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Protective role of electrophile-reactive glutathione for DNA damage repair inhibitory effect of dibromoacetonitrile

第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议

作者： Peng Li Xiaohong Wang Hongliang Liu Ting Xu Huijuan Wang D.r.Gomez Q.L.Nguyen Li-e Wang Yue-e Teng YiPeng Song r.komaki J.Welsh Qingyi Wei Zhongxing Liao DePartments of 1radiation Oncology and 2EPidemiology the University of Texas M. D.Anderson Cancer Center DePartment of Internal Medicine Affiliated Cancer HosPital of Zhengzhou University Duke Cancer Institute Duke University Medical Center DePartment of Medical Oncology the First HosPital of China Medical University DePartment of radiation Oncology Affiliated Yantai Yuhuangding HosPital of Qingdaom University

＜正＞Background The immune system Plays an imPortant role in regulating tumor develoPment as well as outcomes to cancer *** B-lineage lymPhoma b Protein（Cbl-b）is an E3 ubiquitin ligase that Plays a key role in main...

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Journal of Environmental Sciences 2022年第7期34卷 305-314页

作者： Yukako komaki Koki Suganuma Yuko Ibuki Graduate Division of Nutritional and Environmental Sciences University of ShizuokaShizuoka 422-8526Japan

Dibromoacetonitrile(DBAN) is a disinfection byproduct(DBP) and linked with cancer in rodents, but the mechanism of its carcinogenicity has not been fully elucidated. We recently reported that DBAN induced inhibition of nucleotide excision repair(NEr). In this study, we investigated if glutathione(GSH) is involved in the DBAN-induced inhibition of NEr. Human keratinocytes Ha Ca T were pretreated with L-buthionine-(S,r)-sulfoximine(BSO) to deplete intracellular GSH. BSO treatment markedly potentiated the DBAN-induced NEr inhibition as well as intracellular oxidation. The recruitment of NEr proteins(transcription factor IIH, and xeroderma pigmentosum complementation group G) to DNA damage sites was inhibited by DBAN, which was further exacerbated by BSO treatment. Our results suggest that intracellular GSH protects cells from DBAN-induced genotoxicity including inhibition of DNA damage repair.

关键词： Disinfection byproducts Haloacetonitriles Pyrimidine dimers Glutathione DNA damage repair

Investigation of nuclear enzyme topoisomerase as a putative molecular target of monohaloacetonitrile disinfection by-products

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Journal of Environmental Sciences 2017年第8期29卷 231-238页

作者： Yukako komaki Michael J.Plewa Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL 61801 United States Safe Global Water Institute University of Illinois at Urbana-Champaign Urbana IL 61801 United States Department of Crop Sciences University of Illinois at Urbana-Champaign Urbana IL 61801 United States

Disinfection by-products occur widely as the unintended effect of water disinfection and are associated with toxicity and adverse human health effects. Yet the molecular mechanisms of their toxicity are not well understood. To investigate the molecular basis of hyperploidy induction by monohaloacetonitriles, the interaction of monohaloacetonitriles with topoisomerase Ⅱ in Chinese hamster ovary cells was examined. We showed a concentration-dependent inhibition of DNA decatenation activity of topoisomerase under acellular conditions while in vitro monohaloacetonitrile treatment expressed mixed results. The working hypothesis, that topoisomerase Ⅱ is a molecular target of monohaloacetonitriles, was only partially ***, this research serves as a starting point toward molecular mechanisms of toxic action of monohaloacetonitriles.

关键词： Disinfection by-products Mammalian cell toxicity Topoisomerase Ⅱ Mitosis inhibition Cell cycle disruption

Systemic review and network meta-analysis:Prophylactic antibiotic therapy for spontaneous bacterial peritonitis

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World Journal of Hepatology 2020年第5期12卷 239-252页

作者： Nolan Faust Akihiro Yamada Haider Haider Yuga komaki Fukiko komaki Dejan Micic Atsushi Sakuraba Department of Medicine The University of ChicagoChicagoIL 60637United States Section of Gastroenterology Hepatology and NutritionDepartment of MedicineThe University of Chicago MedicineChicagoIL 60637United States Section of Gastroenterology Department of Internal MedicineToho University Sakura Medical CenterSakura 2850841Japan Digestive and Lifestyle Diseases Kagoshima University Graduate School of Medical and Dental SciencesKagoshima 890-8544Japan

BACKGrOUND Spontaneous bacterial peritonitis(SBP)is an important prognostic factor for outcomes in patients with *** prophylaxis is recommended in patients at high risk for developing SBP,but the choice of antibiotics remains *** To evaluate the efficacy of various antibiotics for prophylaxis of SBP based on randomized control trials(rCTs).METHODS Electronic databases were searched through November 2018 for rCTs evaluating the efficacy of therapies for primary or secondary prophylaxis of *** primary outcome was the development of *** analyses limited to studies of primary or secondary prophylaxis and studies reported after 2010 were *** secondary outcome was the risk of all-cause mortality or *** outcomes were assessed by rank of therapies based on network *** meta-analyses were also *** Thirteen rCTs(1742 patients)including norfloxacin,ciprofloxacin,rifaximin,trimethoprim-sulfamethoxazole(TMP-SMX),or placebo/no comparator were *** meta-analyses showed superiority of rifaximin over norfloxacin as well as norfloxacin and TMP-SMX over *** metaanalysis demonstrated the rank of efficacy in reducing the risk of SBP as:rifaximin,ciprofloxacin,TMP-SMX,norfloxacin,and placebo/no *** ranked highest in sensitivity analyses limited to studies of primary or secondary prophylaxis and studies reported after ***,rifaximin ranked highest in reducing the risk of death/*** The present comprehensive network meta-analysis provides rCT based evidence for superior efficacy of rifaximin compared to other antibiotics for the prophylaxis of SBP and reducing risk of death/*** rCTs are warranted to confirm our findings.

关键词： Spontaneous bacterial peritonitis Prophylaxis Antibiotics Network metaanalysis Systemic review Cirrhosis

Performances and rotating Flows of rotary Jet Pump

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Open Journal of Fluid Dynamics 2012年第4期2卷 375-379页

作者： Keiichi komaki Toshiaki Kanemoto Kenji Sagara Faculty of Engineering Kyushu Institute of Technology Kitakyushu City Japan Graduate School of Engineering Kyushu Institute of Technology Kitakyushu City Japan

The rotary jet pumps, namely the pitot pumps, are composed of the rotating casing with the impeller channels and the stationary pick-up tube for discharging, are known as the one of high pressure pumps in the U.S. market. The pumps, however, have been prepared experientially, because of poor knowledge for the flow conditions and the pump performances. Then, this paper discusses the pump performances and the internal flow conditions in the rotating casing. Three types of the pick-up tube were prepared for the experiments to know the pump performances and the flow conditions in the rotating casing. The flow in the rotating casing is nearly in the forced vortex type and gives the higher pressure at the pick-up tube inlet. The more cross-sectional area of the pick-up tube channel is large, the more head and discharge are higher with excellent efficiency. Moreover, the authors confirmed that the secondary flow runs toward the rotating center at the wake flow region behind the pick-up tube.

关键词： rotation Casing Type Pump Pitot Pump High Pressure Pump Pick-Up Tube Forced Vortex Secondary Flow

Efficacy of various endoscopic modalities in detecting dysplasia in ulcerative colitis:A systematic review and network meta-analysis

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World Journal of Gastrointestinal Endoscopy 2020年第5期12卷 159-171页

作者： Bilal Gondal Haider Haider Yuga komaki Fukiko komaki Dejan Micic David T rubin Atsushi Sakuraba Section of Gastroenterology Hepatology and NutritionDepartment of MedicineThe University of Chicago MedicineChicagoIL 60637United States Section of Gastroenterology Carle HospitalUniversity of IllinoisUrbanaIL 61801United States Digestive and Lifestyle Diseases Kagoshima University Graduate School of Medical and Dental SciencesKagoshima 890-8544Japan

BACKGrOUND Longstanding ulcerative colitis(UC)is associated with an increased risk of colonic *** endoscopic modalities,such as chromoendoscopy(CE),narrow band imaging(NBI)and random biopsy have been introduced for surveillance,however,there exists a paucity of direct comparisons between *** aimed to conduct a network meta-analysis of randomized controlled trials(rCTs)performed for surveillance of neoplasia in *** To provide a comparative evaluation of the efficacy of the above-mentioned various *** We searched MEDLINE/PubMed,Web of Science,Embase,Google Scholar and Cochrane Central registry through May 2016 for rCTs evaluating the efficacy of endoscopic modalities for surveillance of neoplasia in *** primary outcomes of interest were dysplasia(low-or high-grade)detection rates per biopsy and per patient,and dysplasia numbers per *** were simultaneously analyzed using a random-effects network meta-analysis under the Bayesian framework to identify the modality with the highest dysplasia detection *** best ranking probability for the dysplasia detection rate was analyzed by surface under the cumulative ranking(SUCrA)*** Six prospective rCTs of a total 1038 patients were *** identified 4 different modalities;white light(WL)high definition(HD)or standard definition(SD),CE HD,and NBI *** dysplasia per biopsy,direct meta-analysis showed superiority of NBI HD over WL HD and CE HD over WL *** meta-analysis demonstrated the rank order of best modality as NBI HD,CE HD,WL HD and WL SD with close SUCrA scores of the first *** dysplasia per patient,direct meta-analyses showed equivocal results between each *** meta-analysis demonstrated the rank order of best modality as WL HD,NBI HD,CE HD and WL SD with small differences of the SUCrA score among the first *** dysplasia numbers per patient,direct meta-analysis showed superiority of CE HD over WL *** meta-analysis

关键词： Ulcerative colitis Surveillance Dysplasia Network meta-analysis Endoscopy

Acute Kidney Injury with Epstein Barr Virus-Associated Hemophagocytic Syndrome

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Case reports in Clinical Medicine 2016年第7期5卷 233-237页

作者： ryo Ishida Kazumi komaki Tetsuro Kusaba Tsuneyuki Nakanouchi Japanese red Cross Kyoto Daiichi Hospital Kyoto Japan Division of Nephrology Department of Medicine Kyoto Prefecture University of Medicine Kyoto Japan

A 59-year-old man, who was treated for schizophrenia and psoriasis vulgaris with risperidone and cyclosporine, presented with high fever and myalgia. Those did not respond to treatment for neuroleptic malignant syndrome for two weeks, and multiple organ dysfunction developed, so he was admitted to our hospital, but died two days later. Autopsy detected the hemophagocytosis, Epstein Barr Virus (EBV)-reactivated cells, and the absence of glomerulonephritis and interstitial tubulitis. We considered that hemophagocytic syndrome (HPS) and myalgia were caused by reactivated EBV and the viremia under immunosuppression, and renal failure was caused by sepsis-like state by cytokine storm of HPS.

关键词： Hemophagocytic Syndrome Epstein Barr Virus Acute Kidney Injury

Exome-wide variation in a diverse barley panel reveals genetic associations with ten agronomic traits in Eastern landraces

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Journal of Genetics and Genomics 2023年第4期50卷 241-252页

作者： June-Sik Kim Kotaro Takahagi komaki Inoue Minami Shimizu Yukiko Uehara-Yamaguchi Asaka Kanatani Daisuke Saisho ryuei Nishii Alexander ELipka Takashi Hirayama Kazuhiro Sato Keiichi Mochida Bioproductivity Informatics research Team RIKEN Center for Sustainable Resource ScienceYokohama 230-0045Japan Institute of Plant Science and resources Okayama UniversityKurashiki 710-0046Japan Kihara Institute for Biological research Yokohama City UniversityYokohama 244-0813Japan Graduate School of Nanobioscience Yokohama City UniversityYokohama 236-0027Japan School of Information and Data Sciences Nagasaki UniversityNagasaki 852-8521Japan Department of Crop Sciences University of IllinoisUrbanaIL 61801USA Microalgae Production Control Technology Laboratory RIKEN Baton Zone ProgramRIKEN Cluster for ScienceTechnology and Innovation HubYokohama 230-0045Japan

Barley(Hordeum vulgare ***)is one of the first crops to be domesticated and is adapted to a wide range of *** barley germplasm collections possess valuable allelic variations that could further improve barley *** barley genomics has offered a global picture of allelic variation among varieties and its association with various agronomic traits,polymorphisms from East Asian varieties remain *** this study,we analyze exome polymorphisms in a panel of 274 barley varieties collected worldwide,including 137 varieties from East Asian countries and *** reveal the underlying population structure and conduct genome-wide association studies for 10 agronomic ***,we examin genome-wide associations for traits related to grain size such as awn length and glume *** results demonstrate the value of diverse barley germplasm panels containing Eastern varieties,highlighting their distinct genomic signatures relative to Western subpopulations.

关键词： Barley Exome-seq Genome-wide association study(GWAS) Population structure Allelic variation

Intensity-modulated radiation therapy with concurrent chemotherapy for locally advanced cervical and upper thoracic esophageal cancer

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World Journal of Gastroenterology 2006年第34期12卷 5501-5508页

作者： Shu-Lian Wang Zhongxing Liao Helen Liu( Jaffer Ajani Stephen Swisher James D Cox ritsuko komaki Department of radiation Oncology Cancer Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China Department of radiation Oncology the University of Texas M D Anderson Cancer Center United States Department of Gastrointestinal Medical Oncology the University of Texas M D Anderson Cancer CenterUnited States Department of Cardiovascular and Thoracic Surgical Oncology the University of Texas M D Anderson Cancer Center United States

AIM： To evaluate the dosimetry, efficacy and toxicity of intensity-modulated radiation therapy （IMrT） and concurrent chemotherapy for patients with locally advanced cervical and upper thoracic esophageal cancer. METHODS： A retrospective study was performed on 7 patients who were definitively treated with IMrT and concurrent chemotherapy. Patients who did not receive IMrT radiation and concurrent chemotherapy were not included in this analysis. IMrT plans were evaluated to assess the tumor coverage and normal tissue avoidance. Treatment response was evaluated and toxicities were assessed. rESULTS： Five- to nine-beam IMrT were used to deliver a total dose of 59.4-66 Gy （median： 64.8 Gy） to the primary tumor with 6-MV photons. The minimum dose received by the planning tumor volume （PTV） of the gross tumor volume boost was 91.2%-98.2% of the prescription dose （standard deviation [SD]： 3.7%-5.7%）. The minimum dose received by the PTV Of the clinical tumor volume was 93.8%-104.8% （SD： 4.3%-11.1%） of the prescribed dose. With a median follow-up of 15 rno （range： 3-21 too）, all 6 evaluable patients achieved complete response. Of them, 2 developed local recurrences and 2 had distant metastases, 3 survived with no evidence of disease. After treatment, 2 patients developed esophageal stricture requiring frequent dilation and 1 patient developed tracheal-esophageal fistula. CONCLUSION： Concurrent IMrT and chemotherapy resulted in an excellent early response in patients with locally advanced cervical and upper thoracic esophageal cancer. However, local and distant recurrence and toxicity remain to be a problem. Innovative approaches are needed to improve the outcome.

关键词： Esophageal cancer Intensity-modulated radiation therapy Chemotherapy

Small invasive ductal carcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm

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World Journal of Gastroenterology 2009年第43期15卷 5489-5492页

作者： Hiroki Sakamoto Masayuki Kitano Takamitsu komaki Hajime Imai Ken Kamata Masatomo Kimura Yoshifumi Takeyama Masatoshi Kudo Division of Gastroenterology and Hepatology Department of Internal MedicineKinki University School of Medicine377-2Ohno-HigashiOsaka-Sayama 589-8511Japan Department of Pathology Kinki University School of Medicine377-2Ohno-HigashiOsaka-Sayama 589- 8511Japan Department of Surgery Kinki University School of Medicine377-2Ohno-HigashiOsaka-Sayama 589-8511Japan

Endoscopic ultrasonography （EUS） is a highly sensitive diagnostic method for the detection of small pancreatic carcinomas. recently, there have been some reports describing the utility of contrast-enhanced harmonic EUS （CEH-EUS） which uses sonographic contrast agent for differentiation of a pancreatic mass. This report describes a case of small adenocarcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm （IPMN） in which investigation by EUS took place every 6 mo and diagnosis was made accurately by additional CEH-EUS during the follow-up of the branch duct IPMN. A 68-year-old female was admitted to our hospital because of a branch duct IPMN in the pancreatic body. She had been followed-up by EUS every 6 too. However, after 2 years EUS demonstrated a low echoic area distinct from the branch duct IPMN which was vaguely discernible by EUS, and accurate sizing and differential diagnosis were considered difficult on the EUS imaging. CHEUS with Sonazoid revealed a hypovascular tumor and we suspected small pancreatic carcinoma. The histopathological diagnosis was adenocarcinoma （10 mm） in the pancreatic tail, distinct from the branch duct IPMN of the pancreatic body. EUS and CEH-EUS may play an important role in the correct diagnosis of small pancreatic tumors, including synchronous and metachronous occurrence of IPMN and ductal adenocarcinoma of the pancreas.

关键词： Intraductal papillary mucinous adenoma Small pancreatic cancer Endoscopic ultrasonography Contrast-enhanced harmonic endoscopic ultrasonography Pancreatic cancer Pancreas Contrast enhanced endoscopic ultrasonography