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Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice

Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 391-400,I0008-I0291页

作者： Swapnil Gavhane Chandrakant Gawli Sachin Kumar Biswajit Das Gayatri Marathe Vishal S.patil Harun M.Patel Basavaraj Bommanahalli Chanakya Nath Kundu Chandragouda r.patil r.C.Patel Institute of Pharmaceutical Education and research Karwand NakaShirpurMaharashtra 425405India Department of Pharmacology Delhi Pharmaceutical Sciences and Research UniversityNew Delhi 110017India School of Biotechnology Kalinga Institute of Industrial TechnologyBhubaneshwar 751024India Gadag Institute of Medical Sciences GadagKarnataka 582103India

Objective:To evaluate the effect of trigonelline on bleomycin-induced idiopathic pulmonary fibrosis(IPF)and to explore its underlying mechanisms using network ***:IPF was induced in C57BL/6 mice by a single intratracheal instillation of bleomycin(5 mg/kg).Trigonelline was administered at doses of 25,50,and 100 mg/kg/day orally from the 2nd day post-bleomycin induction up to the 14th *** IPF-induced mice,lung coefficient,immune cell infiltration in bronchoalveolar lavage fluid,and oxidative stress were *** alterations in lung tissues were also ***,network pharmacology approach was conducted to reveal molecular interactions of bleomycin and trigonelline with targets of ***:Trigonelline treatment reduced bleomycin-induced oxidative stress and immune cell infiltration,and mitigated physiological changes in the lung tissues of ***,trigonelline alleviated bleomycin-induced histological alterations in lung *** pharmacology analysis showed that bleomycin and trigonelline interacted with IPF targets,such as NFKB1,HDAC2,HIF1A,and ***:The interaction of trigonelline with key IPF targets and its ameliorative effects on lung damage and oxidative stress highlight its potential in treating *** may be considered an antifibrotic agent for further clinical development.

关键词： Trigonelline Idiopathic pulmonary fibrosis Antifibrotic Bleomycin Network pharmacology

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Analyzing variations in spatial critical gaps at two-way stop controlled intersections using parametric and non-parametric techniques

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第1期8卷 129-138页

作者： Digvijay S.Pawar Gopal r.patil Department of Civil Engineering Indian Institute of Technology HyderabadKandi 502285India Department of Civil Engineering Indian Institute of Technology BombayPowai 400076India

At two-way stop controlled(TWSC)intersections drivers on minor stream are generally at risk because of the difficulty in judging safe gap between major stream *** misjudgment by the driver while choosing gap may result in a collision with major stream *** paper provides important insights for determining and analyzing spatial critical gaps of drivers at high speed and medium speed TWSC *** critical gap line(CGL)fitted for the accepted and rejected gaps using parametric(binary logit model-BLM)and non-parametric(support vector machines-SVM)techniques gives critical gap values at 15 th,50 th and 85 th percentile *** evaluation of spatial critical gap with respect to major road vehicle(conflicting vehicle)speed makes it easier to understand the impact of variation in speed on spatial gaps accepted by the drivers on the minor *** logit models developed revealed that the probability of accepting gap decreases with increase in the speed of the conflicting vehicle and it increases with increase in the distance of conflicting *** spatial critical gaps estimated using support vector machines were found in close approximation with those estimated using binary logit *** study results showed that SVMs have very good potential to be an alternative tool for the estimation of driver's critical *** spatial critical gaps corresponding to 15 th,50 th and 85 th percentile speeds for medium speed intersections were 32 m,38 m and 46 m respectively and for high speed intersections these values were 64 m,76 m and 104 m *** increase in the magnitude of gap value with respect to the percentile speed clearly states the effect of speed on spatial *** insights from the study can be used to suggest various measures to improve the safety of crossing drivers at uncontrolled intersections.

关键词： Traffic engineering Spatial critical gaps Uncontrolled intersections Logit model SVM Driver behavior

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Fluorimetric study of the interaction between ATP and ciprofloxacin-Y^(3+) complex and its application

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Journal of rare Earths 2010年第3期28卷 329-332页

作者： Shailaja r.patil Umesh S.Mote Shivajirao r.patil Sang-Hak Lee Govind B.Kolekar Fluorescence Spectroscopy research Laboratory Department of ChemistryShivaji UniversityKolhapur-416 004MaharashtraIndia Department of Chemistry Kyungpook National UniversityDaeguS.Korea 133-791)

A simple spectrofluorimetric method was developed for determination of trace amount of adenosine disodium triphosphate(ATP).Under the optimum conditions,we studied the interaction between CIP-Y3+-ATP complex by using absorption and fluorescence *** was observed that ATP remarkably enhanced the fluorescence intensity of the CIP-Y3+ complex at λem=415 nm and the enhanced fluorescence intensity of Y3+ ion remained proportional to the concentration of *** developed method was successfully applied for...

关键词： adenosine disodium triphosphate(ATP) ciprofloxacin(CIP) yttrium(Y3+) spectrofluorimetric method rare earths

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Vanadium-Doped Magnesium Oxide Nanoparticles Formation in Presence of Ionic Liquids and Their Use in Photocatalytic Degradation of Methylene Blue

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Acta Metallurgica Sinica(English Letters) 2016年第3期29卷 253-264页

作者： Harshad r.patil Z.V.P.Murthy Department of Chemical Engineering S.V.National Institute of Technology r&D Division Hazira Manufacturing DivisionReliance Industries Limited

Magnesium oxide（MgO） is one of the metal oxides having unique properties with numerous potential industrial *** this study,MgO and vanadium-doped MgO nanoparticles were synthesized by sol–gel method in 1-butyl-3-methylimidazolium tetrafluoroborate [BMIM][BF_4] and 1-octyl-3-methylimidazolium tetrafluoroborate [OMIM][BF_4] ionic ***-doped MgO nanoparticles exhibited nanosphere and nanorod morphologies with 40–80 nm in particle size,primarily due to the influence of ionic liquids as demonstrated by high-resolution scanning electron microscopy and transmission electron *** of nanoparticles were also studied by thermal gravimetric analysis,X-ray diffraction and energy-dispersive X-ray *** ability of synthesized nanoparticles was evaluated for methylene blue（MB） in specially designed UV *** is found to be dependent on doping,and particle characteristics change due to the influence of ionic *** ionic liquid-assisted vanadium-doped MgO nanoparticles showed good reusability under UV irradiation and MB degradation ability under visible light.

关键词： Ionic liquid Vanadium pentoxide Magnesium oxide Sol–gel Photocatalytic activity

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Biomimetic approach for the synthesis of N,N'-diarylsubstituted formamidines catalyzed by β-cyclodextrin in water

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Chinese Chemical Letters 2012年第10期23卷 1125-1128页

作者： Dipak r.patil Dipak S.Dalal Department of Organic Chemistry North Maharashtra UniversityJalgaon 425001M.S.India

An environmentally benign and highly efficient biomimetic approach for the synthesis of N,N＇-diarylsubstituted formamidines in water catalyzed β-cyclodextrin is described under neutral condition with quantitative yi... 详细信息

关键词： β-Cyclodextrin (β-CD) N,N'-Diarylsubstituted formamidines

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Dual-tree complex wavelet transform and super-resolution based video inpainting application to object removal and error concealment

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CAAI Transactions on Intelligence Technology 2020年第4期5卷 314-319页

作者： Gajanan Tudavekar Sanjay r.patil Santosh S.Saraf Department of Electronics&Communication Engineering Angadi Institute of Technology and ManagementBelagaviKarnatakaIndia Visvesvaraya Technological University BelagaviKarnatakaIndia Department of Electronics&Telecommunication Engineering Marathwada Institute of TechnologyAurangabadMaharashtraIndia Department of Electronics&Communication Engineering KLS Gogte Institute of TechnologyBelagaviKarnatakaIndia

Video inpainting is a technique that fills in the missing regions or gaps in a video by using its known *** existing video inpainting algorithms are computationally expensive and introduce seam in the target region that arises due to variation in brightness or contrast of the *** overcome these drawbacks,the authors propose a novel two-stage *** the first step,sub-bands of wavelets of a low-resolution image are obtained using the dualtree complex wavelet *** algorithm and auto-regression technique are then applied to these subbands to inpaint the missing *** fuzzy logic-based histogram equalisation is used to further enhance the image by preserving the image brightness and improve the local *** the second step,the image is enhanced using super-resolution *** process of down-sampling,inpainting and subsequently enhancing the video using the super-resolution technique reduces the video inpainting *** framework is tested on video sequences by comparing and analysing the structural similarity index matrix,peak-signal-to-noise ratio,visual information fidelity in pixel domain and execution time with the state-of-the-art *** experimental analysis gives visually pleasing results for object removal and error concealment.

关键词： resolution video image

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Nrf2 activator corosolic acid meliorates alloxan induced diabetic nephropathy in mice

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Asian Pacific Journal of Tropical Biomedicine 2017年第9期7卷 797-804页

作者： Priti S.Tidke Chandragouda r.patil Department of Pharmacology R.C.Patel Institute of Pharmaceutical Education and ResearchShirpurDist-DhuleMaharashtraIndia

Objective: To determine whether corosolic acid(CA) targeting nuclear protein expression of Nrf2 activation can be used to attenuate renal damage and preserve renal function in alloxan diabetic ***: A mouse model with diabetic nephropathy was established to examine the Nrf2 expression. Mice were randomly divided into control, diabetic control, and CA groups treated at 0.4 mg/kg, 2 mg/kg and 10 mg/kg p.o. for 8 weeks. Diabetes was induced in mice by single intraperitoneal injection of alloxan 200 mg/kg in all groups except the control. The mice with fasting blood glucose level over 200 mg/d L were considered as diabetic and were employed in the study. After 4 th and 8 th weeks, urine samples were collected(using metabolic cages) to measure protein and urea. Animals were euthanized, and serum samples were collected to estimate the glucose, creatinine, total protein, urea and blood urea nitrogen. Kidney was isolated at the end of experiment for histology to evaluate anti-oxidant parameters. Immunohistochemistry was performed to examine the Nrf2 ***: CA treatment showed dose dependent reduction in level of biochemical parameters in serum and urine. CA group(10 mg/kg) showed significantly higher body weight and reduced kidney weight. Histopathological examination revealed reduced inflammation, collagen deposition and glomerulosclerosis in renal tissue. CA attenuated renal dysfunction, oxidative stress and inflammatory pro-cytokine ***: CA treatment exhibited ameliorative effect on kidney in mice with its enhanced Nrf2 expression.

关键词： Corosolic acid Nrf2 Diabetic nephropathy Oxidative stress Inflammation Pentacyclic triterpenoid

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Phloretin-induced suppression of oxidative and nitrosative stress attenuates doxorubicin-induced cardiotoxicity in rats

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Asian Pacific Journal of Tropical Biomedicine 2022年第3期12卷 124-131页

作者： Shivani S.Wagh Kalpesh r.patil Umesh B.Mahajan Pradnya D.Bagal Avinash r.Wadkar Basavraj Bommanhalli Prabhakar r.patil Sameer N.Goyal Shreesh Ojha Chandragouda r.patil Department of Pharmacology R.C.Patel Institute of Pharmaceutical Education and ResearchShirpur-425405Dist.DhuleMaharashtraIndia Department of Pathology Gadag Institute of Medical SciencesGadagKarnatakaIndia Department of Pharmacology Navodaya Medical CollegePost Box No:26Mantralayam RoadNavodaya NagarRaichur-584103KarnatakaIndia Shri Vile Parle Kelavani Mandal's Institute of Pharmacy Dhule-424001MaharashtraIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityP.O.Box 17666Al AinAbu DhabiUAE Department of Pharmacology Delhi Pharmaceutical Sciences and Research UniversityMehrauli-Badarpur RoadPushp Vihar Sector-3New Delhi-110017India

Objective:To compare the cardioprotective efficacy of equimolar doses(50 mM/kg,p.o.)of phloretin and genistein against doxorubicin-induced cardiotoxicity in ***:Cardiotoxicity was induced in rats by intraperitoneal injection of 6 mg/kg doxorubicin on alternative days till the cumulative dose reached 30 mg/*** study included four treatment groups of rats(n=6):the control group(0.5%carboxymethyl cellulose solution-treated),the doxorubicin-treated group(0.5%carboxymethyl cellulose solution along with doxorubicin),the genistein-treated group(50 mM/kg/day;*** with doxorubicin)and phloretin-treated group(50 mM/kg/day;*** with doxorubicin).On the 10th day of dosing,rats were anesthetized for recording ECG,mean arterial pressure,and left ventricular *** stress,nitric oxide levels,and inflammatory cytokines were estimated in the cardiac *** function parameters(creatine kinase MB,lactate dehydrogenase,aspartate aminotransferase,and alanine transaminase)were estimated in the serum ***:Phloretin treatment inhibited doxorubicin-induced oxidative stress and also reduced nitric oxide levels in cardiac tissues of *** administration attenuated doxorubicin-induced alterations in hemodynamic parameters(heart rate,mean arterial blood pressure,and left ventricular function)and suppressed the expression of pro-inflammatory *** cardiac injury markers like creatine kinase MB,lactate dehydrogenase,aspartate aminotransferase,and alanine transaminase were reduced by both genistein and *** these effects of phloretin were more prominent than ***:Phloretin offers cardioprotection that is comparable to genistein,a clinically validated cardioprotectant against doxorubicin-induced *** studies are needed to confirm and establish the therapeutic utility of phloretin as a chemopreventive adjuvant to doxorubicin chemotherapy.

关键词： Cardiotoxicity Chemoprevention Doxorubicin Genistein Phloretin Phytoestrogens Cardiac injury Hemodynamic changes

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Adaptive neuro-fuzzy interface system for gap acceptance behavior of right-turning vehicles at partially controlled T-intersections

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Journal of Modern Transportation 2014年第4期22卷 235-243页

作者： Jayant P.Sangole Gopal r.patil Department of Civil Engineering Indian Institute of Technology Bombay Powai Mumbai 400076 India

Gap acceptance theory is broadly used for evaluating unsignalized intersections in developed coun tries. Intersections with no specific priority to any move ment, known as uncontrolled intersections, are common in India. Limited priority is observed at a few intersections, where priorities are perceived by drivers based on geom etry, traffic volume, and speed on the approaches of intersection. Analyzing such intersections is complex because the overall traffic behavior is the result of drivers, vehicles, and traffic flow characteristics. Fuzzy theory has been widely used to analyze similar situations. This paper describes the application of adaptive neurofuzzy interface system （ANFIS） to the modeling of gap acceptance behavior of rightturning vehicles at limited priority Tintersections （in India, vehicles are driven on the left side of a road）. Field data are collected using video cameras at four Tintersections having limited priority. The data extracted include gap/lag, subject vehicle type, conflicting vehicle type, and driver＇s decision （accepted/rejected）. ANFIS models are developed by using 80 % of the extracted data （total data observations for major road right turning vehicles are 722 and 1,066 for minor road right turning vehicles） and remaining are used for model vali dation. Four different combinations of input variables are considered for major and minor road right turnings sepa rately. Correct prediction by ANFIS models ranges from 75.17 % to 82.16 % for major road right turning and 87.20 % to 88.62 % for minor road right turning. Themodels developed in this paper can be used in the dynamic estimation of gap acceptance in traffic simulation models.

关键词： Partially controlled intersections Gapacceptance Adaptive neuro-fuzzy interface system(ANFIS) - Membership function receiver operatorcharacteristic (rOC) curves Precision-recall (Pr) curves

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Boosting the energy harvesting performance of cantilever structured magneto-mechano-electric generator by controlling magnetic flux intensity on magnet proof mass

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Journal of Materiomics 2023年第4期9卷 735-744页

作者： Deepak r.patil Seungah Lee Atul Thakre Ajeet Kumar Hyunseok Song Dae-Yong Jeong Jungho ryu School of Materials Science and Engineering Yeungnam UniversityGyeongsan38541South Korea Centre for Functional Materials Vellore Institute of TechnologyVellore632014TamilnaduIndia Department of Materials Science&Engineering Inha UniversityIncheon22212South Korea Institute of Materials Technology Yeungnam UniversityDaehak-roGyeongsan38541South Korea

A cantilever-structured magneto-mechano-electric(MME)generator comprising a magnetoelectric composite with a magnet proof mass is a potential candidate for powering autonomous wireless sensor ***,the concept of a magnetic flux concentrator(MFC)to enhance the output performance of the MME generator by focusing the ultralow-intensity magnetic field into the MME generator was ***,the MFC-concentrated magnetic flux mostly focused on the end tip of the MME cantilever rather than at the magnet proof mass located on the cantilever *** that the torque generated by the magnet proof mass contributes more than half of the output power of an MME generator,optimizing the volume and position of the proof-mass with MFC is crucial for better ***,a smaller proof-mass is desirable for the long-term reliability of cantilevertype ***,we investigated the effect of the position and weight(volume)of the magnet proof mass with respect to the MFC on the output performance of the MME generator through finite element analysis and *** MME generator with the lighter magnet proof mass at the optimized position generated a maximum power of 5.35 mW under a 10 Oe magnetic field,which was 210%of that of the MME configuration used in our previous ***,the MME generator showed broadband characteristics around the practical frequency of 60 Hz,which could provide more freedom to design the harvester with high performance.

关键词： Magneto-mechano-electric Magnetic flux concentrator Magnet proof mass Broadband IoT sensor

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