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儿童大剂量移植HLA不相合双亲供者的纯化外周血CD34^+祖细胞

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德国医学 2001年第6期18卷 344-346页

作者：王震张玉平李扬秋 r.Handgretinger T.Klingebiel P.Lang M.Schumm S.Neu P.Bader A.Geiselhart P.G.Schlegel j.Greil D.Stachel r.j.herzog D.Niethammer 暨南大学医学院血液病研究所 Department of Pediatric H ematology/Oncology and Blood Bank University of TübingenTübingen Germany

对于许多恶性和非恶性疾病来说,进行清髓性造血祖细胞异基因移植是唯一行之有效的治疗措施,但大多数需要移植的患者无组织相容性的同胞供者.与同胞移植相比,无关供者移植的移植物抗宿主病(GVHD)、移植排斥和感染的发病率及严重程度均增... 详细信息

对于许多恶性和非恶性疾病来说,进行清髓性造血祖细胞异基因移植是唯一行之有效的治疗措施,但大多数需要移植的患者无组织相容性的同胞供者.与同胞移植相比,无关供者移植的移植物抗宿主病(GVHD)、移植排斥和感染的发病率及严重程度均增加,故移植效果较差 . 若能采用不用进行HLA配型的单倍体供者,由于其快捷的可用性,将提供一些优势.几乎所有可能进行异基因移植的患者都将会在一个特定的时间内找到供者.与应用脐血干细胞移植比较,单倍体供者在发生未植活或排斥反应的情况下仍然可以利用.其后如需要进行移植后免疫治疗如供体淋巴细胞输注时,也可以随时加以利用.然而在过去,清除T细胞的单倍体的移植使急慢性GVHD、未植活或移植物排斥的发病率增加以及免疫失调时间延长,这样就增加了致命性感染和淋巴细胞增殖性疾病的危险.

关键词：儿童骨髓移植 HLA配型 CD34^+祖细胞

在腰骶异常过度中髂腰韧带能否作为腰5椎体的一个可靠的标识符?

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国际医学放射学杂志 2014年第6期 612-612页

作者： N.A.Farshad-Amacker B.Lurie r.j.herzog M.Farshad 蒋光耀 MrI Radiology DepartmentHospital for Special Surgery535 East 70th StreetNew York 10021NYUSA

摘要目的足够样本量的研究来明确髂腰韧带(ILL)在腰骶移行(LSTV)中不能作为腰5(L5)椎体的标识点。方法从770例LSTV病例中选取71例作为病例组,从611例L5椎

关键词：椎体标识点髂腰韧带放射科

椎间盘、终板与椎体骨髓是脊柱退变进程的整体单元

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国际医学放射学杂志 2017年第4期 493-493页

作者： N.A.Farshad-Amacker A.Hughes r.j.herzog B.Seifert M.Farshad 孙海涛 MrI Radiology Department Hospital for Special SurgeryNew York NY USA

摘要目的椎间盘退变(DD)与椎体终板退变(EPD)的关系尚不清楚。本研究旨在寻找节段性DD与EPD的风险预测因素,进而揭示椎间盘、终板和骨髓在退变进程中的变化。方法经伦理委员会批准,对MrI随访至少4年的450个腰椎节段进行回顾性分析,按照P...

摘要目的椎间盘退变(DD)与椎体终板退变(EPD)的关系尚不清楚。本研究旨在寻找节段性DD与EPD的风险预测因素,进而揭示椎间盘、终板和骨髓在退变进程中的变化。方法经伦理委员会批准,对MrI随访至少4年的450个腰椎节段进行回顾性分析,按照Pfirrmann(PFG)标准进行DD分级,按照终板评分(EPS)以及Modic改变(MC)的存在、范围和类型对EPD进行分型。巢式病例对照亚型相匹配,并采

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A comparison of lower limb stiffness and mechanical muscle function in ACL-reconstructed,elite,and adolescent alpine ski racers/ski cross athletes

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journal of Sport and Health Science 2018年第4期7卷 416-424页

作者： Matthew j.jordan Per Aagaard Walter herzog Canadian Sport Institute Calgary Calgary AB T2N IN4Canada Department of Sports Science and Clinical Biomechanics SDU Muscle Research ClusterUniversity of Southern DenmarkOdense DK-5230Denmark Human Performance Laboratory University of CalgaryCalgaryAB T2N IN4Canada Corresponding author.E-mail address： mjordan@ucalgary.ca

Purpose： The aim of this study was to compare mechanical muscle function in the eccentric/concentric phases of vertical bilateral jumping in anterior cruciate ligament-reconstructed （ACLr）, elite （ELITE）, and adolescent （ADOL） alpine ski racers and ski cross athletes. Methods： Alpine ski racers/ski crossers （ACLr： n = 12, age = 26.7 ± 3.8 years; ELITE： n = 12, age = 23.9 ± 3.0 years; ADOL： n = 12, age = 17.8 ± 0.7 years; females： n = 6 per group, males： n = 6 per group） performed 5 maximal countermovement jumps （CMjs） and 5 squat jumps. The ground reaction forces for each limb were analyzed using dual force plate recording to obtain body center of mass （BCM） velocity, displacement, and power. The eccentric deceleration （ECC） and concentric phases were determined from BCM velocity. CMj net concentric and ECC impulses were calculated （body mass normalized） along with the peak and mean BCM power and maximal vertical jump height. CMj lower limb stiffness （LLS） was determined by the slope of the ground reaction forces vs. the BCM displacement curve over the ECC phase. Concentric and ECC asymmetry indices were calculated for each leg, and the left vs. right LLS was compared. Outcome measures （reported as mean ± SD） calculated as a 5-jump mean were normalized to body mass and compared using an analysis of variance. results： No between-group differences were found for peak and mean power or jump heights. There were no group differences for LLS or net concentric phase impulse, but the net ECC impulse was lower in the ADOL group compared with ELITE skiers （ADOL： 1.33 ± 0.32 Ns/kg; ELITE： 1.59 ± 0.16 Ns/kg; p 〈 0.05）. Although no group differences were found for ECC asymmetry indices, a group × limb interaction was found for LLS （p 〈 0.01）, which was systematically higher in the right vs. the left limb of ADOL skiers （right： 54.1 ± 17.9 N/m/kg; left： 48.7 ± 15.7 N/m/kg;p 〈 0.01）. Conclusion： ADOL skiers demonstrated decreased ECC impulse and systematic right limb dominance in

关键词： Between-limb asymmetry Injury prevention Knee injuries Muscle power Vertical jump

Why are muscles strong, and why do they require little energy in eccentric action?

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journal of Sport and Health Science 2018年第3期7卷 255-264页

作者： Walter herzog Human Performance Laboratory Faculty of Kinesiology University of Calgary

It is well acknowledged that muscles that are elongated while activated(i.e.,eccentric muscle action)are stronger and require less energy(per unit of force)than muscles that are shortening(i.e.,concentric contraction)or that remain at a constant length(i.e.,isometric contraction).Although the cross-bridge theory of muscle contraction provides a good explanation for the increase in force in active muscle lengthening,it does not explain the residual increase in force following active lengthening(residual force enhancement),or except with additional assumptions,the reduced metabolic requirement of muscle during and following active *** from the cross-bridge theory,2 other primary explanations for the mechanical properties of actively stretched muscles have emerged:(1)the so-called sarcomere length nonuniformity theory and(2)the engagement of a passive structural element *** this article,these theories are discussed,and it is shown that the last of these—the engagement of a passive structural element in eccentric muscle action—offers a simple and complete explanation for many hitherto unexplained observations in actively lengthening *** by no means fully proven,the theory has great appeal for its simplicity and beauty,and even if over time it is shown to be wrong,it nevertheless forms a useful framework for direct hypothesis testing.

关键词： Cross-bridge theory Eccentric Force-length relationship residual force enhancement Titin

Improved optical enhancement using double-width plasmonic gratings with nanogaps

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Photonics research 2016年第5期4卷 173-180页

作者： Ahmad A.Darweesh Stephen j.Bauman joseph B.herzog Microelectronics-Photonics Graduate Program University of Arkansas Department of Physics University of Arkansas

Plasmonic grating structures have been shown effective at increasing near-field optical enhancement. A doublewidth plasmonic grating design is introduced, where each period has two alternating metal widths separated by a nanogap. With this new design, analysis has shown that plasmonic resonances couple between each metal section,resulting in even greater optical enhancement compared with single-width gratings. The geometry that gives the greatest optical enhancement has been determined with a computational model. This work demonstrates that the increased enhancement is due to hybridized modes that couple between the two grating segments.

关键词： Improved optical enhancement using double-width plasmonic gratings with nanogaps nm

The secrets to running economy

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journal of Sport and Health Science 2022年第3期11卷 273-274页

作者： Walter herzog Human Performance Laboratory Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada

Every once in a while,a sport is revolutionized by a discovery or a new *** the mid-1980s,cross-country skiing was changed forever by the introduction of the skating *** Fosbury revolutionized high-jumping when he won the Olympic Games by crossing the bar“backwards”,and the development of the“klapp-skate”led to vast improvements of world records in speed skating.

关键词： technique. backward revolution

Eccentric vs. concentric muscle contraction： That is the question

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journal of Sport and Health Science 2017年第2期6卷 128-129页

作者： Walter herzog Human Performance Laboratory Faculty of KinesiologyUniversity of Calgary

In their recent papers in the journal of Sport and Health Science on hamstring injuries in sprinting,^(1,2)and their corresponding commentaries on each other's research,3,4Yu et *** Liu et *** different views of the mechanisms of muscle injuries in general,and hamstring injuries in sprinting *** Yu et al.^(1,3)argued that muscle injuries are primarily,if not exclusively,caused by muscle strain magnitude in eccentric contractions,and thus hamstring injuries occur primarily

关键词：心肌收缩偏心肌肉损伤收缩应变受伤短跑

Editorial re:Could sport be part……by ring-Dimitriou et al.

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journal of Sport and Health Science 2019年第4期8卷 348-349页

作者： Walter herzog Human Performance Laboratory Faculty of KinesiologyUniversity of Calgary

Childhood obesity has become a concern in most economically developing *** reasons for this seem clear:too much food and not enough *** dilemma has received much scientific attention,and the question arises:How do we get children to move and make good eating choices?In their opinion piece in this issue of the journal of Sport and Health Science(jSHS),ring-Dimitriou et al.1 make an argument that playing structured and supervised traditional sports will help children with obesity,where traditional sports include football,handball,gymnastics,athletics,and martial arts.

关键词： ring-Dimitriou journal of Sport and Health Science(jSHS) economically developing countries