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Stroke-like presentation of acute toxic leukoencephalopathy due to capecitabine treatment with extensive intramyelinic edema

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慢性疾病与转化医学:英文版 2023年第3期9卷 258-262页

作者： Julia Feige Fritz Klausner Johannes A.r.Pfaff Eugen Trinka Slaven Pikija Mahdi safdarian Department of Neurology Neurocritical Care and NeurorehabilitationCentre of Cognitive NeuroscienceChristian Doppler University HospitalParacelsus Medical UniversitySalzburgMember of EpiCARESalzburgAustria Department of Neuroradiology Christian Doppler University HospitalParacelsus Medical UniversitySalzburgAustria Neuroscience Institute Christian‐Doppler University HospitalParacelsus Medical UniversityCentre for Cognitive NeuroscienceSalzburgAustria Institute of Public Health Medical Decision‐Making and HTAUMIT‐Private University for Health SciencesMedical Informatics and TechnologyHall in TyrolAustria

1|INTrODUCTION Capecitabine is an oral prodrug of 5-fluorouracil(5-FU),which is widely used for adjuvant and neoadjuvant chemotherapy of different solid tumors,particularly breast and colorectal cancers.1 Neurotoxicity of capecitabine has been consistently reported as capecitabine-induced toxic leukoencephalopathy,which includes bilateral lesions in the corpus callosum and corticospinal tract presenting as acute or delayed central nervous system toxicity.2 This side effect requires discontinuation of chemotherapy3;however,neurological symptoms due to capecitabine are reported to be usually reversible upon drug withdrawal.

关键词： capecitabine intramyelinic edema leukoencephalopathy stroke

A superficial siderosis-related transient focal neurological episode in a patient with Marfan syndrome

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慢性疾病与转化医学:英文版 2023年第3期9卷 269-272页

作者： Slaven Pikija Eugen Trinka Pfaff Johannes Andreea Toma Mahdi safdarian Department of Neurology Neurocritical Care and NeurorehabilitationCentre of Cognitive NeuroscienceChristian Doppler University HospitalParacelsus Medical UniversitySalzburgMember of EpiCARESalzburgAustria Department of Neurology Christian Doppler University HospitalCentre of Cognitive NeuroscienceNeuroscience InstituteParacelsus Medical UniversitySalzburgAustria Karl Landsteiner Institute for Neurorehabilitation and Space Neurology SalzburgAustria Department of Neuroradiology Christian Doppler University HospitalCentre of Cognitive NeuroscienceNeuroradiology InstituteParacelsus Medical UniversitySalzburgAustria

To the Editor,Marfan syndrome is an autosomal dominant disorder of connective tissue caused by mutations in the gene encoding a matrix component of microfibrils;fibrillin-1(FBN1),with an incidence of about 1-3 per 10,000 individuals.2.3 Cardinal manifestations include proximal aortic aneurysm,dislocation of the ocular lens,and long-bone overgrowth.Dural ectasia,which is defined as a ballooning or significant widening of the dural sac or neural root sleeves,is also a common finding in these patients,which is reported to present in more than 60%of cases and is considered a major criterion for the clinical diagnosis of this syndrome.

关键词： superficial Marfan balloon

Halophile plant growth-promoting rhizobacteria induce salt tolerance traits in wheat seedlings(Triticum aestivum L.)

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Pedosphere 2020年第5期30卷 684-693页

作者： Maryam safdarian Hossein ASKArl Ghorbanali NEMATZADEH Adriano SOFO Sari Agricultural Sciences and Natural resources University Mazandaran ProvinceSari ***(Iran) Department of Biotechnology Faculty of New Technologies and Energy EngineeringShahid Beheshti UniversityTehran 198396941(Iran) Department of European and Mediterranean Cultures:Architecture EnvironmentCultural Heritage(DiCEM)Universita degli Studi dello BasilicataVia Lanera 20Matera 75100(Italy)

Salinity is one of the most important growth-limiting factors for most crops in arid and semi-arid regions;however,the use of plant growth-promoting rhizobacteria isolated from saline soils could reduce the effects of saline stress in crops.This study aimed to evaluate the efficiency of plant growth-promoting rhizobacteria(PGPrs),isolated from the rhizosphere of halophile plants,for the growth,Na^+/K^+balance,ethylene emission,and gene expression of wheat seedlings{Triticum aestivum L.)grown under saline conditions(100 mmol L^-1 NaCl)for 14 d.A total of 118 isolates obtained from saline soils of the deserts of Iran were tested for their capacity as PGPrs.Out of the 118 isolates,17 could solubilize phosphate(Ca3(P〇4)2),5 could produce siderophores,and 16 could synthesize indole-3-acetic acid.Additionally,PGPrs were also evaluated for aminocyclopropane-l-carboxylate deaminase activity.A pot experiment was conducted to evaluate the ability of 28 PGPr isolates to promote growth,regulate Na^+/K^+balance,and decrease ethylene emissions in plants.The most efficient PGPrs were Arthrobacter aurescens.Bacillus atrophaeus,Enterobacter ashuriae,and Pseudomonas fluorescens.Gene expression analysis revealed the up-regulation of H^+-PPase,HKT1,NHX7,CAT,and APX expression in roots of Enterobacter-inocuVdied salt-stressed plants.Salt-tolerant rhizobacteria exhibiting plant growth-promoting traits can facilitate the growth of wheat plants under saline conditions.Our results indicate that the isolation of these bacteria may be useful for formulating new inoculants to improve wheat cropping systems in saline soils.

关键词： ethylene emission gene expression growth-promoting trait indole-3-acetic acid phosphate solubility saline soil siderophore

Assessment of mechanism, type and severity of injury in multiple trauma patients： A cross sectional study of a trauma center in Iran

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Chinese Journal of Traumatology 2017年第2期20卷 75-80页

作者： Hamidreza reihani Hossein Pirazghandi Ehsan Bolvardi Mohsen Ebrahimi Elham Pishbin Koorosh Ahmadi Mahdi safdarian Soheil Saadat Vafa rahimi-Movaghar Emergency Medicine Department Imam Reza Hospital Mashhad University of Medical Sciences Mashhad Iran Emergency Medicine Department Shahid Beheshti Hospital Sabzevar University of Medical Sciences Sabzevar Iran Department of Emergency Medicine Alborz University of Medical Sciences Karaj Iran Sina Trauma and Surgery research Center Tehran University of Medical Sciences Tehran Iran

PurposeTo 精确地与在马什哈德指 Hasheminejad 大学医院的紧急情况部门的多重损伤在损伤 center.MethodsPatients 的伊朗的多重损伤病人估计损害的机制，类型和严厉，伊朗，从 2013 年 3 月进入了这生气部分研究到 2013 年 12 月。有... 详细信息

PurposeTo 精确地与在马什哈德指 Hasheminejad 大学医院的紧急情况部门的多重损伤在损伤 center.MethodsPatients 的伊朗的多重损伤病人估计损害的机制，类型和严厉，伊朗，从 2013 年 3 月进入了这生气部分研究到 2013 年 12 月。有损害严厉 20 的所有病人(ISS )> 9 在这研究被包括。数据分析被社会科学统计套装软体软件(版本 11.5 ) 和不到 0.05 被认为 differences.resultsAmong 同样重要的 P 值执行 6306 个就医的损伤病人在这个时期期间， 148 有的 ISS > 9。男女比率是 80% 。病人的吝啬的年龄是(33.5 ??????? ‥??? ┲吗？？

关键词：事故，交通损害严厉 20 创伤和损害伊朗

Effect of Advanced Trauma Life Support program on medical interns＇ performance in simulated trauma patient management

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中华创伤杂志：英文版 2013年第3期16卷 145-148页

作者： Koorosh Ahmadi Mohammad Sedaghat Mahdi safdarian Amir Masoud Hashemian Zahra Nezamdoust Mohammad Vaseie Vafa rahimi-Movaghar Emergency Medicine Alborz University of MedicalSciences Karaj Iran Emergency Medicine Tehran University of MedicalSciences Tehran Iran 5th Year Medical Student Tehran University of MedicalSciences Tehran Iran Emergency Medicine Mashhad University of MedicalSciences Mashhad Iran Department of Ophthalmology Medical Researcher inPrivate Practice Tehran Iran General Practitioner Medical Researcher in PrivatePractice Tehran Iran Sina Trauma and Surgery research Center Depart-ment of Neurosurgery Shariati Hospital Tehran Universityof Medical Sciences Tehran Iran research Centre for Neural repair University ofTehran Tehran Iran

Abstract：Since appropriate and timetable methods in trauma care have an important impact on patients' outcome,we evaluated the effect of Advanced Trauma Life Support (ATLS) program on medical interns'performance in simulated trauma patient management.Methods:A descriptive and analytical study before and after the training was conducted on 24 randomly selected undergraduate medical interns from Imam reza Hospital in Mashhad,Iran.On the first day,we assessed interns' clinical knowledge and their practical skill performance in confronting simulated trauma patients.After 2 days of ATLS training,we performed the same study and evaluated their score again on the fourth day.The two findings,preand post-ATLS periods,were compared through SPSS version 15.0 software.P values less than 0.05 were considered statistically significant.results:Our findings showed that interns' ability in all the three tasks improved after the training course.On the fourth day after training,there was a statistically significant increase in interns' clinical knowledge of ATLS procedures,the sequence of procedures and skill performance in trauma situations (P＜0.001,P=0.016 and P=0.01 respectively).Conclusion:ATLS course has an important role in increasing clinical knowledge and practical skill performance of trauma care in medical interns。

关键词： Advanced Trauma Life Support Care Knowledge Inservice training Wounds and injuries

New Modeling for Generation of Normal and Abnormal Heart rate Variability Signals

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Journal of Biomedical Science and Engineering 2014年第14期7卷 1122-1143页

作者： Naser.safdarian Department of Biomedical Engineering Dezful Branch Islamic Azad University Dezful Iran

This research is performed based on the modeling of biological signals. We can produce Heart rate (Hr) and Heart rate Variability (HrV) signals synthetically using the mathematical relationships which are used as input for the Integral Pulse Frequency Modulation (IPFM) model. Previous researches were proposed same methods such as one model of ECG signal synthetically based on rBF neural network, a model based on IPFM with random threshold, method was based on the estimation of produced signals which are dependent on autonomic nervous system using IPFM model with fixed threshold, a new method based on the theory of vector space that based on time-varying uses of IPMF model (TVTIPMF) and special functions, and two different methods for producing HrV signals with controlled characteristics and structure of time-frequency (TF) for using non-stationary HrV analysis. In this paper, several chaotic maps such as Logistic Map, Henon Map, Lorenz and Tent Map have been used. Also, effects of sympathetic and parasympathetic nervous system and an internal input to the SA node and their effects in HrV signals were evaluated. In the proposed method, output amount of integrator in IPFM model was compared with chaotic threshold level. Then, final output of IPFM model was characterized as the Hr and HrV signal. So, from Hr and HrV signals obtaining from this model, linear features such as Mean, Median, Variance, Standard Deviation, Maximum range, Minimum range, Mode, Amplitude range and frequency spectrum, and non-linear features such as Lyapunov Exponent, Shanon Entropy, log Entropy, Threshold Entropy, sure Entropy and mode Entropy were extracted from artificial HrV and compared them with characteristics as extracted from natural HrV signal. Also, in this paper two patients that called high sympathetic Balance and Cardiovascular Autonomy Neuropathy (CAN) which is detected and evaluated by HrV signals were simulated. These signals by changing the values of the some coefficients of the normal simulated signal and with extracted fre

关键词： Artificial HrV Signal Chaotic Map IPFM Model Threshold Level Linear and Non-Linear Feature Extraction Normal and Abnormal HrV Signal

A New Pattern recognition Method for Detection and Localization of Myocardial Infarction Using T-Wave Integral and Total Integral as Extracted Features from One Cycle of ECG Signal

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Journal of Biomedical Science and Engineering 2014年第10期7卷 818-824页

作者： Naser.safdarian Nader Jafarnia Dabanloo Gholamreza Attarodi Department of Biomedical Engineering Dezful Branch Islamic Azad University Dezful Iran Department of Biomedical Engineering Science and Research Branch Islamic Azad University Tehran Iran

In this paper we used two new features i.e. T-wave integral and total integral as extracted feature from one cycle of normal and patient ECG signals to detection and localization of myocardial infarction (MI) in left ventricle of heart. In our previous work we used some features of body surface potential map data for this aim. But we know the standard ECG is more popular, so we focused our detection and localization of MI on standard ECG. We use the T-wave integral because this feature is important impression of T-wave in MI. The second feature in this research is total integral of one ECG cycle, because we believe that the MI affects the morphology of the ECG signal which leads to total integral changes. We used some pattern recognition method such as Artificial Neural Network (ANN) to detect and localize the MI, because this method has very good accuracy for classification of normal signal and abnormal signal. We used one type of radial Basis Function (rBF) that called Probabilistic Neural Network (PNN) because of its nonlinearity property, and used other classifier such as k-Nearest Neighbors (KNN), Multilayer Perceptron (MLP) and Naive Bayes Classification. We used PhysioNet database as our training and test data. We reached over 76% for accuracy in test data for localization and over 94% for detection of MI. Main advantages of our method are simplicity and its good accuracy. Also we can improve the accuracy of classification by adding more features in this method. A simple method based on using only two features which were extracted from standard ECG is presented and has good accuracy in MI localization.

关键词： ECG Signal Classification Signal Processing Myocardial Infarction Features Extraction Neural Network

Designing Wireless Charger Circuit for Hearing Aids Using radio Frequency Waves

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Journal of Biomedical Science and Engineering 2014年第11期7卷 948-962页

作者： Seyed Ataaldin Mahmoudi Nejad Naser.safdarian Department of Biomedical Engineering Dezful Branch Islamic Azad University Dezful Iran

In this paper, an attempt has been made to produce a recipient system of wireless charge for a simple hearing aid so that electrical signal would be generated through detecting and receiving radio frequency waves (rF). The purpose of this design is to receive wireless charge for hearing aids and basically for any electronic device which is not required to a high energy for being setup. In this study, it has been demonstrated that as the amount of radio receiving energy increases, distance of receiver from antenna should be decreased;otherwise, either maximum amount of the receiving energy, or signal power density of the transmitter should be increased. Since it is impossible to be performed, it is decided to set up an energy receiving system constructed by rectenna and charge Circuit and to adjust their parameters to provide energy requirements for a device with low-power consumption. In this paper, different components of an energy receiving system from radio frequency band have been mentioned and a diagram block has been suggested. Subsequently, input impedance of designed antenna has been adjusted by provided relations. This impedance should be adjusted with the total impedance of regarded hearing aid Circuit by which the highest amount of received signal power is transferred to the battery of hearing aids. received signal is converted to a dc voltage by rectifier diode. Finally, by applying a voltage regulator which has been designed using a common-collector amplifier not only the output voltage is kept constant, but the power is also strengthened. The battery of the hearing aids will be charged using the obtained power and voltage.

关键词： radio Frequency Waves (rF) rectenna Spiral Antenna Charge Circuit Impedance Adjustment or Impedance Matching Array Antenna regulator Circuit Hearing-Aid Circuit

The Effect of Luteal-Phase Support with Triptrolin Administration on Implantation and Clinical Pregnancy rate in Assisted reproductive Technology

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Open Journal of Obstetrics and Gynecology 2017年第5期7卷 571-580页

作者： Marzieh Aghahosseini Ashraf Alleyassin Leili safdarian Saeedeh Gharahjeh Hojat Saeidi Fatemeh Sarvi Sedigheh Hosseini Nooshin Mohammadi Golamreza roshandel Jalal Gharajeh Department of Infertility Tehran University of Medical Sciences Tehran Iran Department of Perinatology Tehran University of Medical Sciences Tehran Iran Golestan research Center of Gastroenterology and Hepatology Golestan University of Medical Sciences Golestan Iran

Background: Luteal phase support with GnrH agonist administration has been shown to be effective in improving the outcome of assisted reproductive technology. The goal of this study was to evaluate the effect of single dose Triptrolin (a GnrH agonist) on the probability of the clinical pregnancy rate following embryo transfer (ET) in assisted reproductive techniques (ArT). Methods: In this double blinded randomized clinical trial, 340 infertile women who were candidates for intra-cytoplasmic sperm injection (ICSI) were randomly assigned to receive GnrH agonist (Triptrolin) in the luteal phase or placebo. In the intervention group, 0.1 mg Triptrolin was injected subcutaneously, while the control group received normal saline. The clinical pregnancy and implantation rate were compared between the two groups using chi-2 and t-test. P-values less than 0.05 were considered significant. The registration number of this clinical trial is IrCT 2014030916912N1. results: Administration of 0.1 mg Triptrolin on day 6 after oocyte pick up showed no superiority over placebo in implantation (16.9% - 14%, P = 0.40) and clinical pregnancy rates (32% - 29%, P = 0.66), but the rate of clinical pregnancy was higher in women who were below 27 years of age and those with PCO. Conclusion: Administration of Triptrolin was not superior to placebo for luteal phase support.

关键词： Luteal Phase Support GnrH Agonist Implantation rate Clinical Pregnancy