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Establishment, Growth kinetics, and Susceptibility to AcMNPV of Heat Tolerant Lepidopteran Cell Lines

Virologica Sinica 2011年第3期26卷 198-205页

作者： Yan-lei WU Lei Jiang Yoshifumi hashimoto robert r. Granados Guo-xun Li The Center for Advanced Invertebrate Cell Engineering Collaboration with BTI USA Qingdao AgriculturalUniversity Qingdao 266109 China＇~ Boyce Thompson Institute for Plant research at Cornell University Ithaca NY 14853 USAJ

Lepidopteran heat-tolerant (ht) cell lines have been obtained with sf-9, sf-21 and several Bombyx cells. They have a distinct karyotype, membrane lipid composition, morphology and growth kinetics from the parental cell lines. In this paper, we report the development of ht cell lines from other insect species and examination of their growth characteristics and virus susceptibility. Adaptation of cell lines sf-9, BTI-TN-5B1-4 (High5) and BTI-TN-MG1 (MG1) to 33℃ and 35℃ was carried out by shifting the culture temperature between 28℃ and higher temperatures by a gradual stepwise increase in temperature. The process of adaption to a higher culture temperature was accomplished over a period of 2 months. The cell lines with the temperature adaption were designated as sf9-ht33, sf9-ht35, High5-ht33, High5-ht35, MG1-ht33, MG1-ht35. These cell lines have been subcultured over 70 passages. Adaption to high temperatures was confirmed by a constant population doubling time with individual cell lines. The population doubling time of heat adapted cell lines were 1-4 h less than these of parental cell lines. Cell shapes did not show obvious change, however, the cell size of sf9-ht cells was enlarged and those of High5 and MG1 ht cells were reduced after heat adaption. When the cell lines were infected with Autographa californica nuclear polyhedrosis virus (AcMNPV) at 28℃, 33℃, 35℃ and 37℃, production of budded virus and occlusion bodies in each cell line was optimum at its own adapted temperature.

关键词： AcMNPV 生长动力学细胞株鳞翅目耐热核型多角体病毒敏感性培养温度

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Original single-incision laparoscopic cholecystectomy for acute inflammation of the gallbladder

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World Journal of Gastroenterology 2012年第9期18卷 944-951页

作者： Kazunari Sasaki Goro Watanabe Masamichi Matsuda Masaji hashimoto Department of Digestive Surgery Hepato Pancreato Biliary Surgery UnitToranomon Hospital

AIM:To investigate the safety and feasibility of our original single-incision laparoscopic cholecystectomy (SILC) for acute inflamed gallbladder (AIG).METHODS:One hundred and ten consecutive patients underwent original SILC for gallbladder disease without any selection criteria and 15 and 11 of these were diagnosed with acute cholecystitis and acute gallstone cholangitis,respectively.A retrospective review was performed not only between SILC for AIG and non-AIG,but also between SILC for AIG and traditional laparoscopic cholecystectomy (TLC) for AIG in the same ***:Comparison between SILC for AIG and nonAIG revealed that the operative time was longer in SILC for AIG (97.5min vs 85.0min,P=0.03).The open conversion rate (2/26 vs 2/84,P=0.24) and complication rate (1/26 vs 3/84,P=1.00) showed no differences,but a need for additional trocars was more frequent in SILC for AIG (5/24 vs 3/82,P=0.01).Comparison between SILC for AIG and TLC for AIG revealed no differences based on statistical ***:Our original SILC technique was ade-quately safe and feasible for the treatment of acute cholecystitis and acute gallstone cholangitis.

关键词：急性炎症腹腔镜胆囊切口切除术安全性

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Comparison of luminescent properties of helicene-like bibenzothiophenes with o-carborane and 5,6-dicarba-nidodecaborane

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Science China Chemistry 2018年第8期61卷 940-946页

作者： Kenta Nishino Kazushi hashimoto Kazuo Tanaka Yasuhiro Morisaki Yoshiki Chujo Department of Polymer Chemistry Graduate School of Engineering Kyoto University Department of Applied Chemistry for Environment School of Science and Technology Kwansei Gakuin University

This article describes comparison of the anchoring effect on electronic properties of the helicene-like bibenzothiophene between o-carborane and 5,6-dicarba-nido-decaborane. The o-carborane and nido-decaborane-fused bibenzothiophenes were simultaneously obtained in the same reaction and successfully isolated. Initially, the X-ray single crystal analysis revealed that the helicene-like distorted structure was realized in the nido-decaborane-fused bibenzothiophene. From optical measurements in the solution state, distinct different characteristics depending on the type of anchors were observed. It was summarized that the absorption and luminescent properties originated from weak π-conjugation at the bibenzothiophene moiety in the o-carboranefused compound were obtained, whereas robust π-conjugation and significant emission from the intramolecular charge transfer state were detected from the nido-decaborane-fused compound. These data can be explained by the theoretical results that π-conjugation was restrictedly developed within the bibenzothiophene moiety in frontier orbitals of the o-carborane-fused compound. In contrast, π-conjugation can be constructed even through the distorted bibenzothiophene because of the nido-decaborane unit. Moreover, the intramolecular charge transfer state should be realized because of electronic interaction involving the nido-decaborane unit in the excited state. Furthermore, it was demonstrated that the nido-decaborane-fused compound possessed solid-state emission and mechanochromic luminescent properties. The π-conjugation on the distorted structure supported by the nido-decaborane anchor should play a significant role in suppressing aggregation-caused quenching followed by presenting solid-state emission with stimuli responsiveness.

关键词：光性质硼碳电子相互作用混合物电子性质状态抛锚

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Extended criteria donors in liver transplantation—from marginality to mainstream

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Hepatobiliary Surgery and Nutrition 2018年第5期7卷 386-388页

作者： Amit Nair Koji hashimoto Department of General Surgery Digestive Disease and Surgery Institute Cleveland Clinic Cleveland OH USA

Further to refinements in immunosuppression and the significant gains witnessed in outcomes over recent decades, liver transplantation has firmly established itself as the definitive treatment for end stage liver disease and selected instances of hepatic malignancy. However, there exists a constant divide between organ supply and demand, with the numbers of new entrants to liver transplant waiting lists consistently and significantly outstripping that of transplants performed annually, as exemplified by United Network for Organ Sharing (UNOS) data from the United States (1).

关键词： annually stripping lists

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LATTICE QUANTUM CHrOMODYNAMICS

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Chinese Physics C 2016年第10期40卷 310-320页

作者： S. hashimoto J. Laiho S.r. Sharpe KEK Syracuse University University of Washington

Many physical processes considered in the review of Particle Properties （rPP） involve hadrons. The properties of hadrons--which are composed of quarks and gluons--are governed primarily by Quantum Chromodynamics （QCD）（with small corrections from Quantum Electrodynamics [QED]）. Theoretical calculations of these properties require non-perturbative methods, and Lattice Quantum Chromodynamics （LQCD） is a tool to carry out such calculations. It has been successfully applied to many properties of hadrons. Most important for the rPP are the calculation of electroweak form factors, which are needed to extract Cabbibo-Kobayashi-Maskawa （CKM） matrix elements when combined with the corresponding experimental measurements. LQCD has also been used to determine other fundamental parameters of the standard model, in particular the strong coupling constant and quark masses. This review describes the theoretical foundations of LQCD and sketches the methods used to calculate the quantities relevant for the rPP. It also describes the various sources of error that must be controlled in a LQCD calculation. results for hadronic quantities are given in the corresponding dedicated reviews.

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relationships among alcoholic liver disease,antioxidants,and antioxidant enzymes

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World Journal of Gastroenterology 2016年第1期22卷 37-49页

作者： Kyu-Ho Han Naoto hashimoto Michihiro Fukushima Department of Food Science Obihiro University of Agriculture and Veterinary MedicineInadaObihiroHokkaido 080-8555Japan Upland Farming resource research Division NARO Hokkaido Agricultural Research CenterKasaiHokkaido 082-0071Japan

Excessive consumption of alcoholic beverages is a serious cause of liver disease *** metabolism of ethanol generates reactive oxygen species,which play a significant role in the deterio-ration of alcoholic liver disease(ALD).Antioxidant phytochemicals,such as polyphenols,regulate the expression of ALD-associated proteins and peptides,namely,catalase,superoxide dismutase,glutathione,glutathione peroxidase,and glutathione *** plant antioxidants have electrophilic activity and may induce antioxidant enzymes via the Kelch-like ECH-associated protein 1--NF--E2--related factor--2 pathway and antioxidant responsive ***,these antioxidants are reported to alleviate cell injury caused by oxidants or inflammatory *** phenomena are likely induced via the regulation of mitogen--activating protein kinase(MAPK)pathways by plant antioxidants,similar to preconditioning in ischemia-reperfusion *** the relationship between plant antioxidants and ALD has not been adequately investigated,plant antioxidants may be preventive for ALD because of their electrophilic and regulatory activities in the MAPK pathway.

关键词： Electrophile Mitogen-activating proteinkinase Plant antioxidants reactive oxygen species Preconditioning

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Generating and Focusing of Underwater Expansion Wave using a Silicon resin reflector

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Journal of Thermal Science 2013年第3期22卷 209-215页

作者： Takafumi Nakabaru Tokitada hashimoto Shigeru Matsuo Toshiaki Setoguchi G.rajesh Graduate School of Science and Engineering Saga University Department of Advanced Technology Fusion Graduate School of Science and Engineering Saga University Institute of Ocean Energy Saga University Keimyung University

In the present study, an ellipsoid reflector was designed and produced using silicon resin in order to generate and focus expansion wave in water for the purpose of a medical application. Across an expansion wave the static pressure, temperature and density decrease, as a result, negative pressure is given behind the expansion wave generated in the water, and then a tensile stress is induced. As an acoustic impedance of the silicon resin is almost similar to that of water, the interface of air-silicon resin would be regarded as the same with that of the air-water. A high voltage discharge was used as an energy source of underwater shock wave. When the underwater shock wave reflects on this interface, it is already clear that the shock wave converts to the expansion wave. The generation and focusing of the expansion wave were carried out and the phenomena were observed by flow visualization using a high-speed camera.

关键词： medical application, under water expansion wave, focusing technique, acoustic impedance

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Control of Transonic Flow Fields Using Local Occurrence of Non-Equilibrium Condensation

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Journal of Thermal Science 2013年第4期22卷 327-332页

作者： Junji Nagao Shigeru Matsuo Tokitada hashimoto Toshiaki Setoguchi Heuy Dong Kim Department of Advanced Technology Fusion Saga University Institute of Ocean Energy Saga University School of Mechanical Engineering Andong National University

Control of supersonic flow fields with shock wave is important for some industrial fields. There are many studies for control of the supersonic flow fields using active or passive control. When non-equilibrium condensation occurs in a supersonic flow field, the flow is affected by latent heat released. Many studies for the condensation have been conducted and the characteristics have been almost clarified. Further, it was found that non-equilibrium condensation can control the flow field. In these studies, the condensation occurs across the passage of the flow field and it causes the total pressure loss in the flow field. However, local occurrence of non-equilibrium condensation in the flow field may change the characteristics of total pressure loss compared with that by the condensation across the passage of the nozzle and there are few for researches of locally occurred non-equilibrium condensation in supersonic flow field. The purpose in the present study is to clarify the effect of local occurrence of non-equilibrium condensation on the transonic flow field in a nozzle with a circular bump. As a result, local occurrence of non-equilibrium condensation reduced the shock strength and total pressure loss in the transonic flow field by flowing the moist air from trailing edge of the circular bump to the mainstream.

关键词：跨声速流场水汽凝结被动控制非平衡超音速流场总压损失跨音速流场工业领域

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Stable Vertical Ladder Climbing with rung recognition for a Four-limbed robot

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Journal of Bionic Engineering 2021年第4期18卷 786-798页

作者： Xiao Sun Kenji hashimoto Shota Hayashi Masahiro Okawara Takashi Mastuzawa Atsuo Takanishi Department of Mechatronics University of YamanashiYamanashiKofu400-8511Japan Department of Mechanical Engineering Informatics Meiji UniversityTokyo214-8571Japan Faculty of Science and Engineering Waseda UniversityTokyo162-8480Japan

This paper proposes a system for stable ladder climbing of the human-sized four-limbed robot“WArEC-1”,including the following 3 components:(a)Whole-body motion planning;(b)rung recognition system and(c)reaction force *** 3 components guarantee appropriate ladder climbing motion,successful rung grub and proper reaction force distribution at contact points throughout the climbing motion,*** this system,(1)Stable ladder climbing in 2-point contact gait by a human-sized robot and(2)Successful and stable climbing of an irregular ladder(with a higher or inclined rung)in both 3-point and 2-point contact gait with the capability of recognizing the target rung and the corresponding motion planning are realized,which have rarely been realized by former ***,experiment results and data of the robot ladder climbing are also presented to evaluate the proposed system.

关键词： legged robot ladder climbing stability proximity sensor feedback force control

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On the Eve of Upgrading Antidepressants:(r)-Ketamine and Its Metabolites

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Neuroscience Bulletin 2016年第6期32卷 565-568页

作者： Kai Yuan Ying Han Kenji hashimoto Lin Lu Institute of Mental Health National Clinical Research Center for Mental DisordersKey Laboratory of Mental Health and Peking University Sixth HospitalPeking University Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain research Peking University National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking University Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health

Ketamine is a noncompetitive N-methyl-D-aspartate receptor （NMDAr） antagonist that has attracted wide- spread attention for its rapid-onset antidepressant effects, especially in individuals with treatment-resistant depres- sion and suicidal ideation [1-3]. Compared with the tra- ditional antidepressants that take weeks, if not months, to benefit patients and are associated with a high rate of relapse, ketamine exerts its antidepressant effects within several hours. These clinical benefits can last for 2 weeks after a single injection [1, 2, 4]. However, ketamine still has limited clinical application, psychotomimetic side-effects and liability of abuse. A recent paper in Nature [5] showed that the ketamine metabolite enantiomer （2r,6r）-hydroxynorketamine （HNK） has rapid and sustained antidepressant effects without the side-effects associated with ketamine, such as abuse potential. The discovery of （r）-ketamine is a land- mark in the field of depression. Investigations of its mechanism of action will inspire the development of a new

关键词： NMDAr Ketamine and Its Metabolites On the Eve of Upgrading Antidepressants

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