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Bayesian regularized quantile regression:A robust alternative for genome-based prediction of skewed data

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The Crop Journal 2020年第5期8卷 713-722页

作者： Paulino Pérez-rodríguez Osval A.Montesinos-lópez Abelardo Montesinos-lópez JoséCross Colegio de Postgraduados MontecillosEdo.de México 56230Mexico Facultad de Telemática Universidad de ColimaColima 28040Mexico Departamento de Matemáticas Centro Universitario de Ciencias Exactas e Ingenierías(CUCEI)Universidad de GuadalajaraGuadalajaraJalisco 44430Mexico International Maize and Wheat Improvement Center(CIMMYT) Km 45 Carretera México-VeracruzTexcocoEdo.de México 56237Mexico

Genomic prediction(GP)has become a valuable tool for predicting the performance of selection candidates for the next breeding cycle.A vast majority of statistical linear models on which GP is based rely on the assumption of normality of the residuals and therefore on the response variable *** this study,we propose to use Bayesian regularized quantile regression(BrQr)in the context of GP;the model has been successfully used in other research *** evaluated the prediction ability of the proposed model and compared it with the Bayesian ridge regression(Brr;equivalent to genomic best linear unbiased predictor,GBlUP).In addition,BlUP can be used with pedigree information obtained from the coefficient of coancestry(ABlUP).We have found that the prediction ability of BrQr is comparable to that of Brr and,in some cases,better;it also has the potential to efficiently deal with outliers.A program written in the r statistical package is available as supplementary material.

关键词： laplace distribution robust regression Bayesian quantile regression Genomic-enabled prediction

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural regeneration research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri H.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Non-human primate pluripotent stem cells for the preclinical testing of regenerative therapies

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Neural regeneration research 2022年第9期17卷 1867-1874页

作者： Ignacio rodríguez-Polo rüdiger Behr research Platform Degenerative Diseases German Primate Center-Leibniz Institute for Primate ResearchGöttingenGermany German Center for Cardiovascular research(DZHK) Partner Site GöttingenGöttingenGermany

Non-human primates play a key role in the preclinical validation of pluripotent stem cell-based cell replacement *** stem cells used as advanced therapy medical products boost the possibility to regenerate tissues and organs affected by degenerative ***,the methods to derive human induced pluripotent stem cell and embryonic stem cell lines following clinical standards have quickly developed in the last 15 *** the preclinical validation of cell replacement therapies in non-human primates,it is necessary to generate non-human primate pluripotent stem cell with a homologous quality to their human ***,pluripotent stem cell technologies have developed at a slower pace in non-human primates in comparison with human cell *** recent years,however,relevant progress has also been made with non-human primate pluripotent stem *** review provides a systematic overview of the progress and remaining challenges for the generation of non-human primate induced pluripotent stem cells/embryonic stem cells for the preclinical testing and validation of cell replacement *** focus on the critical domains of(1)reprogramming and embryonic stem cell line derivation,(2)cell line maintenance and characterization and,(3)application of non-human primate pluripotent stem cells in the context of selected preclinical studies to treat cardiovascular and neurodegenerative disorders performed in non-human primates.

关键词： embryonic stem cells induced pluripotent stem cells non-human primates pluripotent stem cells preclinical regeneration reprogramming translational research

Fungal contamination of stored automobile-fuels in a tropical environment

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Journal of Environmental Sciences 2010年第10期22卷 1595-1601页

作者： Carlos E.rodríguez-rodríguez Evelyn rodríguez rigoberto Blanco Ivannia Cordero Daniel Segura research Center in Tropical Diseases and laboratory of research in Anaerobic Bacteriology Faculty of MicrobiologyUniversity of Costa Rica Department of Chemical Engineering School of EngineeringAutonomous University of Barcelona research Center in Electrochemistry and Chemical Energy University of Costa Rica

Because of the lack of reports, the base levels of microbial contamination on stored fuels are unknown in tropical regions and it is unclear whether these levels have some influence on fuel quality parameters. Therefore, fungal quality in automobile fuels stored across Costa rican territory was evaluated during two years according to the standard ASTM D6974-04. For a total of 96 samples, counts and identification of molds and yeasts were performed on regular gas, premium gas and diesel taken from the bottom and superior part of the container tanks. The highest contamination was found on the bottom of the tanks, where an aqueous phase was usually identified, showing populations over the ones present in the hydrocarbon itself （up to 108 CFU/l）. Diesel was the most contaminated fuel （up to 107 CFO/l）; however, an alteration on the physicochemical parameters was not observed in any kind of fuel. Seventy-five mold strains were isolated, Penicillium sp. being the most common genus （45.8% of the samples）, and ten yeast strains, from the genera Candida sp. and rhodotorula sp. Four of the yeasts were able to grow on diesel as the sole carbon source, at concentrations ranging from 0.5% to 25%. Increasing the frequency of tank cleaning, adding antimicrobial agents and monitoring microbial populations are recommended strategies to improve microbial quality of stored fuels.

关键词： fuel microbial contamination biodegradation molds yeasts

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural regeneration research 2025年第9期20卷 2520-2537页

作者： Chonglin su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural regeneration research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-Pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Are assemblages of the fireworm Hermodice carunculata enhanced in sediments beneath offshore fish cages?

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Acta Oceanologica Sinica 2014年第4期33卷 108-111页

作者： rodrigo riera Oscar Pérez Myriam rodríguez Eva ramos óscar Monterroso Centro de Investigaciones Medioambientales del Atlántico (CIMA Sl) Department of Biodiversity Qatar Environment and Energy Research Institute (QEERI)

Abundances of the fireworm Hermodice carunculata were counted through a monitoring assessment study of fish cages in Barranco Hondo（NE Tenerife）. Seven campaigns were conducted from November 2007 to June 2010 and temporal variations were found, as well as differences among sampling stations. The polychaete H. carunculata obtained its highest abundance in sediments beneath fish cages throughout the study period. Thus, the assemblages of this omnivorous species were favoured by the presence of fish cages.

关键词： aquaculture organic enrichment environmental impact Polychaeta Hermodice carunculata Tenerife Canary Islands Atlantic Ocean

A role for lipids as agents to alleviate stroke damage： the neuroprotective effect of 2-hydroxy arachidonic acid

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Neural regeneration research 2017年第8期12卷 1273-1275页

作者： Irene F.Ugidos Diego Pérez-rodríguez Arsenio Fernández-lópez Area de Biologia Celular Instituto de Biomedicina Universidad deLeon Leon Spain

Cerebrovascular accident（CVA）or stroke is one of the world＇s leading causes of death and permanent *** high social and medical costs associated with this pathology mean there is an urgent need to find effective ***... 详细信息

关键词： the neuroprotective effect of 2-hydroxy arachidonic acid FFA OAA A role for lipids as agents to alleviate stroke damage MCAO

META-r:A software to analyze data from multi-environment plant breeding trials

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The Crop Journal 2020年第5期8卷 745-756页

作者： Gregorio Alvarado Francisco M.rodríguez Angela Pacheco Juan Burgueño JoséCrossa Mateo Vargas Paulino Pérez-rodríguez Marco A.lopez-Cruz Biometrics and Statistics Unit International Maize and Wheat Improvement Center(CIMMYT)MexicoDF 6-64106600Mexico Centro de Investigación en Matemáticas(CIMAT)A.C. Jalisco S/NCol.ValencianaGuanajuatoGto 40236023Mexico Universidad Autónoma Chapingo Carretera Federal México-Texcoco km 38.5TexcocoMéxico 6356230Mexico Colegio de Postgraduados Carretera México-Texcoco Km.36.5MontecilloTexcoco 6356231Mexico Department of Plant Soil and Microbial SciencesMichigan State University1066 Bogue StEast LansingMI 48824USA

META-r(multi-environment trial analysis in r)is a suite of r scripts linked by a graphical user interface(GUI)designed in Java *** objective of META-r is to accurately analyze multi-environment plant breeding trials(METs)by fitting mixed and fixed linear models from experimental designs such as the randomized complete block design(rCBD)and the alpha-lattice/lattice ***-r simultaneously estimates the best linear and unbiased estimators(BlUEs)and the best linear and unbiased predictors(BlUPs).Additionally,it computes the variance-covariance parameters,as well as some statistical and genetic parameters such as the least significant difference(lSD)at 5%significance,the coefficient of variation in percentage(CV),the genetic variance,and the broad-sense *** parameters are very important in the selection of top performing genotypes in plant ***-r also computes the phenotypic and genetic correlations among environments and between traits,as well as their statistical *** genetic correlations between environments or traits can be visualized in a biplot graph or a tree diagram(dendrogram).Genetic correlations are very important for identifying environments with similar behavior or making indirect selection and identifying the most highly associated ***-r performs multi-environment analyses by using the residual maximum likelihood(rEMl)method;these analyses can be done by environment,across environments by grouping factors(stress conditions,nitrogen content,etc.)and across environments;the analyses across environments can be done with a pre-defined degree of heritability.

关键词： environments breeding variance