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外科医生和病理医生对胸腺恶性肿瘤切除标本的处理方法和程序

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中国肺癌杂志 2014年第2期17卷 95-103页

作者：付浩中国胸腺瘤协作组全体成员 Frank C.Detterbeck Cesar Moran James Huang Saul Suster Garrett Walsh Lawrence kaiser Mark Wick 北京大学肿瘤医院 Division of Thoracic Surgery Deportment of SurgeryYale University School of Medicine Department of Surgery Thoracic ServiceUniversity of TexasMD Anderson Cancer Center Department of Pathology Memorial Sloan-Kettering Cancer Center Department of Pathology Medical College of Wisconsin Department of Thoracic and Cardio-vascular Surgery University of Texas MD Anderson Cancer Center UT Health Science Center Department of Pathology University of Virginia Health System

胸腺恶性肿瘤发病率低，临床病例分散，需要结合多中心经验才能进行良好的研究，但由于在诸多方面没有统一标准，使得研究与研究之间的可比性差。其中外科医生和病理医生对胸腺恶性肿瘤切除标本的处理是统一标准中至关重要的部分。针对... 详细信息

胸腺恶性肿瘤发病率低，临床病例分散，需要结合多中心经验才能进行良好的研究，但由于在诸多方面没有统一标准，使得研究与研究之间的可比性差。其中外科医生和病理医生对胸腺恶性肿瘤切除标本的处理是统一标准中至关重要的部分。针对目前胸腺瘤的常用手术方式胸骨劈开根治性r0切除术的标本处理作如下规定，包括切除胸腺瘤及周围的受累结构说明如何处理手术切除标本。活检或细胞学标本的处理另文描述[1]。本文首先由国际胸腺肿瘤协作组织（International hTymic Malignacy Interest Group, ITMIG）中病理医生和外科医生组成的小组回顾相关文献形成初步建议[2,3]，交扩展组审议提炼后分发给ITMIG成员进讨论，再将ITMIG成员回馈的建议和几个大中心试点的情况进行提炼，最终形成的建议经ITMIG批准并被采用。因此，既强调证据又代表ITMIG成员的广泛共识。

关键词：手术切除标本恶性肿瘤病理医生外科医生胸腺瘤程序统一标准细胞学标本

促性腺激素释放激素受体基因(GNrHr)新错义变异的功能研究

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促性腺激素释放激素受体基因(GNRHR)新错义变异的功能研究

中华医学会第十三次全国内分泌学学术会议

作者：聂敏闵乐茅江峰张宏冰伍学焱 Ursula kaiser 中国医学科学院北京协和医学院北京协和医院内分泌科 Division of Endocrinology Diabetesand HypertensionBrigham and Women's Hospital and Harvard Medical School 中国医学科学院北京协和医学院基础医学研究所

目的促性腺激素释放激素受体基因(GNrHr)突变是导致嗅觉正常的特发性低促性腺激素性性功能减退症(IHH)的主要病因之一。本课题组前期通过基因芯片靶基因捕获联合二代测序的方法,在IHH患者中发现了14个GNrHr基因变异,其中缺失移码、剪切...

目的促性腺激素释放激素受体基因(GNrHr)突变是导致嗅觉正常的特发性低促性腺激素性性功能减退症(IHH)的主要病因之一。本课题组前期通过基因芯片靶基因捕获联合二代测序的方法,在IHH患者中发现了14个GNrHr基因变异,其中缺失移码、剪切位点、和无义突变各1个,错义变异11个。本研究拟对10个未报到的新错义变异进行体外功能研究,以明确其致病性及其作用机制。方法 PCr产物直接Sanger法测序,验证GNrHr基因变异是否真实存在;查询SNP数据库排除多态性位点;对确定为新错义变异的位点进行体外功能研究:①测定不同

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并发脉络膜上腔出血:一个病例对照研究

世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 21-22页

作者： Moshfeghi D.M. Kim B.Y. kaiser P.K. 司冰心

To identify the risk factors, prognostic factors, and clinical outcomes of pat ients with perioperative appositional suprachoroidal hemorrhage (ASCH). Case-co ntrol study. Tertiary referral center. Subjects included all patients with perio perative ASCH documented by B-scan ultrasound between May 1990 and March 2001. Two or three control patients were selected for each case, matched by surgeon, p rocedure, and date of surgery within 1 month. Surgery was performed as necessary . main outcome measures. The odds of ASCH associated with clinical risk factors. secondary outcome measure: visual acuity. Thirty-seven cases with ASCH were identified. Ninety-two proce dure-and surgeon-matched control subjects (2.48:1) were selected. Twenty-six cases (71%) of ASCH were related to a glaucoma operation. risk factors for the development of ASCH included previous vitrectomy (P=.003, odds ratio of 12) and older age (P=.007, odds ratio 1.57/decade of increasing age). Hypertension was f ound to be protective (P=.02, odds ratio of 0.33). Factors associated with a poo r visual outcome in patients with ASCH included apposition >30 days (P=.01), his tory of uveitis (P=.04), history of dry age-related macular degeneration (P=.05 ), and history of extracapsular cataract extraction (P=.05). Median pre-ASCH vi sual acuity was 20/100, and final median visual acuity was 20/1600. risk factors for the development of ASCH include previous vitrectomy and older age. Patients with these risk factors should be informed of their greater chance of poor visu al acuity and anatomic outcomes secondary to the development of ASCH.

关键词：脉络膜上腔病例对照研究玻璃体切割术手术日期青光眼手术围手术期临床危险因素葡萄膜炎诊疗中心临床疗效

从文化的视角来评判耶弗他的许愿（士10:6-12:7）

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金陵神学志 2014年第2期 13-21页

作者：凯习德杜娜娜金陵神学院福建省连江县基督教两会

挑战在《士师记》中,士师耶弗他战时的许愿和他献女儿为祭的故事,交织出现于他的生平故事中,整个叙事单元始于10章6节,终于12章7节,可谓是《旧约》中最扰人的一段经文。耶弗他为何要许下如此不合乎常理的心愿(unconventional vow)?为何... 详细信息

挑战在《士师记》中,士师耶弗他战时的许愿和他献女儿为祭的故事,交织出现于他的生平故事中,整个叙事单元始于10章6节,终于12章7节,可谓是《旧约》中最扰人的一段经文。耶弗他为何要许下如此不合乎常理的心愿(unconventional vow)?为何坚持献独生女为祭?对于这样一件可憎之事,为何耶弗他与叙事者都保持沉默,未加以评论?更为奇怪的是,《新约》竟然将耶弗他列入信心伟人之列(参

关键词：耶弗他叙事者耶和华亚扪人以色列人

Prevalence of Depression in Pre-Dialytic Chronic Kidney Disease Patients Attending at a Tertiary Care Hospital in Bangladesh

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Journal of Biosciences and Medicines 2020年第12期8卷 135-148页

作者： A. K. M. Shahidur rahman Mohammad Shamsul Ahsan Mohammad Kamrul Ahsan A. B. M. Mobasher Alam Tanvir rahman Shahida Mullah Md. Mustafizur rahman Salahuddin Feroz Amir Mohammad kaiser Md. Shariful Haque Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Holy Family red Crescent Medical College Hospital (HFrCMCH) Dhaka Bangladesh Department of Nephrology Rangpur Medical College Hospital (RMCH) Rangpur Bangladesh Department of Nephrology United Hospital Limited Dhaka Bangladesh Department of Medicine Sarkari Karmachari Hospital Dhaka Bangladesh Department of Nephrology Sheikh Hasina Medical College Tangail Bangladesh Sheikh Hasina National Institute of Burn and Plastic Surgery Dhaka Bangladesh Department of Nephrology & Dialysis Gonoshaystha Somazvittik Medical College and Gonoshaystha Nagar Hospital Dhaka Bangladesh Department of Nephrology Shaheed M. Monsur Ali Medical College Sirajgonj Bangladesh

Background: Depression is a common and serious medical illness around the world. It occurs more frequently in patients with chronic illness than in the general population. It is a common psychiatric problem in patient... 详细信息

rong>Background:rong> Depression is a common and serious medical illness around the world. It occurs more frequently in patients with chronic illness than in the general population. It is a common psychiatric problem in patients with chronic kidney disease (CKD). rong>Objective: rong>To assess the level of depression in pre-dialytic CKD patients attending at a tertiary care hospital in Bangladesh. rong>Methodology:rong> This cross sectional study was conducted at Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from January 2020 to June 2020. A total of 100 pre-dialytic CKD patients were selected by convenience sampling technique and their level of depression was assessed by Zung Self-rating Depression Scale (ZSDS). Data were collected by existing questionnaire with face to face interview and analyzed by statistical test. rong>results:rong> The mean age of the participants was 49.70 ± 11.80 years. Among them 64% were male, 95% were muslim, 98% were married, 65% were completed secondary/above higher secondary level education, 65% were unemployed and 55% were lived in urban area. It was observed that 65% participants were economically dependent to their family, only 6% were engaged in regular exercise, 14% had family history of depression, 8% were smoker and 12% were alcohol/drug abuser. According to the Zung Self-rating Depression Scale (ZSDS) we found 29% participants were mildly depressed, 39% participants were moderately depressed and 18% participants were severely depressed. Prevalence of depression was 86% in pre-dialytic CKD patients. Of them, 7% was in CKD stage-I, 17.4% was in CKD stage-II, 19.8% was in CKD stage-III, 22.1% was in CKD stage-IV and 33.7% was in CKD stage-V. rong>Conclusion:rong> Depression is highly prevalent in pre-dialytic CKD patients and more frequent in the advanced stages of CKD.

关键词： Chronic Kidney Disease (CKD) Depression Zung Self-rating Depression Scale (ZSDS)

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炭黑填充氢化丁腈橡胶低温性能的研究

特种橡胶制品 2023年第2期44卷 1-5页

作者： Martin Hoch 毛杰蒋鲸喆 Victor Nasreddine Marjan Hemstede-van Urk Christoph Gogelein Andreas kaiser 阿朗新科高性能弹性体(常州)有限公司阿朗新科美国有限公司阿朗新科荷兰有限公司阿朗新科德国有限公司

采用玻璃化转变温度(Tg)、低温回缩(Tr)、吉门扭转温度和低温压缩永久变形等研究了过氧化物用量和填料类型及其用量对HNBr LT 2004,HNBr 3407及两者并用胶低温性能的影响。结果表明,HNBr LT 2004(低温牌号)低温压缩永久变形、Tr70和吉... 详细信息

采用玻璃化转变温度(Tg)、低温回缩(Tr)、吉门扭转温度和低温压缩永久变形等研究了过氧化物用量和填料类型及其用量对HNBr LT 2004,HNBr 3407及两者并用胶低温性能的影响。结果表明,HNBr LT 2004(低温牌号)低温压缩永久变形、Tr70和吉门扭转温度(Gehman)容易受到填料用量及表面活性的影响,加入较低活性炭黑的胶料具有较好低温柔顺性。随着交联密度(过氧化物用量)的增大,低温压缩永久变形显著改善。HNBr 3407的低温回缩、吉门扭转温度和低温压缩永久变形均高于HNBr LT 2004(低温牌号),但HNBr 3407在低于其玻璃化转变温度下仍具有一定柔顺性。通过HNBr低温牌号与耐油牌号并用,可保持良好低温性能,同时还可调节耐液体性能。

关键词：氢化丁腈橡胶低温性能丙烯腈含量过氧化物低温压缩永久变形

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非填充氢化丁腈橡胶低温性能相关性的研究

特种橡胶制品 2023年第1期44卷 1-6页

作者： Martin Hoch 毛杰蒋鲸喆 Victor Nasreddine Marjan Hemstede-van Urk Christoph Gögelein Andreas kaiser 阿朗新科高性能弹性体(常州)有限公司江苏常州213127 阿朗新科美国有限公司美国匹兹堡阿朗新科荷兰有限公司荷兰格林阿朗新科德国有限公司德国多马根

采用玻璃化转变温度(T_(g))、温度回缩(Tr)、吉门扭转温度和低温压缩永久变形等表征了非填充硫化氢化丁腈橡胶的低温性能,并研究了丙烯腈含量、双键含量、交联密度和门尼粘度等对低温性能的影响。结果表明,氢化丁腈橡胶Tr值和DSC T_(g)... 详细信息

采用玻璃化转变温度(T_(g))、温度回缩(Tr)、吉门扭转温度和低温压缩永久变形等表征了非填充硫化氢化丁腈橡胶的低温性能,并研究了丙烯腈含量、双键含量、交联密度和门尼粘度等对低温性能的影响。结果表明,氢化丁腈橡胶Tr值和DSC T_(g)随ACN含量的变化而变化,其中低温牌号因存在第三单体破坏了亚甲基链段结晶,使氢化丁腈橡胶低温性能更加优异。交联密度对低温参数有不同程度的影响,但对吉门扭转值和Tr10几乎没有影响;随着交联密度的增大,Tr70和低温压缩永久变形显著改善。双键含量对低温性能的影响与交联密度的影响一致。门尼粘度对吉门扭转温度、Tr10和DSC T_(g)的影响较小,门尼粘度较高时有利于Tr70。

关键词：氢化丁腈橡胶低温性能丙烯腈含量双键含量交联密度门尼粘度

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增塑剂对氢化丁腈橡胶低温性能的影响研究

特种橡胶制品 2023年第3期44卷 1-5页

作者： Martin Hoch 毛杰蒋鲸喆 Victor Nasreddine Marjan Hemstede-van Urk Christoph Gogelein Andreas kaiser 阿朗新科高性能弹性体(常州)有限公司江苏常州213127 阿朗新科美国有限公司美国匹兹堡阿朗新科荷兰有限公司荷兰格林阿朗新科德国有限公司德国多马根

采用玻璃化转变温度(Tg)、温度回缩(Tr)、吉门扭转温度和低温压缩永久变形等研究了增塑剂DIDS和增塑剂TP 759分别对HNBr LT 2004和HNBr LT 1757低温性能的影响,并探究了交联网络对低温性能所起的关键作用。结果表明,良好的低温压缩永久... 详细信息

采用玻璃化转变温度(Tg)、温度回缩(Tr)、吉门扭转温度和低温压缩永久变形等研究了增塑剂DIDS和增塑剂TP 759分别对HNBr LT 2004和HNBr LT 1757低温性能的影响,并探究了交联网络对低温性能所起的关键作用。结果表明,良好的低温压缩永久变形和Tr70取决于硫化胶弹性交联网络,而增塑剂会稀释弹性交联网络。吉门扭转模量和Tr10取决于增塑胶料的柔顺性。低温牌号HNBr与增塑剂的结合能拓宽胶料使用温度范围,为低温条件下的密封应用提供更多选择。

关键词：氢化丁腈橡胶低温性能交联密度增塑剂

整合素αvβ6可作为乳腺癌的不良预后因素——中国与孟加拉国的比较研究（英文）

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中国现代普通外科进展 2016年第5期19卷 376-380页

作者： kaiser ABM 牛威 Biswas Siddartha Barua Subrata Nahar Nur 梁本甲李泽群牛军山东大学齐鲁医院肝胆外科山东济南250012

目的:分析整合素αvβ6在中国与孟加拉国乳腺癌标本中的表达情况。方法:免疫组化方法检测78例中国患者及42例孟加拉患者的乳腺癌标本及癌旁组织中αvβ6的表达情况,并统计分析其临床意义。结果:整合素αvβ6的表达情况与病理组织分级(... 详细信息

目的:分析整合素αvβ6在中国与孟加拉国乳腺癌标本中的表达情况。方法:免疫组化方法检测78例中国患者及42例孟加拉患者的乳腺癌标本及癌旁组织中αvβ6的表达情况,并统计分析其临床意义。结果:整合素αvβ6的表达情况与病理组织分级(中国患者组P=0.032,孟加拉患者组P=0.013)、腋淋巴结受累情况(中国患者组P=0.010,孟加拉患者组P=0.001)密切相关。利用Kaplan-Meier检验进行生存分析发现,与整合素αvβ6表达阴性患者相比,整合素αvβ6表达阳性患者中位生存期显著降低(中国患者组P=0.021,孟加拉患者组P=0.002,log-rank检验)。结论:在中国与孟加拉国,整合素αvβ6均为乳腺癌浸润与转移的标记物,将来有望成为乳腺癌治疗的靶点。

关键词：整合素αvβ6 乳腺癌免疫组化临床病理资料