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Dietary carbohydrate-to-protein ratio influences growth performance,hepatic health and dynamic of gut microbiota in atlantic salmon(Salmo salar)

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Animal Nutrition 2022年第3期10卷 261-279页

作者： Alejandro Villasante Carolina ramírez hector rodríguez Patricio Dantagnan Adrian hernandez Elías Figueroa Jaime romero Facultad de Medicina Veterinaria y Agronomía Universidad de Las AmericasSantiagoChile Laboratorio de Biotecnología de Alimentos Unidad de AlimentosInstituto de Nutricion y Tecnología de Los Alimentos(INTA)Universidad de ChileSantiagoChile Programa de Anatomía y Biología Del Desarrollo Facultad de MedicinaUniversidad de ChileSantiagoChile Núcleo de Investigacion en Produccion Alimentaria Facultad de Recursos NaturalesUniversidad Catolica de TemucoTemucoChile

Atlantic salmon(Salmo salar)fed a carbohydrate-rich diet exhibit suboptimal growth performance,along with other metabolic *** is well known that gut microbes play a pivotal role in influencing metabolism of the host,and these microbes can be modified by the *** main goal of the present study was to determine the effect of feeding graded levels of digestible carbohydrates to Atlantic salmon on the distal intestine digesta microbiota at 3 sampling times(i.e.,weeks 4,8 and 12),during a 12-week trial.A low carbohydrate-to-high protein diet(LC/hP,0%wheat starch),a medium carbohydrate-tomedium protein diet(MC/mp,15%wheat starch)or a high carbohydrate-to-low protein diet(hC/LP,30%wheat starch)was fed to triplicate fish tanks(27 to 28 fish per tank).We performed an in-depth characterization of the distal intestine digesta ***,growth parameters,liver histology and the expression of genes involved in hepatic neolipogenesis in fish were *** fed a hC/LP diet showed greater hepatosomatic and viscerosomatic indexes(P=0.026 and P=0.018,respectively),lower final weight(P=0.005),weight gain(P=0.003),feed efficiency(P=0.033)and growth rate(P=0.003)compared with fish fed the LC/hP ***,feeding salmon a high digestible carbohydrate diet caused greater lipid vacuolization,steatosis index(P=0.007)and expression of fatty acid synthase(fas)and delta-6 fatty acyl desaturase(d6fad)(P=0.001 and P=0.001,respectively)in the liver compared with fish fed the LC/hP ***,the major impact of feeding a carbohydrate-rich diet to Atlantic salmon in beta diversity of distal intestine digesta microbiota was observed at week 4(hC/LP vs MC/mp and hC/LP vs LC/hP;P=0.007 and P=0.008,respectively)and week 8(hC/LP vs MC/mp;P=0.04),no differences between experimental groups were detected after 12 weeks of ***,at the end of the trial,there was a negative correlation between lactic acid bacteria(LAB)members,including Leuconostoc and Lactobacil

关键词： Microbiota Microbiome Atlantic salmon Steatosis Lactic acid bacteria Probiotics

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Anatomic measures of upper airway structures in obstructive sleep apnea

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World Journal of otorhinolaryngology-head and Neck Surgery 2017年第2期3卷 85-91页

作者： Jose E.Barrera Candace Y.Pau Veronique-lsabelle Forest Andrew B.holbrook Gerald r.Popelka Division of Sleep Surgery Department of Otolaryngology Stanford University USA

objective:Determine if anatomic dimensions of airway structures are associated with airway obstruction in obstructive sleep apnea (oSA) ***:Twenty-eight subjects with (n =14) and without (n =14) oSA as determined by clinical symptoms and sleep studies;volunteer *** and soft tissue dimensions were measured from radiocephalometry and magnetic resonance *** soft palate thickness,mandibular plane-hyoid (mp-h) distance,posterior airway space (PAS) diameters and area,and tongue volume were ***:Compared to controls,the oSA group demonstrated a significantly longer mp-h distance (P =0.009) and shorter nasal PAS diameter (P =0.02).The PAS area was smaller (P =0.002) and tongue volume larger in the oSA group (P =0.004).The mp-h distance,PAS measurements,and tongue volume are of clinical relevance in oSA ***:A long mp-h distance,and small PAS diameters and area are significant anatomic measures in oSA;however the most substantial parameter found was a large tongue volume.

关键词： obstructive sleep apnea Anatomy Anatomic measurement Posterior airway space Tongue volume hyoid position

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四川盆地北部上三叠统须家河组高成熟煤系烃源岩芳烃热演化与应用

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中国科学：地球科学 2015年第11期45卷 953-962页

作者：李颖朱扬明郝芳邹华耀郭彤楼浙江大学地球科学系杭州310027 中国地质大学资源学院武汉430074 中国石油大学地球科学学院北京102249 中国石化勘探南方分公司成都610000

基于40余个芳烃组分的GC-MS及相关分析资料，阐明了四川盆地北部上三叠统须家河组煤系烃源岩在成熟晚期到过成熟阶段（ro=1．13％-2．85％）芳烃组成的热演化特征，并剖析了适用于高一过成熟烃源岩有机质生源和沉积环境判识的芳烃指标... 详细信息

基于40余个芳烃组分的GC-MS及相关分析资料，阐明了四川盆地北部上三叠统须家河组煤系烃源岩在成熟晚期到过成熟阶段（ro=1．13％-2．85％）芳烃组成的热演化特征，并剖析了适用于高一过成熟烃源岩有机质生源和沉积环境判识的芳烃指标．研究结果表明，在高热演化阶段这些烃源岩中低碳环数的萘及菲系列随成熟度增高而减少，而苊、苯并萤葸、苯并[e]芘等高碳环数化合物逐渐相对富集，且母体化合物趋于增多，是高地温条件下的裂解和持续的脱氢作用所引起的聚合反应所致．它们的mpI-值随成熟度（r。）呈两段式线性变化趋势，在ro〈1．80％时随之升高，ro〉1．8％时降低，两者的关系式分别为ro=0．98mp11＋0．37和ro=-0．90mpI1＋3．02，不同于前人的结果．当ro值高于1．1％时二苯并呋喃类化合物开始急剧减少，导致芳烃三芴系列组成发生显著变化，因而不适用于高一过成熟煤系烃源岩的沉积环境识别,4-／1-MDBT比值可作为反映有机相变化的有效指标，能区分高成熟煤与泥岩．2,6-／2，10-Dmp，1,7-／1，9-Dmp比值和三芳甾烷丰度可作为高演化烃源岩的有机质生物源参数，能指示陆源输入与水生生物贡献的大小．

关键词：高成熟烃源岩芳烃甲基菲指数三芴系列须家河组四川盆地

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Interactions of Li, Ca, and Al with aromatic carbon materials: an ab initio study

Interactions of Li, Ca, and Al with aromatic carbon material...

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中国化学会第九届全国量子化学学术会议

作者： Y. L. Zhao Institute of Material Science and Engineering, ocean University of China, Qingdao, 266003, P. r. China

＜正＞The interactions of benzene （C6h6）, naphthalene （C10h8）, and perinaphthene （C13h9） with metal atoms （Li, Ca, and Al） were studied using second-order Mφller-Plesset perturbation （mp2） theory. By analyzing the frontier molecular orbitals, geometric structures, binding energies, and charge transfers, it was found that these metal atoms can bond strongly with C13h9, but can only bond weakly with C6h6 and C10h8. The bonding nature between a metal atom and C13h9 at their ground

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人参总皂甙对人血细胞生成的研究

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浙江中医学院学报 1998年第6期22卷 37-38页

作者：高瑞兰金锦梅 B.h.Chong 浙江中医学院附属医院杭州310006 澳大利亚新南威尔士大学血栓与血管研究中心

从人参中提取有效成份人参总皂甙（TSPG），测定它对人骨髓粒单系祖细胞（CFU-GM），红系祖细胞（CFU-E，BFU—E）和多向祖细胞（CFU—GEMM）的刺激增殖作用。结果显示：在培养中加入不同浓度的TSPG5，25，50，75，100mg／L，可促进造... 详细信息

从人参中提取有效成份人参总皂甙（TSPG），测定它对人骨髓粒单系祖细胞（CFU-GM），红系祖细胞（CFU-E，BFU—E）和多向祖细胞（CFU—GEMM）的刺激增殖作用。结果显示：在培养中加入不同浓度的TSPG5，25，50，75，100mg／L，可促进造血祖细胞增殖，在体外形成集落。在TSPGS～75mg／L时，CFU—GM集落产率均明显高于不加TSPG的对照组（P均＜0．01）；同样浓度的TSPG也能增加BFU—E和CFU—EI落产率（P＜0．01）。在CFU—GEMM培养中，5～75mp／L浓度的TSPG4集落产率明显高于对照组（P＜0．01）。提示TSPG是一个能促进红系细胞、粒系细胞和巨核系细胞三系造血祖细胞增殖的有效成份，其作用可能通过增加造血生长因子活性，或与生长因子起协同作用而促进造血。虽然TSPG来源于植物，不同于蛋白质生长因子，但它显示出类生长因子的作用。

关键词：人参总皂甙造血祖细胞细胞增殖 CFU-GM

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法国立体定向脑电图指南

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癫痫杂志 2018年第4期4卷 354-361页

作者： Isnard J Taussig D Bartolomei F Bourdillon P Catenoix h Chassoux F Chipaux M Clémenceau S Colnat-Coulbois S Denuelle M Derrey S Devaux B Dorfmüller G Gilard V Guenot M Job-Chapron AS LandréE Lebas A Maillard L McGonigal A Minotti L Montavont A Navarro V Nica A reyns N Scholly J Sol JC Szurhaj W Trebuchon A Tyvaert L Valenti-hirsch mp Valton L Vignal JP Sauleau P 龙绮婷张翠荣尚力张玮刘兴洲

立体定向脑电图(SEEG)在上世纪60年代诞生于法国,由***和***共同发明。SEEG为一种介入方法,可用于耐药性局灶癫痫,对癫痫放电在三维空间内进行实时记录,为"解剖-电关联分析"及精确外科切除提供客观依据。尽管这种方法被部分欧洲癫痫中... 详细信息

立体定向脑电图(SEEG)在上世纪60年代诞生于法国,由***和***共同发明。SEEG为一种介入方法,可用于耐药性局灶癫痫,对癫痫放电在三维空间内进行实时记录,为"解剖-电关联分析"及精确外科切除提供客观依据。尽管这种方法被部分欧洲癫痫中心专家沿用长达数十年,然而,仅在近十年来才在世界范围内逐渐推广应用。在当代医疗实践中,SEEG不仅为诊断方法,也被用于治疗,如射频热凝治疗等。为达到临床上更加合理应用SEEG的目的,我们认为需要有正式指南,为此成立了特别工作组,由全法国各地大型癫痫中心(过去连续5年中每年完成SEEG超过10例)专家组成。先由工作组会议形成初步建议,然后由全体专家依据已有方法学对其进行评分。指南第一部分包括下列主题内形成框架建议:SEEG适应证与局限性;SEEG计划与实施;外科技术;电生理操作技术;SEEG解读;SEEG引导下射频热凝。指南的第二部分,由各个专家小组基于现有文献以及他们个人经验对这些议题的具体内容进一步详述。这项工作旨在向应用SEEG的癫痫中心提供了解法国专家共识的机会,尤其是那些正处在起步阶段的癫痫中心,可以作为参考蓝本。该指南的编写得到法国临床神经生理学会、国际抗癫痫联盟法国分支机构的支持。

关键词：成年人儿童耐药癫痫癫痫外科局灶癫痫指南介入检查立体定向脑电图热凝

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Identification and Evolutionary Aanlysis of Agouti gene Intron 2 in mink(Neovison vison)

Identification and Evolutionary Aanlysis of Agouti gene Intr...

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中国毛皮动物科学研究进展——2014年全国毛皮动物专业学术研讨会

作者： X.C.Song C.Xu Z.G.Yue L.Wang B.Cong L.L.Liu F.h.Yang State Key Laboratory of Special Economic Animal Molecular Biology Institute of Special Animal and Plant SciencesChinese Academy of Agricultural Sciences

Agouti gene plays a critical role in the synthesis and distribution of coat color in domestic *** order to investigate the sequence structure characteristics of(Neovison vison)Agouti gene and it’s mechanism to regulate the pelage color for fur animals,in the present study,the complete intron 2 nucleotide sequence of Agouti gene from the American shorthaired black mink was obtained by PCr amplification and clone *** results showed that the obtained Agouti gene of black mink was 1335 bp in length,including complete intron 2(1256 bp),partial exon 2(28 bp)and exon 3(51 bp),which had been submitted to the GenBank database and the accession number was *** nucleotide composition for intron 2 sequence was 30.73%(A),28.26%(T),21.66%(C),and 19.35%(G).TheA+T ratio(58.99%)was higher than that of G+C ratio(41.01%).The sequence similarity of Agouti gene intron 2 between American short-haired black mink and coffee mink,red fox,dog,giant panda,domestic cat,horse,pig,alpaca,sheep,goat,cattle and rabbit were 99.8%,84.6%,84.2%,84.9%,82.2%,80.7%,77.3%,77.1%,76.3%,76.4%,75.6%and 71.2%,*** result of homology analysis showed that the genetic relationship between black mink and coffee mink was the highest,which was consistent with that they all belong to Mustela of the Mustelida animals in tranditional *** on the sequence of Agouti gene intron 2,three phylogenetic trees were constructed for mink and other 11 species using Clustal X 1.83and MEGA 5.0 software by means of NJ,UPGMA and mp method,*** analysis revealed that black mink and coffee mink were sisters in their own clade,which was basically consistent with the taxonomy in the NationalCenter for Biotechnology *** above these findings would provide certain important biological informations to some extent for exploring the formation mechanism of different pelage colors and artificially cultivating a new coat color breed of mink.

关键词： Neovison vison Agouti gene similarity analysis phylogenetic evolution

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Nonlocal Probing of Amplitude Mode Dynamics in Charge-Density-Wave Phase of EuTe4

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Ultrafast Science 2023年第6期3卷 25-37页

作者： ranjana rathore himanshu Singhal Vivek Dwij Mayanak K Gupta Abhishek Pathak juzer Ali Chakera ranjan Mittal Aditya Prasad roy Arun Babu ruta Kulkarni A Thamizhavel Ayman h Said Dipanshu Bansal Laser Plasma Division Raja Ramanna Centre for Advanced TechnologyIndoreMP 452013India homi Bhabha National Institute Training School ComplexAnushaktinagarMumbaiMH 400094India Department of Mechanical Engineering Indian Institute of Technology BombayMumbaiMH 400076India Department of Condensed Matter Physics&Materials Science Tata Institute of Fundamental ResearchMumbaiMH 400005India Solid State Physics Division Bhabha Atomic Research CentreMumbaiMH 400085India Advanced Photon Source Argonne National Laboratory9700 South Cass AvenueLemontIL 60439USA Center for research in Nano Technology and Science Indian Institute of Technology BombayMumbaiMH 400076India

Amplitude mode is collective excitation emerging from frozen lattice distortions below the charge-density-wave(CDW)transition temperature TCDW and relates to the order ***,the amplitude mode is non-polar(symmetry-even)and does not interact with incoming infrared ***,if the amplitude mode is polar(symmetry-odd),it can potentially couple with incoming photons,thus forming a coupled phonon-polariton quasiparticle that can travel with light-like speed beyond the optically excited ***,we present the amplitude mode dynamics far beyond the optically excited depth of ∼150 nm in the CDW phase of ∼10-μm-thick single-crystal EuTe4 using time-resolved x-ray *** observed oscillations of the CDW peak,triggered by photoexcitation,occur at the amplitude mode frequency ω***,the underdamped oscillations and their propagation beyond the optically excited depth are at odds with the observation of the overdamped nature of the amplitude mode measured using meV-resolution inelastic x-ray scattering and polarized raman *** ωAM is found to decrease with increasing fluence owing to a rise in the sample temperature,which is independently confirmed using polarized raman scattering and ab-initio molecular dynamics *** rationalize the above observations by explicitly calculating two coupled quasiparticles—phonon-polariton and *** data and simulations cannot conclusively confirm or rule out the one but point toward the likely origin from propagating *** observed non-local behavior of amplitude mode thus provides an opportunity to engineer material properties at a substantially faster time scale with optical pulses.

关键词： excited phonon excitation

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应用组织芯片技术研究细胞凋亡、EB病毒在经典型hodgkin淋巴瘤中的表达

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白血病．淋巴瘤 2003年第6期12卷 357-359页

作者：王晋芬郗彦凤王平刘冬梅 Taylor C r 山西省肿瘤医院山西太原030013 Department of Pathology Keck School of MedicineUniversity of Southern Cali-forniaUS

目的 :探讨细胞凋亡和 EB病毒与经典型 hodgkin淋巴瘤的相关关系。方法 :应用组织芯片、免疫组化和原位杂交双标记技术检测 p5 3、bcl- 2、细胞凋亡、L mp- 1、EBEr在 6 2例经典型hodgkin淋巴瘤中的表达。结果 :6 2例经典型 hodgkin淋... 详细信息

目的 :探讨细胞凋亡和 EB病毒与经典型 hodgkin淋巴瘤的相关关系。方法 :应用组织芯片、免疫组化和原位杂交双标记技术检测 p5 3、bcl- 2、细胞凋亡、L mp- 1、EBEr在 6 2例经典型hodgkin淋巴瘤中的表达。结果 :6 2例经典型 hodgkin淋巴瘤中 1 4例表达 p5 3,35例表达 bcl- 2 ,37例EB病毒阳性 ;6 2例背景非肿瘤细胞均有细胞凋亡 ,而在 h- rS细胞仅有 1 0例凋亡 ;h- rS细胞表达bcl- 2与细胞凋亡呈负相关性 (P0 .0 5 )。结论 :细胞凋亡可能在经典型 hodgkin淋巴瘤的生长与浸润方面起着重要作用 ,经典型 hodgkin淋巴瘤属 EB病毒相关性 ,但它的作用机制尚不清楚。 CD30 结合其他抗体或探针双标记方法可以有针对性地对 h -

关键词：细胞凋亡 EB病毒组织芯片淋巴瘤肿瘤

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A New optimization Neural Network for high resolution Time-Frequency Analysis

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电路与系统学报 1997年第1期 1-7页

作者： Z.S. Wang,Y.S.Xia,J.D.Z. Chen,W.h.Li,Z.Y.he,(Dept. of radio Engineering, Southeast University, Nanjing, 210096)(Dept. of Mathematics,Nanjing University of Posts & Telecommunications)(Institute for healthcare researc, Baptist Medical Center, oklahoma City,

The authors present a new optimization neural network, which can be called as constrained smallest l1-norm neural network (CSl1NN), to implement the Basis Pursuit(BP)[1][2][3]for high resolution time-frequency analysis. As the new and generalized one of the communities of overcomplete signal representations, the BP is considered as a large-scale linear programming problem. In contrast with the Simplex-BP or Interior-BP in [2],the proposed CSl1NN-BP dose not double the optimizing scale and can be implemented in real time through hardware. Taking non-stationary artificial signals and Electrogastrograms (EGGs) to test, our simulations show that the CSl1 NN presents an excellent convergence performance for a wide range of time-frequency(TF)dictionaries and has a higher joint TF resolution not only than the traditional Wigner Distribution (WD), but also than recently rising other overcomplete representation methods, such as Method of Frames (MoF)[9], Best orthogonal Basis (BoB)[10] and Matching Pursuit (mp)[4]. Combining the high resolution with the fast implementation,the CSl1NN-BP will be very promising for on-line time frequency analysis of various kinds of non-stationary signals,such as linear chirp,qUadric chirp,bumps etc., and medical signals,such as ECG,EEGand EGG,etc., with high quality.

关键词： Neural network optimization overcomplete signal representation Basis pursuit Wavelet Time-frequency analysis

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