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Suppressed estrogen supply via extra-ovarian progesterone receptor membrane component 1 in menopause

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The Journal of Biomedical research 2021年第3期35卷 228-237页

作者： Sang rlee Hyun Yang Seong Lae Jo Young Ho lee Hye Won lee Bae-keun Park Eui-Ju Hong College of Veterinary Medicine Chungnam National UniversityDaejeon 34134Republic of Korea KM Convergence research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea

In post-menopausal women,intra-mammary estrogen,which is converted from extra-ovarian estrone(E1),promotes the growth of breast *** the aromatase inhibitor letrozole does not suppress 17β-estradiol(E2)production from E1,high intra-mammary E1 concentrations impair letrozole's therapeutic *** receptor membrane component 1(Pgrmc1)is a non-classical progesterone receptor associated with breast cancer *** the present study,we introduced a Pgrmc1 heterozygous knockout(hetero KO)murine model exhibiting low Pgrmc1 expression,and observed estrogen levels and steroidogenic gene ***ïve Pgrmc1 hetero KO mice exhibited low estrogen(E2 and E1)levels and low progesterone receptor(Pr)expression,compared to wild-type *** contrast,Pgrmc1 hetero KO mice that have been ovariectomized(OVX),including letrozole-treated OVX mice(OVX-letrozole),exhibited high estrogen levels and Pr *** extra-ovarian estrogen production in Pgrmc1 hetero KO mice was observed with the induction of steroid sulfatase(STS).In MCF-7 cell,letrozole suppressed Pr expression,but PGrMC1 knockdown increased Pr and STS *** presented results highlight the important role of Pgrmc1 in modulating estrogen production when ovary-derived estrogen is limited,thereby suggesting a potential therapeutic approach for letrozole resistance.

关键词： extra-ovarian Pgrmc1 steroid sulfatase estrogen letrozole

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《美国手语句法:功能语类和等级结构》述评

当代语言学 2005年第3期7卷 274-279页

作者： C.Neidle J.Kegl D.MacLaughlin B.Bahan r.lee 李汝亚 410082 湖南长沙湖南大学外国语学院

(Syntax of American Sign Language:Functional Categories and Hierarchical Structure)一书由MIT出版社于2000年出版,作者是Carol Neidle,Judy Kegl,Dawn MacLaughlin,Benjamin Bahan和robert ***.

关键词：等级结构功能语类美国手语句法 American Language 述评 2000年 Sign

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铝电解槽废内衬的处理研究及其发展

轻金属 1984年第4期 31-33+17页

作者： r.lee Byers 程金秀

铝电解使用两种内衬材料:一种是可减少热损失的保温砖,另一种主要是由无烟煤和沥青组成的材料。后者主要用做铝电解槽的阴极。一台电解槽到两种内衬破损为止一般可使

关键词：废槽衬灰口铁水泥窑萤石水泥生产氟化物灰铁非金属矿物卤化物铝电解槽硅酸盐水泥波特兰水泥美国铝业公司内衬

入侵植物粗毛牛膝菊根际土壤和根系真菌群落会沿海拔扩散路径发生变化

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Journal of Plant Ecology 2023年第1期16卷 105-122页

作者： rui-Ling Liu Wen-Gang Zhang Benjamin r.lee Gang Liu Xing-Jiang Song Xiao-Yan Chen Jia-Bin Zou Fang-Fang Huang Zhi-Hong Zhu College of Life Sciences Shaanxi Normal UniversityXi’an 710119China Carnegie Museum of Natural History PittsburghPA 15213USA Department of Biological Sciences University of PittsburghPittsburghPA 15213USA Holden Forest and Gardens KirtlandOH 44094USA National Engineering Laboratory for resource Development of Endangered Crude Drugs in Northwest China Shaanxi Normal UniversityXi’an 710119China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China

与入侵植物相关的真菌群落可能会随着海拔发生变化,这可能会影响入侵植物的表现和入侵力。我们最近的研究表明,入侵植物粗毛牛膝菊(Galinsoga quadriradiata)的根系AMF侵染率随着海拔的升高而下降。然而,尚不清楚这是否与真菌群落沿海... 详细信息

与入侵植物相关的真菌群落可能会随着海拔发生变化,这可能会影响入侵植物的表现和入侵力。我们最近的研究表明,入侵植物粗毛牛膝菊(Galinsoga quadriradiata)的根系AMF侵染率随着海拔的升高而下降。然而,尚不清楚这是否与真菌群落沿海拔的变化相关。为此,我们采用高通量测序技术、功能分组和线性分析等方法,研究了秦巴山区的粗毛牛膝菊根际土壤和根系真菌群落组成与结构沿海拔的变化趋势。研究结果表明,粗毛牛膝菊根际土壤和根系真菌群落物种多样性和种类组成随海拔升高发生了显著变化。在根际土壤中真菌群落香农-威纳多样性指数随着海拔升高呈上升趋势,而在根系中则呈下降趋势。同时,在根际土壤中共生真菌的相对丰度随海拔高度没有发生显著变化,而在根系中呈下降趋势;在根际土壤中病原真菌的相对丰度随着海拔呈下降趋势,而在根系中呈上升趋势。这些研究结果暗示,该种在向研究区域高海拔地区入侵时,土壤共生真菌的供给并不会缺乏,但其与这些真菌之间建立并维持共生关系的能力降低了;在向高海拔扩张过程中,该种倾向于在根系中积累更多的病原真菌,而减少对共生真菌的依赖。这些研究结果说明,入侵植物与真菌群落之间的相互作用会沿着海拔梯度发生显著变化,植物地下部分与真菌的相互作用可能是我们理解外来种如何在高海拔环境中入侵成功的关键。

关键词：入侵植物范围扩张真菌多样性真菌丰度共生菌病原菌

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小议多线程的渲染与物理模拟

程序员（游戏创造） 2008年第6期 13-18页

作者： rajshree Chabukswar Adam T．Lake Mary r.lee 房燕良（译）

本文通过一个简单的物理模拟Demo来研究如何在一个多线程的环境中分离渲染和物理模拟。文中的代码可以作为一个示例，也可以直接用于读者们自己的游戏引擎中。

关键词：物理模拟多线程渲染 Demo 游戏引擎代码

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大数据驱动的原旨主义研究

法律方法 2020年第2期26卷 3-55页

作者： [美]托马斯·李詹姆斯·菲利普斯宋丽珏(译) 美国犹他州最高法院杨百翰大学斯坦福大学法学院宪法法律中心伯克利大学华东政法大学外语学院

挖掘美国《宪法》中词汇的原初含义是原旨主义研究者长久以来面临的难题。词典仅可释义单词,无法定义短语或更大的语言单位。本文总结了建国时期美国英语语料库的建设现状,运用语料库语言学研究方法,包括考察索引行、搭配、词簇,以及频... 详细信息

挖掘美国《宪法》中词汇的原初含义是原旨主义研究者长久以来面临的难题。词典仅可释义单词,无法定义短语或更大的语言单位。本文总结了建国时期美国英语语料库的建设现状,运用语料库语言学研究方法,包括考察索引行、搭配、词簇,以及频率统计来辅助原义研究。针对如何利用语料库数据确定词汇或短语的语义进行说明。并量化分析了《宪法》中商业、公共使用、自然出生公民等几项长期以来充满争议的词汇,以及其他仍需进一步明确的概念如内部暴力,并兼谈语料库语言学方法应用于原旨主义研究的局限性。

关键词：大数据原旨主义法律解释语料库宪法语义

PGLYrP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural regeneration research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural regeneration research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus rNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus rNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Optimization of an Artificial Intelligence Database and Camera Installation for recognition of risky Passenger Behavior in railway Vehicles

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Computers, Materials & Continua 2025年第1期82卷 1277-1293页

作者： Min-kyeong Kim Yeong Geol lee Won-Hee Park Su-hwan Yun Tae-Soon Kwon Duckhee lee railroad Test&Certification Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea railroad Safety Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea

Urban railways are vital means of public transportation in *** than 30%of metropolitan residents use the railways,and this proportion is expected to *** enhance safety,the government has mandated the installation of closed-circuit televisions in all carriages by ***,cameras still monitored *** address this limitation,we developed a dataset of risk factors and a smart detection system that enables an immediate response to any abnormal behavior and intensive monitoring *** created an innovative learning dataset that takes into account seven unique risk factors specific to Korean railway *** data collection was conducted across the Shinbundang Line of the Incheon Transportation Corporation,and the Ui-Shinseol *** observed several behavioral characteristics and assigned unique annotations to *** also considered carriage *** performance was evaluated by camera placement and *** the camera installation plan was *** dataset will find immediate applications in domestic railway *** artificial intelligence algorithms will be verified shortly.

关键词： AI railway vehicle risk factor smart detection AI training data