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GUI-Based DL-Network Designer for KISTI’s Supercomputer Users

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Computers, Materials & Continua 2021年第11期69卷 1611-1629页

作者： Jaegwang lee Jongsuk r.lee Sunil Ahn Korea Institute Science and Technology Information Daejeon34141Korea

With the increase in research on AI(Artificial Intelligence),the importance of DL(Deep Learning)in various fields,such as materials,biotechnology,genomes,and new drugs,is increasing significantly,thereby increasing the number of deep-learning framework ***,to design a deep neural network,a considerable understanding of the framework is *** solve this problem,a GUI(Graphical User Interface)-based DNN(Deep Neural Network)design tool is being actively researched and *** GUI-based DNN design tool can design DNNs quickly and ***,the existing GUI-based DNN design tool has certain limitations such as poor usability,framework dependency,and difficulty encountered in changing GUI *** this study,a deep learning algorithm that solves the problem of poor usability was developed using a template to increase the accessibility for ***,the proposed tool was developed to save and share only the necessary parts for quick *** solve the framework dependency,we applied ONNX(Open Neural Network Exchange),which is an exchange standard for neural networks,and configured it such that DNNs designed with the existing deep-learning framework can be ***,to address the difficulty encountered in changing GUI components,we defined and developed the JSON format to quickly respond to version *** developed DL neural network designer was validated by running it with KISTI’s supercomputer-based AI Studio.

关键词： Deep neural network design ONNX GUI design tool deep learning

Techniques to resect the distal ureter in robotic/laparoscopic nephroureterectomy

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Asian Journal of Urology 2016年第3期3卷 120-125页

作者： Weil r.Lai Benjamin r.lee Department of Urology Tulane University School of MedicineNew OrleansLAUSA Division of Urology University of Arizona College of MedicineTucsonAZUSA

Treatment of clinically-organ confined high grade urothelial carcinoma of the upper tract has historically comprised open nephroureterectomy,with the distal ureter and bladder cuff mobilized through a separate open pelvic *** decrease morbidity,urologists have increasingly adopted laparoscopy and robotics in performing *** many published series of laparoscopic nephroureterectomy,the distal ureter and bladder cuff are detached from the bladder endoscopically by a variation of the“pluck”technique,with the resulting bladder defect left to heal by prolonged indwelling urethral catheter *** the distal ureter and bladder cuff can be excised laparoscopically,it does require advanced laparoscopic *** the wrist articulation and stereoscopic vision in robotic surgery,robotic nephroureterectomy(rNU)and bladder cuff excision can be performed in antegrade fashion to mimic the open technique together with the ability to intracorporeally close the bladder defect in a watertight,mucosa to mucosa fashion after excising the bladder *** this review,we discuss the published minimally invasive techniques in resecting the distal ureter and bladder cuff during laparoscopic and rNU.

关键词： Transitional cell carcinoma robotic nephroureterectomy Laparoscopy robotic surgical procedures Ureteral neoplasms

Prevalence of hyponatremia in acute medical admissions in tropical Asia Pacific Australia

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Asian Pacific Journal of Tropical Medicine 2014年第1期7卷 40-43页

作者： Usman H.Malabu David Porter Venkat N.Vangaveti Monsur Kazi r.lee Kennedy Department of Medicine Townsville Hospital/James Cook UniversityQueenslandAustralia Department of Pathology Townsville Hospital/James Cook UniversityQueenslandAustralia Department of Medicine Deakin UniversityVictoriaAustralia

Objective:To determine prevalence of hyponatremia in acute medical admissions in Northern ***:We studied 469 consecutive acute medical admissions to a hospital in Australia's Far North Queensland during the colder months of June and July *** of hyponatremia and its relationship with gender,age,diagnosis and prognosis in acute medical admissions were ***:On admission,hyponatremia(plasma sodiumresent in 39.4%of patients,with mild(130—135 mmol/L),moderate(126-129 mmol/L)and severe?126 mmol/L)hyponatremia being present in 25.2%,10.7*and 3.6****,adding together admission hyponatremia with that developing during admission,45.2%of patients were affected with 11.5%moderate hyponatremia cases and 4.1%severe *** and hyperkalemia were present in 17.0%and 18.1*,***,275/469 patients(58.6*)presented with an electrolyte *** were significant correlations of hyponatremia with age but not with gender and in-hospital *** of hyponatremia was high across all diagnostic ***:The prevalence of hyponatremia appears to be high in the tropical North Australian population,being the highest prevalence reported amongst acute hospital *** previously reported correlations with age and mortality do appear to hold good for this population with a high prevalence of electrolyte *** prospective analysis on a larger population in the area is needed to confirm our findings.

关键词： Hyponatremia Prevalence Acute admissions Tropical Asia Pacific Australia

Bacillary layer detachment presenting with posterior scleritis:case report

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Annals of Eye Science 2022年第3期7卷 67-71页

作者： Gregory W.Bligard Andrew r.lee Lynn M.Hassman Department of Ophthalmology and Visual Sciences Washington University in St.Louis School of MedicineSt.LouisMOUSA

Background:Bacillary layer detachment(BALAD)is a phenomenon characterized by fluid accumulation at the myoid region of the inner photoreceptor segments identifiable on optical coherence tomography(OCT)*** finding has been recently described in patients with diverse primary diagnoses which share the common feature of serous exudation in the posterior ***,thus far there have been very few reports in the literature of BALAD in patients with posterior *** Description:A 16-year-old male presented with unilateral vision changes that acutely worsened overnight to significant unilateral vision *** was eventually diagnosed with idiopathic posterior scleritis with associated BALAD on *** to other reported cases of BALAD,he experienced anatomic restoration of the outer retina followed by good visual recovery after treatment with high dose steroid,ultimately with complete recovery of both retinal anatomy and vision within 4 ***:This case provides further evidence that posterior scleritis can be a cause of *** rapid presentation and excellent visual and anatomical outcome of this case is entirely consistent with known descriptions of BALAD in a variety of other conditions,further supporting the categorization of BALAD as an entity which retinal specialists should be able to recognize as distinct from other forms of intraretinal fluid,retinal detachment,and retinoschisis.

关键词： Case report bacillary layer detachment(BALAD) photoreceptor scleritis inner segment

不同来源的豆饼、日粮中氯和非植酸磷水平对肉用仔鸡胫骨软骨症的影响

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中国农业科学 1990年第6期23卷 75-81页

作者：罗兰,Steve r.lee 中国农业科学院畜牧研究所美国阿肯色州大学动物科学系

本试验研究不同来源的豆饼,日粮中氯和非植酸磷水平对肉用仔公鸡生长性能和胫骨软骨症(TD)的影响。采用9种不同来源的豆饼,2种日粮,共18个日粮处理。日粮中氯和非植酸磷水平分别为0.15%和0.44%,为对照日粮;0.35%和1.00%,为TD-诱发日粮... 详细信息

本试验研究不同来源的豆饼,日粮中氯和非植酸磷水平对肉用仔公鸡生长性能和胫骨软骨症(TD)的影响。采用9种不同来源的豆饼,2种日粮,共18个日粮处理。日粮中氯和非植酸磷水平分别为0.15%和0.44%,为对照日粮;0.35%和1.00%,为TD-诱发日粮。试验结果表明,根据饲喂不同来源的豆饼,采食对照日粮的鸡其TD发病率为2.5-38.8%;采食TD-诱发日粮的鸡其TD发病率为61.3-97.5%。TD发病率与鸡生长速度之间相关系数为r=0.52(P<0.01)。高磷、高氯日粮导致TD的发病率高,对鸡胫骨灰分无影响(P<0.05)。商品用豆饼对仔鸡TD发病率的影响存在差异。豆饼中铝、钡、铜、钠、硅、锌元素的水平显著地影响小鸡TD的发病率。

关键词：肉用仔鸡豆饼非植酸磷氯胫骨软骨症

First demonstration of an all-solid-state optical cryocooler

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Light(Science & Applications) 2018年第1期7卷 922-931页

作者： Markus P.Hehlen Junwei Meng Alexander r.Albrecht Eric r.lee Aram Gragossian Steven P.Love Christopher E.Hamilton richard I.Epstein Mansoor Sheik-Bahae Los Alamos National Laboratory P.O.Box 1663Los AlamosNM 87545USA Department of Physics&Astronomy University of New MexicoAlbuquerqueNM 87131USA

Solid-state optical refrigeration uses anti-Stokes fluorescence to cool macroscopic objects to cryogenic temperatures without *** such as Yb3+-doped YLiF4(YLF:Yb)have previously been laser-cooled to 91 *** this study,we show for the first time laser cooling of a payload connected to a cooling crystal.A YLF:Yb crystal was placed inside a Herriott cell and pumped with a 1020-nm laser(47 W)to cool a HgCdTe sensor that is part of a working Fourier Transform Infrared(FTIr)spectrometer to 135 *** first demonstration of an all-solid-state optical cryocooler was enabled by careful control of the various desired and undesired heat *** heating of the payload was minimized by using a single-kink YLF thermal link between the YLF:Yb cooling crystal and the copper coldfinger that held the HgCdTe *** adhesive-free bond between YLF and YLF:Yb showed excellent thermal *** laser-cooled assembly was then supported by silica aerogel cylinders inside a vacuum clamshell to minimize undesired conductive and radiative heat loads from the warm *** structure can serve as a baseline for future optical cryocooler devices.

关键词： optical pumped desired

An open-label multiyear study of sargramostim-treated Parkinson’s disease patients examining drug safety,tolerability,and immune biomarkers from limited case numbers

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Translational Neurodegeneration 2023年第1期12卷 529-545页

作者： Katherine E.Olson Mai M.Abdelmoaty Krista L.Namminga Yaman Lu Helen Obaro Pamela Santamaria r.lee Mosley Howard E.Gendelman Department of Pharmacology and Experimental Neuroscience Center for Neurodegenerative DisordersUniversity of Nebraska Medical CenterOmahaNE 68198USA Great Plains Center for Clinical and Translational research Nebraska MedicineOmahaNEUSA Neurology Consultants of Nebraska PC and Nebraska MedicineOmahaNEUSA

Background The clinical utility and safety of sargramostim has previously been reported in cancer,acute radiation syndrome,autoimmune disease,inflammatory conditions,and Alzheimer’s *** safety,tolerability,and mecha-nisms of action in Parkinson’s disease(PD)during extended use has not been *** As a primary goal,safety and tolerability was assessed in five PD patients treated with sargramostim(Leukine®,granulocyte-macrophage colony-stimulating factor)for 33 *** goals included numbers of CD4+T cells and monocytes and motor ***,metabolic,immune,and neurological evaluations were assessed during a 5-day on,2-day off therapeutic regimen given at 3μg/*** 2 years,drug use was discon-tinued for 3 *** was then followed by an additional 6 months of *** Sargramostim-associated adverse events included injection-site reactions,elevated total white cell counts,and bone *** drug,blood analyses and metabolic panels revealed no untoward side effects linked to long-term *** Parkinson’s Disease rating Scale scores remained stable throughout the study while regulatory T cell number and function were *** the initial 6 months of treatment,transcriptomic and proteomic mono-cyte tests demonstrated autophagy and sirtuin *** finding paralleled anti-inflammatory and antioxidant activities within both the adaptive and innate immune profile *** Taken together,the data affirmed long-term safety as well as immune and anti-inflammatory responses reflecting clinical stability in PD under the sargramostim *** in larger patient populations is planned in a future phase II evaluation.

关键词： Parkinson’s disease Granulocyte-macrophage colony-stimulating factor Unified Parkinson’s Disease rating Scale regulatory T cells Neuroprotection Sargramostim therapy

Investigation of confocal microscopy for differentiation of renal cell carcinoma versus benign *** an optical biopsy be performed?

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Asian Journal of Urology 2020年第4期7卷 363-368页

作者： Michael C.Phung Andrew r.rouse Jayce Pangilinan robert C.Bell Erika r.Bracamonte Sharfuddeen Mashi Arthur F.Gmitro Benjamin r.lee Department of Urology University of Arizona College of MedicineArizonaUSA Department of Medical Imaging University of Arizona College of MedicineArizonaUSA Department of Pathology University of Arizona College of MedicineArizonaUSA ringgold Standard Institution Aminu Kano Teaching HospitalKanoNigeria Biomedical Engineering University of Arizona College of MedicineArizonaUSA

Objective:Novel optical imaging modalities are under development with the goal of obtaining an“optical biopsy”to efficiently provide pathologic *** such modality is confocal microscopy which allows in situ visualization of cells within a layer of tissue and imaging of cellular-level *** goal of this study is to validate the ability of confocal microscopy to quickly and accurately differentiate between normal renal tissue and ***:Specimens were obtained from patients who underwent robotic partial nephrectomy for renal *** of suspected normal and tumor tissue were extracted from the excised portion of the kidney and stained with acridine *** stained samples were imaged on a Nikon E600 C1 Confocal *** samples were then submitted for hematoxylin and eosin processing and read by an expert pathologist to provide a gold-standard diagnosis that can later be compared to the confocal ***:This study included 11 patients,17 tissue samples,and 118 confocal *** the 17 tissue samples,10 had a gold-standard diagnosis of cancer and seven were *** 118 confocal images,66 had a gold-standard diagnosis of cancer and 52 were *** confocal images were used as a training set to train eight *** observers were asked to rate the test images on a six point scale and the results were analyzed using a web based receiver operating characteristic curve *** average accuracy,sensitivity,specificity,and area under the empirical receiver operating characteristic curve for this study were 91%,98%,81%,and 0.94 ***:This preliminary study suggest that confocal microscopy can be used to distinguish cancer from normal tissue with high sensitivity and *** observers in this study were trained quickly and on only six *** expect even higher performance as observers become more familiar with the confocal images.

关键词： renal cell carcinoma Confocal microscopy Optical biopsy

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森林小气候学

森林小气候学