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中国中山吉宝盛世湾

世界建筑导报 2019年第1期34卷 116-123页

作者： Gordana Jakimovska Joerg Lonkwitz Adriana rodriguez Ossio Alexander Schramm Alice Yi-Ting Chiu Iris pastor Caroline Filice Smith Jean Chaussavoine Jun Wang Irina Bogdan Leo Xinyu Li Gilles Greis Alexander Meyers Sam Jia Jun ren Tamim Salah EI Negm Evan Jon Shieh rafael Carbonero Vicario Tom roe

吉宝盛世湾项目在我们亚洲工作室的努力下于近期大功告成。由UNStudio亚洲工作室由合伙人HannesPfau执掌领衔。我们亚洲的上海工作室目前有约40名员工,正在进行的监建项目有6个,香港工作室目前有约15名员工,3个监建项目。所有图片均由To... 详细信息

吉宝盛世湾项目在我们亚洲工作室的努力下于近期大功告成。由UNStudio亚洲工作室由合伙人HannesPfau执掌领衔。我们亚洲的上海工作室目前有约40名员工,正在进行的监建项目有6个,香港工作室目前有约15名员工,3个监建项目。所有图片均由Tomroe制作。吉宝湾码头吉宝湾新码头位于中国广东省中山市,座落于西江沿岸。该项目总体规划面积达50,000平方米,包括一个直通西江的码头、一座游艇俱乐部、高端住宅别墅以及海关大楼、桥梁、道路和周边外堤等配套基础设施。吉宝湾码头是中国境内首个,也是唯一个外国移民所有的私营港口。

关键词：中国境内中山市游艇俱乐部工作室海关大楼基础设施码头亚洲

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Dendritic cell vaccination in glioblastoma after fluorescenceguided resection

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World Journal of Clinical Oncology 2012年第11期3卷 142-149页

作者： ricardo Diez Valle Ascension Lopez-Diaz de Cerio Susana Inoges Sonia Tejada Fernando pastor Helena Villanueva Jaime Gallego Jaime Espinos Javier Aristu Miguel Angel Idoate Enrique Andreu Maurizio Bendandi Department of Neurosurgery University of Navarra Hospital 31008 Pamplona Navarra Spain Lab of Immunotherapy CIMA 31008 Pamplona Navarra Spain Immunotherapy Program University of Navarra Hospital 31008 Pamplona Navarra Spain Department of Neurology University of Navarra Hospital 31008 Pamplona Navarra Spain Department of Oncology University of Navarra Hospital 31008 Pamplona Navarra Spain Department of Pathology University of Navarra Hospital 31008 Pamplona Navarra Spain Cell Therapy Area University of Navarra Hospital 31008 Pamplona Navarra Spain

AIM: To assess whether the addition of a customized, active immunotherapy to standard of care including fluorescence-guided surgery, may provide hints of an improved survival for patients with poor-prognosis, incurable glioblastoma multiform. METHODS: Preliminary to our ongoing, phase-Ⅱ clinical trial, we conducted a small pilot study enrolling five consecutive patients with resectable glioblastoma. In terms of recursive Partitioning Analysis, four patientswere class Ⅴ and one was class Ⅳ. In all five cases, fluorescence-guided surgery was employed, followed by rapid steroid discontinuation. Patients were then treated with a combination of standard radio-chemotherapy with temozolomide and tumor lysate-pulsed, mature dendritic cell-based ***: Though all five patients ultimately progressed, with any further treatment left to the sole decision of the treating oncologist, active immunotherapy was very well tolerated and induced specific immune responses in all three patients for whom enough material was available for such an assessment. Median progression-free survival was 16.1 mo. Even more important, median and mean overall survival were 27 mo and 26 mo, respectively. Three patients have died with an overall survival of 9 mo, 27 mo and 27.4 mo, while the other two are still alive at 32 mo and 36 mo, the former receiving treatment with bevacizumab, while the latter has now been off therapy for 12 mo. Four of five patients were alive at two ***: Active immunotherapy with tumor lysate-pulsed, autologous dendritic cells is feasible, safe, well tolerated and biologically efficacious. A phase-Ⅱ study is ongoing to possibly improve further on our very encouraging clinical results.

关键词： Immunotherapy Glioblastoma Fluorescence-guided surgery Dendritic cells Tumor-lysate

Enrichment of resveratrol in Wine through a New Vinification Procedure

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Journal of Life Sciences 2015年第7期9卷 327-333页

作者： raul Francisco pastor Magdalena raquel Gargantini Marcelo Murgo Sebastian Prieto Humberto Manzano Carla Aruani Claudia In6s Quini Maria-Isabel Covas roberto H6ctor Iermoli Section Polyphenols Wine and Health Fourth Chair in Internal Medicine Clinics Hospital University of Buenos Aires BuenosAires C1408FZB Argentina Department Special Analytical Standards National Wine Institute Mendoza M5500AAR Argentina Department Oenological and Sensory Studies National Wine Institute Mendoza M5500AAR Argentina NUPrOAS Handesbolag Sicka Alle Nacka 13165 Sweden

Sulphur dioxide is used in the vinification process as an antimicrobial agent, but it is also considered as an important risk factor for liver diseases. Stilbenes have inhibitory effects on the growth of lactic acid bacteria strains isolated from wine. The authors investigated the viability of obtaining free-SO2 resveratrol-enriched red wines. Substitution of sulfite (7 g/100kg) for resveratrol (150 mg/L and 300 mg/L) in the vinification process did not change the basic physical and chemical properties of wine or its sensorial profile. To the best of the authors" knowledge this is the first time that this type of vinification procedure is reported.

关键词：红葡萄酒酿造过程白藜芦醇富集生长抑制作用二氧化硫危险因素肝脏疾病

钆塞酸增强MrI和房室模型评估晚期肝纤维化大鼠的肝细胞双向转运功能

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国际医学放射学杂志 2017年第4期 479-479页

作者： C.Giraudeau B.Leporq S.Doblas M.Lagadec C.M.pastor J.L.Daire 朱珍 Laboratory of Imaging Biomarkers UMR1149 Inserm University Paris Diderot Sorbonne Paris Cité Hpital Beaujon

摘要目的晚期肝纤维化过程中肝细胞膜转运蛋白表达的改变降低了肝脏对有机阴离子的转运功能。本研究目的是通过对肝胆运输Mr对比剂钆塞酸的药代动力学分析,来研究能否评估肝细胞转运功能的变化。方法 17只晚期纤维化大鼠和8只正常大鼠...

摘要目的晚期肝纤维化过程中肝细胞膜转运蛋白表达的改变降低了肝脏对有机阴离子的转运功能。本研究目的是通过对肝胆运输Mr对比剂钆塞酸的药代动力学分析,来研究能否评估肝细胞转运功能的变化。方法 17只晚期纤维化大鼠和8只正常大鼠进行动态钆塞酸增强MrI。反卷积处理后,通过肝细胞三腔模型分析来计算肝细胞流入、胆汁流出和血窦回流率。通过逆转录聚合酶链反应检测来分析

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神经干/祖细胞移植对脑损伤导致的胶质细胞活化有调节作用并有助于移植细胞与宿主胶质细胞间缝隙连接的建立

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神经损伤与功能重建 2014年第2期9卷 F0003-F0003页

作者： rocío Talaverón Esperanza r.Matarredona rosa r.de la Cruz David Macías Victoria Gálvez and Angel M. Pastor Departamento de Fisiología Facultad de Biología Universidad de Sevilla Avenida Reina Mercedes

移植神经干/祖细胞有助于受损脑组织形态和功能的恢复。移植部位的微环境及移植细胞与宿主细胞间的通讯在神经干/祖细胞移植的神经保护机制中有重要意义。笔者既往研究显示,对中枢轴索损伤动物进行神经干/祖细胞移植有助于恢复损伤神经... 详细信息

移植神经干/祖细胞有助于受损脑组织形态和功能的恢复。移植部位的微环境及移植细胞与宿主细胞间的通讯在神经干/祖细胞移植的神经保护机制中有重要意义。笔者既往研究显示,对中枢轴索损伤动物进行神经干/祖细胞移植有助于恢复损伤神经元的电活动及突触联系,并可增加神经营养因子的释放。本研究拟观察移植的神经干/祖细胞与宿主胶质细胞间的解剖关系,以探讨神经干/祖细胞移植的神经保护作用的可能机制。从新生大鼠的脑室下区提取神经干/祖细胞移植到内侧纵束横断伤模型大鼠脑内。移植后8周取脑进行相关检测。免疫组化检测结果显示,与未移植神经干/祖细胞的大鼠相比,移植了神经干/祖细胞的大鼠脑内更多的小胶质细胞被激活。移植的神经干/祖细胞聚集在激活的小胶质细胞和星形胶质细胞附近。缝隙连接蛋白CX-43表达在损伤部位的神经干/祖细胞和胶质细胞上,且较多的存在于移植细胞和胶质细胞相连接的部位。移植的神经干/祖细胞和宿主胶质细胞及宿主小胶质细胞间均形成了缝隙连接,但移植的神经干/祖细胞和宿主胶质细胞间的缝隙连接较多。本研究结果显示,神经干/祖细胞移植对脑损伤导致的胶质细胞活化有调节作用,并可能通过在移植细胞和宿主细胞间建立缝隙连接来调节细胞间的通讯,这可能是细胞移植的神经保护作用的机制之一。

关键词：星形胶质细胞轴索断裂缝隙连接蛋白-43 小胶质细胞脑室下区

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