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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural regeneration research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua jo jonggeol Na j.jay Liu Young-ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University resources Engineering Plant research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USrDSCHArDOLLAr3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

Two distinct Paleozoic metamorphic events in the Tarim-North China Collage

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National Science review 2023年第2期10卷 7-8页

作者： jérémie Soldner State Key Laboratory of Isotope Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences CAS Center for Excellence in Deep Earth Science

The Central Asian Or ogenic Belt(CAOB) [1],which includes the Altaids in Central and Northern Asia [2],is the largest accretionary orogen formed during the subduction of the Paleo-Asian Ocean and the Panthalassa Ocean in the period of the Late Proterozoic to Late Paleozoic [3].Closure of the Paleo-Asian Ocean is attributed to the northward drift of the North China and Tarim cratons leading to the massive shortening and oroclinal buckling of the CAOB accretionary system in the Permian [4].

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Harnessing artificial intelligence for identifying conflicts of interest in research

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World journal of Methodology 2025年第1期15卷 6-8页

作者： Abdulqadir j Nashwan Department of Nursing&Midwifery research Hamad Medical CorporationDoha 3050Qatar

This editorial explores the transformative potential of artificial intelligence(AI)in identifying conflicts of interest(COIs)within academic and scientific *** harnessing advanced data analysis,pattern recognition,and natural language processing techniques,AI offers innovative solutions for enhancing transparency and integrity in *** editorial discusses how AI can automatically detect COIs,integrate data from various sources,and streamline reporting processes,thereby maintaining the credibility of scientific findings.

关键词： Artificial intelligence Conflicts of interest Transparency research integrity Natural language processing

Moore-Gibson-Thompson theory for thermoelastic dielectrics

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Applied Mathematics and Mechanics(English Edition) 2021年第2期42卷 309-316页

作者： j.r.FErNANDEZ r.QUINTANILLA Department of Applied Mathematics I University of VigoCampus As Lagoas MarcosendeVigo 36310Spain Department of Mathematics Polytechnic University of CataloniaTerrassa 08222Spain

We consider the system of equations determining the linear thermoelastic deformations of dielectrics within the recently called Moore-Gibson-Thompson(MGT)***,we obtain the system of equations for such a ***,we consider the case of a rigid solid and show the existence and the exponential decay of ***,we consider the thermoelastic case and obtain the existence and the stability of the *** decay of solutions in the one-dimensional case is also recalled.

关键词： Moore-Gibson-Thompson(MGT)thermoelastic dielectrics existence semigroup exponential decay

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural regeneration research 2025年第3期20卷 819-820页

作者： rayudu Gopalakrishna jennifer Aguilar Emily Lee William j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Alpha-particle decays from excited states in ^(24)Mg

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Science China(Physics,Mechanics & Astronomy) 2011年第S1期54卷 130-135页

作者： LIOTTA r j royal Institute of Technology (KTH) AlbaNova University Center Stockholm S-10691 Sweden

Using a cluster model based on the Woods-Saxon potential, alpha-particle decays from excited states in 24Mg have been system atically investigated. Calculations can in general reproduce experimental data, noticing the fact that the preformation factor P of alpha particle in alpha-decaying nuclei is of order from 100 to 10?2. This can be the evidence for the α+20Ne structure in 24Mg. Meanwhile, the results also show the existence of other configurations, such as 16O+2α. Since the calculated decay widths are very sensitive to the angular momentum carried by the outgoing cluster (α particle), our results could serve as a guide to experimental spin assignments.

关键词： alpha decay cluster structure cluster model 24Mg

A higher-order porous thermoelastic problem with microtemperatures

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Applied Mathematics and Mechanics(English Edition) 2023年第11期44卷 1911-1926页

作者： j.r.FErNáNDEZ r.QUINTANILLA Department of Applied Mathematics I University of VigoETSI de Telecomunicacion Campus As Lagoas Marcosende s/nVigo 36310Spain Department of Mathematics Polytechnical University of CatalunyaTerrassa 08222BarcelonaSpain

In this paper,we study a porous thermoelastic problem with microtemperatures assuming parabolic higher order in time derivatives for the thermal *** model is derived and written as a coupled linear ***,a uniqueness result is proved by using the logarithmic convexity method in the case that we do not assume that the mechanical energy is positive ***,the existence of the solution is obtained by introducing an energy function and applying the theory of linear semigroups.

关键词： higher order thermoelasticity microtemperature logarithmic convexity method existence and uniqueness

General aspects on structural integrity

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Chinese journal of Aeronautics 2019年第1期32卷 114-132页

作者： j.j.XIONG r.A.SHENOI School of Transportation Science and Engineering Beihang University Faculty of Engineering and Environment University of Southampton

This paper seeks to mark the fruitful collaborative research between scholars in the University of Southampton and Beihang University for last 25 years on structural integrity. Their efforts addressed some important issues in structural integrity such as fatigue and fracture behavior,fatigue load spectra, fatigue and fracture lifetimes, reliability-based service period, adhesively bonded composite patch repairs, Plain Woven Fabric(PWF) composites and composite *** advances in engineering approaches, experimental methods, numerical algorithms and understanding of failure mechanisms relating to structural integrity are highlighted. Probable limits(or drawbacks) are also discussed. This review provides an insight into the general aspects on structural integrity and constitutes a basis for pointers to the further works on structural integrity.

关键词： Composites Fatigue Fracture reliability repair Structural integrity