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Dual PPAr delta/gamma agonist offer therapeutic potential for Alzheimer's disease

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Neural regeneration research 2024年第6期19卷 1175-1176页

作者： Ian Steinke meenakshi Singh rajesh Amin Department of Drug Discovery and Development Auburn UniversityAuburn AlabamaALUSA

The increasing incidence of Alzheimer's disease(AD)in the aging population,indicates the critical need for the development of novel targeted molecular therapies for ameliorating AD ***,clinical and preclinical evidence demonstrates that peroxisomal proliferator activating receptors(PPAr)agonists regulate energy and lipid homeostasis in models of diabetes,as well as improve spatial memory in animal models of AD(Khan et al.,2019).

关键词： Alzheimer clinical homeostasis

Efficient Communication in Wireless Sensor Networks Using Optimized Energy Efficient Engroove Leach Clustering Protocol

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Tsinghua Science and Technology 2024年第4期29卷 985-1001页

作者： N.meenakshi Sultan Ahmad A.V.Prabu J.Nageswara rao Nashwan Adnan Othman Hikmat A.M.Abdeljaber r.Sekar Jabeen Nazeer SrM Institute of Science and Technology KattankulathurChennai 603203India Department of Computer Science College of Computer Engineering and SciencesPrince Sattam Bin Abdulaziz UniversityAlkharj 11942Saudi Arabia University Center for research and Development(UCrD) Department of Computer Science and EngineeringChandigarh UniversityGharuanMohali 140413India Department of ECE Koneru Lakshmaiah Education FoundationVaddeswaramGuntur 522502India Department of Computer Science and Engineering Lakireddy Balireddy College of Engineering(A)NTR District 521230India Department of Computer Engineering College of EngineeringKnowledge UniversityErbil 44001Iraq Department of Computer Science Faculty of Information TechnologyApplied Science Private UniversityAmman 11937Jordan Department of Electronics and Communication Engineering(ECE) School of EngineeringPresidency UniversityBangalore 834001India

The Wireless Sensor Network(WSN)is a network that is constructed in regions that are inaccessible to human *** widespread deployment of wireless micro sensors will make it possible to conduct accurate environmental monitoring for a use in both civil and military *** make use of these data to monitor and keep track of the physical data of the surrounding environment in order to ensure the sustainability of the *** data have to be picked up by the sensor,and then sent to the sink node where they may be *** nodes of the WSNs are powered by batteries,therefore they eventually run out of *** energy restriction has an effect on the network life span and environmental *** objective of this study is to further improve the Engroove Leach(EL)protocol’s energy efficiency so that the network can operate for a very long time while consuming the least amount of *** lifespan of WSNs is being extended often using clustering and routing *** Meta Inspired Hawks Fragment Optimization(MIHFO)system,which is based on passive clustering,is used in this study to do *** cluster head is chosen based on the nodes’residual energy,distance to neighbors,distance to base station,node degree,and node *** on distance,residual energy,and node degree,an algorithm known as Heuristic Wing Antfly Optimization(HWAFO)selects the optimum path between the cluster head and Base Station(BS).They examine the number of nodes that are active,their energy consumption,and the number of data packets that the BS *** overall experimentation is carried out under the MATLAB *** the analysis,it has been discovered that the suggested approach yields noticeably superior outcomes in terms of throughput,packet delivery and drop ratio,and average energy consumption.

关键词： wireless sensor networks energy efficient engroove leach protocol meta inspired Hawks fragment optimization heuristic wing antfly optimization

Federated Learning on Internet of Things:Extensive and Systematic review

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Computers, Materials & Continua 2024年第5期79卷 1795-1834页

作者： meenakshi Aggarwal Vikas Khullar Sunita rani Thomas AndréProla Shyama Barna Bhattacharjee Sarowar Morshed Shawon Nitin Goyal Chitkara University Institute of Engineering and Technology Chitkara UniversityRajpuraPunjab140401India Department of CSE&IT BPS Mahila VishwavidyalayaKhanpur KalanSonipatHaryana131305India Engineering research&Innovation Group Universidad Europea del AtlánticoC/Isabel Torres 21Santander39011Spain Department of Project Management Universidad Internacional IberoamericanaAreciboPR00613USA Department of Project Management Universidade Internacional do CuanzaEstrada Nacional 250Bairro KaluapandaCuito-BiéAngola Department of Computer Science and Engineering University of Science and Technology Chittagong(USTC)Chattogram4202Bangladesh Deptartment of EEE University of Science and Technology Chittagong(USTC)Chattogram4202Bangladesh Department of Computer Science and Engineering School of Engineering and TechnologyCentral University of HaryanaMahendragarhHaryana123031India

The proliferation of IoT devices requires innovative approaches to gaining insights while preserving privacy and resources amid unprecedented data ***,FL development for IoT is still in its infancy and needs to be explored in various areas to understand the key challenges for deployment in real-world *** paper systematically reviewed the available literature using the PrISMA guiding *** study aims to provide a detailed overview of the increasing use of FL in IoT networks,including the architecture and challenges.A systematic review approach is used to collect,categorize and analyze FL-IoT-based *** was performed in the IEEE,Elsevier,Arxiv,ACM,and WOS databases and 92 articles were finally *** measures were published in English and with the keywords“FL”and“IoT”.The methodology begins with an overview of recent advances in FL and the IoT,followed by a discussion of how these two technologies can be *** be more specific,we examine and evaluate the capabilities of FL by talking about communication protocols,frameworks and *** then present a comprehensive analysis of the use of FL in a number of key IoT applications,including smart healthcare,smart transportation,smart cities,smart industry,smart finance,and smart *** key findings from this analysis of FL IoT services and applications are also ***,we performed a comparative analysis with FL IID(independent and identical data)and non-ID,traditional centralized deep learning(DL)*** concluded that FL has better performance,especially in terms of privacy protection and resource *** is excellent for preserving privacy becausemodel training takes place on individual devices or edge nodes,eliminating the need for centralized data aggregation,which poses significant privacy *** facilitate development in this rapidly evolving field,the insights presented are intended to help practitioners and re

关键词： Internet of Things federated learning PrISMA framework of FL applications of FL data privacy communication

Design & Test of an Advanced Web Security Analysis Tool (AWSAT)

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Journal of Software Engineering and Applications 2024年第5期17卷 448-461页

作者： meenakshi S. P. Manikandaswamy Vijay Madisetti School of Cybersecurity and Privacy Georgia Institute of Technology Atlanta USA

Considering the escalating frequency and sophistication of cyber threats targeting web applications, this paper proposes the development of an automated web security analysis tool to address the accessibility gap for non-security professionals. This paper presents the design and implementation of an automated web security analysis tool, AWSAT, aimed at enabling individuals with limited security expertise to effectively assess and mitigate vulnerabilities in web applications. Leveraging advanced scanning techniques, the tool identifies common threats such as Cross-Site Scripting (XSS), SQL Injection, and Cross-Site request Forgery (CSrF), providing detailed reports with actionable insights. By integrating sample payloads and reference study links, the tool facilitates informed decision-making in enhancing the security posture of web applications. Through its user-friendly interface and robust functionality, the tool aims to democratize web security practices, empowering a wider audience to proactively safeguard against cyber threats.

关键词： Web Security Automated Analysis Vulnerability Assessment Web Scanning Cross-Site Scripting SQL Injection Cross-Site request Forgery

Improving the training abilities of ophthalmic educators: the Ophthalmology Foundation’s initiatives

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Annals of Eye Science 2024年第1期9卷 1-3页

作者： Karl Golnik Yip Chee Chew Gabriela Palis meenakshi Swaminathan Department of Ophthalmology at the University of Cincinnati CincinnatiOHUSA. Department of Ophthalmology and Visual Sciences Khoo Teck Puat HospitalSingaporeSingapore Ophthalmology Department Hospital Italiano de Buenos AiresBuenos AiresArgentina Capstone Clinic ChennaiIndia Sri ramachandra Medical College ChennaiIndia

Our goal as medical educators is for our students to learn what they need to know and competently perform ophthalmic *** addition,the students need to have good communication skills and behave professionally and ethically(1,2).Most medical educators are not taught how to teach but rather learn by role-modeling their *** can be good or bad depending on the mentor!In addition,the amount of knowledge and numbers of surgical procedures is ever increasing and yet,in most countries,the amount of time to train and become competent is not ***,our goal of creating competent ophthalmologists is ever more challenging.

关键词： Ophthalmology Foundation teaching skills feedback

Facile synthesis and characterization of acetate intercalated Co-La layered double hydroxide

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Journal of rare Earths 2017年第5期35卷 474-479页

作者： meenakshi Pokhriyal Sitharaman Uma rajamani Nagarajan Materials Chemistry Group Department of Chemistry University of Delhi

Layered double hydroxide（LDH） comprising of Co^2＋ and La^3＋-ions with acetate counter anion was successfully synthesized by hydrogen peroxide catalyzed hydrolysis reaction and characterized extensively. The observed reflections in the powder X-ray diffraction pattern could be indexed in P3 space group with a=0.316 nm and c=2.97 nm. Lattice fringes of distances corresponding to the peaks observed in X-ray diffraction pattern were observed in high resolution transmission electron microscopic images. UV-visible diffuse reflectance spectroscopy results confirmed the presence of Co（OH）6 along with the presence of charge-transfer band due to the interlayer carboxylate anion. Magnetization measurements at room temperature indicated high spin configuration of Co^2＋-ion in the sample exhibiting paramagnetic behavior. The mixed metal oxide from calcination was used to reconstruct the parent layered structure. Intercalation experiments with other organic anions in Co-La LDH proved be successful.

关键词： layered acetate interlayer hydroxide hydrolysis anion calcination carboxylate reconstruct intercalation

response of loose bonding on reflection and transmission of elastic waves at interface between elastic solid and micropolar porous cubic crystal

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Applied Mathematics and Mechanics(English Edition) 2010年第5期31卷 605-616页

作者： rajneesh KUMAr.meenakshi PANCHAL Department of Mathematics Kurukshetra University

The problem of reflection and transmission of plane periodic waves incident on the interface between the loosely bonded elastic solid and micropolar porous cubic crystal half spaces is investigated. This is done by assuming that the interface behaves like a dislocation, which preserves the continuity of traction while allowing a finite amount of slip. Amplitude ratios of various reflected and transmitted waves have been depicted graphically. Some special cases of interest have been deduced from the present investigation.

关键词： micropolar porous cubic crystal reflection coefficients transmission coefficients bonding parameter

Study on the Effect of Surface Modification on the Mechanical and Thermal Behaviour of Flax,Sisal and Glass Fiber

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Journal of renewable Materials 2019年第2期7卷 153-169页

作者： C.M.meenakshi A.Krishnamoorthy Department of Mechanical Engineering Sathyabama Institute of Science and TechnologyChennaiTamil NaduIndia

Natural fiber-reinforced hybrid composites can be a better replacement for plastic composites since these plastic composites pose a serious threat to the *** aim of this study is to analyze the effect of surface modification of the natural fibers on the mechanical,thermal,hygrothermal,and water absorption behaviors of flax,sisal,and glass fiber-reinforced epoxy hybrid *** mechanical properties of alkaline treated sisal and flax fibers were found to increase ***,flexural and impact strength of glass/flax-fiber-reinforced hybrid samples improved by 58%,36%,and 51%,respectively,after surface alkaline *** addition,the hygrothermal analysis and water absorption capacity are studied and also the Interfacial bonding properties were analyzed using Scanning Electron Microscopic *** thermal analysis using thermogravimetric analyzer reveals that the decomposition temperature for hybrid fiber reinforced composites are between 306 and 312℃.In conclusion,surface treatment improves the performance of natural fiber in hybrid fiber-reinforced composites,particularly flax fiber.

关键词： Hybrid composite surface treatments mechanical testing thermal analysis hygrothermal testing water absorption SEM analysiss

Assessment of groundwater quality with special emphasis on nitrate contamination in parts of Gautam Budh Nagar district,Uttar Pradesh, India

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Acta Geochimica 2019年第5期38卷 703-717页

作者： Meenu Agarwal meenakshi Singh Jakir Hussain Galgotias University Plot No.2Sector 17-A Yamuna ExpresswayGreater NoidaGautam Budh NagarUttar PradeshIndia National river Water Quality Laboratory Central Water CommissionNew Delhi 110016India

Progressive developments in industrial and agricultural activities are causing a critical stress on groundwater quality in developing *** objective of this paper is to assess and evaluate the contamination level of groundwater caused by leachate in 11 villages of the Gautam Budh Nagar district in Uttar Pradesh,*** systematically sampled 22 groundwater samples and 13 leachate samples to ascertain the source of pollution on groundwater *** standard analytical methods given by the American Public Health Association(APHA)(Standard methods for examination of water and wastewater,23rd ***,AWWA,WPCF,Washington,2017)were used for quantitative estimation of hydrochemical parameters of collected *** results of the analysis of groundwater samples indicate that pH values range from 7.31 to *** mean magnesium concentration in groundwater samples is 58.93±21.44 mg/*** of the groundwater samples taken,approximately 41%and 73%of samples analysis results have been found beyond the acceptable limit with respect to the parameters of turbidity and total dissolved solids,respectively,according to the Bureau of Indian Standards(Indian standard specification for drinking water(IS:10500).BIS,Manak Bhawan,New Delhi,2012)for drinking *** 95.4%of groundwater samples and 92.3%of leachate samples have high nitrate concentrations above the standard limit of BIS(45 mg/L),*** Piper plot shows that 50%of the samples belong to the Ca^2+-Mg^2+-HCO3^-*** and Durov's diagrams indicate that the mean concentrations of ions are in the order of Na^+>Mg^2+>Ca^2+>K^+(for cations)and HCO3^->NO3^->C1^->SO42^->CO32^->F-(for anions)in groundwater of the study *** spatial variation of the hydrochemical parameters shows that groundwater is heavily contaminated with respect to *** results indicate that the groundwater of villages Achheja,Bisrakh road,Dujana,Badalpur and Sadopur is not suitable for drinking.

关键词： Leachate Hydrochemical parameters Piper plot Ternary and Durov's diagram Spatial variation