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Association of Congenital Heart Defects (CHD) with Factors related to Maternal Health and Pregnancy in newborns in Puerto rico

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Congenital Heart Disease 2024年第1期19卷 19-31页

作者： Yamixa Delgado Caliani Gaytan naydi Perez Eric Mir.n.a bryan Colón Morales Mónica Santos Biochemistry&Pharmacology Department San Juan Bautista School of MedicineCaguas00726Puerto Rico Hispanic Alliance for Clinical and Tr.n.lational research University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico Department of Internal Medicine University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico

Background:Given the pervasive issues of obesity and diabetes both in Puerto rico and the broader United States,there is a compelling need to investigate the intricate interplay among body mass index(BMI),pregesta-tional,and gestational maternal diabetes,and their potential impact on the occurr.n.e of congenital heart defects(CHD)dur.n. neonatal ***:Using the comprehensive System of Vigilance and Surveillance of Congenital Defects in Puerto rico,we conducted a focused analysis on neonates diagnosed with CHD between 2016 and *** assessment encompassed a r.n.e of variables,including maternal age,gestational age,BMI,pregestational diabetes,gestational diabetes,hypertension,history of abortion,and presence of ***:A cohort of 673 patients was included in our *** average maternal age was 26 years,within a r.n.e of 22 to 32 *** mean gestational age measured 39 weeks,with a median span of 38 to 39 *** the 673 patients,274(41%)mothers gave birth to neonates diagnosed with *** this group,22 cases were linked to pre-gestational diabetes,while 202 were not;20 instances were associated with gestational diabetes,compared to 200 without;and 148 cases exhibited an overweight or obese BMI,whereas 126 displayed a normal ***:We identiﬁed a statistically signiﬁcant correlation between pre-gestational diabetes mellitus and the occurr.n.e of ***,our analysis did not show a statistically signiﬁcant association between maternal BMI and the likelihood of *** results may aid in developing effective strategies to prevent and manage CHD in neonates.

关键词： Congenital heart defects(CHD) obesisty maternal health diabetes body mass index(BMI)

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Mid-term survival of the Optimys short stem: A prospective case series of 500 patients

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World Journal of Orthopedics 2024年第3期15卷 257-265页

作者： bryan Hamans Sheryl de Waard Sjoerd Kaarsemaker Esther r C Janssen Inger.n.Sierevelt Gino M M J Kerkhoffs Daniël Haverkamp Department of Orthopaedic Surgery Xpert ClinicAmsterdam 1101EANetherlands Department of Orthopedic Surgery Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Esther r C Janssen Department of Orthopaedic SurgeryViecuri Medisch CentrumVenlo 5912 BLNetherlands Centre for Orthopaedic research Spaarne ZiekenhuisHoofddorp 2134 TMNetherlands Department of Orthopaedic Surgery and Sports Medicine Amsterdam UMC-Location AMCAmsterdam 1105 AZNetherlands Department of Orthopedic Surgery Xpert Orthopedic Surgery ClinicAmsterdam 1101 EANetherlands

BACKGrOUnD In recent years,there has been an increase in the number of total hip arthroplasty procedures in the younger patient *** active group has higher expectations of their prosthesis in comparison to the older population,and there is a greater physical demand for the *** femoral stems were in-troduced to retain proximal bone stock and joint biomechanics and became more common to implant in this specific ***,the long-term survival and functional outcomes of various short stems are still being investigated in differ.n. *** To determine the 5-year survival of the Optimys hip *** This was a prospective multicenter cohort study of 500 patients conducted in two hospitals in the *** patients received the Optimys short stem(Mathys Ltd,Bettlach,Switzerland).The primary outcome measure was survival of the hip stem,with revision as the *** secondary outcome measurements included patient-reported outcome measures(PrOMs).Kaplan-Meier analysis was used to calculate the 5-year survival ***-minus-log tr.n.formation was performed to calculate the 95%confidence interval(95%CI).Mixed model analyses were performed to assess the course of the PrOMs dur.n. the 1st 2 years after *** were modeled separately for the 1st and 2nd years to calculate the yearly change in PrOMs dur.n. both follow-up periods with accompanying 95%*** The mean age of the total 500 patients was 62.3 years(standard deviation:10.6)and 202 were male(40%).At a median follow-up of 5.5 years(interquartile r.n.e:4.5-6.7),7 patients were deceased and 6 revisions were registered,for infection(n=3),subsidence(n=2)and malposition(n=1).This resulted in an overall 5-year survival of 98.8%(95%CI:97.3-99.5).If infection was left out as reason for revision,a stem survival of 99.4%(95%CI:98.1-99.8)was *** questionnaires were completed by 471 patients(94%),317 patients(63%)completed the 1-year follow-up questionna

关键词： Total hip arthroplasty Femoral stem Short stem Optimys Survival 5-year survival revision PrOMs

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循证指南：弥散和灌注MrI在急性缺血性卒中诊断中的作用美国神经病学学会治疗和技术评价委员会的报告

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国际脑血管病杂志 2010年第11期18卷 801-807页

作者： P.D. Schellinger[] r.n. bryan[] L.r. Caplan[] J.A. Detre[] r.r. Edelman[] C. Jaigobin[] C.S. Kidwell[] J.P. Mohr[] M. Sloan[] A.G. Sor.n.en[] S. Warach[] 章娟娟(译) 王国颖(译) 汪凯(译) national Institutes of neurological Disorders and Stroke NIH BethesdaMD Department of neurology University of Erlangen Germany Departments of radiology University of Pennsylvania Philadelphia Department of neurology Beth Israel Deaconess Medical Center BostonMA Departments of neurology University of Pennsylvania Philadelphia Department of radiology Northwestern University Evanston Division of neurology Toronto General Hospital Canada Department of neurology Georgetown University WashingtonDC Columbia University New York NY Department of neurology University of South Florida Tampa Department of radiology MGH BostonMA 安徽医科大学第一附属医院神经内科合肥230022

目的评价弥散加权成像（diffusion-weighted imaging,DWI）和灌注加权成像（perfusionweighted imaging PWI）在急性缺血性卒中患者诊断中应用的证据.方法对1966年至2008年1月期间有关DWI和PWI诊断和预后价值的文献进行系统分析.结果... 详细信息

目的评价弥散加权成像（diffusion-weighted imaging,DWI）和灌注加权成像（perfusionweighted imaging PWI）在急性缺血性卒中患者诊断中应用的证据.方法对1966年至2008年1月期间有关DWI和PWI诊断和预后价值的文献进行系统分析.结果和推荐对于发病12 h内的急性缺血性卒中的诊断,DWI已被确认为有效的评价手段,且其诊断价值应高于非增强CT.为了最准确地诊断急性缺血性卒中,应进行DWI（A级推荐）;然而,在疑似急性卒中患者的总体样本中,DWI诊断缺血性卒中的敏感性并不完美.DWI诊断脑出血的准确性不在本指南的范围之内.根据Ⅱ级和Ⅲ级证据,基线DWI体积可预测前循环卒中的基线卒中严重程度（B级推荐）,但不能预测椎基底动脉系统卒中的基线卒中严重程度（C级推荐）.基线DWI病变体积可预测（最终）梗死体积（B级推荐）,并且有可能预测早期和远期临床转归（C级推荐）.与DWI相比,基线PWI体积预测基线卒中严重程度的价值较小（C级推荐）.尚无足够的证据支持或反对PWI在急性缺血性卒中诊断中的价值（U级推荐）.

关键词：急性缺血性卒中弥散加权成像美国神经病学学会循证指南 I诊断灌注MrI 椎基底动脉系统委员会

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Defining minimal invasive surgical therapy for benign prostatic obstruction surgery: Perspectives from a global knowledge, attitude, and practice survey

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Asian Journal of Urology 2024年第1期11卷 55-64页

作者： bryan Kwun-Chung Cheng Steffi Kar-Kei Yuen Daniele Castellani Marcelo Langer Wroclawski Hongda Zhao Mallikarjuna Chiruvella Wei-Jin Chua Ho-Yee Tiong Yilor.n.Tanidir Jean de la rosette Enrique rijo Vincent Misrai Amy Krambeck Dean S.Elterman Bhaskar K.Somani Jeremy Yuen-Chun Teoh Vineet Gauhar Department of Surgery United Christian HospitalHong KongChina S.H.Ho Urology Centre Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Urology University Hospital“Ospedali Riuniti”and Polytechnic University of Marche RegionAnconaItaly Hospital Israelita Albert Einstein Sao PauloSPBrazil BP—A Beneficencia Portuguesa de Sao Paulo Sao PauloSPBrazil Faculdade de Medicina do ABC Santo AndreSPBrazil Department of Urology Asian Institute of Nephrology and UrologyHyderabadTGIndia Department of Urology National University HospitalSingapore Department of Urology Marmara University School of MedicineIstanbulTurkey Department of Urology Medipol Mega University HospitalIstanbul Medipol UniversityIstanbulTurkey Department of Urology Hospital Quiron BarcelonaBarcelonaSpain Department of Urology Clinique PasteurToulouseFrance Department of Urology Indiana University School of MedicineIndianapolisINUSA Division of Urology Department of SurgeryUniversity Health NetworkUniversity of TorontoTorontoCanada Department of Urology University Hospital Southampton NHS TrustSouthamptonUK Department of Urology Ng Teng Fong General HospitalNUHSSingapore

Objective:To scrutinize the definitions of minimal invasive surgical therapy(MIST)and to investigate urologists’knowledge,attitudes,and practices for benign prostatic obstruction ***:A 36-item survey was developed with a Delphi *** on definitions of MIST and attitudes and practices of benign prostatic obstruction surgeries were *** were invited globally to complete the online *** was achieved when more than or equal to 70%responses were“agree or str.n.ly agree”and less than or equal to 15%responses were“disagree or str.n.ly disagree”(consensus agree),or when more than or equal to 70%responses were“disagree or str.n.ly disagree”and less than or equal to 15%responses were“agree or str.n.ly agree”(consensus disagree).results:The top three qualities for defining MIST were minimal blood loss(n=466,80.3%),fast post-operative recovery(n=431,74.3%),and short hospital stay(n=425,73.3%).The top three surgeries that were regarded as MIST were Urolift®(n=361,62.2%),rezum®(n=351,60.5%),and endoscopic enucleation of the prostate(EEP)(n=332,57.2%).Consensus in the knowledge section was achieved for the superiority of Urolift®,rezum®,and iTInD®over tr.n.urethral resection of the prostate with regard to blood loss,recovery,day surgery feasibility,and post-operative *** in the attitudes section was achieved for the superiority of Urolift®,rezum®,and iTInD®over tr.n.urethral resection of the prostate with regard to blood loss,recovery,and day surgery *** on both sections was achieved for EEP as the option with the better symptoms and flow improvement,lower retreatment rate,and better suitable for prostate more than 80 ***:Minimal blood loss,fast post-operative recovery,and short hospital stay were the most important qualities for defining ***®,rezum®,and EEP were regarded as MIST by most urologists.

关键词： Benignprostate hyperplasia Minimalinvasive surgical therapy Surgery Bladderoutlet obstruction

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Electrochemical reduction of Cr(Ⅵ)in the presence of sodium alginate and its application in water purification

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Journal of Envir.n.ental Sciences 2021年第3期33卷 304-312页

作者： bryan Butter Paola Santander Guadalupe del CPizarro Diego POyarzún Federico Tasca Julio Sánchez Facultad de Química y Biología Universidad de Santiago de ChileUSACHCasilla 40Correo 33SantiagoChile Departamento de Química Universidad Tecnológica MetropolitanaJ.P.Alessandri 1242SantiagoChile Laboratorio de nanotecnología Recursos Naturales y Sistemas ComplejosFacultad de Ciencias NaturalesUniversidad de AtacamaCopayapu 485CopiapóChile

Chromium(Cr)is used in many manufactur.n. processes,and its release into natural waters is a major envir.n.ental problem *** concentrations of Cr(Ⅵ)are toxic to human health and living organisms due to the carcinogenic and mutagenic nature of this *** work examined the conversion of Cr(Ⅵ)to Cr(Ⅲ)via electrochemical reduction using gold electrode in an acidic sodium alginate(SA)solution and subsequent removal of the produced Cr(Ⅲ)-SA by the polymer-enhanced ultrafiltration(PEUF)technique.A solution of SA in nitric acid was used both as an electrolytic medium dur.n. the voltammetric measurements and bulk electrolysis and as an extracting agent dur.n. the PEUF *** electroanalysis of Cr(Ⅵ)was performed by linear sweep voltammetry in the presence of acidic SA solution to study its voltammetric behavior as a function of the Cr(Ⅵ)concentration,pH,presence of Cr(Ⅲ),SA concentration and scan *** addition,the quantitative reduction of Cr(Ⅵ)to Cr(Ⅲ)was studied through the bulk electrolysis *** results showed efficient reduction with well-defined peaks at approximately 0.3 V ***/AgCl,using a gold working *** the pH increased,the reduction signal str.n.ly decreased until its *** optimum SA concentration was 10 mmol/L,and it was observed that the presence of Cr(Ⅲ)did not interfere in the Cr(Ⅵ)*** the quantitative reduction by bulk electrolysis in the presence of acidic SA solution,it was possible to reduce all Cr(Ⅵ)to Cr(Ⅲ)followed by its removal via PEUF.

关键词： Alginate solution Chromium Electroanalytical chemistry Ultrafiltration Water purification

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Genome and clonal hematopoiesis stability contrasts with immune,cfDnA,mitochondrial,and telomere length changes dur.n. short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand narayanan Eliah G.Overbey Kirill Grigorev Krista A.ryon Marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.Schmidt nuria Mencia-Tr.n.hant remi Klotz Ver.n.ca Ortiz Jonathan Foox Christopher Chin Deena najjar Ir.n. Matei Ir.n.eus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease Juan Mor.n. Andrew Boddicker Junhua Zhao bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HrH Pr.n.e Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Childr.n.s Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineer.n. Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Envir.n.ental and radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineer.n. Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,dur.n.,and post-flight for DnA *** length was measured by quantitative PCr,while whole genome and cfDnA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred dur.n. spaceflight and shortened after return to ***-free DnA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space envir.n.ent persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a refer.n.e point for studying the early development of CHIP in astr.n.uts,an understudied phenomenon as previous studies have focused on career *** study will serve as a refer.n.e point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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Experimental observation of effective gravity and two-time physics in ferrofluid-based hyperbolic metamaterials

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Advanced Photonics 2020年第5期2卷 45-52页

作者： Vera n.Smolyaninova John Cartelli bryan Augstein Stephanie Spickard Mary S.Devadas Igor I.Smolyaninov Towson University Department of Physics Astronomy and GeosciencesTowsonMarylandUnited States University of Maryland Department of Electrical and Computer EngineeringCollege ParkMarylandUnited States

recently,it was predicted that extraordinary light waves in hyperbolic metamaterials may exhibit two-time physics *** report experimental observation of this effect via investigation of gravity-like nonlinear optics of ir.n.cobalt-based ferrofluid hyperbolic *** addition to conventional temporal coordinates,the spatial coordinate oriented along the optical axis of the metamaterial also exhibits timelike character,which leads to very unusual two-time physics behavior in these systems on small scales.

关键词： hyperbolic metamaterial nonlinear optics ferrofluid

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A private SUSY 4HDM with FCnC in the up-sector

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Chinese Physics C 2021年第2期45卷 326-340页

作者： M.A.Arroyo-Ureña Lor.n.o Díaz-Cruz bryan O.Larios-López M.A.Pérez de León Facultad de Estudios Superiores Cuautitlan-UnAM Cuautitlan Edo de MexMéxico Mesoamerican Center for Theoretical Physics UNACHChiapasMéxico CIFFU and Facultad de Ciencias Físico-Matemáticas Benemérita Universidad Autónoma de Puebla ApdoPostal 1364CP72000PueblaPueMéxico Departamento de Gravitación y Altas Energías Facultad de Ciencias Universidad Nacional Autónoma de Honduras Ciudad UniversitariaTegucigalpa MDCHonduras

We present a SUSY model with four Higgs doublets of the"private type,"in which all fermion types(up,down,and charged leptons)obtain their masses from a differ.n. Higgs doublet H_f(f=u_1,d,e) .The conditions for anomaly cancellation imply that the remaining Higgs doublet of the model( H_(u_2) )must have the same hypercharge as H_(u_1) ,and thus,can only couple to up-type quarks,which opens the possibility to have FCnCs only in this *** study the Lagr.n.ian of the model,and in particular,the Higgs potential,to identify the Higgs mass-eigenstates and their interactions;for the Yukawa matrices,we consider the four-texture *** obtain constraints on the model parameters by using LHC measurements on the properties of the 125 GeV Higgs boson(h),and identify viable regions of the parameter ***,these constraints are used to evaluate the prospects for detecting the FCnC decay mode t→ch at the future high-luminosity(HL)option for the LHC,which are compared with curr.n. limits from ***,we evaluate the FCnC decay of the next heavier Higgs boson H_(2)→tc ,which can typically reach Br(H_2→tc)≈(10^(-4)-10^(-5)) .The search for the signal at HL-LHC is also studied,and it is found that it may be detectable for specific regions of the model parameter space.

关键词： Higgs physics top quark supersymmetry collider physics

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C:n:P stoichiometry and nutrient limitation of the soil microbial biomass in a grazed grassland site under experimental P limitation or exces

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Ecological Processes 2012年第1期1卷 66-76页

作者： bryan S Griffiths Annette Spilles Michael Bonkowski Teagasc Environment Research CentreJohnstown CastleWexfordCoWexfordIreland Curr.n. address:SAC King's BuildingsWest Mains RoadEdinburgh EH93JGUK Mathematisch naturwissenschaftliche Fakultät der Universität zu Köln Zoologisches Institut Abt.TerrestrischeÖkologieBiowissenschaftliches ZentrumOtto-Fischer-Str.6D-50674KölnGermany

Introduction:The availability of essential nutrients,such as nitrogen(n)and phosphorus(P),can feedback on soil carbon(C)and the soil microbial *** cycles can be supplemented by agricultural fertiliser addition,and we determined whether the stoichiometry and nutrient limitation of the microbial biomass could be affected by an unbalanced nutrient ***:Samples were taken from a long-term trial(in effect since 1968)with annual applications of 0,15 and 30 kg P ha^(−1) with constant n and *** and microbial biomass CnP contents were measured and nutrient limitation assessed by substrate-induced *** regression and discriminant analyses were used to identify the variables explaining nutrient ***:Soil and biomass CnP increased with increasing P fertiliser,and there was a significant,positive,correlation between microbial biomass P and biomass C,apart from at the highest level of P fertilisation when the microbial biomass was over-saturated with *** molar ratios of C:n:P in the microbial biomass remained constant(homeostatic)despite large changes in the soil nutrient *** growth was generally limited by C and n,except in soil with no added P when C and P were the main limiting nutrients.C,n and P,however,did not explain all the growth limitation on the soils with no added ***:Increased soil C and n were probably due to increased net primary *** results confirm that C:n:P ratios within the microbial biomass were constrained(***)under.n.ar optimum soil *** with no added P were characterised by str.n. microbial P limitation and soils under high P by over-saturation of microorganisms with *** changes in biomass C:P can be indicative of nutrient limitation within a site.

关键词： Carbon nitrogen nutrient limitation Phosphorus Soil microbial biomass Stoichiometry

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EFFECTS OF rIVEr ICE On STAGE-DISCHArGE rELATIOnSHIPS——A CASE STUDY OF THE YELLOW rIVEr

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International Journal of Sediment research 2007年第4期22卷 263-272页

作者： r.n.ld THr.n. bryan W. KArnEY Prof. Environmental Engineering University of Northern British Columbia 3333 University Way Prince George BC Canada V2N 4Z9 Prof. Department of Civil Engineering University of Toronto 35 St. George Street Toronto ON Canada M5S 1A4

Using field observations at four gauging stations along the Inner Mongolia reach of the Yellow river in China, this paper explores effects of the ice on the hydraulics of this river reach for four differ.n. conditions, namely: under open channel flow, dur.n. ice-r.n.ing period, the ice-covered period, and the river break-up period. The rating curves were found to be well recognized under open channel situations, but were sometimes poorly defined and extremely variable under ice conditions. The results also show that the water level is insensitive to flowing ice prior to freeze-up. However, significant, but hardly surprising, variations were observed dur.n. ice-covered conditions. The rating curves for both the ice covered condition and river ice breakup period are developed and some related hydraulic issues are examined. Additionally, the impacts of the ice accumulation and associated riverbed deformation dur.n. ice period on the rating curves are discussed.

关键词： Ice-r.n.ing period Ice covered period rating curve riverbed deformation river ice break-up

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