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Spatio-temporal Evolution and Driving Force Analysis of Carbon Storage in Anhui Province Coupled with PLUS-InVEST-GeoDetector Model

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Huanjing Kexue/Environmental Science 2025年第3期46卷 1703-1715页

作者： Jia, Ji-Ang guo, Wei-Ling Xu, Liu-Yang Gao, Chang School of Spatial Information and Surveying Engineering Anhui University of Science and Technology Huainan232001 China

To explore the impact of land use change on carbon storage and the driving factors of spatial differentiation of carbon storage in Anhui Province under the strategic goal of "dual carbon"and to predict the land use pattern of Anhui Province in 2035 under different scenarios is theoretically and practically important. The coupling PLUS-InVEST model was used to analyze the spatial and temporal variation characteristics of land use pattern and carbon storage in Anhui Province under the scenarios of natural development,ecological protection,cultivated land protection,and ecological cultivated land protection in 2035,and the driving force of spatial differentiation of carbon storage was analyzed by using geographic detectors. The results showed that:① From 1990 to 2020,the land use pattern of Anhui Province showed a trend of continuous decrease in cultivated land and forest land area and significant expansion of urban area. ② From 1990 to 2020,the carbon storage in Anhui Province decreased by 1.39×107t,showing a continuous decreasing trend,and the conversion of cultivated land to urban was the major reason for the decrease in carbon storage,accounting for 65.96% of the total carbon storage loss. ③ The explanatory power of elevation on carbon storage was the strongest under single factor detection(q value of 0.185),and the explanatory power of natural environmental factors on carbon storage spatial differentiation was dominant. ④ In 2035,the carbon storage under different scenarios will be decreasing,and the reduction of inhibited carbon storage under the cultivated land ecological dual protection scenario will be the most significant. © 2025 Science Press. All rights reserved.

关键词： Carbon sequestration

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Gradient microstructure,recrystallization and mechanical properties of copper processed by high pressure surface rolling

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Journal of Materials Science & Technology 2022年第31期126卷 182-190页

作者： J.guo q.Y.He q.S.Mei X.Huang G.L.Wu O.V.Mishin College of Materials Science and Engineering Chongqing UniversityChongqing400045China Southwest Technology and Engineering research Institute Chongqing 400039China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Department of Mechanical Engineering Technical University of Denmark2800 Kgs.LyngbyDenmark

The microstructure,hardness and tensile properties have been studied in copper processed by high pressure surface rolling(HPSr)both in the as-deformed condition and after subsequent annealing at 150℃.It is found that a gradient structure with significant differences in the scale of microstructural features is formed by *** deformed microstructure varies from nano-and ultrafine-scale structures with a large fraction of high angle boundaries near the surface to lightly deformed grains at depths of 1-3 mm below the *** tests of 1-mm-thick specimens demonstrate that the asdeformed material has a high strength and a low uniform *** at 150℃results in partial recrystallization,which creates new through-thickness *** for the topmost layer and several bands in the adjacent layer,recrystallization is more pronounced close to the *** fraction recrystallized is at least 80%at depths of 60-300μm after annealing for 960 *** fraction recrystallized in the subsurface decreases with increasing depth,and the deformed layer at depths greater than 500μm re-mains largely non-recrystallized after *** partially recrystallized condition demonstrates an improved combination of strength and ductility.

关键词： High pressure surface rolling Copper Gradient microstructure Annealing Hardness Strength Ductility

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Dendrobium officinale extract exerts antioxidant effects against skin photoaging through MMP9-TNF pathway

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Traditional Medicine research 2025年第3期10卷 32-41页

作者： Bei-Bei Dong Yun Wang Han Zhao Wu-Yan guo Bo Zhang College of Pharmacy Nankai UniversityTianjin 300350China Hepatobiliary Pancreatic Center Xuzhou Central HospitalXuzhou 221009China Clinic for Kidney and Hypertensive Diseases Hanover Medical SchoolHanover 30625Germany Tianjin JiAnKang Bio&TCM-technology Development Co. Ltd.Tianjin 300457China Institute for TCM-X MOE Key Laboratory of BioinformaticsBioinformatics DivisionBNRistDepartment of AutomationTsinghua UniversityBeijing 100084China

Background:Skin photoaging is a physiological or pathological process caused by multiple *** anti-skin photoaging drugs is a hot topic in cosmetology research *** purpose of this study was to explore the therapeutic effect of Dendrobium officinale(***)on skin ***:The ingredients of *** were detected by UHPLC-q-TOF/*** targets of *** were screened by Swiss Target Prediction ***,NCBI,and OMIM databases were utilized to find out the targets associated with skin *** targets of *** and skin photoaging were obtained by Venn *** ingredient-disease target network and protein-protein interaction network were constructed by using the STrING database and Cytoscape *** key compounds and hub genes were obtained by analyzing *** DAVID database was applied for Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the overlapping *** Vina software was used to simulate molecular docking and the results were visualized using ***,the skin photoaging models of cells and mice were established to validate the results predicted by network ***:In ***,a total of 59 compounds and 595 targets were detected,of which 59 proteins were intersectional with skin photoaging *** top 10 active ingredients(Dendrophenol,Herbacetin,Lyoniresinol,Trans-ferulaldehyde,Naringenin,and so on)and 8 hub genes(AKT1,TNF,VEGFA,MAPK3,CASP3,MMP9,CTNNB1,and EGFr)were *** the key active compounds could bind well with core protein targets(binding energyrapeutic targets were related to the response to reactive oxygen species,collagen catabolic process,extracellular matrix organization,and apoptotic process,*** also found that *** could enhance the cell viability and activity of anti-oxidases,reduce reactive oxygen species and MMP9 levels,and stable mitoc

关键词： Dendrobium officinale skin photoaging matrix metalloproteinase anti-oxidative stress

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Exploring the mechanism of Xiaoaiping Injection inhibiting autophagy in prostate cancer based on proteomics

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Chinese Journal of Natural Medicines 2025年第1期23卷 64-76页

作者： qiuping Zhang qiuju Huang Zhiping Cheng Wei Xue Shoushi Liu Yunnuo Liao Xiaolan Li Xin Chen Yaoyao Han Dan Zhu Zhiheng Su Xin Yang Zhuo Luo Hongwei guo Department of Traditional Chinese Medicine the First Affiliated Hospital of Guangxi Medical University Guangxi Key Laboratory of Bioactive Molecules research and Evaluation & College of Pharmacy Guangxi Medical University Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education & Center for Translational Medicine Guangxi Medical University

Xiaoaiping(XAP) Injection demonstrates the anti-prostate cancer(PCa) effects, yet the underlying mechanism remains unclear. This study aims to investigate the impact of XAP on PCa and elucidate its mechanism of action. PCa cell proliferation was evaluated using a cell counting kit-8(CCK-8) assay. Cell apoptosis was assessed through Hoechst staining and Western blotting assays. Proteomics technology was employed to identify key molecules and significant signaling pathways modulated by XAP in PCa cells. To further validate potential key genes and important pathways, a series of assays were conducted, including acridine orange(AO)staining, transmission electron microscopy, and immunofluorescence assays. The molecular mechanism of XAP against PCa in vivo was examined using a PC3 xenograft mouse model. results demonstrated that XAP significantly inhibited cell proliferation in multiple PCa cell *** C4-2 and prostate cancer cell line-3(PC3) cells, XAP induced cellular apoptosis, evidenced by reduced B-cell lymphoma 2(Bcl-2) levels and elevated Bcl-2-associated X(Bax) levels. Proteomic, immunofluorescence, and quantitative reverse transcription-polymerase chain reaction(q rT-PCr) investigations revealed a strong correlation between forkhead box O3a(Fox O3a) autophagic degradation and the anti-PCa action of XAP. XAP hindered autophagy by reducing the expression levels of autophagy-related protein 5(Atg5)/autophagy-related protein 12(Atg12) and enhancing Fox O3a expression and nuclear translocation. Furthermore,XAP exhibited potent anti-PCa action in PC3 xenograft mice and triggered Fox O3a nuclear translocation in tumor tissue. These findings suggest that XAP induces PCa apoptosis via inhibition of Fox O3a autophagic degradation, potentially offering a novel perspective on XAP injection as an effective anticancer therapy for PCa.

关键词： Apoptosis Autophagy Forkhead box O3a Prostate cancer Xiaoaiping Injection

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GroupⅢmetabotropic glutamate receptors and drug addiction

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Frontiers of Medicine 2013年第4期7卷 445-451页

作者： Limin Mao Minglei guo Daozhong Jin Bing Xue John q.Wang Department of Basic Medical Science School of MedicineUniversity of Missouri-Kansas CityKansas CityMO 64108USA

Neuroadaptations of glutamatergic transmission in the limbic reward circuitry are linked to persistent drug *** data have demonstrated roles of ionotropic glutamate receptors and groupⅠandⅡmetabotropic glutamate receptors(mGlurs)in this *** evidence also identifies Gαi/o-coupled groupⅢmGlurs(mGlur4/7/8 subtypes enriched in the limbic system)as direct substrates of drugs of abuse and active regulators of drug ***-and heteroreceptors of mGlur4/7/8 reside predominantly on nerve terminals of glutamatergic corticostriatal and GABAergic striatopallidal pathways,*** presynaptic receptors regulate basal and/or phasic release of respective transmitters to maintain basal ganglia *** response to operant administration of common addictive drugs,such as psychostimulants(cocaine and amphetamine),alcohol and opiates,limbic groupⅢmGlurs undergo drastic adaptations to contribute to the enduring remodeling of excitatory synapses and to usually suppress drug seeking *** a result,a loss-of-function mutation(knockout)of individual groupⅢreceptor subtypes often promotes drug *** review summarizes the data from recent studies on three groupⅢreceptor subtypes(mGlur4/7/8)expressed in the basal ganglia and analyzes their roles in the regulation of dopamine and glutamate signaling in the striatum and their participation in the addictive properties of three major classes of drugs(psychostimulants,alcohol,and opiates).

关键词： groupⅢmetabotropic glutamate receptors cocaine amphetamine alcohol opiate

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Experimental Study and Numerical Simulation of the Casting-Forging Complex Near Net Forming of Alternator Claw-pole

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上海交通大学学报 2004年第z2期38卷 79-82页

作者： J.L.Song D.J.Hu q.C.Wang H.q.Chen H.G.guo School of Mechanical and Power Engineering Shanghai Jiaotong University Shanghai200030 China Scool of Materials Science and Engineering Taiyuan Heavy Machinery Institute Taiyuan030024 China School of Mechanical and Power Engineering Shanghai Jiaotong University Shanghai200030 China Scool of Materials Science and Engineering Taiyuan Heavy Machinery Institute Taiyuan030024 China Scool of Materials Science and Engineering Taiyuan Heavy Machinery Institute Taiyuan030024 China Scool of Materials Science and Engineering Taiyuan Heavy Machinery Institute Taiyuan030024 China

As a newly developed precision technology, casting-forging complex near net forming process is utilized to produce complex components with a short lead time, low cost and high precision, thus to accelerate the response speed of the market and enhance the competitive power of products. In this paper, the casting-forging complex near net forming process of alternator claw pole was developed and investigated with a combination of experimental and numerical simulation method. qualified near net workpiece was manufactured, mechanical parameter and relative field information during the forming process was also obtained. While the alternator claw-pole is processed with this technology, the forming force is small, the process is short and the quality of forgings is perfect. Therefore, the complex casting-forging near net forming process of claw-pole is an energy and material saving technology, which will have a vast developing and application prospect in the future.

关键词： alternator claw-pole casting-forging near net forming numerical simulation

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Macroscopic and microscopic mechanical behaviors of climbing tendrils

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Acta Mechanica Sinica 2019年第3期35卷 702-710页

作者： q.guo J.J.Dong Y.Liu X.H.Xu q.H.qin J.S.Wang Tianjin Key Laboratory of Modern Engineering Mechanics Department of MechanicsTianjin UniversityTianjin 300054China State Key Laboratory of Nonlinear Mechanics (LNM) Institute of MechanicsChinese Academy of ScienceBeijing 100080China research School of Engineering Australian National UniversityCanberraACT 2601Australia

Tendril-bearing climbing plants must recur to the tendril helices with chiral perversion or dual chirality for climbing and to obtain sun exposure. Despite researchers' prolonged fascination with climbing tendrils since Darwin's time and even earlier, why the soft and slender tendrils can bear heavy loads such as the self-weight of a plant or additional load caused by rain remains elusive. In this paper, we take towel gourd tendrils as an example and investigate the macroscopic and microscopic mechanical behaviors of tendrils through experiments and simulations. Our study indicates that the tendril filament exhibits rubber-like hyperelastic behaviors and can particularly endure large elongation, which is mainly attributed to the superelasticity of the cellulose fibril helix contained in the cell wall. Combination of the tendril helical structure with dual chirality or chiral perversion at a macroscale and a cellulose filament helix at a subcellular level creates superior elasticity for biological species relying on support and climbing. This study provides deep insight into the structure-property relationship of climbing tendrils, and the relationship is useful for the bioinspired design of composite systems with superior elasticity.

关键词： Climbing tendril Mechanical behaviors Structure-property relationship Large elongation

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BIBr1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： qin Wang qing-rong Li Lei Xu Zi-Chun Yuan Xiao Liu Mao-Ju Tang Man Luo Xiao-Wu Zhong qiang Ma Xiao-Lan guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGrOUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an rNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBr1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of rESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBr1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTErT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBr1532 upregulated the expression of the DDr protein,γ-H2AX,and activated the ataxia telangiectasia and rad3-related protein(ATr)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TrF1),TrF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBr1532 significantly suppressed tumor growth,reduced hTErT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBr1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

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Matching while Learning: Wireless Scheduling for Age of Information Optimization at the Edge

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China Communications 2023年第3期20卷 347-360页

作者： Kun guo Hao Yang Peng Yang Wei Feng Tony q.S.quek School of Communications and Electronics Engineering East China Normal UniversityShanghai 200241China Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal UniversityChongqing 401120China Zhejiang University/University of Illinois at Urbana-Champaign Institute Zhejiang UniversityHaining 314400China School of Electronic and Information Engineering Beihang UniversityBeijing 100083China Beijing National research Center for Information Science and Technology Department of Electronic EngineeringTsinghua UniversityBeijing 100084China Information Systems Technology and Design(ISTD)Pillar Singapore University of Technology and DesignSingapore 487372

In this paper,we investigate the minimization of age of information(AoI),a metric that measures the information freshness,at the network edge with unreliable wireless ***,we consider a set of users transmitting status updates,which are collected by the user randomly over time,to an edge server through unreliable orthogonal *** begs a natural question:with random status update arrivals and obscure channel conditions,can we devise an intelligent scheduling policy that matches the users and channels to stabilize the queues of all users while minimizing the average AoI?To give an adequate answer,we define a bipartite graph and formulate a dynamic edge activation problem with stability ***,we propose an online matching while learning algorithm(MatL)and discuss its implementation for wireless ***,simulation results demonstrate that the MatL is reliable to learn the channel states and manage the users’buffers for fresher information at the edge.

关键词： information freshness Lyapunov opti-mization multi-armed bandit wireless scheduling

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EFFECT　OF　P，S　AND　Si　ON　THE　SOLIDIFICATION，SEGrEGATION，MICrOSTrUCTUrE　AND　MECHANICAL　PrOPErTIES　IN　Fe－Ni　BASE　SUPErALLOYS

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Acta Metallurgica Sinica(English Letters) 1996年第6期9卷 443-452页

作者： Z.q. Hu W.r.Sun and S.r. guo(Institute of Metal research, Chinese Academy of Sciences, Shenyang 110015, China

The effects of the trace elements, P, S and Si,on the solidification, segregation,microstructure and mechanical properties of GH761 and In718 alloys were *** was found that the segregation of the P,S and Si can be greatly aggravated or relieved by the precipitation taking place during the solidification. In the heat treated state,P enhances the intergranular precipitation in the GH761 *** refinement of P in In718 alloy causes the appearance of a film-like δ*** increases the intergranular precipitation of the M_6C and the Laves Phase in the In718 alloy.P, S and Si play diverse roles in the tensile and the stress rupture properties of the GH761 and In718 alloys. The most striking effect is that P significantly prolongs the stress rupture lives of the GH761 and In718 alloys in a wide range of 0.00050.015 wt% .The mechanisms by which P,S and Si influence the superalloys are discussed in the text.

关键词： superalloy,segregation microstructure mechanical property

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