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degradation of gaseous hydrocarbons in aerated stirred bioreactors inoculated with rhodococcus erythropolis:Effect of the carbon source and SIFT-MS method development

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Journal of Environmental Sciences 2025年第1期147卷 268-281页

作者： Paula Alejandra Lamprea Pineda Kristof demeestere Allan Augusto Alvarado-Alvarado Frank devlieghere Nico Boon Herman van Langenhove Christophe Walgraeve research group EnVOC Department of Green Chemistry and TechnologyFaculty of Bioscience EngineeringGhent UniversityCoupure Links 6539000Ghent Belgium research group FMFP Department of Food TechnologySafety and HealthFaculty of Bioscience EngineeringGhent UniversityCoupure Links 6539000Ghent Belgium Center for Microbial Ecology and Technology-CMET Department of BiotechnologyFaculty of Bioscience EngineeringGhent UniversityCoupure Links 6539000Ghent Belgium

The study of microbial hydrocarbons removal is of great importance for the development of future bioremediation *** this study,we evaluated the removal of a gaseous mixture containing toluene,m-xylene,ethylbenzene,cyclohexane,butane,pentane,hexane and heptane in aerated stirred bioreactors inoculated with rhodococcus erythropolis and operated under non-sterile *** the real-time measurement of hydrocarbons,a novel systematic approachwas implemented using Selected-Ion Flow TubeMass Spectrometry(SIFTMS).The effect of the carbon source(~9.5 ppmv)on(i)the bioreactors’performance(Br1:dosed with only cyclohexane as a single hydrocarbon versus Br2:dosed with a mixture of the 8 hydrocarbons)and(ii)the evolution of microbial communities over time were *** results showed that cyclohexane reached a maximum removal efficiency(rE)of 53%±4%in *** Br2,almost complete removal of toluene,m-xylene and ethylbenzene,being the most water-soluble and easy-to-degrade carbon sources,was *** below 32%were obtained for the remaining *** exposing the microbial consortium to only the five most recalcitrant hydrocarbons,rEs between 45%±5%and 98%±1%were *** addition,we observed that airborne microorganisms populated the bioreactors and that the type of carbon source influenced the microbial communities *** abundance of species belonging to the genus rhodococcus was below 10%in all bioreactors at the end of the *** work provides fundamental insights to understand the complex behavior of gaseous hydrocarbon mixtures in bioreactors,along with a systematic approach for the development of SIFT-MS methods.

关键词： Hydrocarbons SIFT-MS rhodococcus erythropolis Biodegradation Bioreactors

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可满足高炉严格使用要求的高性能MTT金属管铸铜冷却壁

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钢铁 2007年第3期42卷 79-82页

作者： E.van Stein Callenfels r.van Laar 达涅利康力斯

达涅利康力斯推出一种新的冷却概念,它将铜冷却壁与浇铸在其中的蒙乃尔铜-镍合金管结合为一个整体。蒙乃尔铜-镍合金管构成冷却水通道。它不仅可使冷却水拥有一条光滑的无泄漏通道,而且具有足够的尺寸灵活性,以满足躲避现有高炉炉壳开... 详细信息

达涅利康力斯推出一种新的冷却概念,它将铜冷却壁与浇铸在其中的蒙乃尔铜-镍合金管结合为一个整体。蒙乃尔铜-镍合金管构成冷却水通道。它不仅可使冷却水拥有一条光滑的无泄漏通道,而且具有足够的尺寸灵活性,以满足躲避现有高炉炉壳开口的要求,还可以省去在高炉炉壳内的任何焊接。

关键词：高炉长寿冷却壁

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LEPTONIC deCAYS OF CHArGED PSEUDOSCALAr MESONS

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Chinese Physics C 2016年第10期40卷 731-745页

作者： J. rosner S. Stone r. van de water Univ. Chicago Syracuse Univ. FNAL

We review the physics of purely leptonic decays of 7π^±, K^±, D±, Ds±, and B± pseudoscalar mesons. The measured decay rates are related to the product of the relevant weak-interactionbased CKM matrix element of the constituent quarks and a strong interaction parameter related to the overlap of the quark and antiquark wave-functions in the meson, called the decay constant .fp.

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Surgery in (pre)malignant celiac disease

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World Journal of Gastroenterology 2015年第43期21卷 12403-12409页

作者： Jolanda MW van de water Petula Nijeboer Laura r de Baaij Jessy Zegers Gerd Bouma Otto J Visser Donald L van der Peet Chris JJ Mulder Wilhelmus JHJ Meijerink department of Gastroenterology and Hepatology Coeliac Center AmsterdamVU University Medical Center department of Haematology Coeliac Center AmsterdamVU University Medical Center department of Surgery Coeliac Center Amsterdam VU University Medical Center

AIM: To report the outcome of surgery in patients with(pre)malignant conditions of celiac disease(CD) and the impact on ***: A total of 40 patients with(pre)malignant conditions of CD,ulcerative jejunitis(n = 5) and enteropathy associated T-cell lymphoma(EATL)(n = 35),who underwent surgery between 2002 and 2013 were retrospectively evaluated. Data on indications,operative procedure,post-operative morbidity and mortali ty,adjuvant therapy and overal l survival(OS) were collected. Eleven patients with EATL who underwent chemotherapy without resection were included as a control group for survival analysis. Patients were followed-up every three months during the first year and at 6-mo intervals ***: Mean age at resection was 62 years. The majority of patients(63%) underwent elective laparotomy. Functional stenosis(n = 1 3) and perforation(n = 12) were the major indications for surgery. In 70% of patients radical resection wasperformed. Early postoperative complications,mainly due to leakage or sepsis,occurred in 14/40(35%) of patients. Eight patients required reoperation. More patients who underwent resection in the acute setting(n = 3,20%) died compared to patients treated in the elective setting. With a median follow-up of 20 mo,seven patients(18%) required reoperation due to long-term complications. Significantly more patients who underwent acute surgery could not be treated with adjuvant chemotherapy. Patients who first underwent surgical resection showed significantly better OS than patients who received chemotherapy without ***: Although the complication rate is high,the preferred first step of treatment in(pre)malignant CD consists of local resection as early as possible to improve survival.

关键词： Enteropathy associated T-cell lymphoma Ulcerative

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Metastatic pattern in esophageal and gastric cancer:Influenced by site and histology

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World Journal of Gastroenterology 2020年第39期26卷 6037-6046页

作者： Moniek HP Verstegen Mitchell Harker Carlijn van de water Jolanda van Dieren Niek Hugen Iris D Nagtegaal Camiel rosman rachel S van der Post department of Surgery Radboud Institute for Health SciencesRadboud University Medical CenterRadboud University Medical CenterNijmegen 6525 GANetherlands department of Pathology Radboud Institute for Molecular Life SciencesRadboud University Medical CenterRadboud University Medical CenterNijmegen 6525 GANetherlands department of Gastroenterology Oncology Netherlands Cancer InstituteAmsterdam 1066 CXNetherlands

BACKGrOUND detailed information on metastatic patterns in of patients with esophageal and gastric cancer is *** recognition of metastases is important to avoid futile locoregional ***,knowledge on metastatic patterns is necessary for further development of personalized treatment *** To gain insight into the metastatic pattern of gastroesophageal *** A nationwide retrospective autopsy study of 3876 patients with adenocarcinoma(AC)or squamous cell carcinoma(SCC)of the esophagus or stomach between 1990 and 2017 was *** patient with metastases were included for *** metastatic pattern was analyzed according to the primary tumor location and histological *** Metastatic disease was found in 268 esophageal and 331 gastric cancer *** esophageal cancer,the most common metastatic locations were liver(56%),distant lymph nodes(53%)and lung(50%).Esophageal AC showed more frequently metastases to the peritoneum and bone compared with esophageal *** gastric cancer,the most common metastatic locations were distant lymph nodes(56%),liver(53%)and peritoneum(51%).Intestinal-type AC of the stomach showed metastases to the liver more frequently,whereas metastases to the bone,female reproductive organs and colorectum were observed more frequently in diffuse-type gastric *** This study showed differences in metastatic patterns of patients with esophageal and gastric cancer according to the primary tumor location and histological subtype.

关键词： Esophageal cancer Gastric cancer Metastases Histology Gastroesophageal junction Adenocarcinoma Carcinoma Squamous cell

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Landslide Susceptibility Mapping Using rBFN-Based Ensemble Machine Learning Models

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 467-500页

作者： Duc-Dam Nguyen Nguyen Viet Tiep Quynh-Anh Thi Bui Hiep van Le Indra Prakash romulus Costache Manish Pandey Binh Thai Pham Faculty of Civil Engineering University of Transport TechnologyThanh XuanHa Noi100000Vietnam Faculty of Hydraulic Engineering Hanoi University of Civil EngineeringHa Noi100000Vietnam DDG(r)Geological Survey of India Gandhinagar382010India research Institute of the University of Bucharest Bucharest050663Romania National Institute of Hydrology and water Management Bucharest013686Romania department of Civil Engineering Transilvania University of BrasovBrasov500152Romania Danube delta National Institute for research and development Tulcea820112Romania Marwadi University research Center(MUrC) Marwadi UniversityRajkotGujaratBharat360003India department of Civil Engineering Faculty of Engineering&TechnologyMarwadi UniversityRajkotGujaratBharat360003India

This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined radial Basis Function Networks(rBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-rBFN,MB-rBFN,and ***,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and *** models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to *** factors were instrumental in predicting the output variable,which was the probability of landslide *** analysis of the models’performance indicated that the DG-rBFN model,with an Area Under rOC Curve(AUC)of 0.931,outperformed the other *** AB-rBFN model achieved an AUC of 0.929,the MB-rBFN model had an AUC of 0.913,and the MLP model recorded an AUC of *** results suggest that the advanced ensemble ML model DG-rBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making.

关键词： Landslide susceptibility map spatial analysis ensemble modelling information values(IV)

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Paxillin serine 178 phosphorylation in control of cell migration and metastasis formation through regulation of EGFr expression in breast cancer

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Journal of Cancer Metastasis and Treatment 2019年第6期4卷 71-86页

作者： Saertje Verkoeijen Ya-Feng Ma Wies van roosmalen reshma Lalai Martine H.A.M.van Miltenburg Marjo de Graauw Bob van de water Sylvia E.Le Dévédec Institute for Life Sciences&Chemistry Hogeschool Utrecht HUUtrecht 3501 AAthe Netherlands Division of Drug Discovery and Safety Leiden Academic Centre for Drug ResearchLeiden UniversityLeiden 2300 RAthe Netherlands

Aim:Paxillin is a well-known multidomain scaffold protein that is involved in the regulation of cell-matrix adhesion dynamics,a process required for the tumor cell migration and *** of the serine residue 178 requires c-Jun NH2-terminal kinase(JNK)activation,which occurs downstream of epidermal growth factor receptor(EGFr)-mediated signaling and drives cell *** this study,we investigated the significance of paxillin Ser178 phosphorylation in breast cancer ***:We employed the rat mammary carcinoma MTLn3 cell line with which we established stabile variants of both wild type and mutant GFP-paxillin *** those,we next performed several in vitro assays including cell proliferation,migration and focal adhesion ***,we monitored the metastatic spread of both cell line variants in an othrotopic mouse model for breast ***:Here we show that expression of the phospho-defective mutant paxillinS178A in the metastatic mammary adenocarcinoma MTLn3 cell-line significantly decreased EGF-induced cell migration,which was correlated with impaired focal adhesion ***,paxillinS178A attenuated lung metastasis formation in an orthotopic in vivo mammary gland tumor/metastasis model,demonstrating the importance of JNK-mediated paxillin phosphorylation in breast cancer *** of paxillinS178A caused a decrease in EGFr expression, ;while re-expression of EGFr in MTLn3-paxillinS178A cells fully restored EGF-driven cell motility and focal adhesion ***,re-expression of EGFr in MTLn3-paxillinS178A rescued spontaneous metastasis from breast to ***:Overall our data show an important role for JNK-mediated paxillin Ser178 phosphorylation in the regulation of EGFr expression and thereby,in EGF-driven cell migration and metastasis formation.

关键词： Paxillin c-Jun NH2-terminal kinase focal adhesion epidermal growth factor receptor cell migration metastasis breast cancer

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Competition for shelter between four invasive gobiids and two native benthic fish species

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Current Zoology 2011年第6期57卷 844-851页

作者： N. van KESSEL M. DOrENBOSCH M.r.M. de BOEr r.S.E.W. LEUVEN G. van der VELde radboud University Nijmegen Institute for Water and Wetland Research Department of Animal Ecology and Ecophysiology EO. Box 9010 6500 GL Nijmegen The Netherlands radboud University Nijmegen Institute for Water and Wetland Research Department of Environmental Science P.O. Box 9010 6500 GL Nijmegen The Netherlands Natuurbalans - Limes Divergens P.O. Box 31070 6503 CB Nijmegen The Netherlands Netherlands Institute of Ecology （NIOO - KNAW） EO. Box 50 6700 AB Wageningen The Netherlands Netherlands Centre for Biodiversity Naturalis EO. Box 9517 2300 RA Leiden The Netherlands

recent invasions by non-native gobiid fish species that are ongoing in the Western European rivers rhine and Meuse, will lead to interactions with native benthic fish species. Since both non-native gobiids and native benthic species are bottom dwelling species with a preference for shelter during at least part of their life cycle, it is likely that competition for shelter will occur between these non-native and native species when shelter is a limiting factor. To investigate the importance of this mecha- nism for species replacements, various habitat choice experiments were conducted between two common native benthic fish spe- cies （Cottus perifretum and Barbatula barbatula） and four invasive non-native gobiid species （Proterorhinus semilunaris, Neogo- bius melanostomus, N. kessleri and N. fluviatilis）. The first series of single specimen experiments determined the habitat choice of each individual fish species. In a second series of competition experiments, shifts in habitat choice in comparison with the previ- ously observed habitat choice, were determined when a native benthic fish species co-occurred with non-native gobiid species. Native C. perifretum displayed a significant shift in habitat choice in co-occurrence with the gobiids N. kessleri or P. semilunaris. C. perifretum was outcompeted and moved from the available shelter place to less preferred habitat types. During the competition experiments no change in habitat choice of B. barbatula was shown. Our study therefore suggests that competition for shelter is likely to occur in rivers invaded by N. kessleri and P. semilunaris at sites where shelter is limiting

关键词： Bullhead Exotic species Habitat choice Invasive gobies rivers rhine and Meuse Stone loach

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Three subspecies of Black-tailed Godwit share non-breeding sites in the world's largest river delta

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Avian research 2025年第01期 1-10页

作者： delip K.Das Wouter M.G.vansteelant Bingrun Zhu Shariful Islam Naim Khandakar Marco van der Velde Chris J.Hassell Jesse r.Conklin Pierrick Bocher Jos C.E.W.Hooijmeijer Yvonne I.Verkuil Theunis Piersma department of Zoology Faculty of Life and Earth Sciences Jagannath University Conservation Ecology Group Groningen Institute for Evolutionary Life Sciences University of Groningen Bird Eyes Centre for Global Ecological Change at the Faculties of Science & Engineering and Campus Fryslan University of Groningen Theoretical and Computational Ecology Institute for Biodiversity and Ecosystem Dynamics University of Amsterdam Hunan Global Messenger Technology Co. Ltd Behavioural & Physiological Ecology Groningen Institute for Evolutionary Life Sciences University of Groningen Global Flyway Network Littoral Environnement et Sociétés UMr LIENSs 7266 CNrS La Rochelle University NIOZ royal Netherlands Institute for Sea research Department of Coastal Systems

During the non-breeding season(September–April), Black-tailed Godwits(Limosa limosa) are commonly seen in coastal and inland wetlands of the Ganges-Brahmaputra-Meghna delta in Bangladesh. We hypothesize that the Ganges-Brahmaputra-Meghna delta, at the overlap between the Central Asian and East Asian–Australasian flyways, may host three subspecies that breed in disjunct areas of temperate and northern Asia: L. l. limosa, L. l. melanuroides, and L. l. bohaii. We used mitochondrial DNA(mt DNA) haplotype network and biometric analysis to determine subspecies in captured individuals, and deployed GPS–GSM transmitters to verify breeding areas of individuals with subspecies assignments. To test for differential habitat preferences, we sampled birds at two ecologically distinct habitats known to host the largest concentrations of non-breeding Black-tailed Godwits in Bangladesh: Nijhum Dweep National Park, a tidal coastal habitat with brackish water on the south-central coast, and Tanguar Haor(‘backmarsh'), a seasonal freshwater floodplain in the north. During the non-breeding seasons of 2021–2022 and 2022–2023, we sampled and measured 93 Black-tailed Godwits, 54 of which were equipped with GPS–GSM transmitters. Our mt DNA haplotype network analysis confirmed the presence of limosa, melanuroides, and bohaii subspecies at the study sites. Thus, indeed, Black-tailed Godwits subspecies, despite having distinct breeding ranges, exhibit(partially) overlapping non-breeding ranges in Asia. The subspecies composition differed significantly between sites, with limosa and bohaii dominating in Tanguar Haor and melanuroides in Nijhum Dweep. Of the 21 individuals that were tracked to their breeding grounds, 18 migrated to the expected breeding range of their respective subspecies. However, one bird with a limosa haplotype migrated to a known breeding area of bohaii, whereas two birds with melanuroides haplotypes migrated to the supposed breeding range of limosa. Therefore, while ecologic

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胚胎内耳葡萄糖胺聚糖的组织化学观察

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中华耳鼻咽喉头颈外科杂志 1990年第2期25卷 113-113,129页

作者：苏鸿禧 Thomas r. van de water 北京市耳鼻咽喉科研究所美国爱因斯坦医学院耳发育生物学实验室

葡萄糖胺聚糖(Glycosaminoglycan)是胚胎细胞外基质的主要成分,是细胞繁殖、移行、发育和分化的重要因素。哺乳动物内耳发育的早期,听泡的神经外胚层被头部中胚层的疏松间充质所包裹,之后间充质发生一系列变化,包括细胞的聚集,细胞外基... 详细信息

葡萄糖胺聚糖(Glycosaminoglycan)是胚胎细胞外基质的主要成分,是细胞繁殖、移行、发育和分化的重要因素。哺乳动物内耳发育的早期,听泡的神经外胚层被头部中胚层的疏松间充质所包裹,之后间充质发生一系列变化,包括细胞的聚集,细胞外基质和耳囊软骨的形成。这些变化对软骨性耳囊作为骨迷路形成的模板和在成年骨迷路中残留软骨结构将起重要的作用。细胞外基质硫酸化葡萄糖胺聚糖的合成与耳囊

关键词：内耳/代谢内耳/胚胎学葡糖氨基聚糖类/分析

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