检索结果-南通市图书馆

revisiting cerebral endothelial cells in Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： s.sAUrABH r.KIrAN D.sINGH r.VAIsH V.s.CHAUHAN school of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(Hr), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词： finite element method (FEM) nonlinear Green-Lagrange inverse hyperbolic shear deformation theory (IHsDT) bio-inspired composite plate helicoidal O322

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Estimates of Maize Plant Density from UAV rGB Images Using Faster-rCNN Detection Model:Impact of the spatial resolution

在线全文

学校读者我要写书评

暂无评论

Plant Phenomics 2021年第1期3卷 181-196页

作者： K.Velumani r.lopez-Lozano s.Madec W.Guo J.Gillet A.Comar F.Baret Hiphen sAs 120 Rue Jean DaussetAgroparcBâtiment Technicité84140 AvignonFrance INrAE UMR EMMAHUMT CAPTE228 Route de l'AérodromeDomaine Saint Paul-Site Agroparc CS 4050984914 Avignon Cedex 9France Arvalis 228Route de l'Aérodrome-CS 4050984914 Avignon Cedex 9France International Field Phenomics research Laboratory Institute for Sustainable Agro-Ecosystem ServicesGraduate School of Agricultural and Life SciencesThe University of TokyoTokyoJapan

Early-stage plant density is an essential trait that determines the fate of a genotype under given environmental conditions and management *** use of rGB images taken from UAVs may replace the traditional visual counting in fields with improved throughput,accuracy,and access to plant ***,high-resolution images are required to detect the small plants present at the early *** study explores the impact of image ground sampling distance(GsD)on the performances of maize plant detection at three-to-five leaves stage using Faster-rCNN object detection *** collected at high resolution(GsD≈0:3 cm)over six contrasted sites were used for model *** additional sites with images acquired both at high and low(GsD≈0:6 cm)resolutions were used to evaluate the model *** show that Faster-rCNN achieved very good plant detection and counting(rrMsE=0:08)performances when native high-resolution images are used both for training and ***,good performances were observed(rrMsE=0:11)when the model is trained over synthetic low-resolution images obtained by downsampling the native training high-resolution images and applied to the synthetic low-resolution validation ***,poor performances are obtained when the model is trained on a given spatial resolution and applied to another spatial *** on a mix of high-and low-resolution images allows to get very good performances on the native high-resolution(rrMsE=0:06)and synthetic low-resolution(rrMsE=0:10)***,very low performances are still observed over the native low-resolution images(rrMsE=0:48),mainly due to the poor quality of the native low-resolution ***,an advanced super resolution method based on GAN(generative adversarial network)that introduces additional textural information derived from the native high-resolution images was applied to the native low-resolution validation *** show some signi

关键词： rCNN Faster Image

Coarse to Fine: The role of severe Plastic Deformation in Advancing Titanium-Based Medical Implants - A Comprehensive review

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials science) 2025年第1期40卷 295-306页

作者： Dragana r Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko r Djokić Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear sci-ences-National Institute of the republic of serbia University of Belgrade11001BeogradSerbia Innovation Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(sPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the sPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the sPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the sPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

Free vibration and transient response of double curved beams connected by intermediate straight beams

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： r.A.JAFArI-TALOOKOLAEI H.GHANDVAr E.JUMAEV s.KHATIr T.CUONG-LE school of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and science Center for Engineering Application and Technology solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANsYs, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

关键词：

Mixed Wastes Vitrification by Transferred Plasma

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Plasma science and Technology 2007年第6期9卷 721-724页

作者： J.TAPIA-FABELA M.PACHECO-PACHECO J.PACHECO-sOTELO C.TOrrEs-rEYEs r.VALDIVIA-BArrIENTOs J.BENITEZ-rEAD r.lopez-callej.s F.rAMOs-FLOrEs s.BOsHLE G.ZIssIs Technological National Plasma and Energy Conversion Laboratory 118 Narbonne AveToulousecedex 4431062France

Thermal plasma technology provides a stable and long term treatment of mixed wastes through vitrification processes. In this work, a transferred plasma system was realized to vitrify mixed wastes, taking advantage of its high power density, enthalpy and chemical reactivity as well as its rapid quenching and high operation temperatures. To characterize the plasma discharge, a temperature diagnostic is realized by means of optical emission spectroscopy （OEs）. To typify the morphological structure of the wastes samples~ scan- ning electron microscopy （sEM）, and X-ray diffraction （XrD） techniques were applied before and after the plasma treatment.

关键词： mixed wastes vitrification transferred plasma plasma characterisation

risk of progression of Barrett's esophagus in patients with cirrhosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第18期23卷 3287-3294页

作者： Tehilla Apfel rocio lopez Madhusudhan r sanaka Prashanthi N Thota Department of General Internal Medicine Cleveland Clinic Foundation Department of Biostatistics Cleveland Clinic Foundation Department of Gastroenterology and Hepatology Digestive Disease and Surgery InstituteCleveland Clinic Foundation

To study Barrett’s esophagus (BE) in cirrhosis and assess progression to esophageal adenocarcinoma (EAC) compared to non-cirrhotic BE *** patients who were found to have endoscopic evidence of BE confirmed by the presence of intestinal metaplasia on histology from 1/1/2000 to 12/1/2015 at Cleveland Clinic were included. Cirrhotic patients were matched 1:4 to BE controls without cirrhosis. Age, gender, race, BE length, hiatal hernia size, Child-Pugh (CP) class and histological findings were recorded. Cases and controls without high-grade dysplasia (HGD)/EAC and who had follow-up endoscopies were studied for incidence of dysplasia/EAC and to assess progression rates. Univariable conditional logistic regression was done to assess differences in baseline characteristics between the two *** total of 57 patients with cirrhosis and BE were matched with 228 controls (BE without cirrhosis). The prevalence of dysplasia in cirrhosis and controls were similar with 8.8% vs 12% with low grade dysplasia (LGD) and 12.3 % vs 19.7% with HGD or EAC (P = 0.1). In the incidence cohort of 44 patients with median follow-up time of 2.7 years [interquartile range 1.0, 4.8], there were 7 cases of LGD, 2 cases of HGD, and 2 cases of EAC. There were no differences in incidence rates of HGD/EAC in nondysplastic BE between cirrhotic cases and noncirrhotic controls (1.4 vs 1.1 per 100 person- years, P = 0.8). In LGD, cirrhotic patients were found to have higher rates of progression to HGD/EAC compared to control group though this did not reach statistical significance (13.7 vs 8.1 per 100 person- years, P = 0.51). A significant association was found between a higher CP class and neoplastic progression of BE in cirrhotic patients (Hr =7.9, 95%CI: 2.0-30.9, P = 0.003).CONCLUsIONCirrhotics with worsening liver function are at increased risk of progression of BE. More frequent endoscopic surveillance might be warranted in such patients.

关键词： Liver cirrhosis Barrett’s esophagus Dysplasia Esophageal neoplasm Progression