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Deadly case of Pasteurella multocida aortitis and mycotic aneurysm following a cat bite

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world Journal of Clinical Cases 2016年第6期4卷 142-145页

作者： Dennis Dane Cho Yaniv Berliner David carr Division of Emergency Medicine Department of Medicine University of Toronto Department of Emergency Medicine University Health Network

Animal bites are frequently encountered in the emergency department(ED). Aortitis leading to mycotic abdominal aortic aneurysm is a rare and potentially deadly complication of Pasteurella multocida(P. multocida) following an animal bite. we present the case of a 68-year-old male who presented to the ED after falling at home. He complained of weakness and abdominal pain. He was in septic shock and was treated empirically with broad-spectrum antibiotics and intravenous fluids. He reported previous antibiotic treatment of a cellulitis secondary to a cat bite injury to his right thumb four weeks prior. Abdominal ultrasound and subsequent computed tomography scan revealed a leaking mycotic abdominal aneurysm that was surgically repaired. Blood cultures and aortic wall tissue cultures grew P. multocida. Given how common animal bite presentations are in the ED, this case highlights the need to consider aortitis and mycotic abdominal aortic aneurysm in an unwell patient with an animal bite.

关键词： Mycotic aneurysm Emergency department Cat bite Pasteurel a multocida Aortitis

Sesamum indicum(sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response

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Asian Pacific Journal of Tropical Biomedicine 2020年第7期10卷 316-324页

作者： Amin FMajdalawieh Jenna F.Farraj ronald I.carr Department of Biology Chemistryand Environmental SciencesFaculty of Arts and SciencesAmerican University of SharjahSharjahP.O.Box 26666United Arab Emirates Department of Microbiology and Immunology Faculty of MedicineSir Charles Tupper Medical BuildingDalhousie UniversityHalifaxNova ScotiaCanada B3H 4R2

Objective:To evaluate the potential immunomodulatory effects of an aqueous extract of Sesamum indicum seeds with regard to splenocyte proliferation,Th1/Th2 balance,macrophage function,and the cytotoxic activity of natural killer(NK)***:Splenocyte proliferation was measured by[~3H]-thymidine *** assay was performed to evaluate the production of nitric oxide by *** levels of cytokines secreted by splenocytes and macrophages were measured by *** assay was performed to examine the cytotoxic activity of NK cells against YAC-1 tumor ***:Sesamum indicum significantly enhanced splenocyte proliferation in a dose-dependent *** indicum also increased and suppressed the secretion of Th1 and Th2 cytokines,respectively,by *** secretion of key pro-inflammatory mediators(IL-6,TNFα,and nitric oxide)by primary macrophages was significantly inhibited by Sesamum ***,Sesamum indicum increased the cytotoxic activity of NK cells against YAC-1 tumor ***:Sesamum indicum shows potent immunomodulatory,anti-inflammatory,and anti-cancer *** of Sesamum indicum may be used as effective therapeutic agents in regulating immune reactions implicated in various infectious and noninfectious conditions including cancer.

关键词： Sesamum indicum Anti-cancer Inflammation Immunomodulation Macrophages NK cells

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural regeneration research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse w.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional rating Scale-revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Geo-vegetation Mapping and Soil Geochemical Characteristics of the Indikolapelessa Serpentinite Outcrop,Southern Sri Lanka

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Journal of Earth Science 2014年第1期25卷 152-168页

作者： Tilak Hewawasam G w A r Fernando Danushka Priyashantha Department of Natural resources Sabaragamuwa University of Sri Lanka Department of Geography University of Peradeniya Department of Physics Open University of Sri Lanka

The serpentinite blocks of Indikolapelessa, located along an identified litho-tectonic boundary between the Highland Complex （HC） and the Vijayan Complex （VC） of Sri Lanka, have undergone extensive lateralization with metal enrichment. Characteristic serpentinite vegetation with some endemic species was recognized in the soils and supergene deposits develop on serpentinite lithology. This type of geological and ecological relationship forms vegetation covers on serpentinite lithologies which are sharply demarcated from the surrounding metamorphic terrains. The aforesaid ＂geo-ecological phenomenon＂ can be used as a tool for geo-vegetation mapping in ultramafic terrains to trace the geological boundaries in landscapes where rock outcrops are virtually absent. we success- fully applied the concept of geo-vegetation mapping in order to demarcate the boundary of underlain serpentinite rocks from surrounding non-serpentinite metamorphic rocks （e.g. granitic gneiss）. The hypothesis was supported by the geochemical variations of soils/supergene deposits found at serpen- tinite and non-serpentinite sites, especially immobile elements and some trace elements. Based on whole rock chemistry and soil chemical data obtained, we suggest that the Indikolapelessa serpentinite outcrop, together with the other four serpentinite outcrops, is more likely to represent the Mg-rich mantle fragments at the time of overthrusting of the two crustal blocks of HC and VC during the Pan- African event.

关键词： serpentinite serpentinite soil geochemistry geo-vegetation ultramafic rock Sri Lanka.

Modeling flow in naturally fractured reservoirs： effect of fracture aperture distribution on dominant sub-network for flow

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Petroleum Science 2017年第1期14卷 138-154页

作者： J. Gong w. r. rossen Department of Geoscience and Engineering Delft University of Technology 2628 CN Delft The Netherlands

Fracture network connectivity and aperture （or conductivity） distribution are two crucial features controlling flow behavior of naturally fractured reservoirs. The effect of connectivity on flow properties is well documented. In this paper, however, we focus here on the influence of fracture aperture distribution. we model a two dimensional fractured reservoir in which the matrix is impermeable and the fractures are well connected. The fractures obey a power-law length distribution, as observed in natural fracture networks. For the aperture distribution, since the information from subsurface fracture networks is limited, we test a number of cases： log-normal distributions （from narrow to broad）, power-law distributions （from narrow to broad）, and one case where the aperture is pro- portional to the fracture length. we find that even a well- connected fracture network can behave like a much sparser network when the aperture distribution is broad enough （c~ 〈 2 for power-law aperture distributions and σ ≥ 0.4 for log-normal aperture distributions）. Specifically, most fractures can be eliminated leaving the remaining dominant sub-network with 90% of the permeability of the original fracture network. we determine how broad the aperture distribution must be to approach this behavior and the dependence of the dominant sub-network on the parameters of the aperture distribution. we also explore whether one can identify the dominant sub-network without doing flow calculations.

关键词： Naturally fractured reservoir Non-uniformflow Effective permeability Percolation waterflood

MECHANISM ANALYSIS OF THICKNESS EFFECT ON MIXED MODE Ⅰ/Ⅱ FrACTUrE OF LC4-CS ALUMINUM ALLOY

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Acta Metallurgica Sinica(English Letters) 2004年第3期17卷 255-262页

作者： H.r. Dong w.L. Guo The State Key Laboratory of Mechanical Structural Strength and Vibration Xi'an Jiaotong UniversityXi'an 710049 China The Engineering Institute Air Force Engineering University Xi'an 710038 ChinaThe State Key Laboratory of Mechanical Structural Strength and Vibration Xi'an Jiaotong UniversityXi'an 710049 China Department of Aircraft Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

Mixed mode Ⅰ/Ⅱ fracture erperiments of LC4-CS aluminum alloy were conductedby using tension--shear specimens with thicknesses of 2, 4, 8 and 14mm. Fracturemechanisms of thickness effect on mixed mode Ⅰ/Ⅱ fracture were first examined fromfracture surface morphology to correlate with the macroscopic fracture behavior andstress state. It is found that specimen thickness has a strong influence on mixed modefracture. As thickness varies from thin to thick the macroscopic fracture surfacesappear the characteristics of plane stress state (2mm, 4mm--thick specimen), three--dimensional stress state (8mm--thick specimens), and plane strain state (14mm--thickspecimens), respectively. The specimens of all kinds of thicknesses are typical of ten-sile type failure under mode Ⅰ loading condition and shear type failure under mode Ⅱloading condition. Two distinct features coexist on the fracture surfaces under mixedmode loading conditions, and the corresponding proportion varies with loading mix-ity. Void--growth processes are the failure mechanism in both predominately tensile-and shears--type fractures. The size and depth of dimples on the fracture surface varygreatly with thickness. Therefore, it is extraordinary necessary to take into accountthe thickness effect when a mixed mode fracture criterion is being established.

关键词： LC4-CS aluminum alloy mixed mode Ⅰ/Ⅱ fracture thickness effect macroscopic fracture appearance SEM

Full noncontact laser ultrasound:first human data

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Light(Science & Applications) 2019年第1期8卷 11-21页

作者： Xiang Zhang Jonathan r.Fincke Charles M.wynn Matt r.Johnson robert w.Haupt Brian w.Anthony Department of Mechanical Engineering Massachusetts Institute of Technology77 Massachusetts Ave.CambridgeMA 02139USA Institute for Medical Engineering&Science Massachusetts Institute of Technology45 Carleton St.CambridgeMA 02142USA Lincoln Laboratory Massachusetts Institute of Technology244 Wood StreetLexingtonMA 02421USA

Full noncontact laser ultrasound(LUS)imaging has several distinct advantages over current medical ultrasound(US)technologies:elimination of the coupling mediums(gel/water),operator-independent image quality,improved repeatability,and volumetric *** light-based ultrasound utilizing tissue-penetrating photoacoustics(PA)generally uses traditional piezoelectric transducers in contact with the imaged tissue or carries an optical fiber detector close to the imaging *** PA,the LUS design presented here minimizes the optical penetration and specifically restricts optical-to-acoustic energy transduction at the tissue surface,maximizing the generated acoustic source *** an appropriate optical design and interferometry,any exposed tissue surfaces can become viable acoustic sources and *** operates analogously to conventional ultrasound but uses light instead of piezoelectric ***,we present full noncontact LUS results,imaging targets at~5 cm depths and at a meterscale standoff from the target *** results demonstrating volumetric imaging and the first LUS images on humans are presented,all at eye-and skin-safe optical exposure *** progression of LUS imaging from tissue-mimicking phantoms,to excised animal tissue,to humans in vivo is shown,with validation from conventional ultrasound *** LUS system design insights and results presented here inspire further LUS development and are a significant step toward the clinical implementation of LUS.

关键词： laser piezoelectric image

Unusual Polarization Properties of Supernova remnant G4.8＋6.2 at 1400MHz

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Chinese Physics Letters 2003年第6期20卷 969-971页

作者： ZHANGXi-Zhen r.G.Strom w.reich NationalAstronomicalObservatories ChineseAcademyofSciencesBeijing100012 AstronomicalInstitute UniversityofAmsterdamNetherlands Max-Planck-Institutfuerradioastronomie Postfach202453010BonnGermany

Unusual polarization properties of the high galactic latitude supernova remnant (SNr) G4.8+6.2 are reported. The percentage polarization is larger than 70% over the two main shells of G4.8+6.2 at 1400 MHz. It is the second SNr with such high polarization at such a low frequency among the known 225 SNrs. we show that this is very unusual for an SNr. Its morphology and polarization are very similar to those of the supernova remnant DA530 (G93.0+6.5), which is another high Galactic latitude SNr.

关键词： Supernova remnants Polarization Galaxies

rapid Identification of rice Samples Using an Electronic Nose

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Journal of Bionic Engineering 2009年第3期6卷 290-297页

作者： John westbrook w.C.Hoffmann r.E.Lacey USDA-ArS College Station Department of Biological and Agricultural Engineering Texas A&M UniversityCollege Station

Four rice samples of long grain type were tested using an electronic nose (Cyranose-320).Samples of 5 g of each variety of rice were placed individually in vials and were analyzed with the electronic nose unit consisting of 32 polymer *** Cyranose-320 was able to differentiate between varieties of *** chemical composition of the rice odors for differentiating rice samples needs to be *** optimum parameter settings should be considered during the Cyranose-320 training process especially for multiple samples,which are helpful for obtaining an accurate training model to improve identification ***,it is necessary to investigate the E-nose sensor selection for obtaining better classification accuracy.A re- duced number of sensors could potentially shorten the data processing time,and could be used to establish an application pro- cedure and reduce the cost for a specific electronic *** research is needed for developing analytical procedures that adapt the Cyranose-320 as a tool for testing rice quality.

关键词： rice grain identification electronic nose data analysis pattern recognition