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Acta Geochimica 2021年第4期40卷 484-497页

作者： justin B.richardson LeAnn X.Zuniga Department of Geosciences University of MassachusettsMorrill Science Center 3611 North Pleasant StreetAmherstMA 01003USA

Manganese is ubiquitous in terrestrial environments and most studies have focused on dissolution of Mn oxides,but aluminosilicates also release ***,we evaluated oxic Mn dissolution from six rocks and minerals(amphibolite,anorthosite,kaolinite,kyanite,muscovite,orthoclase feldspar) and soils from four Critical Zone Observatories(CZOs) under four LMWOLs treatments(catechol,citric acid,oxalic acid,control).Overall rock and mineral Mn mass-normalized release was 1.4 ± 0.5 nM μM^(-1) 14 d^(-1) and dissolution rate was 2403 ± 935 nM m^(-2) d^(-1) x 10^(3).Overall CZO soil Mn release was 16.7±5.1 nM μM^(-1) 14 d^(-1) and dissolution rate was 7010 ± 2570 nM m^(-2) d^(-1) × 10^(3).Anorthosite and kyanite had the highest Mn dissolution rates but kaolinite and kyanite had the highest Mn mass-normalized release *** hypothesize the structural location of Mn,surface area,and potential inclusions of highly-weatherable-phases control Mn dissolution for rocks and *** soils with the highest solid phase Mn had the highest Mn release and dissolution *** acid and catechol had higher Mn release and dissolution rates than the control while oxalic acid did *** rocks and minerals,we found pH 4 had higher Mn release and dissolution rates than pH6,but not for control treatments without *** study highlights that the abundance of Mn drove Mn release in soils but not rocks and ***,LMWOLs are important for Mn dissolution,even under acidic pH conditions.

关键词： Aluminosilicates Weathering rates organic acids Critical zone Mn oxides

Effect of prophylactic clip placement following endoscopic mucosal resection of large colorectal lesions on delayed polypectomy bleeding: A meta-analysis

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World Journal of Gastroenterology 2019年第18期25卷 2251-2263页

作者： Fares Ayoub Donevan r Westerveld justin J Forde Christopher E Forsmark Peter V Draganov Dennis Yang Department of Medicine University of Florida Division of Gastroenterology Hepatology and Nutrition University of Florida

BACKGrOUND The role of prophylactic clipping for the prevention of delayed polypectomy bleeding(DPB) remains unclear and conclusions from prior meta-analyses are limited due to the inclusion of variety of resection techniques and polyp *** To conduct a meta-analysis on the effect of clipping on DPB following endoscopic mucosal resection(EMr) of colorectal lesions ≥ 20 *** We performed a search of PubMed and the Cochrane library for studies comparing the effect of clipping vs no clipping on DPB following endoscopic resection. The Cochran Q test and I^2 were used to test for heterogeneity. Pooling was conducted using a random-effects *** Thirteen studies with a total of 7794 polyps were identified, of which data was available on 1701 cases of EMr of lesions ≥ 20 mm. Prophylactic clipping was associated with a lower rate of DPB(1.4%) when compared to no clipping(5.2%)(pooled Or: 0.24, 95%CI: 0.12-0.50, P r of lesions ≥ 20 *** was no significant heterogeneity among the studies(I^2 = 0%, P = 0.67).CONLUSION Prophylactic clipping may reduce DPB following EMr of large colorectal *** trials are needed to further identify risk factors and stratify high risk cases in order to implement a cost-effective preventive strategy.

关键词： Meta-analysis Clipping Endoscopic resection Endoscopic mucosal resection

Attribution of Fano resonant features to plasmonic particle size, lattice constant, and dielectric wavenumber in square nanoparticle lattices

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Photonics research 2014年第1期2卷 15-23页

作者： Drew DeJarnette justin Norman D.Keith roper Microelectronics and Photonics Graduate Program University of ArkansasFayettevilleArkansas 72701USA Department of Chemical Engineering University of ArkansasFayettevilleArkansas 72701USA

Fano resonances between plasmons and diffracted light offer tunable energies and locales,but attribution of Fano resonance features to geometry and physicochemistry of metal nanostructures and adjacent dielectrics has been confounded by complexity and computational *** work shows predictable modal shifts of Fano resonance in square lattices of plasmonic nanostructures can be attributed directly to changes in medium wavenumber,particle size,and lattice constant that alter plasmon polarizability and diffractive *** 45 to 80 nm radius particles,a window of lattice constants that support Fano resonances is identified in a range from 500 to 900 *** constants that support high intensity resonances are determined by individual particle polarizability and medium *** resonance wavelengths redshift from diffracted photon energies as local refractive index(rI)changes due to coupling with particle polarizability in the *** sensitivities for quadrupole,dipole,and Fano resonances are 150,348,and 541 nm,respectively,per rI *** resonance intensity may be enhanced more than tenfold by selecting nanoparticle sizes and lattice *** quantitative effects of such parametric changes are rapidly and intuitively distinguished using a semi-analytic approach,consisting of an exact expression for particle polarizability,a trigonometric description of diffraction,and a semianalytical coupled dipole approximation.

关键词： lattice particle wave

Unveiling a new regulator: Vacuolar V-ATPase mediates brassinosteroid signaling in Arabidopsis

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Molecular Plant 2024年第2期17卷 227-229页

作者： Shikha Malik justin W.Walley Department of Plant Pathology Entomologyand Microbiologylowa State UniversityAmesIA 50011USA

Plant growth and development are intricately regulated by hormones such as auxins,gibberellins,jamonates,cytokinins,and brassinosteroids(Brs).Brs are a group of plant steroid hormones that play a vital role in plant growth and response to the *** regulate many biological processes including cell elongation,cell division,and male fertility,as well as abiotic and biotic stress responses.

关键词： media fertility brassinosteroid

Prospect for China–Korea Economic relations

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China & World Economy 2006年第1期14卷 57-70页

作者： justin Yifu Lin Peking University and Hong Kong University of Science and Technology

This paper briefly reviews the economic performance of China＇s economic reform starting in 1978, and which it presents personal views on the experiences of Korea ＇s economic development and lessons for China＇s economic reform. The paper reviews the China- Korea economic relationship, and explores both the opportunities of China＇s economic development for Korea and the prospeets for Bilateral Economic cooperation. It is estimated that the Chinese economy will maintain dynamic growthJbr the coming decade. The 2008 Olympic Games and the 2010 Worm Expo in China will provide further impetuses for Chinese economic development. China＇s huge market and its rapid economic growth can help the further recovery and development of the Korean economy. At the same time, the .further development of the Chinese economy can benefit from financial, technical and managerial supportfrom Korea. The eomplementarities between the industrial structures of China and Korea will surely push their future economic cooperation into a broader and deeper stage. Bilateral trade will enhance the competitiveness of both nations in the global market and help them achieve mutual prosperity and development.

关键词： bilateral economic cooperation China-Korea economic relations Economic Development

Genetic polymorphism in pathogenesis of irritable bowel syndrome

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World Journal of Gastroenterology 2014年第47期20卷 17693-17698页

作者： Cynthia KY Cheung justin CY Wu Institute of Digestive Disease The Chinese University of Hong Kong

Irritable bowel syndrome (IBS) is a complex symptom-based disorder without established biomarkers or putative pathophysiology. IBS is a common functional gastrointestinal disorder which is defined as recurrent abdominal pain or discomfort that has at least two of the following symptoms for 3 d per month in the past 3 mo according to rOME III: relief by defecation, onset associated with a change in stool frequency or onset with change in appearance or form of stool. recent discoveries revealed genetic polymorphisms in specific cytokines and neuropeptides may possibly influence the frequencies and severity of symptoms, as well as the therapeutic responses in treating IBS patients. This review gives new insights on how genetic determinations influence in clinical manifestations, treatment responses and potential biomarkers of IBS.

关键词： Irritable bowel syndrome Genetic polymorphism Cytokines Serotonin Psychiatric distress Endocannabinoids

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Journal of Sport and Health Science 2020年第6期9卷 664-669页

作者： Xihe Zhu justin A.Haegele Haichun Sun Department of Human Movement Sciences Old Dominion UniversityNorfolkVA 23529USA Department of Teaching and Learning University of South FloridaTampaFL 33620USA

Background:Health-related fitness knowledge(HrFK)has been an essential concept for many health and physical education *** has been limited understanding and longitudinal investigation on HrFK *** longitudinal study examined HrFK growth and its individual-and school-level correlates in middle school years under 1 curriculum condition:Five for ***:Participants were 12,044 students from 47 middle *** were collected at both individual/participant and school/institution ***-level variables included gender,grade,and HrFK test ***-level variables included percentage of students receiving free and reduced meals(FArM),student-to-faculty ratio for physical education,and school academic performance(SAP).We used hierarchical linear modeling to examine HrFK 3-year growth in relation to individual-and school-level ***:The average HrFK score at 6th grade for females was 42.81%±1.32%.The predicted HrFK growth was 17.06%±1.02%per year,holding other factors constant.A 1-standard deviation increase in FArM correlated with a 14.68%-point decrease in predicted test score(p=0.02).A 1-standard deviation increase in SAP was associated with an 11.90%-point increase in HrFK *** had a significantly lower growth rate than females during the middle school years(0.78%/year,p=0.02).Conclusion:The result showed that both individual-and school-level variables such as gender,FArM,and SAP influenced HrFK *** should heed gender differences in growth curves and recognize the correlates of school-level variables.

关键词： Academic achievement Fitness concept Learning rate Physical education Socioeconomic status(SES)

Industrial Policy and China＇s Economic Development： From the Perspective of New Structural Economics

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Fudan Journal of the Humanities and Social Sciences 2017年第4期10卷 419-429页

作者： justin Yifu Lin Center for New Structural Economics Peking University Beijing 100871 China

Although industrial policies in many countries have failed, a country＇s economic development is bound to be unsuccessful without industrial policy. The responsibility of an economist is not to object to any kind of industrial policy for fear of failure, nor unconditionally support all kinds of industrial policies because industrial policy is a necessary condition for the success of economic development. An economist should explore the causes behind the success or failure of industrial policies so as to help government reduce the chance of failure and improve the probabilities of success in applying industrial policies. This paper analyzes why industrial policy is necessary for successful economic development. This paper notes that synergy of ＂efficient market＂ and ＂facilitating state＂ is indispensable for economic development, and also analyzes why developed and developing countries failed in applying industrial policies. From the perspective of New Structural Economics, in this paper industries in China are divided into five types： catching-up industries, leading-edge industries, comparative advantage-losing industries, short innovation cycle industries and comparative advantage-defying strategic industries. The paper also analyzes how to formulate effective industrial policy in China. It is noted that, based on the characteristics of each industry, ＂efficient market＂ and ＂facilitating state＂ should both play their respective roles in promoting China＇s industrial transformation and upgrading.

关键词： Industrial policy - Economic development New StructuralEconomics

Single-nucleotide editing for zebra3 and wsl5 phenotypes in rice using CrISPr/Cas9-mediated adenine base editors

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aBIOTECH 2020年第2期1卷 106-118页

作者： Kutubuddin A.Molla justin Shih Yinong Yang Department of Plant Pathology and Environmental Microbiology and the Huck Institute of the Life Sciences The Pennsylvania State UniversityUniversity ParkPA 16802USA ICAr-National rice research Institute Cuttack 753006India

The CrISPr/Cas9-mediated base editing technology can efficiently generate point mutations in the genome without introducing a double-strand break(DSB)or supplying a DNA donor template for homology-directed repair(HDr).In this study,adenine base editors(ABEs)were used for rapid generation of precise point mutations in two distinct genes,OsWSL5,and OsZEBrA3(Z3),in both rice protoplasts and regenerated *** precisely engineered point mutations were stably inherited to subsequent *** single nucleotide alterations resulted in single amino acid changes and associated wsl5 and z3 phenotypes as evidenced by white stripe leaf and light green/dark green leaf pattern,*** selfing and genetic segregation,transgene-free,base edited wsl5 and z3 mutants were obtained in a short period of *** noticed a novel mutation(V540A)in Z3 locus could also mimic the phenotype of Z3 mutation(S542P).Furthermore,we observed unexpected non-A/G or T/C mutations in the ABE editing window in a few of the edited *** ABE vectors and the method from this study could be used to simultaneously generate point mutations in multiple target genes in a single transformation and serve as a useful base editing tool for crop improvement as well as basic studies in plant biology.

关键词： Adenine base editor CrISPr/Cas9 genome editing Plant base editing Precise point mutation Transgene-free rice

Aberrant expression of enzymes regulating m^6A mrNA methylation: implication in cancer

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Cancer Biology & Medicine 2018年第4期15卷 323-334页

作者： Natalia Pinello Stephanie Sun justin Jong-Leong Wong Epigenetics and rNA Biology Program Centenary Institute The University of Sydney Sydney Medical School The University of Sydney

N^6-methyladenosine(m^6 A) is an essential rNA modification that regulates key cellular processes, including stem cell renewal,cellular differentiation, and response to DNA damage. Unsurprisingly, aberrant m^6 A methylation has been implicated in the development and maintenance of diverse human cancers. Altered m^6 A levels affect rNA processing, mrNA degradation, and translation of mrNAs into proteins, thereby disrupting gene expression regulation and promoting tumorigenesis. recent studies have reported that the abnormal expression of m^6 A regulatory enzymes affects m^6 A abundance and consequently dysregulates the expression of tumor suppressor genes and oncogenes, including MYC, SOCS2, ADAM19, and PTEN. In this review, we discuss the specific roles of m^6 A missing space "writers", "erasers", and "readers" in normal physiology and how their altered expression promotes tumorigenesis. We also describe the potential of exploiting the aberrant expression of these enzymes for cancer diagnosis, prognosis, and the development of novel therapies.

关键词： rNA modification N^6-methyladenosine (m^6A) cancer tumor suppressor oncogene