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Elenoside increases intestinal motility

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World Journal of Gastroenterology 2006年第44期12卷 7143-7148页

作者： E Navarro SJ Alonso r Navarro J Trujillo E jorge Department of Pharmacology Faculty of Medicine University of La Laguna 38071 La Laguna Apdo. 55 Tenerife Canary Islands Spain Department of medical and Chirurgical Sciences University of Las Palmas Gran Canaria Canary Islands Spain Centro de Productos Naturales y Agrobiologia CSIC Tenerife Canary Islands Spain

AIm： TO study the effects of elenoside, an arylnaphthalene lignan from Justicia hyssopifolia, on gastrointestinal motility in vivo and in vitro in rats. mETHODS： routine in vivo experimental assessments were catharsis index, water percentage of boluses, intestinal transit, and codeine antagonism. The groups included were vehicle control （propylene glycol-ethanolplant oil-tween 80）, elenoside （i.p. 25 and 50 mg/kg）, cisapride （i.p. 10 mg/kg）, and codeine phosphate （intragastric route, 50 mg/kg）. In v/tro approaches used isolated rat intestinal tissues （duodenum, jejunum, and ileum）. The effects of elenoside at concentrations of 3.2 ×10^4, 6.4 ×10^4 and 1.2 ×10^3 mol/L, and cisapride at 10^6 mol/L were investigated. rESULTS： Elenoside in vivo produced an increase in the catharsis index and water percentage of boluses and in the percentage of distance traveled by a suspension of activated charcoal. Codeine phosphate antagonized the effect of 25 mg/kg of elenoside. In vitro, elenoside in duodenum, jejunum and ileum produced an initial decrease in the contraction force followed by an increase. Elenoslde resulted in decreased intestinal frequency in duodenum, jejunum, and ileum. The in vitro and in vivo effects of elenoside were similar to those produced by cisapride. CONCLUSION： Elenoside is a lignan with an action similar to that of purgative and prokinetics drugs. Elenoside, could be an alternative to cisapride in treatment of gastrointestinal diseases as well as a preventive therapy for the undesirable gastrointestinal effects produced by opioids used for mild to moderate pain.

关键词： Elenoside Gastrointestinal motility, Smail intestine preparation

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural regeneration research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Biodiesel production from waste frying oil in sub- and supercritical methanol on a zeolite Y solid acid catalyst

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Frontiers of Chemical Science and Engineering 2013年第4期7卷 401-407页

作者： jorge mEDINA-VALTIErrA jorge rAmIrEZ-OrTIZ Department of Chemical & Biochemical Engineering Aguascalientes Institute of Technology Aguascalientes Ags. 20256 M6xico Academic Unit of Chemical Sciences Autonomous University of Zacatecas Zac. 98160 Mexico

Waste frying oil （WFO） is a very important feedstock for obtaining biodiesel at low cost and using WFO in transesterification reactions to produce biodiesel helps eliminate local environmental problems. In this study biodiesel was produced from WFO in sub- and super- critical methanol on a zeolite Y solid acid catalyst. The procedure was optimized using a design of experiments by varying the methanol to WFO molar ratio, the reaction temperature, and the amount of catalyst. Typical biodiesel yields varied from 83 to nearly 100% with methyl esters content ranging from 1.41-1.66mol.L-~ and typical dynamic viscosities of 22.1-8.2 cE Gas chromatography was used to determine the molecular composition of the biodiesel. The reaction products contained over 82 wt-% methyl esters, 4.2 wt-% free acids, 13.5 wt-% monoglycer- ides, and 0.3 wt-% diglycerides. The transesterification of WFO with methanol around its critical temperature combined with a zeolite Y as an acid catalyst is an efficient approach for the production of biodiesel with acceptable yields.

关键词： biodiesel methanol critical temperature,waste frying oil zeolite Y

Proteomic Analysis Shows Constitutive Secretion of mIF and p53-associated Activity of COX-2-/-Lung Fibroblasts

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Genomics, Proteomics & Bioinformatics 2017年第6期15卷 339-351页

作者： mandar Dave Abul B.m.m.K.Islam roderick V.Jensen Agueda rostagno jorge Ghiso Ashok r.Amin Department of rheumatology New York University Hospital for Joint DiseasesNew YorkNY 10003USA Department of Science STEM DivisionUnion County CollegeCranfordNJ 07016USA Department of Genetic Engineering and Biotechnology University of DhakaDhaka 1000Bangladesh Department of Biological Sciences College of ScienceVirginia TechBlacksburgVA 24060USA Departments of Pathology New York University School of MedicineNew YorkNY 10003USA Department of Bio-medical Engineering Virginia TechBlacksburgVA 24060USA rheumatric Inc. BlacksburgVA 24061USA

The differential expression of two closelyassociated cyclooxygenase isozymes, COX-1 and COX-2, exhibited functions beyond eicosanoid metabolism. We hypothesized that COX-1 or COX-2 knockout lung fibroblasts may display altered protein profiles which may allow us to further differentiate the functional roles of these isozymes at the molecular level. Proteomic analysis shows constitutive production of macrophage migration inhibitory factor （mIF） in lung fibroblasts derived from COX-2 / but not wild-type （WT） or COX-1-/- mice. mIF was spontaneously released in high levels into the extracellular milieu of COX2 /- fibroblasts seemingly from the pre- formed intracellular stores, with no change in the basal gene expression of mIF. The secretion and regulation of mIF in COX-2-/- was ＂prostaglandin-independent.＂ GO analysis showed that concurrent with upregulation of mIF, there is a significant surge in expression of genes related to fibroblast growth, FK506 binding proteins, and isomerase activity in COX-2 ! cells. Furthermore, COX-2-/- fibroblasts also exhibit a significant increase in transcriptional activity of various regu- lators, antagonists, and co-modulators of p53, as well as in the expression of oncogenes and related transcripts. Integrative Oncogenomics Cancer Browser （IntroGen） analysis shows downregulation of COX-2 and amplification of mIF and/or p53 activity during development of glioblastomas, ependymoma, and colon adenomas. These data indicate the functional role of the mIF-COX- p53 axis in inflammation and cancer at the genomic and proteomie levels in COX-2-ablated cells. This systematic analysis not only shows the proinflammatory state but also unveils a molecular signature of a pro-oncogenic state of COX-1 in COX-2 ablated cells.

关键词： mIF p53 Cyclooxygenases Cancer Proteomics

All-electron ZOrA triple zeta basis sets for the elements Cs-La and Hf-rn

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Chinese Physics B 2023年第9期32卷 242-249页

作者： Antônio Canal Neto Francisco E.jorge Henrique r.Cda Cruz Departamento de Física Universidade Federal do Espírito Santo29075-910 VitóriaESBrazil

Segmented all-electron basis set of triple zeta valence quality plus polarization functions(TZP)for the elements of the fifth row to be used together with the zero-order regular approximation(ZOrA)is carefully *** correctly describe electrons distant from atomic nuclei,the basis set is augmented with diffuse functions giving rise to a set designated as *** the ZOrA-B3LYP theoretical level,these sets are used to calculate the ionization energy and mean dipole polarizability of some atoms,bond length,dissociation energy,and harmonic vibrational frequency of diatomic ***,these results are compared with the theoretical and experimental data found in the *** considering that our sets are relatively compact,they are sufficiently accurate and reliable to perform property calculations involving simultaneously electrons from the inner shell and outer *** performances of the ZOrA and second-order Douglas-Kroll-Hess Hamiltonians are evaluated and the results are also discussed.

关键词： TZP-ZOrA and ATZP-ZOrA basis sets ZOrA-B3LYP method Cs-La and Hf-rn elements atomic and molecular properties

Distal nucleotides affect the rate of stop codon read-through

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Quantitative Biology 2023年第1期11卷 44-58页

作者： Luciana I.Escobar Andres m.Alonso jorge r.ronderos Luis Diambra CrEG Universidad Nacional de La Plata-CONICETLa Plata CP 1900Argentina INTechUniversidad Nacional de San MartinChascomus CP 7130Argentina FCNyMUniversidad Nacional de La PlataLa Plata CP 1900Argentina

Background:A key step in gene expression is the recognition of the stop codon to terminate translation at the correct ***,it has been observed that ribosomes can misinterpret the stop codon and continue the translation in the 3′UTr *** phenomenon is called stop codon read-through(SCr).It has been suggested that these events would occur on a programmed basis,but the underlying mechanisms are still not well ***:Here,we present a strategy for the comprehensive identification of SCr events in the Drosophila melanogaster transcriptome by evaluating the ribosomal density *** associated ribosomal leak rate was estimated for every event identified.A statistical characterization of the frequency of nucleotide use in the proximal region to the stop codon in the sequences associated to SCr events was ***:The results show that the nucleotide usage pattern in transcripts with the UGA codon is different from the pattern for those transcripts ending in the UAA codon,suggesting the existence of at least two mechanisms that could alter the translational termination ***,a linear regression models for each of the three stop codons was developed,and we show that the models using the nucleotides at informative positions outperforms those models that consider the entire sequence context to the stop ***:We report that distal nucleotides can affect the SCr rate in a stop-codon dependent manner.

关键词： translational readthrough stop codons translational termination ribosomal density profiles nucleotide usage frequency

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImrAN T.ASGHAr Z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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Brain-penetrating neurotrophic factor mimetics: HEr-096 as a disease-modifying therapy for Parkinson’s disease

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Neural regeneration research 2025年第4期20卷 1094-1095页

作者： natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Arctic sea-ice extent: No record minimum in 2023 or recent years

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 52-55页

作者： Ola m.Johannessen Tor I.Olaussen Nansen Scientific Society BergenNorway Nansen Environmental and remote Sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. In general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic minimum ice Climate