检索结果-南通市图书馆

Pre-ischemia electro-acupuncture potentiates the expression of Bcl-2 and transforming gr.wth factor-beta 1 in rat brains

引用

Neural regeneration research 2012年第24期7卷 1859-1865页

作者： Ka Keung Yip Samuel CL Lo Kwok-fai So Dora MY Poon mason CP Leung Department of rehabilitation Sciences the Hong Kong Polytechnic UniversityHung HomHong Kong Special Administrative RegionChina Department of Applied Biology and Chemical Technology the Hong Kong Polytechnic UniversityHung HomHong Kong Special Administrative RegionChina Department of Anatomy the University of Hong KongPokfulamHong Kong Special Administrative RegionChina

The expression of the anti-apoptotic molecules Bcl-2 and transforming gr.wth factor-beta 1 is known to confer protective effects on the cerebral ischemia-reperfusion *** current study investigated the expression levels of Bcl-2 and transforming gr.wth factor-beta 1 in response to multiple pre-ischemia electro-acupuncture at acupoints Zusanli（ST36）and Fengchi（GB20） *** were divided into five groups：uninjured,control,non-acupoint,GB20 and ST36. rats in the non-acupoint,GB20 and ST36 groups received 30 minutes（3 times or 18 times）of electro-acupuncture stimulation before experimental cerebral ischemia was ***-2 and transforming gr.wth factor-beta 1 were found to be significantly increased in the ST36 groups with either 3 or 18 electro-acupuncture treatments（P〈0.05）.The production was higher.with 18 electro-acupuncture treatments in the ST36 groups（P〈0.05）.In the GB20 groups,significant increase was only observed in transforming gr.wth factor-beta 1 with 18 electro-acupuncture treatments（P〈0.05）.No significant elevation of the level of transforming gr.wth factor-beta 1 was observed in the non-acupoint ***,the production of Bcl-2 increased with 18 treatments in the non-acupoint groups（P〈0.05）.The data suggest that multiple pre-ischemia electro-acupuncture at ST36 was effective in conferring neuroprotective effect on the brain by means of upregulation of Bcl-2 and transforming gr.wth factor-beta 1 and the effect was increase with the number of treatment.

关键词： cerebral ischemia stroke prevention electro-acupuncture transforming gr.wth factor-beta 1 Bcl-2 acupoint

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Use of the DSI/Ponemah jacketed external telemetry system for ECG assessments in dog telemetry

引用

中国药理学与毒理学杂志 2013年第3期 601-602页

作者： wU rui QU Lin-hai Sue McPHErSON Steve mason Safety Pharmacology WuXi AppTec(Suzhou) Co.Ltd.

OBJECTIVE To demonstrate that the DSI /Ponemah Jet System(v5.00) can generate high quality ECG data with current methods,enabling cardiovascular function to be assessed in free moving dogs in their home *** Four male beagle dogs were used on this *** electrodes were placed on each animal and were connected to each JET *** JET device was then placed into a pocket of an externally worn animal jacket for each *** JET device transmits to a Bluetooth? *** Bluetooth? receiver can receive signals from up to 6 JET devices depending upon the device *** JET device can transmit data up to 10 meters with negligible interference and no cross-talk exists between *** animals underwent acclimatization to jackets prior to commencement of *** dog was placed into a pen and ECG measurements taken simultaneously using the DSI /Ponemah Jet *** were recorded for 1 hour pre-dose and continually for the following 23 hours under control conditions,then dosed with ascending doses of Moxifloxacin at intervals of 48 hours between each *** AND CONCLUSION Prolonged QT and QTcV(Van de water's correction) interval was observed for animals dosed at 100 mg·kg-1 from 4-23 h *** QTcV effects(19% increase with 100 mg·kg-1 Moxifloxacin vs control).The DSI telemetry system performed well when testing the dog to the known pharmacological profile of *** sensitively and efficiently acquired ECG data from the beagle dogs and demonstrated the sensitivity of the system to detect test article induced QT *** allows a colony of dogs to be dedicated for toxicology and safety pharmacology *** DSI /ponemah JET system enables flexibility in study design and can be utilized on a range of study types to facilitate high quality ECGs and reduce the requirement for repeat dosing safety pharmacology *** data generated from this investigation demonstrate the DSI /ponemah JET system(v5.

关键词： ECG dog

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Babies of technology

Babies of technology

引用

作者： mason Mary Ann Ekman Tom

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Investigation of fertility and early embryonic toxicity of caffeine in rats

引用

中国药理学与毒理学杂志 2013年第3期 603-604页

作者： wANG Hong-ping PAN Lei Sue MCPHErSON Steve mason wuXi AppTec(Suzhou) Co. Ltd.

OBJECTIVE To investigate the fertility and early embryonic developmental toxicity of *** 160 rats were assigned to 4 groups of 20 /sex /group,with vehicle or test article administered at dosages of 0,20,40 or 80 mg·kg-1.d-1 once daily by oral *** were dosed for 4 weeks and females were dosed for 2 weeks prior to mating and dosing continued during the cohabitation *** were treated thereafter to termination after a dosing duration of 54 to 63 *** females mated successfully and were dosed thereafter up to gesation day(GD) *** were c-sectioned on *** Compared to the concurrent vehicle control group,the absolute body weight gain decreased significantly during the dosing period for males dosed at 40-80 mg·kg-1.d-1 and for females dosed at 80 mg·*** decreases were associated with decreased food *** of the test article was also noted to affect spermatogenesis in *** increases in sperm morphological abnormalities and decreases in sperm motility were observed following dosing at 40-80 mg·*** addition,a significant decrease in sperm count was also observed for animals dosed at 80 mg·*** were no test article-related changes in cohabitation duration,estrus cycle(start from 7 d prior to mating,and continued during pairing period),fertility data,uterine observations(*** corpora lutea,implantations,live fetuses,embryonic resorptions,pre-implantation loss,post-implantation loss),reproductive organ weights,and macroscopic *** findings were considered to indicate that caffe-ine dosed at 20-80 mg·kg-1.d-1 did not affect female fertility and early embryonic development to *** The No-Observed-Adverse-Effect-Level(NOAEL) of caffeine on spermatogenesis was considered to be 20 mg·kg-1.d-1,and the NOAEL of caffeine on female fertility and early development to implantation was considered to be 80 mg·kg-1.d-1.

关键词： caffeine embryonic toxicity

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Getting better at treating prostate cancer: what clinicians should want from scientists

引用

Journal of Cancer Metastasis and Treatment 2017年第1期3卷 271-277页

作者： Malcolm mason School of Medicine Cardiff UniversityCardiff CF103XQWalesUK.

If the treatment landscape for prostate cancer is to be transformed,clinicians and scientists must work together ever more *** cancer defeats physicians when patients are not accurately stratified according to patients’risk of dying of disease,when the effects of tumor heterogeneity are insufficiently understood,and when attempts at therapy by clinicians spur further disease evolution and the emergence of new resistance *** the same time,clinicians’over-treat men who in reality do not need it,and some of those men needlessly suffer long term side effects as a *** commentary is aimed at stimulating debate about how we as clinicians and scientists can assist one another and improve our knowledge to the benefit of patients dying from metastatic disease.

关键词： Prostate cancer metastasis androgen deprivation therapy abiraterone STAMPEDE trial LATTITUDE trial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mathematical Model of a Hyperbolic Hydraulic Fracture with Tortuosity

引用

Journal of Applied Mathematics and Physics 2021年第5期9卷 1121-1157页

作者： M. r. r. Kgatle-Maseko D. P. mason School of Computer Science and Applied Mathematics DST-NRF Centre of Excellence in Mathematical and Statistical Sciences University of the Witwatersrand Johannesburg South Africa

The aim of the research is to study the propagation of a hydraulic fracture with tortuosity due to contact areas between touching asperities on opposite crack walls. The tortuous fracture is replaced by a model symmetric partially open fracture with a hyperbolic crack law and a modified reynolds flow law. The normal stress at the crack walls is assumed to be proportional to the half-width of the model fracture. The Lie point symmetry of the nonlinear diffusion equation for the fracture half-width is derived and the general form of the group invariant solution is obtained. It was found that the fluid flux at the fracture entry cannot be prescribed arbitrarily, because it is determined by the group invariant solution and that the exponent n in the modified reynolds flow power law must lie in the range 2 n ry value problem is solved numerically using a backward shooting method from the fracture tip, offset by 0 δ ≪ 1 to avoid singularities, to the fracture entry. The numerical results showed that the tortuosity and the pressure due to the contact regions both have the effect of increasing the fracture length. The spatial gradient of the half-width was found to be singular at the fracture tip for 3 n r the reynolds flow law n = 3 and to be zero for 2 n roximation breaks down at the fracture tip for 3 n while it remains valid for increasingly tortuous fractures with 2 n rities is to decrease the width averaged fluid velocity. An approximate analytical solution for the half-width, which was found to agree well with the numerical solution, is derived by making the approximation that the width averaged fluid velocity increases linearly with distance along the fracture.

关键词： Hyperbolic Crack Law Partially Open Fracture with Tortuosity Modified reynolds Flow Law Backward Shooting Method Approximate Analytical Solution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translating current biomedical therapies for long duration,deep space missions

引用

Precision Clinical Medicine 2019年第4期2卷 259-269页

作者： Sonia Iosim Matthew MacKay Craig westover Christopher E.mason Department of Physiology and Biophysics Weill Cornell MedicineNew YorkNY 10021USA The HrH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA The Feil Family Brain and Mind research Institute Weill Cornell MedicineNew YorkNY 10021USA The worldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

It is been shown that spaceflight-induced molecular,cellular,and physiologic changes cause alterations across many modalities of the human body,including cardiovascular,musculoskeletal,hematological,immunological,ocular,and neurological *** Twin Study,a multi-year,multi-omic study of human response to spaceflight,provided detailed and comprehensive molecular and cellular maps of the human response to radiation,microgravity,isolation,and *** rich data identified epigenetic,gene expression,inflammatory,and metabolic responses to spaceflight,facilitating a better biomedical roadmap of features that should be monitored and safe-guarded in upcoming ***,by exploring new developments in pre-clinical models and clinical trials,we can begin to design potential cellular interventions for exploration-class missions to Mars and potentially *** paper.will discuss the overall risks astronauts face during spaceflight,what is currently known about human response to these risks,what pharmaceutical interventions exist for use in space,and which tools of precision medicine and cellular engineering could be applied to aerospace and astronaut medicine.

关键词： NASA spaceflight International Space Station NASA Twin Study multi-scale omics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Use and Exchange of Biological Control Agents for Food and Agriculture

引用

中国生物防治学报 2010年第S1期26卷 123-127页

作者： J.C.van Lenteren M.J.w.Cock J.Brodeur B.Barratt F.Bigler K.Bolckmans F.Haas P.G.mason J.r.P.Parra Laboratory of Entomology Wageningen UniversityP.O.Box80316700 EH WageningenNetherlands CABI Europe-Switzerland Rue des Grillons 1CH-2800 DelémontSwitzerland Institut de recherche en biologie végétale Universitéde Montréal4101rue Sher-brooke EstMontréal(Québec)Canada Agresearch Limited Invermay Agricultural CentrePuddle AlleyPrivate Bag 50034Mos-gielNew Zealand Agroscope reckenholz-Tanikon research Station ArT Reckenholzstrasse 191CH-8046 ZurichSwitzerland Koppert B.V. Veilingweg 14Postbus 1552650 AD Berkel en RodenrijsThe Netherlands Icipe Duduville CampusKasaraniP.O.Box30772-00100NairobiKenya Agriculture and Agri-Food Canada Research CentreK.W.Neatby Building960 Carling AvenueOttawaOntario K1A0C6Canada Departamento de Entomologia Fitopatologia e Zoologia AgrícolaESALQ/USP.Caixa Postal0913418-900 Piracicaba-SPBrazil

The report sets out to summarize the past and current situation regarding the practice of biologicalcontrol inrelationtothe use and exchange of genetic resources relevant for *** considers the twomain categories of biological control:classical and *** access to BCAs for use inanother country imposes no risk of liability to the source *** scientific knowledge abouthabitats,fauna andflora,can be

关键词： The Use and Exchange of Biological Control Agents for Food and Agriculture

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mice with a heterozygous Lrp6 deletion have impaired fracture healing

引用

Bone research 2016年第2期4卷 101-109页

作者： Travis A Burgers Juan F Vivanco Juraj zahatnansky Andr.w J Vander Moren James J mason Bart O williams Center for Cancer and Cell Biology Program for Skeletal Disease and Tumor Microenvironment Van Andel Research Institute Grand Rapids MhUSA Faculfad de Ingenieria y Ciencias Adolfo Ib6fiez University Vifia del Mar Chile padnos College of Engineering and Computing Grand Valley State University Grand Rapids MI USA

Bone fracture non-unions, the failure of a fracture to heal, occur in 10%-20% of fractures and are a costly and debilitating clinical problem. The wnt/fl-catenin pathway is critical in bone development and fracture healing. Polymorphisms of linking low-density lipoprotein receptor-related protein 6 （LrP6）, a wnt-binding receptor, have been associated with decreased bone mineral density and fragility fractures, although this remains controversial. Mice with a homozygous deletion of Lrp6 have severe skeletal abnormalities and are not viable, whereas mice with a heterozygous deletion have a combinatory effect with Lrp5 to decrease bone mineral density. As fracture healing closely models embryonic skeletal development, we investigated the process of fracture healing in mice heterozygous for Lrp6 （Lrp6~/-） and hypothesized that the heterozygous deletion of Lrp6 would impair fracture healing. Mid-diaphyseal femur fractures were induced in Lrp6~^- mice and wild-type controls （Lrp6~/~）. Fractures were analyzed using micro-computed tomography （~CT） scans, biomechanical testing, and histological analysis. Lrp6~/- mice had significantly decreased stiffness and strength at 28 days post fracture （PF） and significantly decreased BV/TV, total density, immature bone density, and mature area within the callus on day-14 and -21 PF; they had significantly increased empty callus area at days 14 and 21 PF. Our results demonstrate that the heterozygous deletion of Lrp6 impairs fracture healing, which suggests that Lrp6 has a role in fracture healing.

关键词： bone Mice with a heterozygous Lrp6 deletion have impaired fracture healing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advancement in Indoor Vertical Farming for Microgreen Production

引用

American Journal of Plant Sciences 2019年第8期10卷 1397-1408页

作者： Preethi rajan rajasekaran r. Lada mason T. MacDonald Department of Plant Food and Environmental Sciences Faculty of Agriculture Dalhousie University Truro Truro N.S. Canada

with the gr.wing global urban population and the emergence of megacities, there is a huge demand for arable land to meet the food demand and reduce malnutrition. Conventional agricultural practices lead to deforestation of the land for crop production and agricultural intensification to produce higher yield per unit area. These activities have been established to have negative impact on the environment thereby causing soil and water pollution. It is important to consider the use of vertical farming technology, which utilizes both horizontal and vertical space, and efficiently uses nutrients, water, and time (off season production with artificial lighting) more effectively to produce higher yield per unit volume of space than the conventional outdoor farming. Microgreens are taken into consideration to be gr.wn under innovative vertical farming technology since they are rich in phytonutrients and they can be harvested in a short period of time. This paper reviews the current gr.wing conditions of microgreens in vertical farming such as crop selection, media, light, nutrient solution, and containers while identifying knowledge gaps. Further, study in this area may lead to improved gr.wing conditions to help solve the global issues and challenges surrounding food security, safety, and resource optimization.

关键词： Vertical Farming Microgreens Phytonutrients BioStrate Light Emitting Diodes Plant Nutrition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：