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Hydro-mechanical behavior of an argillaceous limestone considered as a potential host formation for radioactive waste disposal

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Journal of rock Mechanics and Geotechnical Engineering 2018年第6期10卷 1063-1081页

作者： T.S.Nguyen Zhenze Li Grant Su M.H.B.Nasseri r.p.young Canadian Nuclear Safety Commission OttawaCanada Department of Civil Engineering University of TorontoTorontoCanada

The Canadian Nuclear Safety Commission(CNSC), Canada’s nuclear regulator, conducts regulatory research in order to develop independent knowledge on safety aspects related to the deep geological disposal of radioactive wastes. In Canada, the Cobourg limestone of the Michigan Basin is currently considered as a potential host formation for geological disposal. The understanding of the hydromechanical behavior of such a host rock is one of the essential requirements for the assessment of its performance as a barrier against radionuclide migration. The excavation of galleries and shafts of a deep geological repository(DGr) can induce damage to the surrounding rock. The excavation damaged zone(EDZ) has higher permeability and reduced strength compared to the undisturbed rock and those factors must be considered in the design and safety assessment of the DGr. The extent and characteristics of the EDZ depend on the size of the opening, the rock type and its properties, and the in situ stresses, among other factors. In addition, the extent and characteristics of the EDZ can change with time due to rock strength degradation, evolution of fractures within the EDZ, and the redistribution of pore pressure around the excavation. In this research project initiated by the CNSC, the authors conducted experimental and theoretical research in order to assess the hydro-mechanical behavior of the Cobourg limestone under undamaged and damaged conditions, both in the short and long terms. The short-term behavior was investigated by a program of triaxial tests with the measurement of permeability evolution on specimens of Cobourg limestone. The authors formulate a coupled hydro-mechanical model to simulate the stress-strain response and evolution of the permeability during those triaxial tests. Using creep and relaxation data from a similar limestone, the model was extended to include its long-term strength degradation. The model successfully simulated both the short-and long-term hydro-me

关键词： Hydro-mechanical behavior Excavation damage Deep geological repository(DGr) Limestone poro-elasto-plasticity

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导致脆性岩石破裂和地震波速变化的数值研究

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世界地震译丛 2004年第6期35卷 12-16页

作者： J．F．Hazzard r.p.young 邢秀芬李世愚不详地震出版社

对脆性岩石中由于应力和损伤而导致地震波速变化的数值研究技术作了介绍。通过耦合质点的链接模拟岩石样本,将其置于静水压和偏荷载状况下。在静水压加载期间,通过新的接触的形成和波速增大直至裂纹闭合。在偏荷载过程中,通过在裂纹开... 详细信息

对脆性岩石中由于应力和损伤而导致地震波速变化的数值研究技术作了介绍。通过耦合质点的链接模拟岩石样本,将其置于静水压和偏荷载状况下。在静水压加载期间,通过新的接触的形成和波速增大直至裂纹闭合。在偏荷载过程中,通过在裂纹开口的正交方向上耦合链的破坏和波速降低形成新裂纹。所模拟的波速变化特性与在实验室中观测到的接近。这个模型提供了独特的性能,具有直接检查微观过程,引导观测波速变化的能力。

关键词：脆性岩石地震波速数值研究耦合质点链接模拟

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A New Encryption Mechanism Supporting the Update of Encrypted Data for Secure and Efficient Collaboration in the Cloud Environment

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 813-834页

作者： Chanhyeong Cho Byeori Kim Haehyun Cho Taek-young Youn Department of Cyber Security Dankook UniversityYongin16890Republic of Korea Department of Software Soongsil UniversitySeoul07027Republic of Korea

With the rise of remote collaboration,the demand for advanced storage and collaboration tools has rapidly ***,traditional collaboration tools primarily rely on access control,leaving data stored on cloud servers vulnerable due to insufficient *** paper introduces a novel mechanism that encrypts data in‘bundle’units,designed to meet the dual requirements of efficiency and security for frequently updated collaborative *** bundle includes updated information,allowing only the updated portions to be reencrypted when changes *** encryption method proposed in this paper addresses the inefficiencies of traditional encryption modes,such as Cipher Block Chaining(CBC)and Counter(CTr),which require decrypting and re-encrypting the entire dataset whenever updates *** proposed method leverages update-specific information embedded within data bundles and metadata that maps the relationship between these bundles and the plaintext *** utilizing this information,the method accurately identifies the modified portions and applies algorithms to selectively re-encrypt only those *** approach significantly enhances the efficiency of data updates while maintaining high performance,particularly in large-scale data *** validate this approach,we conducted experiments measuring execution time as both the size of the modified data and the total dataset size *** show that the proposed method significantly outperforms CBC and CTr modes in execution speed,with greater performance gains as data size ***,our security evaluation confirms that this method provides robust protection against both passive and active attacks.

关键词： Cloud collaboration mode of operation data update efficiency

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University resources Engineering plant research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USrDSCHArDOLLAr3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

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A rapid Adaptation Approach for Dynamic Air‑Writing recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li Wei Yue Nam‑young Kim Yang Li Guozhen Shen Jong‑Chul Lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea radio Frequency Integrated Circuit(rFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural regeneration research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural regeneration research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (rGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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pan-TrK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-ra Jeon Changmin Shin Sun-young Kwon Sojin Shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of pathology and Institute for Cancer research Keimyung University School of MedicineDaegu 42601South Korea

BACKGrOUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTrK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TrK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTrK-fusion *** SUMMArY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TrK IHC-positive but lacked NTrK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTrK sarcoma with positive immunochemical pan-TrK ***,subsequent next generation sequencing revealed no NTrK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTrK gene fusion lies in potential treatment with TrK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

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Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EMBL partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

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Silicification in Mississippian Lodgepole Formation,Northeastern Flank of Williston Basin,Manitoba,Canada

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Journal of Earth Science 2012年第1期23卷 1-18页

作者： Harvey r young Moe Kuroda Department of Geology Brandon University

Five types of replacement silica are recognized in the Lower Mississippian Virden Member carbonates on the northeastern flank of Williston basin： microcrystalline quartz, chalcedonic quartz, anhedral megaquartz, euhedral megaquartz, and stringy megaquartz. Silica tends to replace various bioclasts, and all except the stringy megaquartz also occur as non-replacive void-filling cement or as silica forming chert nodules and silicified limestone. Although crinoids, brachiopods, corals, bryozoans, molluscs, trilobites, forams, and ostracodes are present in the sediments studied, only the first three show evidence of silicification. Crinoids are commonly replaced by microcrystalline quartz whereas brachiopods typically by spherules of length slow chalcedony. Coalesced spherules, often in concentric rings （beekite rings）, may form sheet-like masses on the surface of corals and brachiopods. Although bryozoans are common in the Virden Member, none showed any evidence of silicification. The difference in the susceptibility to silicification may be related to the shell microstructure, biological group, size of organism, skeletal mineralogy, and organic content of the bioclasts. Biogenic silica derived from the dissolution of siliceous sponge spicules is considered to be the most likely silica source for silicification. Most silica is believed to be released during early diagenesis before the sediments were deeply buried. The Virden Member carbonate may have experienced two episodes of replacement, the first affecting the bioclasts, the second producing silicified limestone and chert nodules.

关键词： silicification Williston basin Lodgepole Formation Virden Member Mississippian carbonate.

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