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Communications in Mathematics and Statistics 2022年第3期10卷 413-434页

作者： M.el-Morshedy M.S.eliwa A.el-Gohary Ehab M.Almetwally r.el-desokey Department of Mathematics College of Science and Humanities in Al-KharjPrince Sattam Bin Abdulaziz UniversityAl-Kharj 11942Saudi Arabia Department of Mathematics Faculty of ScienceMansoura UniversityMansoura 35516Egypt Faculty of Business Administration Delta University of Science and TechnologyMansouraEgypt Faculty of Graduate Studies for Statistical research Cairo UniversityGiza 12613Egypt

In this paper,a new 4-parameter exponentiated generalized inverse flexible Weibull distribution is *** of its statistical properties are *** aim of this paper is to estimate the model parameters via several approaches,namely,maximum likelihood,maximum product spacing and *** to Bayesian approach,several techniques are used to get the Bayesian estimators,namely,standard error function,Linex loss function and entropy loss *** estimation herein is based on complete and censored *** Chain Monte Carlo simulation is used to discuss the behavior of the estimators for each ***,two real data sets are analyzed to obtain the flexibility of the proposed model.

关键词： Weibull distribution Hazard rate function Maximum likelihood estimation Maximum product spacing estimation Bayesian estimation Censored samples Simulation

remote Monitoring of electric Vehicle Charging Stations in Smart Campus Parking Lot

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Journal of Modern Power Systems and Clean Energy 2020年第1期8卷 124-132页

作者： Mohamed A.Ahmed Mohamed r.el-Sharkawy Young-Chon Kim Department of electronic Engineering Universidad Técnica Federico Santa MaríaValparaíso 2390123Chile Department of Communications and electronics Higher Institute of Engineering&TechnologyKing MarriottAlexandria 23713Egypt Department of Automotive and Tractor Engineering Minia UniversityEl-Minia 61111Egypt Department of Computer Engineering Chonbuk National UniversityJeonju 561-756Korea

Smart parking lots are smart places capable of supporting both parking and charging services for.electric vehicles(EVs).In order to manage EV charging,the parking lot local controller(PLLC)requires data exchange with EV charging stations(EVCSs)through communication ***,data losses and communication delays are unavoidable and may significantly degrade the system *** work aims to investigate the underlying communication networks for remote monitoring of EVCSs in a smart campus parking *** communication network consists of two subnetworks:parking area network(PAN)and campus area network(CAN).PAN covers communication among EVs,charging stations and PLLC,while CAN enables dedicated communication between PLLCs and a global controller of the *** one of the major obstacles in EV system is the lack of unified communication architecture to integrate EVCS in the power grid,we develop communication models for the in-vehicle system and EVCSs based on logical node concept of IEC 61850 ***,we implement network models for EVCSs using OPNET *** communication technologies and configurations are considered in modeling and simulations,and end-toend delay is evaluated and discussed.

关键词： Communication network electric vehicle(EV) electric vehicle charging station(EVCS) IEC 61850 OPNET smart parking lot

A Synergistic Multi-Attribute Decision-Making Method for Educational Institutions Evaluation Using Similarity Measures of Possibility Pythagorean Fuzzy Hypersoft Sets

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 501-530页

作者： Khuram Ali Khan Saba Mubeen Ishfaq Atiqe Ur rahman Salwa el-Morsy Department of Mathematics University of SargodhaSargodha40100Pakistan Department of Mathematics University of Management and TechnologyLahore54000Pakistan Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

Due to the numerous variables to take into account as well as the inherent ambiguity and uncertainty,evaluating educational institutions can be *** concept of a possibility Pythagorean fuzzy hypersoft set(pPyFHSS)is more flexible in this regard than other theoretical fuzzy set-like models,even though some attempts have been made in the literature to address such *** study investigates the elementary notions of pPyFHSS including its set-theoretic operations union,intersection,complement,Or-and *** results related to these operations are also modified for ***,the similarity measures between pPyFHSSs are formulated with the assistance of numerical examples and ***,an intelligent decision-assisted mechanism is developed with the proposal of a robust algorithm based on similarity measures for solving multi-attribute decision-making(MADM)problems.A case study that helps the decision-makers assess the best educational institution is discussed to validate the suggested *** algorithmic results are compared with the most pertinent model to evaluate the adaptability of pPyFHSS,as it generalizes the classical possibility fuzzy set-like theoretical ***,while considering significant evaluating factors,the flexibility of pPyFHSS is observed through structural comparison.

关键词： Hypersoft set Pythagorean fuzzy hypersoft set computational complexity multi-attribute decision-making optimization similarity measures uncertainty

Synergistic impacts of rifampicin and doxorubicin against thioacetamide-induced hepatocellular carcinoma in rats

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Liver research 2023年第4期7卷 352-360页

作者： Zahraa r.elshahawy Entsar A.Saad rana r.el-Sadda Chemistry Department Faculty of ScienceDamietta UniversityDamiettaEgypt Gastroenterology Surgical Center Faculty of MedicineMansoura UniversityMansouraEgypt

Background and aims:Combination therapy is a promising new strategy that has been proposed to increase the efficacy of cancer *** aimed to investigate the anti-cancer activity of rifampicin monotherapy and its combination with doxorubicin against hepatocellular carcinoma(HCC).Materials and methods:The in vitro half maximal inhibitory concentration(IC50)and selectivity index(SI)of the drugs under investigation against HepG2 and human lung fibroblast(WI38)cell lines were *** the in vivo experiment,male Sprague-Dawley albino rats were injected with thioacetamide at 200 mg/kg twice a week for 90 days;HCC development was confirmed *** HCC induction,the rats were treated with intraperitoneal doxorubicin,rifampicin,or their combination for 45 or 90 *** sacrifice,the livers were examined *** levels of aminotransferases,albumin,bilirubin,malondialdehyde,superoxide dismutase(SOD),catalase(CAT),total antioxidant capacity(TAC),and nitric oxide were measured by ***,cancer antigen 19-9,tumor necrosis factor-alpha,interleukin-6,Bcl-2-associated X protein,caspase 3,caspase 8,and p53 were estimated using ***:In vitro,the combination of doxorubicin and rifampicin showed the highest SI of *** vivo,among the measured markers,the levels of TAC,CAT,SOD,and p53 decreased(Prest of the measured marker levels increased(Pring rats;after treatment in all groups,all these changes improved toward normal in a time-dependent *** combination of doxorubicin and rifampicin optimized the effects of the two individual drugs and exerted the best antioxidant ***:In general,compared with rifampicin or doxorubicin alone,combination therapy has favorable *** on our results,the combination of rifampicin and doxorubicin might be applicable for HCC chemotherapy.

关键词： Hepatocellular carcinoma(HCC) rifampicin Doxorubicin Bcl-2-associated X protein(Bax) Caspase Protein 53(p53) Thioacetamide

The dual-function of bioactive peptides derived from oyster (Crassostrea gigas) proteins hydrolysates

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Food Science and Human Wellness 2023年第5期12卷 1609-1617页

作者： Dongyang Zhu Zhen Yuan Di Wu Chao Wu Hesham r.el-Seedi Ming Du School of Food Science and Technology National Engineering Research Center of SeafoodDalian Polytechnic UniversityDalian 116034China Pharmacognosy Group Department of Pharmaceutical BiosciencesUppsala UniversityBiomedical CentreUppsala SE 75124Sweden International research Center for Food Nutrition and Safety Jiangsu UniversityZhenjiang 212013China

Oysters(Crassostrea gigas)have a wide range of functionality due to their nutritional and bioactive components. However, the bioactive peptides of oyster proteins are rarely reported, particularly their antidiabetes effects and antioxidants. Oyster proteins were extracted from fresh oysters using phosphatebuffered saline and simulated gastrointestinal digestion was performed. The degree of hydrolysis(DH), structural characterization, molecular weight(Mw)distribution, free amino acid, anti-diabetic activity, and antioxidant activity were studied during in vitro simulated gastrointestinal digestion. The results showed that the α-glucosidase inhibitory activity, α-amylase inhibitory activity, DPPH radical scavenging activity, and ABTS radical scavenging activity of the oyster protein gastrointestinal digest were increased(P rom 0 to 33.96%, from 9.17% to 44.22%, from 9.01 μg trolox/mg protein to 18.48 μg trolox/mg protein, and from 21.44 μg trolox/mg protein to 56.21 μg trolox/mg protein, respectively. Additionally, the DH, β-turn structure, fluorescence intensity, free amino acid, and short peptide content(Mw reased in the simulated gastrointestinal digestion. These results indicate that the digestive hydrolysates obtained from oyster proteins could be used as natural anti-diabetic and antioxidant agents.

关键词： Oyster proteins Simulated gastrointestinal digestion Anti-diabetic activity Antioxidant activity Free amino acid

Synthesis, in vitro antitumor activity and molecular modeling studies of a new series of benzothiazole Schiff bases

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Chinese Chemical Letters 2016年第3期27卷 380-386页

作者： Moustafa T.Gabr Nadia S.el-Gohary Eman r.el-Bendary Mohamed M.el-Kerdawy Nanting Ni Department of Medicinal Chemistry Faculty of Pharmacy Mansoura University Mansoura 35516 Egypt Department of Chemistry Ceorgia State University Atlanta CA 30303 USA

A new series of benzothiazole Schiff bases 3–29 was synthesized and screened for antitumor activity against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. results indicated that compounds 3, 14, 19, 27 and 28 have promising activity against Hela cell line with IC50 values of 2.41,3.06, 6.46, 2.22 and 6.25 mmol/L, respectively, in comparison to doxorubicin as a reference antitumor agent（IC50 2.05 mmol/L）. In addition, compound 3 displayed excellent activity against COS-7 cell line with IC50 value of 4.31 mmol/L in comparison to doxorubicin（IC50 3.04 mmol/L）. In the present work,structure based pharmacophore mapping, molecular docking, protein-ligand interaction, fingerprints and binding energy calculations were employed in a virtual screening strategy to identify the interaction between the compounds and the active site of the putative target, EGFr tyrosine kinase. Molecular properties, toxicity, drug-likeness, and drug score profiles of compounds 3, 14, 19, 27, 28 and 29 were also assessed.

关键词： Benzothiazole Schiff bases Antitumor activity Molecular modeling In silico studies

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural regeneration research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar.el Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel refai Gerald r.rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Solid Waste Management:A MADM Approach Using Fuzzy Parameterized Possibility Single-Valued Neutrosophic Hypersoft Expert Settings

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 531-553页

作者： Tmader Alballa Muhammad Ihsan Atiqe Ur rahman Noorah Ayed Alsorayea Hamiden Abd el-Wahed Khalifa Department of Mathematics College of SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia 2 Department of Mathematics University of Management and TechnologyLahore54000Pakistan Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

The dramatic rise in the number of people living in cities has made many environmental and social problems *** search for a productive method for disposing of solid waste is the most notable of these *** scholars have referred to it as a fuzzy multi-attribute or multi-criteria decision-making problem using various fuzzy set-like approaches because of the inclusion of criteria and anticipated *** goal of the current study is to use an innovative methodology to address the expected uncertainties in the problem of solid waste site *** characteristics(or sub-attributes)that decision-makers select and the degree of approximation they accept for various options can both be indicators of these *** tackle these problems,a novel mathematical structure known as the fuzzy parameterized possibility single valued neutrosophic hypersoft expert set(ρˆ-set),which is initially described,is integrated with a modified version of Sanchez’s *** this,an intelligent algorithm is *** steps of the suggested algorithm are explained with an example that explains *** compatibility of solid waste management sites and systems is discussed,and rankings are established along with detailed justifications for their *** study’s strengths lie in its application of fuzzy parameterization and possibility grading to effectively handle the uncertainties embodied in the parameters’nature and alternative approximations,*** uses specific mathematical formulations to compute the fuzzy parameterized degrees and possibility grades that are missing from the prior *** is simpler for the decisionmakers to look at each option separately because the decision is *** the computed results,it is discovered that they are consistent and dependable because of their preferred properties.

关键词： Hypersoft expert set Sanchez’s method decision making optimization solid waste management possibility grade fuzzy parameterization

Synthesis,antimicrobial, antiquorum-sensing and cytotoxic activities of new series of benzothiazole derivatives

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Chinese Chemical Letters 2015年第12期26卷 1522-1528页

作者： Moustafa T.Gabr Nadia S.el-Gohary Eman r.el-Bendary Mohamed M.el-Kerdawy Nanting Ni Mona I.Shaaban Department of Medicinal Chemistry Faculty of Pharmacy Mansoura University Department of Chemistry Georgia State University Department of Microbiology Faculty of Pharmacy Mansoura University Department of Microbiology College of Pharmacy Taibah University

New series of benzothiazole derivatives were designed and synthesized. The newly synthesized compounds were screened for their antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus cereus. Compounds 6j and 6o showed the highest activity against E. coli and S. aureus. The antifungal activity of these compounds was also tested against Candida albicans and Aspergillus fumigatus293. Compounds 4c, 4g and 6j exhibited the highest activity against C. albicans. In addition, compounds4 a and 6j displayed promising activity against A. fumigatus 293. The same compounds were examined for their antiquorum-sensing activity against Chromobacterium violaceum ATCC 12472, whereas compounds4 a, 6j and 6p showed moderate activity. The in vitro cytotoxicity testing of the synthesized compounds was performed against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. results indicated that all tested compounds have IC50 values 〉50 mmol/L against both cell lines. Molecular properties, toxicities, drug-likeness, and drug score profiles of compounds 4a–c, 5a, 6g,h, 6j, 6l, 6o and7 c,d were also assessed.

关键词： antibacterial moiety antifungal antimicrobial cytotoxic screened moderate substituent Candida albicans

INrA82 extender enhances semen quality in ram under cooled and cryopreserved stages

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Asian pacific Journal of reproduction 2022年第2期11卷 100-104页

作者： Aya M.Fadl elshymaa A.Abdelnaby Hossam r.el-Sherbiny Theriogenology Department Faculty of Veterinary MedicineCairo UniversityEgypt

Objective:To investigate the effect of INrA82 extender on ram semen quality preserved in cooled and frozen conditions in comparison with Tris-based extenders and to select the suitable extender for ram semen ***:Semen samples were collected and pooled from Awassi rams(n=5)and divided into three *** aliquot was diluted with one of the following extenders:(1)Tris-citrate glucose,(2)Triscitrate fructose,and (3)*** liquid storage,diluted samples were kept at 5℃ for 72 *** motility was measured at 0,24,48 and 72 h after ***,viability,morphology,membrane,acrosome and DNA integrities were evaluated at 24 h *** cryopreservation,diluted samples were cooled,equilibrated,loaded and frozen in liquid *** samples were evaluated in the same manner as cooled ***:Seminal characteristics were improved after cooling and thawing in samples diluted with INrA-82 compared to those diluted with Tris-citrate glucose or Tris-citrate fructose(Pram semen with INrA-82 improves semen ***,INrA-82,as a stimulating diluent,can be successfully used to reserve viability and sustainability of cooled and cryopreserved ram semen.

关键词： Cryopreservation Dilution INrA-82 ram Tris-citrate glucose Tris-citrate fructose