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作者： A.Friedrich D.Z.Tobias P.P.Leo D. Junker G.Schfer r.pichler 秦乃姗 Departments of radiology Medical University InnsbruckAnichstr. 35 6020 Innsbruck Austria

摘要目的评估实时超声弹力成像(rTE)对于睾丸病变诊断及鉴别诊断的可行性。材料与方法此回顾性研究获得机构审查委员会批准,无需签署知情同意书。2004年12月-2010年8月,50例睾丸病变病人(18～81岁,平均42岁)进行灰阶超声、彩色和(或)能... 详细信息

摘要目的评估实时超声弹力成像(rTE)对于睾丸病变诊断及鉴别诊断的可行性。材料与方法此回顾性研究获得机构审查委员会批准,无需签署知情同意书。2004年12月-2010年8月,50例睾丸病变病人(18～81岁,平均42岁)进行灰阶超声、彩色和(或)能量多普勒超声与rTE检查以评价睾丸组织弹

关键词：实时超声 rTE 弹力能量多普勒超声非肿瘤性病变灰阶超声

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Multiscale structural analysis inspired by exceptional load cases concerning the immersed tunnel of the Hong Kong-Zhuhai-Macao Bridge

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Underground Space 2018年第4期3卷 252-267页

作者： Hui Wang Eva Binder Herbert Mang Yong Yuan Bernhard pichler Institute for Mechanics of Materials and Structures TU Wien–Vienna University of TechnologyKarlsplatz 13/202A-1040 ViennaAustria College of Civil Engineering Tongji UniversityShanghaiChina

This paper contains an assessment of the added value of multiscale material models for concrete in the context of macroscopic struc-tural analysis of(steel-reinforced)concrete *** examples are *** are inspired by the possibility of car accidents inside the immersed tunnel of the Hong Kong-Zhuhai-Macao Bridge(HZMB).The first example deals with vehicles crashing into the tunnel *** high-dynamic strengthening effect of concrete is studied based on an engineering mechanics *** structural nature of the dynamic strength increase factor(DIF)is demonstrated by means of high-dynamic strength values measured on mortar cylinders of different ***,the evolution of the DIF as a function of hardening of concrete at material ages beyond 28 days is studied.A validated multiscale model for concrete renders a customized analysis for the specific concrete used for the aforementioned tunnel *** is found that the DIF decreases with progressive hardening of concrete at material ages beyond 28 *** second example is inspired by tunnel fires as may happen after car *** study refers to thermal stresses in steel-reinforced concrete beams sub-jected to sudden *** thermal expansion coefficient of the concrete of the tunnel is quantified by means of a multiscale *** is used as input for linear thermo-mechanical Finite-Element simulations of steel-reinforced concrete *** essential macroscopic simulation results are temperature distributions and associated stress *** are employed for top-down quantification of micro-scopic stress states inside the cement paste and the *** allows for quantifying two sources of microstructural stress fluctu-ations:(i)the macro-to-micro stress concentration and(ii)the mismatch of microscopic thermal expansion *** both examples,the multiscale models for concrete have increased the informative content of the structural simulations.

关键词： Concrete linings High-dynamic strength Thermal stresses

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FGFr3 alterations in bladder cancer:Sensitivity and resistance to targeted therapies

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Cancer Communications 2024年第10期44卷 1189-1208页

作者： Maxim Noeraparast Katarina Krajina renate pichler Dora Nieders-Beke Shahrokh F Shariat Viktor Grünwald Sascha Ahyai Martin pichler Translational Oncology II.Med Clinics Hematology and OncologyAugsburgGermany Department of Urology Medical University of InnsbruckInnsbruckAustria Department of Hematology and Oncology Clinics OttakringViennaAustria Department of Urology Medical University of ViennaViennaAustria Interdisciplinary Genitourinary Oncology Clinic for UrologyClinic for Medical OncologyUniversity Hospital EssenHufelandstrase 55EssenGermany Department of Urology Medical University of GrazGrazAustria

In this review,we revisit the pivotal role of fibroblast growth factor receptor 3(FGFr3)in bladder cancer(BLCA),underscoring its prevalence in both nonmuscle-invasive and muscle-invasive forms of the ***3 mutations in up to half of BLCAs play a well-established role in tumorigenesis,shaping distinct tumor initiation patterns and impacting the tumor microenvironment(TME).Emphasizing the importance of considering epithelial-mesenchymal transition profile and TME status,we revisit their relevance in predicting responses to immune checkpoint inhibitors in FGFr3-mutated *** writing highlights the initially promising yet transient efficacy of the FGFr inhibitor Erdafitinib on FGFr3-mutated BLCA,stressing the pressing need to unravel resistance mechanisms and identify co-targets for future combinatorial studies.A thorough analysis of recent preclinical and clinical evidence reveals resistance mechanisms,including secondarymutations,epigenetic alterations in pathway effectors,phenotypic heterogeneity,and population-specific variations within FGFr3 mutational ***,we discuss the potential of combinatorial treatments and concepts like synthetic lethality for discovering more effective targeted therapies against FGFr3-mutated BLCA.

关键词： Bladder Cancer Erdafitinib FGFr inhibition FGFr3 mutations resistance to Erdafitinib Tumor Microenvironment

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Modelling the utility of group testing for public health surveillance

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Infectious Disease Modelling 2021年第1期6卷 1009-1024页

作者： Günther Koliander Georg pichler Acoustics research Institute Austrian Academy of SciencesWohllebengasse 12-141040ViennaAustria Institute of Telecommunications TU WienGußhausstraße 25/E3891040ViennaAustria

In epidemic or pandemic situations,resources for testing the infection status of individuals may be *** group testing can help to significantly increase testing capabilities,the(repeated)testing of entire populations can exceed the resources of any *** thus propose an extension of the theory of group testing that takes into account the fact that definitely specifying the infection status of each individual is *** theory builds on assigning to each individual an infection status(healthy/infected),as well as an associated cost function for erroneous *** cost function is versatile,e.g.,it could take into account that false negative assignments are worse than false positive assignments and that false assignments in critical areas,such as health care workers,are more severe than in the general *** on this model,we study the optimal use of a limited number of tests to minimize the expected *** specifically,we utilize information-theoretic methods to give a lower bound on the expected cost and describe simple strategies that can significantly reduce the expected cost over currently known strategies.A detailed example is provided to illustrate our theory.

关键词： Group testing Public health surveillance Source coding rate-distortion theory

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On the added value of multi-scale modeling of concrete

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Frontiers of Structural and Civil Engineering 2022年第1期16卷 1-23页

作者： Jiaolong ZHANG Eva BINDEr Hui WANG Mehdi AMINBAGHAI Bernhard LA pichler Yong YUAN Herbert A MANG College of Civil Engineering Tongji UniversityShanghai 200092China Department of Building Technology Linnaeus UniversityVaxjo 35195Sweden School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Institute for Mechanics of Materials and Structures TU WienVienna 1040Austria

This review of the added value of multi-scale modeling of concrete is based on three representative *** first one is concerned with the analysis of experimental data,taken from four high-dynamic *** structural nature of the high-dynamic strength increase can be explained by using a multi-scale *** accounts for the microstructure of the *** second example refers to multi-scale thermoelastic analysis of concrete pavements,subjected to solar heating.A sensitivity analysis with respect to the internal relative humidity(rH)of concrete has underlined the great importance of the rH for an assessment of the risk of microcracking of *** third example deals with multi-scale structural analysis of a real-scale test of a segmental tunnel *** has turned out that multi-scale modeling of concrete enables more reliable predictions of crack opening displacements in tunnel segments than macroscopic models taken from codes of ***,it is concluded that multi-scale models have indeed a significant added ***,its degree varies with these *** any case,it can be assessed by means of a comparison of the results from three sources,namely,multi-scale structural analysis,conventional structural analysis,and experiments.

关键词： experiments multi-scale analysis conventional structural analysis concrete reinforced concrete

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Mapping the clinical practice of traditional,complementary and integrative medicine in oncology in Western countries:A multinational cross-sectional survey

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Journal of Integrative Medicine 2024年第1期22卷 64-71页

作者： Matthias Huemer Sandro Graca Sarah Bitsche Guenter Hofmann Mike Armour Martin pichler Palliative Care Unit Division of OncologyDepartment of Internal MedicineMedical University of Graz8036 GrazAustria Northern College of Acupuncture York YO16LJUnited Kingdom School of Health and Society Faculty of EducationHealth and WellbeingUniversity of WolverhamptonWolverhampton WV11LYUnited Kingdom National Institute of Complementary Medicine Health research Institute Western Sydney UniversityPenrith NSW 2751Australia Translational Health research Institute Western Sydney UniversityPenrith NSW 2751Australia Medical research Institute of New Zealand Wellington 6021New Zealand Translational Oncology University Hospital of Augsburg86156 AugsburgGermany

Background Many cancer patients seek adjunctive therapies to biomedical cancer treatments at some point of their disease *** acupuncture is increasingly recommended by leading oncological associations,limited evidence exists concerning the evidence-informed practice and adherence to current guidelines of traditional complementary and integrative medicine(TCIM)practitioners treating cancer *** An international online-survey assessed the demographical data,clinical practice,and sources of information used by TCIM practitioners in Austria,Germany,United States of America,Australia,and New *** In total,404 respondents completed the survey,of which 254(62.9%)treated cancer *** practitioners were acupuncturists and herbalists(57.1%),had(16.8±9.9)years of clinical experience and see a median of 2(1,4)cancer patients per *** cancer(61.8%)is the most common cancer type seen in TCIM *** TCIM treatments are frequently concurrent with the patient’s cancer specific treatment(39.9%),which is also reflected by the main goal of a TCIM treatment to alleviate side effects(52.4%).However,only 28.0%of the respondents are in contact with the treating *** to the respondents,pain is most effectively treated using acupuncture,while herbal medicine is best for cancer-related *** practitioners mostly use certified courses(33.1%)or online databases(28.3%)but often believe that experts are more reliable to inform their practice(37.0%)than research publications(32.7%).Conclusion Acupuncturists and herbalists commonly treat cancer *** practitioners use TCIM as an adjunct to biomedicine as supportive care and use it largely in accordance with current oncological guidelines.

关键词： Integrative medicine Acupuncture Oncology Evidence-informed practice International survey

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