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philippine retinoblastoma initiative multi-eye center study 2010-2020

International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： roland Joseph D.Tan Gary John V.mercado patricia E.cabrera paulita pamela p.Astudillo rolando Enrique D.Domingo Josept mari s.poblete charmaine Grace m.cabebe Adriel Vincent r.Te melissa Anne s.Gonzales Jocelyn G.sy Beltran Alexis A.Aclan Jayson T.so Fatima G.regala Kimberley Amanda K.comia Josemaria m.castro mara Augustine s.Galang Aldous Dominic c.cabanlas Benedicto Juan E.Aguilar Gabrielle s.Evangelista Jo michael maniwan Andrei p.martin calvin Y.martinez John Alfred H.Lim rena Ivy Bascuna rachel m.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine rose V.Apostol Beatriz m.prieto Department of Ophthalmology and Visual sciences Philippine General HospitalManila 1000Philippines Department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Department of Ophthalmology Manila Doctors HospitalManila 1000Philippines Department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines Department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines Department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines Department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye center Legazpi City 4500Philippines Department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIm:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the philippines namely Luzon,Vizayas and mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(pse from the Visayas(psed on the International retinoblastoma staging system,only 35%of patients had stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).Delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma philippines clinical profile

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Benchmarks for pirá2.0,a reading comprehension Dataset about the Ocean,the Brazilian coast,and climate change

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Data Intelligence 2024年第1期6卷 29-63页

作者： paulo pirozelli marcos m.José Igor silveira Flávio Nakasato sarajane m.peres Anarosa A.F.Brandão Anna H.r.costa Fabio G.cozman Universidade de são paulo ringgold standard Institution-Instituto de Estudos Avançados Av.370 São Paulo 05508-900Brazil Universidade de são paulo ringgold standard Institution-Instituto de matemática e Estatística Av.370 São Paulo 05508-900Brazil Universidade de são paulo Rua Cayowaá876 apto 141SÃO PAULO 05018-001Brazil Universidade de são paulo ringgold standard Institution Escola Politécnica Av.370São Paulo 05508-900Brazil.

piráis a reading comprehension dataset focused on the ocean,the Brazilian coast,and climate change,built from a collection of scientific abstracts and reports on these *** dataset represents a versatile language resource,particularly useful for testing the ability of current machine learning models to acquire expert scientific *** its potential,a detailed set of baselines has not yet been developed for pirá.By creating these baselines,researchers can more easily utilize piráas a resource for testing machine learning models across a wide range of question answering *** this paper,we define six benchmarks over the pirádataset,covering closed generative question answering,machine reading comprehension,information retrieval,open question answering,answer triggering,and multiple choice question *** part of this effort,we have also produced a curated version of the original dataset,where we fixed a number of grammar issues,repetitions,and other ***,the dataset has been extended in several new directions,so as to face the aforementioned benchmarks:translation of supporting texts from English into portuguese,classification labels for answerability,automatic paraphrases of questions and answers,and multiple choice *** results described in this paper provide several points of reference for researchers interested in exploring the challenges provided by the pirádataset.

关键词： Natural language processing Question answering Benchmarks Language resource DomainOriented dataset scientific knowledge text dataset

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A functional gel polymer electrolyte based on pVDF-HFp/gelatin toward dendrite-free lithium metal batteries

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Nano research 2024年第4期17卷 2790-2799页

作者： Xiaoyi Hu Kangli Liu shijie Zhang Guosheng shao s.ravi p.silva peng Zhang state center for International cooperation on Designer Low-carbon and Environmental materials(cDLcEm) School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Zhengzhou materials Genome Institute(ZmGI) ZhongyuanzhiguXingyang 450100China Nanoelectronics center Advanced Technology InstituteUniversity of SurreyGuildfordGU27XHUK

The leakage of liquid electrolyte and the formation of lithium dendrites pose challenges to safety and stability of lithium metal batteries(LmBs).The appearance of gel polymer electrolyte(GpE)has obviously improved the safety of traditional ***,the limited inhibition of GpE on lithium dendrites is detrimental to the safety of ***,a kind of poly(vinylidene fluoride-co-hexafluoropropylene)(pVDF-HFp)/gelatin(GN)GpE with high ionic conductivity,high-temperature resistance,and flame-retardancy,was prepared by electrospinning and soaking *** the electrospinning network of pVDF-HFp,its affinity to liquid electrolytes,makes this GpE more beneficial to ions transport and the formation of ***,the GN with sol–gel properties,enhances the mechanical property(13.5 mpa)of HFp-GN ***,X-ray photoelectron spectroscopy(Xps)and density functional theory(DFT)suggest that the attraction of polar groups of GN to Li+can regulate the distribution of Li+and protect Li ***,the application of HFp-GN GpEs to LmBs with cathodes of LiFepO_(4) and LicoO_(2) deliver excellent electrochemical performances:after 300 cycles,the LiFepO_(4)/HFp-GN GpE/Li battery keeps a low capacity decay rate of 0.09%at 5 c;after 400 cycles at 2 c,the LicoO_(2)/HFp-GN GpE/Li cell retains a high capacity retention of 74%.This GpE is demonstrated for the application prospect of safe LmBs.

关键词： poly(vinylidene fluoride-co-hexafluoropropylene)(pVDF-HFp) gelatin polar groups lithium metal battery lithium dendrite

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Exposure of juvenile chinook salmon to effluent from a large urban wastewater treatment *** *** profiling

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Aquaculture and Fisheries 2024年第3期9卷 367-377页

作者： James p.meador suzanne c.Ball c.Andrew James Jenifer K.mcIntyre Dept.of Environmental and Occupational Health sciences School of Public Health4225 Roosevelt Way NESuite 100SeattleWA98105-6099USA Washington state University School of the EnvironmentPuyallup Research and Extension Center2606 W Pioneer AvePuyallupWA98371USA University of Washington Tacoma Center for Urban Waters326 East D StreetTacomaWA98421-1801USA

Targeted metabolomic analysis was conducted on juvenile chinook salmon exposed for 10 days to wastewater effluent(WWE)from a large urban treatment *** included five dilutions of WWE(20%,5.3%,1.4%,0.4%,and 0.1%)and a control with 7 replicates per *** was extracted from fish and analyzed via liquid chromatography–mass spectrometry(Lc-ms)for 361 endogenous metabolites,of which 185 were ***-versus-treatment comparisons identified several metabolites that were associated with altered biochemical pathways observed for all treatments,including several that are important for energy generation and *** altered pathways are crucial for fish health and may be an early indicator of potential adverse effects on growth,reproduction,behavior,and immune *** ocean-type chinook salmon spend several days to weeks in the nearshore estuary where they may encounter high concentrations of WWE *** are exposed to a wide range of potent pharmaceuticals,personal care products,and industrial compounds from WWE that have the potential to affect physiological homeostasis and disrupt their normal life cycle.

关键词： Wastewater effluent metabolomics physiology chinook salmon pharmaceuticals metabolic pathways Estuary

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Lower limb balance,ankle dorsiflexion,orofacial tissue pressure,and occlusal force of rugby players

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sports medicine and Health science 2024年第2期6卷 173-178页

作者： rafael r.machado marcelo palinkas paulo B.de Vasconcelos sara Gollino Veridiana W.Arnoni marcos Vinicios r.prandi Isabela H.regalo selma siessere simone c.H.regalo school of Dentistry of ribeirao preto University of Sao PauloBrazil National Institute for Translational medicine(INcT-Tm) Ribeirao PretoBrazil

This cross-sectional study examined the lower limb balance,ankle dorsiflexion,orofacial tissue pressure,and occlusal strength of rugby ***-six participants were divided into groups:rugby players(n=13)and healthy sedentary adults(n=13).participants underwent an analysis of lower limb balance using a composite score(Y-Balance Test).Ankle dorsiflexion was measured using the Lunge *** Iowa Oral performance Instrument was employed to measure orofacial tissue *** force was measured with a dynamometer,and T-scan assessed occlusal contact *** were analyzed using the t-test(pcOVA with age and weight as covariates,where it is possible to verify that these factors did not influence the results *** differences were observed in the balance of the right(p=0.07)and left(p=0.02)lower limbs,where rugby players had lower composite *** were significant differences in the right(p=0.005)and left(p=0.004)lunges,with rugby players showing lower values,as well as lower tongue pressure(p=0.01)and higher lip pressure(p=0.03),with significant differences to sedentary *** was no significant difference in molar bite force and distribution occlusal contacts between *** seems to reduce lower limb displacement,cause ankle hypomobility,lead to changes in orofacial tissues,particularly the tongue and *** study is significant for identifying significant differences between rugby players and sedentary individuals,providing new insights into the impact of rugby on health and performance,which can benefit sports training and injury prevention.

关键词： rugby Y-balance test Lunge test Orofacial tissues Occlusal force

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prompt neutron emission in ^(250)No spontaneous fission associated with ground and isomeric state decays

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chinese physics c 2024年第6期48卷 112-117页

作者： r.s.mukhin A.V.Isaev A.V.Andreev m.L.chelnokov V.I.chepigin H.m.Devaraja I.N.Izosimov A.A.Kuznetsova O.N.malyshev A.G.popeko Yu.A.popov A.rahmatinejad B.sailaubekov T.m.shneidman E.A.sokol A.I.svirikhin m.s.Tezekbayeva m.A.Bychkov A.V.Yeremin O.Dorvaux B.Gall K.Kessaci K.Hauschild A.Lopez-martens Joint Institute for Nuclear research Dubna141980Russia Dubna state University Dubna141982Russia Institute of Nuclear physics Almaty050032Kazakhstan L.N.Gumilyov Eurasian National University Astana010008Kazakhstan Kazan Federal University Kazan420008Russia Universitéde strasbourg CNRSStrasbourg67000France IJcLab IN2P3-CNRSUniversitéParis-SaclayOrsay91400France

The complete-fusion reaction^(204)pb(^(48)ca,2n)^(250)No was used to study two activities of^(250)No with distinct half-lives.A total of 1357 events were observed in the sFiNx neutron detection *** average number of neutrons emitted per spontaneous fission of^(250)No was determined to be(4.1±0.1).The unusually symmetrical shape of the prompt neutron multiplicity distribution was restored and presented for the first *** tests were performed to compare the prompt neutron multiplicity distributions associated with the ground state and K-isomer state decays.

关键词： spontaneous fission prompt neutrons actinide

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Genetic analyses of ancient tea trees provide insights into the breeding history and dissemination of chinese Assam tea(camellia sinensis ***)

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plant Diversity 2024年第2期46卷 229-237页

作者： miao-miao Li muditha K.meegahakumbura moses c.Wambulwa Kevin s.Burgess michael möller Zong-Fang shen De-Zhu Li Lian-ming Gao cAs Key Laboratory for plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming650201China Germplasm Bank of Wild species Kunming Institute of BotanyChinese Academy of ScienceKunming650201China Kunming college of Life science University of Chinese Academy of SciencesKunming650201YunnanChina Department of Export Agriculture Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadulla90000Sri Lanka Department of Life sciences School of Science and ComputingSouth Eastern Kenya University170-90200KituiKenya Department of Biology Columbus State UniversityUniversity System of GeorgiaColumbusGA31907-5645USA royal Botanic Garden Edinburgh 20A Inverleith RowEdinburghEH35LRScotlandUK Lijiang Forest Biodiversity National Observation and research station Kunming Institute of BotanyChinese Academy of SciencesLijiang674100YunnanChina

chinese Assam tea(camellia sinensis ***)is an important tea crop with a long history of cultivation in Yunnan,*** its potential value as a genetic resource,its genetic diversity and domestication/breeding history remain *** address this issue,we genotyped 469 ancient tea plant trees representing 26 *** *** populations,plus two of its wild relatives(six and three populations of *** and ***,respectively)using 16 nuclear microsatellite *** showed that chinese Assam tea has a relatively high,but comparatively lower gene diversity(H_(s)=0.638)than the wild relative ***(H_s=0.658).clustering in sTrUcTUrE indicated that chinese Assam tea and its two wild relatives formed distinct genetic groups,with considerable interspecific *** chinese Assam tea accessions clustered into three gene pools,corresponding well with their geographic ***,New Hybrids analysis indicated that 68.48%of ancient chinese Assam tea plants from Xishuangbanna were genetic intermediates between the puer and Lincang gene *** addition,10%of the ancient chinese Assam tea individuals were found to be hybrids between chinese Assam tea and *** results suggest that chinese Assam tea was domesticated separately in three gene pools(puer,Lincang and Xishuangbanna)in the mekong river valley and that the hybrids were subsequently selected during the domestication *** the domestication history of chinese Assam tea in southwestern Yunnan remains complex,our results will help to identify valuable genetic resources that may be useful in future tea breeding programs.

关键词： Tea plant Hybrid origin Genetic diversity Domestication history camellia sinensis var.assamica camellia taliensis

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Autoantibodies against beta cells to predict early insulin requirements in pediatric patients with clinically diagnosed type 2 diabetes

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World Journal of Diabetes 2024年第8期15卷 1717-1725页

作者： Jorge m molina patricia G medina rita A Gomez Julia r Herrera Nancy L martínez Brenda Hernández Yesenia García Department of Endocrinology Children’s Hospital Federico GomezMexico 06720Mexico National medical center"siglo XXI" UMAE Hosp EspecialidadesUnidad Invest Med Epidemiol ClinMexican Social Security InstituteMexico 06720Mexico research Division UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIMexican Institute of Social SecurityMexico 06720Mexico Epidemiology research Unit in Endocrinology and Nutrition Federico Gómez Children’s HospitalMexico 06720Mexico Department of Endocrinology Comprehensive Health Unit for Trans PersonsMexico 11340Mexico

BAcKGrOUND Autoimmunity has emerged as a probable disease modifier in patients with clinically diagnosed type 2 diabetes mellitus(T2Dm),that is,patients who have insulin resistance,obesity,and other cardiovascular risk factors,suggesting that the presence of glutamic acid decarboxylase(anti-GAD65),islet antigen 2(anti-IA2),and zinc transporter 8(anti-Zn8T)antibodies could have deleterious effects on beta cell function,causing failure and earlier requirement for insulin *** To evaluate anti-GAD65,anti-IA2 and anti-Zn8T as predictors of early insulin requirement in adolescents with a clinical diagnosis of *** This was a case–control study in patients with clinically diagnosed with T2Dm(68 cases and 64 controls with and without early insulin dependence respectively),male and female,aged 12–18 ***,blood pressure,glucose,insulin,c-peptide,glycated hemoglobin A1c,and lipid profiles were *** was used to measure anti-GAD65,anti-IA2,and anti-Zn8T *** statistics,pearson'sχ2 test,student's t test,and logistic regression was performed.ps considered statistically *** There were 132 patients(53.8%female),with a mean age was 15.9±1.3 years,and there was a disease evolution time of 4.49±0.88 *** presence of anti-GAD65,anti-IA2,and anti-Zn8T positivity was found in 29.5%,18.2%,and 15.9%,*** the groups by early or no insulin dependence showed that the group with insulin had a higher frequency of antibody positivity:anti-GAD65 odds ratio(Or):2.42(1.112–5.303,p=0.026);anti-IA2:Or:1.55(0.859–2.818,p=0.105);and anti-Zn8T:Or:7.32(2.039–26.279,p=0.002).cONcLUsION Anti-GAD65 positivity was high in our ***-GAD65 and anti-Zn8T positivity showed a significantly depleted beta cell reserve phenotype,leading to an increased risk of early insulin dependence.

关键词： Diabetes Obesity Adolescents Autoimmunity Beta cell Insulin requirements

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Towards efficient strain engineering of 2D materials:A four-points bending approach for compressive strain

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Nano research 2024年第6期17卷 5317-5325页

作者： Hao Li Félix carrascoso Ana Borrás Gloria p.moreno Francisco J.Aparicio Ángel Barranco Andrés castellanos Gómez campus de cantoblanco Instituto de Ciencia de Materiales de MadridC.Sor Juana Inés de la Cruz328049 MadridSpain Nanotechnology on surfaces and plasma Lab Instituto de Ciencia de Materiales de Sevilla(CSIC-Universidad de Sevilla).C/Americo Vespucio 49E-41092 SevilleSpain Departamento de Física Aplicada I Escuela Politécnica SuperiorUniversidad de Sevillac/Virgen deÁfrica 7E-41011 SevilleSpain

strain engineering,as a powerful strategy to tune the optical and electrical properties of two-dimensional(2D)materials by deforming their crystal lattice,has attracted significant interest in recent years.2D materials can sustain ultra-high strains,even up to 10%,due to the lack of dangling bonds on their surface,making them ideal brittle *** remarkable mechanical resilience,together with a strong strain-tunable band structure,endows 2D materials with a broad optical and electrical response upon ***,strain engineering based on 2D materials is restricted by their nanoscale and strain quantification *** this study,we have modified a homebuilt three-points bending apparatus to transform it into a four-points bending apparatus that allows for the application of both compressive and tensile strains on 2D *** approach allows for the efficient and reproducible construction of a strain system and minimizes the buckling effect caused by the van der Waals interaction by adamantane encapsulation *** results demonstrate the feasibility of introducing compressive strain on 2D materials and the potential for tuning their optical and physical properties through this approach.

关键词： uniaxial compressive strain polymer encapsulation differential reflectance spectroscopy exciton tunability

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predicting grain size-dependent superplastic properties in friction stir processed ZK30 magnesium alloy with machine learning methods

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Journal of magnesium and Alloys 2024年第5期12卷 1931-1943页

作者： Farid Bahari-sambran Fernando carreno c.m.cepeda-Jiménez Alberto Orozco-caballero physical metallurgy Department CENIM-CSICAv.Gregorio del Amo 828040 MadridSpain Department of mechanical Engineering Chemistry and Industrial DesignPolytechnic University of MadridRonda de Valencia 328012MadridSpain

The aim of this work is to predict,for the first time,the high temperature flow stress dependency with the grain size and the underlaid deformation mechanism using two machine learning models,random forest(rF)and artificial neural network(ANN).With that purpose,a ZK30 magnesium alloy was friction stir processed(Fsp)using three different severe conditions to obtain fine grain microstructures(with average grain sizes between 2 and 3μm)prone to extensive superplastic *** three friction stir processed samples clearly deformed by grain boundary sliding(GBs)deformation mechanism at high *** maximum elongations to failure,well over 400% at high strain rate of 10^(-2)s^(-1),were reached at 400℃ in the material with coarsest grain size of 2.8μm,and at 300℃ for the finest grain size of 2μ***,the superplastic response decreased at 350℃ and 400℃ due to thermal instabilities and grain coarsening,which makes it difficult to assess the operative deformation mechanism at such *** work highlights that the machine learning models considered,especially the ANN model with higher accuracy in predicting flow stress values,allow determining adequately the superplastic creep behavior including other possible grain size scenarios.

关键词： machine learning Artificial intelligence magnesium alloys superplasticity Friction stir processing Grain coarsening

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