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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural regeneration research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio rivera Dina P.Bracho-rincon Luis H.pagan rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Graph neural network modeling of grain-scale anisotropic elastic behavior using simulated and measured microscale data

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npj Computational Materials 2022年第1期8卷 2471-2482页

作者： Darren C.pagan Calvin r.Pash Austin r.Benson Matthew P.Kasemer Pennsylvania State University University ParkPA16802USA Cornell University IthacaNY14853USA University of Alabama TuscaloosaAL35487USA

Here we assess the applicability of graph neural networks(GNNs)for predicting the grain-scale elastic response of polycrystalline metallic *** GNN surrogate models,grain-averaged stresses during uniaxial elastic tension in low solvus high-refractory(LSHr)Ni Superalloy and Ti 7 wt%Al(Ti-7Al)are predicted as example face-centered cubic and hexagonal closed packed alloys,respectively.A transfer learning approach is taken in which GNN surrogate models are trained using crystal elasticity finite element method(CEFEM)simulations and then the trained surrogate models are used to predict the mechanical response of microstructures measured using high-energy X-ray diffraction microscopy(HEDM).The performance of using various microstructural and micromechanical descriptors for input nodal features to the GNNs is explored through comparisons to traditional mean-field theory predictions,reserved full-field CEFEM data,and measured far-field HEDM *** effects of elastic anisotropy on GNN model performance and outlooks for the extension of the framework are discussed.

关键词： grain neural behavior

Who Made the Olympic rings?

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考试(双语读写) 2012年第9期 40-41页

作者： pagan Kennedy

皮埃尔·德·顾拜旦男爵(Baron Pierre de Coubertin)是现代奥林匹克运动会的创始人。他是一位法国贵族,脸上留着浓密的、好像上过蜡似的小胡子,看起来像是个重音符号。1914年,这位男爵宣布他为纪念现代奥林匹克运动会20周年设计了一个... 详细信息

皮埃尔·德·顾拜旦男爵(Baron Pierre de Coubertin)是现代奥林匹克运动会的创始人。他是一位法国贵族,脸上留着浓密的、好像上过蜡似的小胡子,看起来像是个重音符号。1914年,这位男爵宣布他为纪念现代奥林匹克运动会20周年设计了一个标志。"这真的可以称得上是一个国际性的标志,"他描述说,这个标志以五个圆环为素材,相套连成一体,象征着人类团结。那么,男爵的灵感是从哪里获得的呢?1984年,体育历史学家罗伯特·巴尼(robert Barney)正在勘察一处希腊考古遗迹,当他俯身系鞋带时,注意到

关键词：现代奥林匹克运动会顾拜旦历史学家 Who Made the Olympic rings 皇位继承奥运五环

Boosting energy-storage capability in carbon-based supercapacitors using low-temperature water-in-salt electrolytes

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Journal of Energy Chemistry 2022年第7期31卷 521-530,I0013页

作者： Joao Pedro A.Santos Manuel J.Pinzón érick A.Santos rafael Vicentini Cesar J.B.pagan Leonardo M.Da Silva Hudson Zanin Brazilian renewable Energies Center for Innovation on New EnergiesSchool of Electrical and Computer EngineeringUniversity of CampinasSao Paulo 13083-852Brazil Department of Semiconductors Instruments and PhotonicsSchool of Electrical and Computer EngineeringUniversity of CampinasSao Paulo 13083-852Brazil Laboratory of Fundamental and Applied Electrochemistry Department of ChemistryFederal University of Jequitinhonha e Mucuri’s ValleyMinas Gerais 39100-000Brazil

Supercapacitors(SCs) are high-power energy storage devices with ultra-fast charge/discharge *** using concentrated aqueous-based electrolytes can work at low temperatures due to their intrinsic properties, such as higher freezing point depression(FPD) and robustness. Besides the traditional organic-and aqueous-based(salt-in-water) electrolytes used in SCs, water-in-salt(WISE) sodium perchlorate electrolytes offer high FPD, non-flammability, and low-toxicity conditions, allowing the fabrication of safer, environmentally friendly, and more robust devices. For the first time, this work reports a comprehensive study regarding WISE system’s charge-storage capabilities and physicochemical properties under low-temperature conditions(T rous carbon-based electrodes. The effect of temperature reduction on the electrolyte viscosity and electrical properties was investigated using different techniques and the in-situ(or operando) raman spectroscopy under dynamic polarization *** cell voltage, equivalent series resistance, and specific capacitance were investigated as a function of the temperature. The cell voltage(U) increased ~ 50%, while the specific capacitance decreased ~20%when the temperature was reduced from 25 ℃ to -10 ℃. As a result, the maximum specific energy(E = CU^(2)/2) increased ~ 100%. Therefore, low-temperature WISEs are promising candidates to improve the energy-storage characteristics in SCs.

关键词： Carbon supercapacitors Water-in-salt electrolytes Low-temperature charge-storage Specific energy improvement at low temperatures

Ion dynamics into different pore size distributions in supercapacitors under compression

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Journal of Energy Chemistry 2023年第5期80卷 110-119,I0004页

作者： João Pedro Aguiar dos Santos Cesar J.B.pagan rafael Vicentini reinaldo F.Teófilo renato Beraldo Leonardo M.Da Silva Hudson Zanin Brazilian renewable Energies Center for Innovation on New EnergiesSchool of Electrical and Computer EngineeringUniversity of CampinasAv.Albert Einstein 40CampinasSP13083-852Brazil School of Electrical and Computer Engineering University of CampinasSP 13083-852Brazil Multivariate Chemical Data Analysis Laboratory Department of ChemistryUniversidade Federal de Viçosa36570-900 ViçosaMGBrazil Department of Chemistry Laboratory of Fundamental and Applied ElectrochemistryFederal University of Jequitinhonha and Mucuri's ValleyRodovia MGT 367km 5835000 Alto da Jacuba39100-000DiamantinaMGBrazil

Compressing supercapacitor(SCs)electrode is essential for improving the energy storage characteristics and minimizing ions’distance travel,faradaic reactions,and overall ohmic *** comprising the ion dynamics in SC electrodes under compression are still ***,the ionic dynamics of five aqueous electrolytes in electrodes under compression were studied in this work for tracking electrochemical and structural changes under mechanical stress.A superionic state is formed when the electrode is compressed until the micropores match the dimensions with the electrolyte’s hydrated ion sizes,which increases the *** excessive compression is applied,the accessible pore regions decrease,and the capacitance ***,as the studied hydrated ions have different dimensions,the match between ion/pore sizes *** the LiOH and NaClO4electrolytes,increasing the pressure from 60 to 120 and 100 PSI raised the capacitance from 13.5 to 35.2 F g^(-1)and 30.9 to 39.0 F g^(-1),***,the KOH electrolyte with the lowest and LiCl with the biggest combination of hydrated ion size have their point of maximum capacitance(39.5 and 36.7F g^(-1))achieved at 140 and 80 PSI,*** LiCl and KCl electrolytes,overcompression causes a drop in capacitance higher than 23%.

关键词： Mechanic compression Pore size distribution lon dynamics Activated carbon Supercapacitors

Heart rate variability to assess ventilatory thresholds in professional basketball players

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Journal of Sport and Health Science 2017年第4期6卷 468-473页

作者： Domingo Jesús ramos-Campo Jacobo A. rubio-Arias Vicente Avila-Gandia Cristian Marin-pagan Antonio Luque Pedro E. Alcaraz Department of Physical Activity and Sport Science Faculty of Sports Catholic University ofMurcia Murcia 30107 Spain Department of Physiology Catholic University ofMurcia Murcia 30}07 Spain UCAM research Center for High Performance Sport Mureia 30107 Spain

Purpose: The aim of this study was to determine if heart rate variability(HrV) during incremental test could be used to estimate ventilatory threshold(VT) in professional basketball players, with sufficient precision to be used in their training. Furthermore, the second aim was to analyse the association between HrV and 3 methods of VT determination by gas ***: Twenty-four professional basketball players(age: 23.4 ± 4.9 years; height: 195.4 ± 9.8 cm; body mass: 92.2 ± 11.9 kg) performed an incremental running test to exhaustion. First ventilatory threshold(VT1) was determined by ventilatory equivalent(VE) and HrV and second ventilatory threshold(VT2) was determined by 3 methods of gases analysis(V-slope, VE and gas exchange ratio(r), and HrV). Pearson's coefficient(r) was used to detect differences between data and the strength of each relationship. The mean of absolute differences and Bland–Altman analysis were used to evaluate whether there was ***: The results showed no significant differences in Hr and oxygen consumption(VO2) at VT1 between the 2 methods. Furthermore, no significant differences among the methods of gases analysis and HrV were observed in speed, Hr, and VO2 at VT2. Moreover, VTs estimated using HrV and gas methods were significantly correlated. Correlation in Hr values was higher between r and HrV(r = 0.96) and VE and HrV(r = 0.96) than V-slope and HrV(r = 0.90).Conclusion: These findings provide a practical, inexpensive approach for evaluating specific training loads when determining VT2 in basketball players. Therefore, HrV is an alternative method to determine VT2 without the application of expensive technology that limits its use to laboratories.

关键词： Anaerobic threshold Basketball Oxygen uptake Performance Training Ventilatory threshold

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赛马的饲喂管理

饲料研究 2011年第7期34卷 73-74页

作者： Joe D pagan 程宗佳(摘译) 美国大豆协会国际项目北京办事处北京市朝阳区建国门外大街1号国贸大厦2座904室100004 不详

饲料生产商、兽医、马业的专业人士和马场主参加了在列克星敦市举办的第17届肯塔基州马营养研讨会。HalSchott是密歇根州立大学的教授,他谈到了关于耐力运动营养的问题,并对水和作用及电解质消耗问题给予了关注。

关键词：饲喂管理赛马运动营养肯塔基州专业人士州立大学生产商电解质

Bridge Pressure Flow Scour at Clear Water Threshold Condition

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Transactions of Tianjin University 2009年第2期15卷 79-94页

作者：郭俊克 KErENYI Kornel pagan-OrTIZ Jorge E FLOrA Kevin Department of Civil Engineering University of Nebraska-Lincoln PKI 204D 1110 S 67th ST Omaha NE 68182-0178 USA Office of Infrastructure r&D Turner-Fairbank Highway Research Center Federal Highway Administration 6300 Georgetown Pike McLean VA 22101 USA Office of Bridge Technology Federal Highway Administration 1200 New JerSey Avenue SE Washington DC 20590 USA California Department of Transportation (Caltrans) P. O. Box 942873 Sacramento CA 94273-0001 USA

Bridge pressure flow scour at clear water threshold condition is studied theoretically and *** flume experiments reveal that the measured scour profiles under a bridge are more or less 2-dimensional;all the measured scour profiles can be described by two similarity equations,where the horizontal distance is scaled by the deck width while the local scour by the maximum scour depth;the maximum scour position is located just under the bridge about 15% deck width from the downstream deck edge;the scour begins at about one deck width upstream the bridge while the deposition occurs at about 2.5 deck widths downstream the bridge;and the maximum scour depth decreases with increas-ing sediment size,but increases with deck *** theoretical analysis shows that:bridge scour can be divided into three cases,*** unsubmerged,partially submerged,and totally *** downstream unsubmerged flows,the maximum bridge scour depth is an open-channel problem where the conventional methods in terms of critical velocity or bed shear stress can be applied;for partially and totally submerged flows,the equilibrium maximum scour depth can be described by a scour and an inundation similarity number,which has been confirmed by experiments with two decks and two sediment *** application,a design and field evaluation procedure with examples is presented,including the maximum scour depth and scour profile.

关键词： bridge decks bridge design bridge foundations bridge hydraulics bridge inundation bridge scour pressure flows pressure scour submerged flows.

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数字印花技术在缝制产品加工中的应用

纺织导报 2009年第4期 83-85页

作者： Kerry Maguire King Genevieve Garland Lujuanna pagan Jack Nienke ^2公司

纺织品数字印花技术和系统的进步使其成为日益增长的产品和市场的一种可行性工艺选择。当前数字印花技术主要用于独一无二的高端产品开发，满足个性化、小众市场的需求。图像行业将数字印花技术用于软标识领域，而对于T恤印花市场，服... 详细信息

纺织品数字印花技术和系统的进步使其成为日益增长的产品和市场的一种可行性工艺选择。当前数字印花技术主要用于独一无二的高端产品开发，满足个性化、小众市场的需求。图像行业将数字印花技术用于软标识领域，而对于T恤印花市场，服装印花技术的开发和应用备受关注。数字印花技术与缝纫工艺的链接是完全加入缝制产品供应链的第二步。

关键词：数字印花技术产品加工应用缝制产品开发缝纫工艺市场纺织品