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Nonlinear Coupling of kinetic Alfvén Waves and Ion Acoustic Waves in the Inner Heliosphere

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research in Astronomy and Astrophysics 2024年第10期24卷 141-158页

作者： Mani k.Chettri Vivek shrivastav rupak Mukherjee Nidhi Gaur r.P.sharma Hemam D.singh Department of Physics Sikkim UniversityGangtokSikkimIndia DAV Public school Sector 14GurugramHaryanaIndia Plasma simulation Laboratory Department of Energy Science and EngineeringIndian Institute of Technology DelhiDelhiIndia

We study the nonlinear coupling of kinetic Alfvén waves with ion acoustic waves applicable to the Earth’s radiation belt and near-sun streamer belt solar wind using dynamical equations in the form of modified Zakharov *** simulations show the formation of magnetic field filamentary structures associated with density humps and dips which become turbulent at later times,redistributing the energy to higher *** magnetic power spectra exhibit an inertial range kolmogorov-like spectral index value of-5/3 for k_(⊥)ρ_(i)steeper dissipation range spectra with indices~-3 for the radiation belt case and~-4 for the nearsun streamer belt solar wind case,here k_(⊥)andρ_(i)represent the wavevector component perpendicular to the background magnetic field and the ion thermal gyroradius,*** quasilinear theory in terms of the Fokker-Planck equation in the region of wavenumber turbulent spectra,we find the particle distribution function flattening in the superthermal tail population which is the signature of particle energization and plasma heating.

关键词： sun:chromosphere sun:corona sun:heliosphere

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rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

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Journal of Molecular Cell Biology 2024年第1期16卷 54-65页

作者： Peter Zorn Jaime Calvo sánchez Tala Alakhras Barbara schreier Michael Gekle stefan Hüttelmaier Marcel köhn Junior Group‘Non-coding rNAs and rBPs in Human Diseases’ Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany Julius Bernstein Institute of Physiology Medical FacultyUniversity of Halle–Wittenberg06112 Halle(Saale)Germany Institute of Molecular Medicine Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany

Alternative splicing is one of the major cellular processes that determine the tissue-specific expression of protein ***,it remains challenging to identify physiologically relevant and tissue-selective proteins that are generated by alternative ***,we investigated the target spectrum of the splicing factor rbfox1 in the cardiac muscle context in more *** using a combination of in silico target prediction and in-cell validation,we identified several focal adhesion proteins as alternative splicing targets of *** focused on the alternative splicing patterns of vinculin(metavinculin isoform)and paxillin(extended paxillin isoform)and identified both as potential rbfox1 *** analyses suggested that both isoforms are promoted by rbfox1 due to binding in the *** adhesions play an important role in the cardiac muscle context,since they mainly influence cell shape,cytoskeletal organization,and cell–matrix *** data confirmed that depletion of rbfox1 changed cardiomyoblast morphology,cytoskeletal organization,and multinuclearity after differentiation,which might be due to changes in alternative splicing of focal adhesion ***,our results indicate that rbfox1 promotes alternative splicing of focal adhesion genes in cardiac muscle cells,which might contribute to heart disease progression,where downregulation of rbfox1 is frequently observed.

关键词： rbfox1 alternative splicing focal adhesion cardiac muscle cells

Differential roles of seed and sprout regeneration in forest diversity and productivity after disturbance

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Forest Ecosystems 2024年第3期11卷 371-380页

作者： Marek Mejstrík Martin svatek Martina Pollastrini Martin sramek radim Matula Department of Forest Ecology Faculty of Forestry and Wood SciencesCzech University of Life Sciences PragueKamýcka 12916500PragueCzech Republic Department of Forest Botany Dendrology and GeobiocoenologyFaculty of Forestry and Wood TechnologyMendel University in BrnoZemedelska 361300BrnoCzech Republic Department of Agriculture FoodEnvironment and ForestryUniversity of FirenzePiazzale Delle Cascine 2850144FirenzeItaly

Natural regeneration after disturbances is a key phase of forest development,which determines the trajectory of successional changes in tree species composition and *** trees can originate from either seeds or sprouts produced by disturbed trees with sprouting *** both regeneration strategies often develop and co-occur after a disturbance,they tend to affect forest development differently due to significant functional ***,the origin of tree regeneration is rarely distinguished in post-disturbance forest surveys and ecological studies,and the differential roles of seed and sprout regeneration in forest productivity and diversity remain poorly *** address these research gaps,we explored the role of sprout and seed regeneration in the formation of woody species diversity and above-ground biomass(AGB)productivity in early-stage forest *** were collected in two experimental forest stands in the Czech republic,where trees were cut with varying intensities with the density of residual(uncut)trees ranging from 0 to 275 trees per *** trees were mapped and their sizes were measured before cutting and then,either as a stump with sprouts or a residual tree,remeasured 11 years *** addition,all tree saplings were mapped and measured 11 years after logging,and their origin(sprout or seed)was *** assess abundances and productivity,we estimated AGB of all2,685 sprouting stumps of 19 woody species and 504 generative(i.e.,seed origin)individuals of 16 woody species,using allometric ***-effects models were used to analyze the effects of each regeneration strategy on woody species diversity and the total AGB under varying densities of residual *** multidimensional scaling was used to evaluate the effect of regeneration strategies on species *** and diversity of sprouts were significantly higher than those of seed *** formed on average97.1%of

关键词： resprouting seeding residual trees Tree diversity Above-ground biomass

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Cytomegalovirus Transverse Myelitis secondary to Influenza Infection and Early recovery:A Case report

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Infectious Diseases & Immunity 2024年第1期4卷 41-42页

作者： Jill s.Bhavsar Lekhini k.Fultariya Poojan J.Prajapati Archi k.Dhamelia Jaime E.Campos Department of Infectious Disease Hialeah HospitalMiamiFL(affiliated with HerbertWertheim College of MedicineFlorida International University)33013USA

Immunosuppression can lead to opportunistic infections in a *** evidence of viral infections causing immunosuppression in a host for a transient period is gaining *** order to prolong their stay in the human body,viruses affect the human immune systemin various *** viral infections such as influenza can lead to transient lymphocytopenia,which lays the groundwork for more dangerous opportunistic ***(CMV)infection is a rare cause of inflammatory *** present the case of a patient with an influenza infection who progressed to severe acute respiratory distress syndrome,methicillin-resistant staphylococcus aureus necrotizing pneumonia,and idiopathic lymphocytopenia with a CD4 count of 61 perμL on *** 2 weeks,the patient developed complete flaccid paralysis with sensory and autonomic *** his polymerase chain reaction results of cerebrospinal fluid and blood test were positive for CMV infection,he was treated with high doses of steroids and ganciclovir *** to early diagnosis and intervention,the patient was able to recover in 2 months with only minimal residual ***,this case stresses on the importance of looking out for opportunistic infections in patients affected by severe viral infections for their early recovery.

关键词： Influenza,Human Lymphocytopenia Transverse myelitis Case report

Adherence to Advisory Committee on Immunization Practices in diabetes mellitus patients in saudi Arabia:A multicenter retrospective study

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World Journal of Diabetes 2024年第3期15卷 440-454页

作者： saleh Fahad Alqifari Aya k Esmail Dalal M Alarifi Ghalya Y Alsuliman Maram M Alhati May r Mutlaq Mohammed Aldhaeefi shaden A Alshuaibi Palanisamy Amirthalingam Abrar Abdallah Afaf s Wasel Heba r Hamad shoroq Alamin Tasneem H Atia Tariq Alqahtani Department of Pharmacy Practice University of TabukTabuk 71491Saudi Arabia Department of Clinical sciences Sulaiman Alrajhi UniversityQassim 52726Saudi Arabia Department of Family Medicine International Medical CenterJeddah 23214Saudi Arabia Clinical and Administrative Pharmacy sciences College of PharmacyHoward UniversityWashingtonDC 20059United States Department of Pharmacology King Saud Bin Abdulaziz University for Health SciencesKing Abdullah International Medical Research CenterRiyadh 11481Saudi Arabia

BACkGrOUND Patients with diabetes mellitus(DM)are predisposed to an increased risk of infection signifying the importance of vaccination to protect against its potentially severe *** Centers for Disease Control and Prevention/Advisory Committee on Immunization Practices(CDC/ACIP)issued immunization recommendations to protect this patient *** To assess the adherence of patients with DM to the CDC/ACIP immunization recommendations in saudi Arabia and to identify the factors associated with the vaccine adherence *** An observational retrospective study conducted in 2023 was used to collect data on the vaccination records from 13 diabetes care centers in saudi Arabia with 1000 eligible patients in phase I with data collected through chart review and 709 patients in phase II through online *** Among participants,10.01%(n=71)had never received any vaccine,while 85.89%(n=609)received at least one dose of the coronavirus disease 2019(COVID-19)vaccine,and 34.83%(n=247)had received the annual influenza *** 2.96%(n=21),2.11%(n=15),and 1.12%(n=8)received herpes zoster,tetanus,diphtheria,and pertussis(Tdap),and human papillomavirus(HPV)vaccines,*** patients with DM in saudi Arabia,the rate of vaccination for annual influenza and COVID-19 vaccines was higher compared to other vaccinations such as herpes zoster,Tdap,pneumococcal,and *** such as vaccine recommendations provided by family physicians or specialists,site of care,income level,DM-related hospitalization history,residency site,hemoglobin A1c(HbA1c)level,and health sector type can significantly influence the vaccination rate in patients with *** non-vaccinated patients with DM,the most reported barriers were lack of knowledge and fear of side *** signifies the need for large-scale research in this area to identify additional factors that might facilitate adherence to CDC/ACIP vaccine recommendations in patients with *** In s

关键词： Diabetes mellitus Vaccine recommendation COVID-19 vaccine Influenza vaccine Pneumococcal vaccine Immunization retrospective study

Hole-selective Contact with Molecularly Tailorable reactivity for Passivating High-Performing Inverted Perovskite solar Cells

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CCs Chemistry 2024年第7期6卷 1654-1661页

作者： Wenlin Jiang Yingie Hu Fengzhu Li Francis r.Lin Alex k-Y.Jen Department of Materials science and Engineering City University of Hong KongKowloonHong Kong China 999077 Department of Chemistry City University of Hong KongKowloonHong Kong China 999077 Hong kong Institute for Clean Energy City University of Hong KongKowloonHong Kong China 999077 state key Laboratory of Marine Pollution City University of Hong KongKowloonHong Kong China 999077

The precisely customizable attributes of self-assembled monolayers(sAMs)molecules at the atomic level hold the potential to facilitate efficient hole selection and interface passivation ***,the correlation between the exposure of passivating groups on the surface and device performance remains ***,we introduce two newly designed sAM molecules,Cbz2s and Cbz2sMe,incorporating cyclic disulfide or two flanking thiomethyls by modifying the 4,5-position of carbazole to adjust the Lewis basicity of the sAM-modified *** possessing suitable energetic alignment,Cbz2s with more-exposed sulfur atoms exhibited inferior device performance due to excessive reactivity,leading to an overpopulation of PbI2 crystallites at the buried perovskite *** contrast,the screening effect from the methyl groups of Cbz2sMe optimized sAM reactivity,exquisitely integrating buried interface passivation and hole selection ***,the champion inverted perovskite solar cell(PsC)employing Cbz2sMe achieved an impressive power conversion efficiency of 24.42%,accompanied by prolonged *** work demonstrates the feasibility of incorporating Lewis-basic passivation groups into sAM molecules and elucidates the relationship between the reactivity of sAM passivation groups and device *** findings provide valuable insights for the design of novel multifunctional sAM molecules,further advancing the performance of PsCs.

关键词： self-assembled monolayer perovskite solar cell hole-selective layer carbazole derivatives defect passivation

Network analyses:Inhibition of androgen receptor signaling reduces inflammation in the lung through Ar-MAF-IL6 signaling axes

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Genes & Diseases 2024年第3期11卷 140-143页

作者： Albert r.Wang Andrew M.Baschnagel Zijian Ni sean r.Brennan Hypatia k.Newton Darya Buehler Christina kendziorski randall J.kimple Gopal lyer Department of Human Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWI 53705USA University of Wisconsin Carbone Cancer Center MadisonWI 53705USA Department of Biostatistics and Medical Informatics University of Wisconsin-MadisonMadisonWI 53706USA Department of Biology Tufts UniversityMedfordMA 02155USA Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

Androgen receptor(Ar)is a major transcription factor that plays a role in inflammatory response including interleukin-6(IL6)signaling.1 While Ar regulation through paracrine loop signaling in prostate tissue is well-studied,its impact through an IL6 autocrine loop in the lung has not been wellstudied despite the organ's response to respiratory viral *** inhibition and rNA knockdown of Ar identified a bZIP transcription factor MAF to be a common target of inflammation using these perturbations in lung cells.

关键词： inflammation lung respiratory

The soft X-ray Imager(sXI)on the sMILE Mission

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Earth and Planetary Physics 2024年第1期8卷 5-14页

作者： s.sembay A.L.Alme D.Agnolon T.Arnold A.Beardmore A.Belén Balado Margeli C.Bicknell C.Bouldin G.Branduardi-raymont T.Crawford J.P.Breuer T.Buggey G.Butcher r.Canchal J.A.Carter A.Cheney Y.Collado-Vega H.Connor T.Crawford N.Eaton C.Feldman C.Forsyth T.Frantzen G.Galgóczi J.Garcia G.Y.Genov C.Gordillo H-P.Gröbelbauer M.Guedel Y.Guo M.Hailey D.Hall r.Hampson J.Hasiba O.Hetherington A.Holland s-Y.Hsieh M.W.J.Hubbard H.Jeszenszky M.Jones T.kennedy k.koch-Mehrin s.kögl s.krucker k.D.kuntz C.Lakin G.Laky O.Lylund A.Martindale J.Miguel Mas Hesse r.Nakamura k.Oksavik N.Østgaard H.Ottacher r.Ottensamer C.Pagani s.Parsons P.Patel J.Pearson G.Peikert F.s.Porter T.Pouliantis B.H.Qureshi W.raab G.randal A.M.read N.M.M.roque M.E.rostad C.runciman s.sachdev A.samsonov M.soman D.sibeck s.smit J.søndergaard r.speight s.stavland M.steller Tianran sun J.Thornhill W.Thomas k.Ullaland B.Walsh D.Walton C.Wang s.Yang school of Physics and Astronomy University of LeicesterLeicesterLE17RHUK space Park Leicester University of LeicesterLeicesterLE17RHUK Mullard space science Laboratory University College LondonDorkingRH56NTUK Centre for Electronic Imaging Open UniversityMilton KeynesMK76 AAUK Birkeland Centre for space science Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway University of Vienna A-1010 ViennaAustria space research Institute Austrian Academy of SciencesA-8042 GrazAustria National Institute of Aerospace Technology MadridSpain EsTEC European Space Agency2201 AZ NoordwijkNetherlands state key Laboratory of space Weather National Space Science CentreBeijing 100190China University of Applied sciences and Arts Northwestern switzerland CH-5210 WindischSwitzerland koegl space GmbH CH-8157 DielsdorfSwitzerland space Acoustics GmbH CH-8157 DielsdorfSwitzerland Zurich University of Applied sciences 8400 WinterhurSwitzerland Genov solutions N-5172 LoddefjordNorway sTM Engineering N-5165 LaksevagNorway John Hopkins University Applied Physics Laboratory MD 20723USA NAsA/Goddard space Flight Centre MD 20771USA Center for space Physics Boston UniversityBostonMA 02215USA Department of Theoretical Physics and Astrophysics Masaryk University60177 BrnoCzech Republic Institute of Physics E¨otvo¨s Lor´and University1053 BudapestHungary Aerospace Information research Institute Chinese Academy of SciencesBeijing 100045China Centro de Astrobiologia(CAB) CSIC-INTAMadridSpain

The soft X-ray Imager(sXI)is part of the scientific payload of the solar wind Magnetosphere Ionosphere Link Explorer(sMILE)*** is a joint science mission between the European space Agency(EsA)and the Chinese Academy of sciences(CAs)and is due for launch in *** is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the sMILE *** is sensitive to the soft X-rays produced by the solar Wind Charge eXchange(sWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s *** provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field *** sensitivity of the sXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of sMILE will enable such movements to be tracked for segments lasting many *** is led by the University of Leicester in the United kingdom(Uk)with collaborating organisations on hardware,software and science support within the Uk,Europe,China and the United states.

关键词： soft X-ray Imaging micropore optics large area CCD

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A Novel Framework for Learning and Classifying the Imbalanced Multi-Label Data

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Computer systems science & Engineering 2024年第5期48卷 1367-1385页

作者： P.k.A.Chitra s.Appavu alias Balamurugan s.Geetha seifedine kadry Jungeun kim keejun Han Department of Computer science and Engineering SRM Institute of Science and TechnologyTiruchirappalliTamil Nadu603203India Department of Computer science and Engineering Periyar Maniammai Institute of Science&Technology(Deemed to be University)ThanjavurTamil Nadu613403India school of Computer science and Engineering ChennaiTamil Nadu600048India Department of Applied Data science Noroff University CollegeKristiansand4612Norway Artificial Intelligence research Center(AIrC) College of Engineering and Information TechnologyAjman UniversityP.O.Box 346AjmanUnited Arab Emirates Department of Electrical and Computer Engineering Lebanese American UniversityByblos10150Lebanon Department of software Kongju National UniversityCheonan31080Republic of Korea Division of Computer Engineering Hansung UniversitySeoul02876Republic of Korea

A generalization of supervised single-label learning based on the assumption that each sample in a dataset may belong to more than one class simultaneously is called multi-label *** main objective of this work is to create a novel framework for learning and classifying imbalancedmulti-label *** work proposes a framework of two *** imbalanced distribution of themulti-label dataset is addressed through the proposed Borderline MLsMOTE resampling method in phase ***,an adaptive weighted l21 norm regularized(Elastic-net)multilabel logistic regression is used to predict unseen samples in phase *** proposed Borderline MLsMOTE resampling method focuses on samples with concurrent high labels in contrast to conventional *** minority labels in these samples are called difficult minority labels and are more prone to penalize classification *** concurrentmeasure is considered borderline,and labels associated with samples are regarded as borderline labels in the decision *** phase II,a novel adaptive l21 norm regularized weighted multi-label logistic regression is used to handle balanced data with different weighted synthetic *** on various benchmark datasets shows the outperformance of the proposed method and its powerful predictive performances over existing conventional state-of-the-art multi-label methods.

关键词： Multi-label imbalanced data multi-label learning Borderline MLsMOTE concurrent multi-label adaptive weighted multi-label elastic net difficult minority label