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Hormone naive prostate cancer： predicting and maximizing response intervals

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Asian Journal of Andrology 2015年第6期17卷 929-935,I0007,I0008页

作者： judd W moul Division of Urology Department of Urology Duke Cancer Institute Duke South Duke University Medical Center Durham NC 27710 USA.

Hormone naive advanced prostate cancer is subdivided into two disease states： biochemical recurrence and traditional m 1 （metastatic） prostate cancer and characterized by no prior hormonal therapy or androgen deprivation therapy （ADT）. In biochemical recurrence/ prostate-specific antigen （PSA） recurrence, men should be risk-stratified based on their PSA doubling time, the Gleason score and the timing of the recurrence. In general, only men who are at high risk should be considered for early/immediate ADT although this is best done using shared decision with the patient. The type of ADT to be used in biochemical recurrence ranging fr.m.oral-only peripheral blockade （peripheral androgen deprivation） to complete hormonal therapy （combined androgen blockade [CAB]） r.m.ins in debate owing to lack of randomized controlled trials （rCT）. However, there is good rCT support for use of intermittent hormonal therapy （IHT）. There is also limited research on biomarker response （PSA and testosterone decline） to predict prognosis. On the other hand, in the setting of m1 hormone naive prostate cancer, there are many more rCT＇s to inform our decisions. CAB and gonadotrophin-releasing hormone antagonists perhaps provide a slight efficacy advantage while IHT may be slightly inferior with minimal m1 disease. The PSA nadir at 7 months after starting ADT is a powerful prognostic tool for.m. patients. There is growing recognition that ser.m.testosterone （T） control while on ADT is linked to the development of castrate-resistant prostate cancer. Especially for a m 1 patient, maintaining a ser.m.T below 20-30 ng d1-1 prolongs the response to ADT. Novel oral agents （abiraterone and enzalutamide） may soon find use in hormone naive disease and may alter the treatment landscape. Despite over 75 years of experience with ADT, many questions r.m.in, and the field continues to evolve.

关键词： androgen deprivation therapy cancer gonadotrophin-releasing hormone antagonists hormonal therapy luteinizing hormone-releasing hormone agonists prostate prostate-specific antigen testosterone

基于证据推理的电力变压器故障诊断策略(英文)

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中国电机工程学报 2006年第1期26卷 106-114页

作者：董明严璋杨莉 m.D.judd 西安交通大学电气工程学院陕西省西安市710049 卡里多尼亚大学高电压绝缘诊断研究所斯特拉思克莱德大学能源与环境学院

在变压器绝缘劣化之前,可以进行油中溶解气体分析、局部放电检测、传递函数测量等试验方法对其状态进行评估。所有这些试验现象需要很多实际经验才能正确解释。因此人工智能技术逐渐被应用于提高单一试验数据的分析中。但是,仅使用一种... 详细信息

在变压器绝缘劣化之前,可以进行油中溶解气体分析、局部放电检测、传递函数测量等试验方法对其状态进行评估。所有这些试验现象需要很多实际经验才能正确解释。因此人工智能技术逐渐被应用于提高单一试验数据的分析中。但是,仅使用一种方法,可能难以得到满意的诊断结果,如油中溶解气体分析是不能准确对局部放电进行定位。然而,应用不同的方法可能产生各异的诊断结果,因此文中引入模糊信息融合系统来解决此问题,提出了产生一致性结论和处理不同方法中不确定性的证据推理策略。并在信息融合的帮助下,建立了有机组合多种诊断方法系统框架。通过实例证明,基于信息融合的变压器绝缘故障诊断方法是有效的。

关键词：电力变压器状态监测油中溶解气体分析信息融合绝缘诊断学

Effect of radiative loss mechanisms on FIr thermometric par.m.ters of Nd^(3+)-doped lithium tellurite glasses

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Journal of rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.morassuti A.P.L Silva L.A.O.Nunes S.m.Lima L.H.C.Andrade Optical and Photothermal Spectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil renato Archer Information Technology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of São Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are pr.m.sing materials for thermometers based on the fluorescence intensity ratio(FIr)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical reabsorption and cross-relaxation can affect the Nd^(3+)emission,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range fr.m.299 to 371 *** results indicate a strong dependence of the FIr par.m.ters on the Nd^(3+)concentration,due to changes in the emission band profiles caused by optical reabsorption of the Nd^(3+)emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluorescence intensity ratio Optical thermometry judd-Ofelt rare earths

Artemisinin Biosynthesis in Non-glandular Trichome Cells of Artemisia annua

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molecular Plant 2019年第5期12卷 704-714页

作者： rika judd m.Caleb Bagley mingzhuo Li Yue Zhu Caiyan Lei Seyit Yuzuak mans Ekelof Gaobin Pu Xiting Zhao David C.muddiman De-Yu Xie Depar.m.nt of Plant and microbial Biology North Carolina State UniversityRaleighNCUSA Depar.m.nt of Chemistry North Carolina State UniversityRaleighNCUSA

Artemisinin-based combination therapy(ACT)forms the first line of malaria ***,the yield fluctuation of artemisinin has r.m.ined an unsolved problem in meeting the global demand for *** problem is mainly caused by the glandular trichome(GT)-specific biosynthesis of artemisinin in all currently used Artemisia annua ***,we report that non-GT cells of self-pollinated inbred *** plants can express the artemisinin biosynthetic *** expression analysis demonstrated the transcription of six known pathway genes in GT-free leaves and calli of inbred *** ***-qTOF-mS/mS analysis showed that these two types of GT-free materials produce artemisinin,artemisinic acid,and arteannuin *** Ir.m.LDESI image profiling revealed that these three metabolites and dihydroartemisinin are localized in non-GT cells of leaves of inbred *** ***,we employed all the above approaches to examine artemisinin biosynthesis in the reported XL annua glandless(gl)*** resulting data demonstrated that leaves of regenerated gl plantlets biosynthesize ***,these findings not only add new knowledge leading to a revision of the current dogma of artemisinin biosynthesis inannua but also may expedite innovation of novel metabolic engineering approaches for high and stable production of artemisinin in the future.

关键词： Artemisia annua artemisinin glandular trichome norvglandular trichome cell

Technology Deployment to Improve Clinical Outcomes

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中国医疗设备 2016年第1期31卷 1-5页

作者： T.m.judd L.Jacobs m.Jansen B.Birch clinical technology kaiser permanentebrth boardAtlantaGA30305USA the permanente journal presidentbrth boardAtlantaGA30305USA iron bow healthcare solutions AtlantaGAUSA innovation and advanced technology kaiser permanente it0aklandGAUSA

Improved child, newborn, and maternal health(CNm) is a top priority in developing countries. many factors must be addressed simultaneously to improve clinical outcomes for CNm. A public-private project in Haiti that will deploy the World Health Organization(WHO) evidence-based medicine(EBm) and essential interventions utilizing CNm healthcare technologies(HT), is expected to be a model for improving national health systems. The CNm mortality rates in Haiti are the highest in the western hemisphere with rates similar to those found in Afghanistan and several African countries. Several factors perpetuating this crisis are noted, as well as the most cost-effective interventions proven to decrease CNm mortality rates in low-and middle-income countries. To create major change in health system infrastructure, two strategies are presented, requiring appropriate and leading-edge health technologies(HT), e.g., wireless cellular-network-based Telemedicine(Tm):(1) Development of a countrywide network of geographical "Community Care Grids" to facilitate implementation of frontline interventions;(2) The construction of a central hospital(called Bethesda referral and Teaching Hospital-BrTH NGO) that will provide secondary and tertiary care for communities throughout the country, including helping local hospitals and clinics practice EBm care. We believe that these strategies-supported by HT will fast track improvement in CNm mortality rates throughout the country and that in a relatively short period of time Haiti's health care system will be among the leaders in the region. Pr.m.ry factors contributing to the CNm crisis, all addressed by Tm:(1) Limited access: demographics, geography, cost, transportation;(2) Inadequate health care facilities: less than 20 NICU beds for 10 million population; BrTH to provide 80 bed NICU and 40 bed PICU in 225 bed hospital;(3) Health care practitioners: inadequate numbers and training;(4) Low % of skilled attendants now at deliveries;(5) Low % of

关键词：临床医学工程世界卫生组织顾问委员会美国FDA 医疗技术管理医疗设备 301医院临床工程

心脏电影mrI评估左心室长轴功能为射血分数减少病人全因死亡率的独立预测因素:一项多中心研究

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国际医学放射学杂志 2018年第2期 224-225页

作者： S.r.m.no r.m.judd r.J.Kim H.W.Kim I.Klem J.F.Heitner 俞翔 Division of Cardiology Department of Medicine University of Illinois at Chicago

摘要目的本多中心研究旨在通过心脏电影mrI评估左心室(LV)长轴功能的一项简单指标——外侧二尖瓣平面收缩位移(mAPSE)评价射血分数(EF)减少病人预后的价值。

关键词： mrI 左心室全因死亡射血分数多中心研究预测因素

Biofilms in chronic rhinosinusitis:Pathophysiology and therapeutic strategies

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2016年第4期2卷 -页

作者： judd H. Fastenberg Wayne D. Hsueh Ali mustafa Nadeem A. Akbar Waleed m. Abuzeid Depar.m.nt of 0torhinolaryngology e Head&Neck Surgery Montefiore Medical Center Albert Einstein College of Medicine 3400 Bainbridge Ave Bronx NY 10467 USA

Background:There is increasing evidence that biofilms are critical to the patho-physiology of chronic infections including chronic rhinosinusitis (CrS). Until relatively recently, our understanding of biofilms was limited. recent advances in methods for biofilm identifica-tion and molecular biology have offered new insights into the role of biofilms in CrS. With these insights, investigators have begun to investigate novel therapeutic strategies that may disrupt or eradicate biofilms in CrS. Objective:This review seeks to explore the evidence implicating biofilms in CrS, discuss po-tential anti-biofilm therapeutic strategies, and suggest future directions for research. results:The existing evidence strongly supports the role of biofilms in the pathogenesis of CrS. Several anti-biofilm therapies have been investigated for use in CrS and these are at var-iable stages of development. Generally, these strategies: 1) neutralize biofilm microbes; 2) disperse existing biofilms; or 3) disrupt quor.m.sensing. Several of the most pr.m.sing anti-biofilm therapeutic strategies are reviewed. Conclusions:A better understanding of biofilm function and their contribution to the CrS disease process will be pivotal to the development of novel treatments that may augment and, poten-tially, redefine the CrS treatment paradigm. There is tr.m.ndous potential for future research.

关键词： Sinusitis Biofilms Anti-bacterial agents Quor.m.sensing Surface-active agents Active immune response Innate immune response

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估价新生儿

国际护理学杂志 1986年第6期07卷 260-261页

作者： Judy m.judd ,赵国华

估价新生儿的任务虽然不小,但只要系统耐心地进行,检查便可得心应手。避免在刚出生后、新生儿不适时,喂奶前后对新生儿进行仔细检查。检查前应洗手更衣,确保室内光线充足、温度适当。检查开始可观察新生儿的姿式、颜色、面部表情、呼吸... 详细信息

估价新生儿的任务虽然不小,但只要系统耐心地进行,检查便可得心应手。避免在刚出生后、新生儿不适时,喂奶前后对新生儿进行仔细检查。检查前应洗手更衣,确保室内光线充足、温度适当。检查开始可观察新生儿的姿式、颜色、面部表情、呼吸类型、熟睡程度和自发活动,注意明显的异常情况,如大头,腹部凸出、四肢短小。一、身体比例正常新生儿头与身体的比率为1:4。平均头围33.8cm,胸围通常比头围少2.6cm。正常身高为45～52.5cm 不等。二、感觉运动反应与反射估价神经系统要求观察熟练。应估价的神经功能包括活动水平、对刺激的反应、自发警觉、啼哭力量

关键词：新生儿姿式成红细胞增多症估价

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嵌入式逻辑分析仪加速SoPC设计

电子设计应用 2005年第7期 102-102,104-105页

作者： judd Heape Neal Stollon QuickLogic公司 First SiliconSolutions公司

嵌入式标准产品平台的高速发展需要与之相应的调试工具也随之发展。对SoPC而言,用于调试CPU时的传统的JTAG方法和FPGA的逻辑分析同样重要,更重要的是有交互触发的硬/软件环境,以便快速地隔离、甄别并调试复杂问题。理想的SoPC系统分析... 详细信息

嵌入式标准产品平台的高速发展需要与之相应的调试工具也随之发展。对SoPC而言,用于调试CPU时的传统的JTAG方法和FPGA的逻辑分析同样重要,更重要的是有交互触发的硬/软件环境,以便快速地隔离、甄别并调试复杂问题。理想的SoPC系统分析工具应该能够处理上述问题,并且提供监控系统内部总线事件的能力。

关键词：逻辑分析仪 SoPC IEEE802.11i 嵌入式加速系统设计者可编程逻辑互联网协议 AES 系统集成应用实例硬件实现加密标准基础模块安全规范加密算法无线连接 CPU