biomedical Engineering University of Surrey Guildford Surrey GU2 7XH Eastman Dental Institute for Oral Health Care Sciences University College. London 256 Gray's Inn Road. London WC1X 8LD UK

Purpose: Oral squamous cell carcinoma (OSCC) is the eighth most common cancer worldwide。If early stage (stage I) diagnosis occurs, the 2 year survival rate is 87.5% (Cancer research, U。K。)。However, most oral cancers are diagnosed at late stage and, consequently, the overall survival rate for OSCC remains poor (approximately 50% at 5 years post-presentation)。A novel screening assay is proposed in which a malignant cell population derived fi'om the oral mucosa is differentiated fi'om normal oral cells on the basis of its dielectric properties。Methods: Dielectrophoresis (DEP) is a phenomenon whereby a force is exerted on a dielectric particle (a cell) when exposed to a non uniform electric field。The magnitude and direction of the force is dependent, in part, on the dielectric properties of the cell。Therefore, cell populations which exhibit distinct dielectric characteristics will experience different DEP forces。In this study, DEP has been used to determine the dielectric properties of a number of OSCC cell lines and normal human keratinocytes (NHK)。In addition, cells derived from organotypic models of the normal oral mucosa and models of OSCC have been analysed with DEP and their dielectric phenotypes determined。results: The results show significant electrophysiological differences in the cytoplasm of NHK's and malignant keratinocytes。Conclusion: It is proposed that DEP has the potential to be used in a clinical setting as a non-invasive screening tool for OSCC。

关键词：口腔癌治疗方法介电泳临床分析诊断技术

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新生儿MrI可预测早产儿的神经发育预后

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 3-4页

作者： Woodward L.j. Anderson P.j. Austin N.C. 郭俊 Dr.Canterbury Child Development research Group Department of PsychologyUniversity of CanterburyPrivate Bag 4800ChristchurchNew Zealand

BACKGrOUND:Very preterm infants are at high risk for adverse neurodevelopmental *** resonance imaging(MrI)has been proposed as a means of predicting neurodevelopmental outcomes in this ***:We studied 167 very preterm infants(gestational age at birth,30 weeks or less)to assess the associations between qualitatively defined white-matter and gray-matter abnormalities on MrI at term equivalent(gestational age of 40 weeks)and the risks of severe cognitive delay,severe psychomotor delay,cerebral palsy,and neurosensory(hearing or visual)impairment at 2 years of age(corrected for prematurity).rESULTS:At two years of age,17 percent of infants had severe cognitive delay,10 percent had severe psychomotor delay,10 percent had cerebral palsy,and 11 percent had neurosensory ***-to-severe cerebral white-matter abnormalities present in 21 percent of infants at term equivalent were predictive of the following adverse outcomes at two years of age:cognitive delay(odds ratio,3.6;95 percent confidence interval,1.5 to 8.7),motor delay(odds ratio,10.3;95 percent confidence interval,3.5 to 30.8),cerebral palsy(odds ratio,9.6;95 percent confidence interval,3.2 to 28.3),and neurosensory impairment(odds ratio,4.2;95 percent confidence interval,1.6 to 11.3).gray-matter abnormalities(present in 49 percent of infants)were also associated,but less strongly,with cognitive delay,motor delay,and cerebral ***-to-severe white-matter abnormalities on MrI were significant predictors of severe motor delay and cerebral palsy after adjustment for other measures during the neonatal period,including findings on cranial ***:Abnormal findings on MrI at term equivalent in very preterm infants strongly predict adverse neurodevelopmental outcomes at two years of *** findings suggest a role for MrI at term equivalent in risk stratification for these infants.

关键词：神经发育新生儿早产儿预后

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rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder

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National Science review 2023年第11期10卷 34-44页

作者： rongwei Zhai Geya Tong Zheqin Li Weichen Song Yang Hu Sha Xu Qiqi Wei Xiaocheng Zhang Yi Li Bingbing Liao Chenyu Yuan Yinqing Fan Ge Song Yinyin Ouyang Wenxuan Zhang Yaqiu Tang Minghui jin Yuxian Zhang He Li Zhi Yang Guan Ning Lin Dan j.Stein Zhi-Qi Xiong Zhen Wang Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of Sciences Lingang Laboratory 4. Shanghai Center for Brain Science and Brain-Inspired Technology Translational Neuropsychiatry Unit(TNU) Department of Clinical MedicineAarhus University Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of Medicine

Obsessive-compulsive disorder(OCD) is a chronic and debilitating psychiatric disorder that affects ～2%–3% of the population globally. Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder. In large rhesus monkey colonies, we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors(SMBs) in individual-specific sequences that were repetitive, time-consuming and stable over prolonged periods. Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans. Brain imaging showed that monkeys with SMBs had larger gray matter(GM) volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum. The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs. Notably, exposure to a stressor(human presence) significantly increased SMBs. In addition, fluoxetine, a serotonergic medication commonly used for OCD, decreased SMBs in these monkeys. These findings provide a novel foundation for developing better understanding and treatment of OCD.

关键词： obsessive-compulsive disorder (OCD) primate ritualistic behavior model OCD risk genes caudate nucleus fluoxetine

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Vessel Extraction on Ocular Fundus Images by Using Gabor Filter Bank

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Computer Aided Drafting,Design and Manufacturing 2015年第1期25卷 28-36页

作者： SU Ming-jian ZHANG Xue-jun WANG Xi-ming Brent j Liu GAO Xin ZHANG Zuo-jun ZHOU Bin School of Computer Electronics and InformationGuangxi University IPILab Biomedical Engineering DeptUniversity of Southern California Department of Medical Imaging Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of Sciences Cancer Hospital of Guangxi Medical University

Fundus diagnosis is an important part of the whole body examination that may provide rich clinical information to doctors for diagnostic reference. Manual fundus vessel extraction is helpful to quantitative measurement of diseases but obviously it is a tough work for physicians. This paper presents an automatic method by using Gabor filter bank to extract the artery and vein separately in the ocular fundus images. After preprocessing steps that include gray-scale transform, gray value inversion and contrast enhancement, the Gabor filter bank is applied to the extraction of the artery and vein in the ocular fundus images. Finally these two different width types of vessels are selected by post-processing methods such as labeling, corrosion, binarization, etc. Evaluation results show an accurate rate of 90% in vein and 82% in artery from 20 cases, that indicates the effectiveness of our proposed segmentation method.

关键词： Gabor filter bank vessel extraction ocular fundus segmentation

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含弹性纤维针织物的松弛整理新工艺

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国际纺织导报 2005年第7期33卷 60-60,62页

作者： j. Strhle 陈芳云 Benninger公司瑞士

描述了由Benninger公司开发的能在实现针织坯布控制松弛的同时除去表面的硅油和针织油剂的新工艺。大量应用证明在无需热定型的情况下可进一步加工。新工艺适合于针织物连续开幅以及不连续绳状加工工艺。

关键词：松弛整理针织物含弹性纤维棉织物热定型

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人体网状骨受γ辐射后的压缩力学性质

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中国中医骨伤科 1993年第3期1卷 54-56页

作者： MICHAEL j. ANDErSON 刘贤炳湖北省中医药研究院 430074

本文探讨了γ辐射对人骨力学性质的影响,网状骨样品取自冷冻后的新鲜胫骨近端的骨骺区,并按解剖位置分成对照组和辐射组。将辐射组暴露在10000、31000、51000、60000gray(1.O,3.1,5.1,6.0Mrad)的γ射线下照射,然后对样品作压缩试验,确... 详细信息

本文探讨了γ辐射对人骨力学性质的影响,网状骨样品取自冷冻后的新鲜胫骨近端的骨骺区,并按解剖位置分成对照组和辐射组。将辐射组暴露在10000、31000、51000、60000gray(1.O,3.1,5.1,6.0Mrad)的γ射线下照射,然后对样品作压缩试验,确定断裂应力,断裂应变和弹性模量。实验发现断裂应力和弹性模量与密度的平方成正比,只有在60000gray(6.0mrad)的照射下,断裂应力和弹性模量的值表现出显著的差异。结果显示:人的网状胫骨在接受6000gray的辐射时,其压缩断裂应力和弹性模量显著减小,而对移植前接受过消毒剂量辐射(25000gray)的网状胫骨而言,其断裂应力和弹性模量都没有显著变化。

关键词：人网状骨 γ辐射压缩力学弹性模量密度

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检测二尖瓣流入起始与舒张早期二尖瓣环速度起始之间时间差对收缩功能正常且无明确意义E/E'的患者中左室舒张压评估的额外价值

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世界核心医学期刊文摘（心脏病学分册） 2007年第12期3卷 15-16页

作者： jung j.- H. 罗亮

本研究旨在评价当E/E'值处于"灰色带"时,早期经二尖瓣血流速度(E)起始与舒张早期二尖瓣环速度(E')起始之间的时间间隔对于预测左室(LV)舒张期末压力(EDP)是否具有额外价值。E/E'值介于8～15时被定为评估LVEDP的"灰色带"。最近有研究表... 详细信息

本研究旨在评价当E/E'值处于"灰色带"时,早期经二尖瓣血流速度(E)起始与舒张早期二尖瓣环速度(E')起始之间的时间间隔对于预测左室(LV)舒张期末压力(EDP)是否具有额外价值。E/E'值介于8～15时被定为评估LVEDP的"灰色带"。最近有研究表明,E和E'起始时间间隔(TE'-E)延长可能提示充盈压升高。74例收缩功能正常的患者进行了同时的左心导管检查和多普勒超声心动图检查。

关键词：二尖瓣环收缩功能 E/E 患者明确

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