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先天性心脏病:应用血管内血池对比剂的心血管mr成像

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国际医学放射学杂志 2011年第6期 577-577页

作者： m.r.makowski A.J.Wiethoff S.Uribe V.Parish r.m.botnar A.Bell 王霁朏 Division of Imaging Sciences King's College LondonNational Health Service Foundation TrustLambeth Place RoadLondon SE1 7EHEngland

目的比较先天性心脏病(CHD)mr血管成像(mrA)检查的两种方法,即采用血池对比剂的对比剂特异性反转恢复稳态自由进动(inversion-recovery steady state freeprecession,IrSSFP)mrA和采用联合血管内对比剂

关键词：血池对比剂维塞马根维显血管内 mr 先天性心脏病心脏先天畸形心血管

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动脉粥样硬化血管壁疾病的分子mr成像

国际医学放射学杂志 2016年第3期 329-329页

作者： D.Nrenberg H.U.Ebersberger G.Diederichs B.Hamm r.m.botnar m.r.makowski 邵天朋 Department of radiology Charité-University Medicine Berlin

摘要分子成像的目标是提高识别和描述体内病理过程,可视化潜在的生物机制。分子成像技术正越来越多地应用于评估血管炎性改变、重建、细胞迁移、血管组织再生和细胞凋亡。分子mr成像对于心血管疾病的体内冠状动脉和颈动脉、主动脉的血... 详细信息

摘要分子成像的目标是提高识别和描述体内病理过程,可视化潜在的生物机制。分子成像技术正越来越多地应用于评估血管炎性改变、重建、细胞迁移、血管组织再生和细胞凋亡。分子mr成像对于心血管疾病的体内冠状动脉和颈动脉、主动脉的血管壁病变的生物学过程的观察是一种新手段。这包括在斑块形成之前早期发现血管改变、可视化检测

关键词：动脉粥样硬化动脉硬化血管壁不稳定斑块 mr 分子

Adiponectin signalling in bone homeostasis,with age and in disease

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Bone research 2021年第1期9卷 15-25页

作者： Jonathan W.Lewis James r.Edwards Amy J.Naylor Helen m.mcGettrick rheumatology research Group Institute of Inflammation and AgeingUniversity of BirminghamBirmingham B152TTUK Ageing&regeneration research Group Botnar Research CentreUniversity of OxfordOxford OX37LDUK

Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose metabolism and insulin *** the bone,osteoblasts and osteoclasts express the adiponectin receptors,however,there are conflicting reports on the effects of adiponectin on bone formation and *** studies have shown a pro-osteogenic role for adiponectin in in vivo murine models and in vitro:with increased osteoblast differentiation and activity,alongside lower levels of ***,human studies often demonstrate an inverse relationship between adiponectin concentration and bone ***,the presence of multiple isoforms of adiponectin and multiple receptor subtypes has the potential to lead to more complex signalling and functional *** such,we still do not fully understand the importance of the adiponectin signalling pathway in regulating bone homeostasis and repair in health,with age and in *** this review,we explore our current understanding of adiponectin bioactivity in the bone;the significance of its different isoforms;and how adiponectin biology is altered in ***,furthering our understanding of adiponectin regulation of bone biology is key to developing pharmacological and non-pharmacological(lifestyle)interventions that target adiponectin signalling to boost bone growth and repair in healthy ageing,following injury or in disease.

关键词： homeostasis metabolism consequences

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接受体外膜肺氧合技术患儿开放肺活检标本的组织病理学特点

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世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 36-37页

作者： Sebire N.J. ramsay A.D. malone m. 平智广 Department of Paediatric Pathology Camelia Botnar Laboratories Great Ormond Street Hospital London Great Ormond Street London WC1N 3JH United Kingdom

Background: Extracorporeal membrane oxygenation (ECm-O)-has become an established treatment for severe respiratory distress in a range of pediatric conditions. This study describes the histopathological features in a series of 22 children receiving ECmO therapy in whom open lung biopsy was carried out. Aims: To describe the histopathological features of open lung biopsies in children receiving ECmO therapy. Study design: retrospective review of clinical material. Subjects: Children receiving ECmO therapy in whom open lung biopsy was carried out. results: In those investigated in infancy, open lung biopsy allowed a definite diagnosis to be made of the underlying condition in more than 90%of cases. In older children, the histopathological changes were more nonspecific and, although providing useful clinical information, a definitive diagnosis could often not be made. In about a quarter of cases, there are additional pathological features, which may be related to ECmO treatment, such as significant intraalveolar haemorrhage, but ECmO does not in itself impair the diagnostic usefulness of open lung biopsy in these selected patients. Conclusion: Open lung biopsy provides clinically useful information in infants receiving ECmO therapy. The histopathological changes may be complex and represent both the effects of ECmO and progression of the underlying disease.

关键词：开放肺体外膜肺氧合活检标本病理学特点肺活检临床信息呼吸窘迫疾病病情婴儿期接受研究

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The effect of breaking sitting time with physical activity breaks on cognitive performance in young people with cerebral palsy:an exposure response cross-over feasibility design

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Translational Exercise Biomedicine

Translational Exercise Biomedicine 2024年第1期1卷 32-42页

作者： Shelly Coe Jo Cossington Johnny Collett Andy meaney Foteini mavrommati Yujun Ng Hooshang Izadi Will Wade Dominika m.Pindus Oliver Bushnell Luke Whaymand Tim Theologis Emily Swift Ece Akgul Sam Allen Helen Dawes Centre for movement Occupational and rehabilitation Sciences Department of Sport Health Sciences and Social WorkOxford Brookes UniversityOxfordUKOX30BP Oxford Brookes Centre for Nutrition and Health Department of Sport Health Sciences and Social WorkOxford Institute for Applied Health ResearchOxford Brookes UniversityOxfordUKOX30BP medical School University of ExeterExeterUK Specialised Translational research Oxford Neuromuscular Group:STrONG Department of PaediatricsUniversity of OxfordJohn Radcliffe HospitalOxfordUK Cardiovascular medicine University of OxfordJohn Radcliffe HospitalOxfordUK Ace Centre Hollinwood Business CentreOldhamUK University of Illinois at Urbana-Champaign Department of Kinesiology and Community HealthUrbanaILUSA Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-ChampaignUrbanaILUSA Neuroscience Program University of Illinois at Urbana-ChampaignUrbanaILUSA Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal SciencesUniversity of OxfordBotnar Research CentreOxfordUK School of Clinical medicine Centre for Healthy Brain Ageing(CHeBA)Discipline of Psychiatry and Mental HealthUniversity of New South WalesSydneyAustralia NIHr Exeter BrC University of Exeter Medical SchoolDepartment of Public Health and Sports SciencesFaculty of Health and Life SciencesMedical School BuildingCollege of Medicine and HealthSt Lukes CampusExeterUK Nuffield Department of Clinical Neurosciences University of OxfordOxfordUK

Objectives To assess the feasibility of methods and estimate the potential effect of interrupting sedentary behaviour,with intermittent or continuous physical activity breaks,on cognitive performance in young people with Cerebral *** A randomised three-arm exposure response cross-over design with process *** were recruited throughout the Thames Valley,UK between 01/11/2018 to 31/03/*** three 2 h activity exposure visits included:(i)sitting only(controls),(ii)sitting plus 20 min of moderate-to-vigorous activity burst,or(iii)4×5 min of moderate-to-vigorous activity bursts,during a 2.5 h sedentary *** of feasibility were *** performance outcomes(using the Eriksen Flanker task and Forward and Backward Digit Span)were delivered before and after the 2 h testing *** 36 participants were randomised(age 13.2±2.7,Gross-motor Functional Classification System 1–3).Study retention was 83%across all three interventions and overall missing data for measures was 4%.A small intervention effect was found in reaction time in the 4×5 min physical activity exposure session compared to the sedentary control condition(0.42;95%CI 0.40 to 0.79).There were two research-related minor adverse effects,an allergic reaction to the FreeStyle Libre and feeling faint and vomiting after consumption of glucose *** events were resolved and participants continued with the *** The study design and intervention implementing short bursts of physical activity was feasible and indicated a potential effect on reaction time as a measure of cognitive performance in young people with cerebral palsy.

关键词： cerebral palsy physical activity cognitive performance child adolescent