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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

Neural regeneration research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.w.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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PHOSPHOrUS rEMOVAL USING STEEL SLAG

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Acta Metallurgica Sinica(English Letters) 2006年第6期19卷 449-454页

作者： r.w. Smith Metallurgical and Materials Department Nevada University of Reno NV89503 Nevada USA

Steel slag is a byproduct produced in large amounts in the steel-making process. It is an important resource that can be effectively utilized. An experiment was described in which steel slag was tested as an adsorbent for the removal of phosphorus from waste water. Phosphorus removal depended on the amount of steel slag added, the pH value, the contact time, and the initial concentration. Under laboratory conditions when the added slag was 7.5g/L, the contact time 2h, and the pH value was equivalent to 6.5, over 99% of the phosphorus was removed; the experimental data on steel slag adsorption of phosphorus in the water fitted the Freundlich isotherm model. Steel slag was found to be very effective in adsorbing phosphorus.

关键词： steel slag waste water phosphorus removal

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Use of heart-lung interactions to diagnose cardiovascular insufficiency

Use of heart-lung interactions to diagnose cardiovascular in...

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中国病理生理学会危重病医学专业委员会第八届全国大会暨中华呼吸病学会呼吸生理和重症监护学组年会

作者： Michael r.pinsky Department of Critical Care Medicine University of Pittsburgh MDDr hc

The goals of hemodynamic monitoring are multiple,including identification of cardiovascular deterioration,diagnosis and monitor response to *** the context of guiding resuscitation therapies,static hemodynamic variables are singularly not useful for decision making. The combined clinical literature to date support the concept that traditional static measures of left

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Functional hemodynamic monitoring:Use of derived variables to diagnose and manage the critically ill

Functional hemodynamic monitoring:Use of derived variables t...

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中国病理生理学会危重病医学专业委员会第八届全国大会暨中华呼吸病学会呼吸生理和重症监护学组年会

作者： Michael r.pinsky Department of Critical Care Medicine University of Pittsburgh School of Medicine MD Dr hc

Hemodynamic monitoring refers to the measuring of various physiological variables associated with cardiovascular function,such as heart rate,vascular pressures and flow,blood gases and tissue- specific *** presumption behind such monitoring is that deviations from normalcy reflect cardiovascular dysfunction associated with circulatory shock and that if they persist end-

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regional Blood flow Distribution in shock states

Regional Blood flow Distribution in shock states

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中国病理生理学会危重病医学专业委员会第八届全国大会暨中华呼吸病学会呼吸生理和重症监护学组年会

作者： Michael r.pinsky Department of Critical Care Medicine University of Pittsburgh Medical Center MD Dr hc

Introduction The goal of cardiovascular resuscitation is to restore,sustain and augment regional blood flow to levels necessary to insure their normal metabolic *** levels of global blood flow are needed to insure ade...

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Nucleon transition form factors at JLab:status and outlook

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Chinese Physics C 2009年第12期33卷 1216-1221页

作者： r. w. Gothe University of South Carolina Columbia SC 29208 USA

The measurements of exclusive single-meson and double-pion electro-production cross sections off the proton to study nucleon resonances will be extended to higher momentum transfers with the CLAS12 detector and the energy upgraded CEBAF beam. Based on new theoretical developments to extract and interpret the electromagnetic transition form factors and on the experience gained from the most recent results, the newly formed collaboration of experimentalists and theorists shall enable us to provide unprecedented high- precision data, high-quality analyses, and state-of-the-art model and QCD based calculations in a Q2 domain up to 10 GeV2. For the first time nucleon resonance structures will be studied at still unexplored distance scales, where the dressed quark contributions are the dominating degrees of freedom and their strong interaction is responsible for the ground and excited nucleon state formation. These studies also open up a promising opportunity to understand the origin of more than 98% of the nucleon mass that is created by strong fields predominantly at these distance scales by dressing the current quarks.

关键词： baryon structure strong degrees of freedom

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On Poincare-Friedrichs Type Inequalities for the Broken Sobolev Space w^(2,1)

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Numerical Mathematics(Theory,Methods and Applications) 2021年第1期14卷 31-46页

作者： r.H.w.Hoppe Department of Mathematics University of HoustonUSA Department of Mathematics University of AugsburgGermany

we are concerned with the derivation of Poincare-Friedrichs type inequalities in the broken Sobolev space w^(2,1)(Ω;T h)with respect to a geometrically conforming,simplicial triagulation T h of a bounded Lipschitz domainΩin r d,d∈*** inequalities are of interest in the numerical analysis of nonconforming finite element discretizations such as C^(0) Discontinuous Galerkin(C^(0)DG)approximations of minimization problems in the Sobolev space w^(2,1)(Ω),or more generally,in the Banach space BV^(2)(Ω)of functions of bounded second order total *** an application,we consider a C^(0) DG approximation of a minimization problem in BV^(2)(Ω)which is useful for texture analysis and management in image restoration.

关键词： Poincare-Friedrichs inequalities broken Sobolev spaces C^(0)Discontinuous Galerkin approximation image processing

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Biaxiality Dependence of the Fracture Toughness for Glass in Plane Stress State

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Journal of Materials Science & Technology 1998年第5期14卷 457-460页

作者： Bao, Yiwang Steinbrech, r.w. China Bldg Mat Acad Beijing 100024 Peoples R China Juelich res Ctr IWE1 Julich Germany

Fracture toughness of disk specimens with a straight-through crack was measured under biaxial tension and uniaxial tension loads respectively. The difference between them and the reasons for the difference were discussed. The influence of the stress parallel to crack on fracture of brittle material was demonstrated in theory and experiments. The results show that plane stress fracture toughness of glass is not a material constant, and that the fracture toughness measured in biaxial tension state is higher than that measured under uniaxial tension. The conventional fracture criterion upon the stress intensity factor is questioned in the case of biaxial stress problem, and the strain dependence of crack growth was discussed. (Edited author abstract) 15 refs.

关键词： Glass

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Dynamic Deformation of Frozen Soil at a High Strain rate:Experiments and Damage-Coupled Constitutive Model

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Acta Mechanica Solida Sinica 2021年第6期34卷 895-910页

作者： Z.w.Zhu w.r.Tang G.Z.Kang Applied Mechanics and Structural Safety Key Laboratory of Sichuan Province School of Mechanics and EngineeringSouthwest Jiaotong UniversityChengdu610036China Northwest institute of Eco-Environment and resources State Key Laboratory of Frozen Soil EngineeringChinese Academy of SciencesLanzhou730000China

The dynamic compressive deformation of frozen soil was investigated by conducting the split-Hopkinson pressure bar(SHPB)experiments at three temperatures and different high strain rates,and the dynamic stress–strain responses and failure modes of the frozen soil were *** experimental results demonstrate that the frozen soil exhibits evident dependence on the strain rate and temperature under the dynamic loading *** dynamic compressive stress–strain curve of the frozen soil was divided into three parts:the linear,nonlinear rising,and strain softening *** nonlinear rising and strain softening parts were both caused by the damage attributed to the debonding between the ice particles and soil matrix,from which a rate-dependent damage evolution equation was ***,a damage-coupled dynamic viscoelastic constitutive model of frozen soil at high strain rate was derived.A comparison between the theoretically predicted results and the experimental ones showed that the developed dynamic viscoelastic model could well describe the dynamic mechanical behavior of frozen soil at high strain rate.

关键词： Frozen soil Dynamic compression High strain rate Damage Constitutive model

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Utilization of soil nailing technique to increase shear strength of cohesive soil and reduce settlement

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Journal of rock Mechanics and Geotechnical Engineering 2017年第6期9卷 1104-1111页

作者： w.r.Azzam A.Basha Faculty of Engineering Tanta UniversityTantaEgypt Faculty of Engineering Kafrelsheikh UniversityKafrelsheikhEgypt

This article deals with the assessment of the soil nailing technique with a vertical inclusion to improve the geotechnical parameters of cohesive soil. A series of unconfined compression tests and direct shear tests were carried out to establish the stressestrain relationship and strength characteristics of the reinforced clay sample by vertical steel nails. The shear strength performance of the new composite material was tested by varying the number of vertical inclusions, the embedment depth and the alignment radius. The results confirmed that the vertical bars/inclusions shared the vertical applied load with clay. Increase in the number of vertical inclusions significantly increases the shear strength and the stiffness with a remarkable reduction in settlement. when the clay samples were reinforced with six inclusions along the perimeter, the shear strength was increased to 231% for the embedment depth ratio equal to 0.85. To obtain the optimum effect in eliminating shear failure, the vertical inclusions should be extended to a deeper zone with sufficient numbers. It has been found that the vertical inclusions significantly influence the shear strength, and the brittle or general shear failure of the unreinforced sample can be diverted to partial/plastic shear failure.

关键词： Cohesive soil Shear strength Vertical inclusion Stiffness Settlement

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