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Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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Neural regeneration research 2025年第8期20卷 2218-2230页

作者： rahul Mittal Keelin McKenna Grant Keith Evan McKenna Joana r.N.Lemos Jeenu Mittal Khemraj Hirani Diabetes research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

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Optimised hybrid classification approach for rice leaf disease prediction with proposed texture features

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Journal of Control and Decision 2024年第1期11卷 84-97页

作者： Sakhamuri Sridevi K.kiran Kumar Department of Computer Science and Engineering Koneru Lakshmaiah Education FoundationVaddeswaramIndia

This paper aims to frame a new rice disease prediction model that included three major ***,median filtering(MF)is deployed during pre-processing and then‘proposed Fuzzy Means Clustering(FCM)based segmentation’is *** that,‘Discrete Wavelet Transform(DWT),Scale-Invariant Feature Transform(SIFT)and low-level features(colour and shape),Proposed local Binary Pattern(LBP)based features’are extracted that are classified via‘MultiLayer Perceptron(MLP)and Long Short Term Memory(LSTM)’and predicted outcomes are *** exact prediction,this work intends to optimise the weights of LSTM using Inertia Weighted Salp Swarm Optimisation(IW-SSO)***,the development of IW-SSO method is established on varied metrics.

关键词： rice disease improved fuzzy hybrid classifiers optimised LSTM IW-SSO algorithm

Immuolocalization of nestin in pancreatic tissue of mice at different ages

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World Journal of Gastroenterology 2008年第46期14卷 7112-7116页

作者： raj K Dorisetty Sashi G kiran Malathi r Umrani Sesikeran Boindala ramesh r Bhonde Vijayalakshmi Venkatesan Department of Biochemistry National Institute of Nutrition Tissue Engineering and Banking Laboratory National Center for Cell SciencePune University Campus

AIM： To localize nestin positive cells （NPC） in pancreatic tissue of mice of different ages. METHODS： Paraffin sections of 6-8 um of fixed pancreatic samples were mounted on poly-L-lysine coated slides and used for Immunolocalization using appropriate primary antibodies （Nestin, Insulin, Glucagon）, followed by addition of a fluorescently labeled secondary antibody. The antigen-antibody localization was captured using a confocal microscope （Leica SP 5 series）. rESULTS： In 3-6 d pups, the NPC were localized towards the periphery of the endocrine portion, as evident from immunolocalization of insulin and glucagon, while NPC were absent in the acinar portion. At 2 wk, NPC were localized in both the exocrine and endocrine portions. Interestingly, in 4-wk-old mice NPC were seen only in the endocrine portion, towards the periphery, and were colocalised with the glucagon positive cells. In the pancreas of 8- wk-old mice, the NPC were predominantly localized in the central region of the islet clusters, where immunostaining for insulin was at a maximum. CONCLUSION： We report for the first time the immunolocalization of NPC in the pancreas of mice of different ages （3 d to 8 wk） with reference to insulin and glucagon positive cells. The heterogeneous localization of the NPC observed may be of functional and developmental significance and suggest（s） that mice pancreatic tissue can be a potential source of progenitor cells. NPC from the pancreas can be isolated, proliferated and programmed to differentiate into insulin secreting cells under the appropriate microenvironment.

关键词： Nestin Insulin Glucagon Immunolocalization Mice

Non-invasive optical characterization and estimation of Zn porosity in gas tungsten arc welding of Fe–Al joints using Cr model and OES measurements

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Plasma Science and Technology 2023年第11期25卷 133-141页

作者： Sai SrIKAr Tinku KUMAr Degala Venkata kiran reetesh Kumar GANGWAr Department of Physics&CAMOST Indian Institute of Technology TirupatiYerpedu 517619India Department of Mechanical Engineering Indian Institute of Technology TirupatiYerpedu 517619India

In this study,we employed a non-invasive approach based on the collisional radiative(Cr)model and optical emission spectroscopy(OES)measurements for the characterization of gas tungsten arc welding(GTAW)discharge and quantification of Zn-induced porosity during the GTAW process of Fe–Al *** OES measurements were recorded as a function of weld current,welding speed,and input *** OES measurements revealed significant line emissions from Zn-I in 460–640 nm and Ar-I in 680–800 nm wavelength ranges in all experimental *** OES coupled Cr model approach for Zn-I line emission enabled the simultaneous determination of both essential discharge parameters *** temperature and electron ***,these predictions were used to estimate the Zn-induced porosity using OES-actinometry on Zn-I emission lines using Ar as actinometer *** OES-actinometry results were in good agreement with porosity data derived from an independent approach,i.e.x-ray radiography *** current study shows that OES-based techniques can provide an efficient route for real-time monitoring of weld quality and estimate porosity during the GTAW process of dissimilar metal joints.

关键词： optical emission spectroscopy collisional radiative model actinometry GTAW Fe Al joints Zn vapor porosity radiographic imaging(Some figures may appear in colour only in the online journal)

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Formulation and evaluation of co-prodrug of flurbiprofen and methocarbamol

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Asian Journal of Pharmaceutical Sciences 2016年第3期11卷 449-458页

作者： Neela Bhatia kiran Katkar Snehal Ashtekar Department of Quality Assurance Bharati Vidyapeeth College of Pharmacy Near Chitranagari Shivaji University

The current work envisages synthesis of an ester prodrug of flurbiprofen whereby its carboxylic group was condensed with a skeletal muscle relaxant methocarbamol, with the aim of synergistic activity of two drugs, avoid flurbiprofen mediated gastro-intestinal damage and minimize the ulceration tendency of flurbiprofen. The synthesized prodrug was characterized and confirmed by physicochemical and spectroscopic studies. Solubility and partition coefficient studies indicated an increased lipophilicity and thus better suitability for oral administration than the parent drugs and the protein binding studies revealed a low protein binding capacity of the mutual prodrug. Subsequently, in-vitro hydrolysis was studied in different pH, simulated gastric fluid, simulated intestinal fluid and plasma and quantitative evaluation was performed by high performance liquid chromatography. It was found that the prodrug remained unhydrolyzed in the stomach after absorption however, underwent rapid cleavage by the esterases in blood to give the parent drug. Furthermore, the mutual ester prodrug was evaluated for its anti-inflammatory, analgesic, skeletal muscle relaxation, ulcerogenic and total acid content activity and was found to possess comparable activity with that of the parent drugs. Microscopic structures of the stomach tissues revealed significant reduction in gastric ulcer formation of mice gastric mucosa as compared to parent carboxylic acid drug.

关键词： NSAIDs Flurbiprofen Skeletal muscle relaxant Methocarbamol, Ester prodrug rP-HPLC Ulcerogenicity

Tumor microenvironment pathways:Cross regulation in breast cancer metastasis

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Genes & Diseases 2022年第2期9卷 310-324页

作者： rama rao Malla P.kiran Cancer Biology Lab Department of Biochemistry and BioinformaticsInstitute of ScienceGITAM(Deemed to be University)Visakhapatnam 530045India

The tumor microenvironment(TME)is heterogeneous and contains a multiple cell population with surrounded immune cells,which plays a major role in regulating *** multifunctional pathways,Hedgehog(Hh),Wnt,Notch,and NF-kB,cross-regulates metas-tasis in breast *** review presents substantial evidence for cross-regulation of TME components and signaling pathways,which makes breast TME more heterogeneous and com-plex,promoting breast cancer progression and metastasis as a highly aggressive *** discoursed the importance of stromal and immune cells as well as their crosstalk in bridging the *** also discussed the role of Hh and Notch pathways in the intervention be-tween breast cancer cells and macrophages to support TME;Notch signaling in the bidirec-tional communication between cancer cells and components of TME;Wnt signal pathway in controlling the factors responsible for EMT and NF-kB pathway in the regulation of genes con-trolling the inflammatory *** also present the role of exosomes and their mirNAs in the cross-regulation of TME cells as well as pathways in the reprogramming of breast TME to support ***,we examined and discussed the targeted small molecule inhibitors and natural compounds targeting developmental pathways and proposed small molecule nat-ural compounds as potential therapeutics of TME based on the multitargeting *** conclu-sion,the understanding of the molecular basis of the cross-regulation of TME pathways and their inhibitors helps identify molecular targets for rational drug discovery to treat breast can-cers.

关键词： Breast cancer Cross-regulation Hedgehog NF-kB Notch Tumor microenvironment Wnt

Darks and Stripes:Effects of Clothing on Weight Perception

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Journal of Social Computing 2020年第1期1卷 53-70页

作者： Kirill Martynov kiran Garimella robert West D-80636 Munich Germany work done at Ecole Polytechnique Federale de Lausanne(EPFL)and Technische Universit at Munchen(TUM) Institute of Technology(MIT) CambridgeMA 02139USA EPFL CH-1004 LausanneSwitzerland

In many societies,appearing slim(corresponding to a small body-mass index)is considered *** fashion industry has been attempting to cater to this trend by designing outfits that can enhance the appearance of *** anecdotal rules,widespread in the world of fashion,are to choose dark clothes and avoid horizontal stripes,in order to appear *** far,empirical evidence has been unable to conclusively determine the validity of these rules,and there is consequently much controversy regarding the impact of both color and patterns on the visual perception of *** this paper,we aim to close this gap by presenting the results from a series of large-scale crowdsourcing studies that investigate the above two *** gathered a dataset of around 1000 images of people from the Web together with their ground-truth weight and height as well as clothing attributes about colors and *** elicit the effects of colors and patterns,we asked crowd workers to estimate the weight in each *** the analysis,we controlled potential confounds by matching images in pairs where the two images differ with respect to color or pattern,but are similar with respect to other relevant *** created image pairs in two ways:firstly,observationally,i.e.,from two real images;and secondly,experimentally,by manipulating the color or pattern of clothing in a real image via photo *** on our analysis,we conclude that dark clothes indeed decrease perceived weight slightly but statistically significantly,and horizontal stripes have no discernible effect compared to solid light-colored *** results contribute to advancing the debate around the effect of specific clothing colors and patterns and thus provide empirical grounds for everyday fashion ***,our work gives an outlook on the vast opportunities of using crowd sourcing in the modern fashion industry.

关键词： clothing fashion weight perception body size crowdsourcing

The simplest route to generating a train of attosecond pulses

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Light(Science & Applications) 2013年第1期2卷 204-208页

作者： Kazumichi Yoshii John kiran Anthony Masayuki Katsuragawa Department of Engineering Science University of Electro-CommunicationsTokyoJapan

We report on two novel routes to generating a train of attosecond pulses from a broad discrete spectrum in the near-infrared–visible–ultraviolet *** extends an integer-temporal-Talbot(ITT)concept to include high-order spectral dispersions and generates a pulse train that completely satisfies the transform-limited *** other numerically explores the optimum conditions under which we can obtain an attosecond pulse train that approximately satisfies the transform-limited *** second method is more practical than the *** of these methods is extremely simple and robust;we need only to place a few thin dispersive materials in the optical path and to adjust their thicknesses without spatially dispersing the frequency *** numerically demonstrate the generation of a train of attosecond pulses with a transform-limited pulse duration of 728 as and a repetition period of 8.03 fs in gaseous parahydrogen.

关键词： adiabatic excitation of raman transition attosecond pulse generation integer-temporal-Talbot(ITT)method molecular modulation

Impacts of Coriaria nepalensis colonization on vegetation structure and regeneration dynamics in a mixed conifer forest of Indian Central Himalaya

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Journal of Forestry research 2019年第1期30卷 305-317页

作者： Nidhi rani Mourya kiran Bargali Surendra Singh Bargali Department of Botany DSB Campus Kumaun University

This study evaluated impacts of Coriaria nepalensis *** on soil characteristics,vegetation structure and composition,regeneration status and expected future compositional changes,biomass and carbon stock in tree species of a mixed conifer forest of Central *** sites(1 ha each in an old landslide area)differing in Coriaria density(low:20 individuals ha^(-1);medium:120 ***^(-1);high:190 ***^(-1))were used to enumerate the tree species.A total of 9 tree species and 2830 individuals were recorded from the three study sites that represented a gradient of Coriaria *** of species varied from 3 to 7 and the individuals from 690 to 1270 per site with lowest numbers at low Coriaria density and highest at medium Coriaria *** number of seedlings increased with increasing Coriaria density,and the sites were unique in their seedling composition,indicating marked temporal *** wise regeneration analysis showed that regeneration was poor at the site with low Coriaria density and good at the high-density site where many species emerged as *** results indicate that the ameliorative effects of Coriaria in terms of soil buildup,and accumulation of nutrients and organic matter helped more species to colonize the *** facilitative ability of Coriaria can be used to restore degraded forest ecosystems of Indian Central Himalaya.

关键词： Basal area Conifer Coriaria Density Facilitation Species richness

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