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植物病原菌的生物防治:理论到应用

植物医学 1986年第2期 14-17页

作者： r.j.cook 陈宇

生物防治对植物病理学历来是最大挑战之一,值得植物病理学的各个分支学科——病毒学、细菌学、线虫学、真菌学、遗传学、分子生物学、土壤微生物学都予以重视。*** 在1926年的 PHYTO-PATHOLOGY 上首次发表了用桔抗体进行植物病原菌生物... 详细信息

生物防治对植物病理学历来是最大挑战之一,值得植物病理学的各个分支学科——病毒学、细菌学、线虫学、真菌学、遗传学、分子生物学、土壤微生物学都予以重视。*** 在1926年的 PHYTO-PATHOLOGY 上首次发表了用桔抗体进行植物病原菌生物防治的论文“影响马铃薯疮痂病菌致病力的因子”。而 Sanford 和*** 发表的“小麦全蚀病菌的生

关键词：植物病原菌生物防治

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植物病原菌的生物防治

植物病原菌的生物防治

The Triple Combination of Meropenem,Avibactam,and a Metallo-b-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different b-Lactamase Producers

1984年

作者：（美）贝克（K.F.Baker）（美）库克（r.j.cook）兰斌王朝琪译

本书可作为中、高级化学检验职业技能培训教材，也可作为高职高专农业、林业、畜牧、化工等相关专业的分析检测实训教材,

ISBN: (纸本)16144·2686

本书可作为中、高级化学检验职业技能培训教材，也可作为高职高专农业、林业、畜牧、化工等相关专业的分析检测实训教材,

关键词：植物病毒病生物防治

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Engineering 2024年第7期38卷 124-132页

作者： Zhuoren Ling Alistair james Macdonald Farley Aditya Lankapalli Yanfang Zhang Shonnette Premchand-Branker Kate cook Andrei Baran Charlotte Gray-Hammerton Claudia Orbegozo rubio Edgars Suna jordan Mathias jürgen Brem Kirsty Sands Maria Nieto-rosado Maria Mykolaivna Trush Nadira Naznin rakhi Willames Martins Yuqing Zhou Christopher joseph Schofield Timothy Walsh Department of Biology&Ineos Oxford Institute for Antimicrobial research University of OxfordOxford OX13REUK Chemistry research Laboratory Department of Chemistry and the Ineos Oxford Institute for Antimicrobial ResearchUniversity of OxfordOxford OX13TAUK Latvian Institute of Organic Synthesis Riga LV-1006Latvia Department of Medical Microbiology Division of Infection and ImmunitySchool of MedicineCardiff UniversityCardiff CF144XNUK Enzymology and Applied Biocatalysis research Center Faculty of Chemistry and Chemical EngineeringBabes-Bolyai UniversityCluj-Napoca 400028Romania

This work explores the potential of a triple combination of meropenem(MEM),a novel metallo-blactamase(MBL)inhibitor(indole-2-carboxylate 58(InC58)),and a serine-b-lactamase(SBL)inhibitor(avibactam(AVI))for broad-spectrum activity against carbapenemase-producing bacteria.A diverse panel comprising MBL-and SBL-producing strains was used for susceptibility testing of the triple combination using the agar dilution *** frequency of resistance(For)to MEM combined with InC58 was *** were sequenced and tested for cross resistance,fitness,and the stability of the resistance *** with the double combinations of MEM plus an SBL or MBL inhibitor,the triple combination extended the spectrum of activity to most of the isolates bearing SBLs(oxacillinase-48(OXA-48)and Klebsiella pneumoniae carbapenemase-2(KPC-2))and MBLs(New Delhi metallo-blactamases(NDMs)),although it was not effective against Verona integron-encoded metallo-blactamase(VIM)-carrying Pseudomonas aeruginosa(***)and OXA-23-carrying Acinetobacter baumannii(***).The For to MEM plus InC58 ranged from 2.22×10^(-7)to 1.13×10^(-6).The resistance correlated with mutations to ompC and comr,affecting porin C and copper permeability,*** mutants manifested a fitness cost,a decreased level of resistance during passage without antibiotic pressure,and cross resistance to another carbapenem(imipenem)and a b-lactamase inhibitor(taniborbactam).In conclusion,compared with the dual combinations,the triple combination of MEM with InC58 and AVI showed a much wider spectrum of activity against different carbapenemaseproducing bacteria,revealing a new strategy to combat b-lactamase-mediated antimicrobial resistance.

关键词： Carbapenemase Metallo/serine-b-lactamase inhibitor Avibactam Meropenem Antimicrobial resistance

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复合混杂因素校正r2*mapping在肝脏铁MrI定量中的应用

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国际医学放射学杂志 2021年第2期44卷 241-241页

作者： D.Hernando r.j.cook N.Qazi C.A.Longhurst C.A.Diamond S.B.reeder 王萱

摘要目的基于MrI的r2*mapping可以可靠、快速地定量肝脏铁浓度（LIC）。然而,r2*在不同采集协议中的表现和可重复性仍然未知。因此,本研究旨在评估复合混杂因素

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粉末冶金Al-5.6Zn-2Mg合金在热压缩过程中加工硬化特性及本构模型的比较

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journal of Central South University 2024年第2期31卷 346-368页

作者： KATIKA Harikrishna DAMODA r.K. DAVIDSON M.j. SEETHArAM r. KASAGANI Veera Venkata Nagaraju Department of Mechanical Engineering National Institute of TechnologyWarangal 506004India Department of Mechanical Engineering The Indian Institute of Information Technology Design and ManufacturingKurnool 518007India

在300~5000℃、应变速率为0.1~0.0001 s−1的条件下,在万能试验机上对Al-5.6Zn-2Mg铝合金进行热压缩试验,以确定动态再结晶开始时的加工硬化速率曲线σ_(c)(ε_(c))l以及关键特征σ_(c)(ε_(c))l、σ_(p)(ε_(p))和σ_(ss)与Z系数之间的... 详细信息

在300~5000℃、应变速率为0.1~0.0001 s−1的条件下,在万能试验机上对Al-5.6Zn-2Mg铝合金进行热压缩试验,以确定动态再结晶开始时的加工硬化速率曲线σ_(c)(ε_(c))l以及关键特征σ_(c)(ε_(c))l、σ_(p)(ε_(p))和σ_(ss)与Z系数之间的相关性。使用了四个本构模型,Arrhenius模型、改进的johnson-cook模型(MjC)、改进的Zerilli-Armstrong模型(MZA)和开发的人工神经网络(ANN)。结果表明,ANN型模型和Arrhenius模型的相对误差的绝对平均值最低,分别为0.486%和3.36%,MZA型模型和MjC型模型的相对误差的绝对平均值较高,分别为8.84%和3.93%。由于Arrhenius模型能够处理各种因素之间的非线性关系,因此它被认为是最合适的预测模型,但在材料性质未知或实验数据有限的情况下,MjC模型可能是一种更简单的替代方法。MZA模型不适合估计热压缩时的流变应力。此外,训练最好的神经网络模型的预测性能最好,相对误差的绝对平均值为0.486%,r值为0.99。

关键词：加工硬化速率曲线本构建模热压缩 EBSD分析流变曲线

Listening to People and Places teacher's tapescript V j cook.

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Listening to People and Places teacher's tapescript V J COOK...

CCS research Development and Deployment in a Clean Energy Future： Lessons from Australia over the Past Two Decades

1984年

作者： V j cook.

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Engineering 2017年第4期3卷 477-484页

作者： Peter j. cook CO2CrC Ltd.& Peter cook Centre for Carbon Capture and Storage research The University of Melbourne Melbourne VIC 2010 Australia

碳捕集和封存(CCS)技术作为一种碳减排手段,虽未得到全方位认可,但其重要性已得到人们的广泛认可。但是,若要将全球温度上升幅度控制在低于2℃,则此技术的推广应用速度并不能满足相关的需求。虽然大规模推广CCS技术所面临的困难尚无法... 详细信息

碳捕集和封存(CCS)技术作为一种碳减排手段,虽未得到全方位认可,但其重要性已得到人们的广泛认可。但是,若要将全球温度上升幅度控制在低于2℃,则此技术的推广应用速度并不能满足相关的需求。虽然大规模推广CCS技术所面临的困难尚无法全部克服,但通过不断的研究、交流和规划,目前CCS技术已得到了极大丰富。我们知道如何进行相关操作,并自信能安全有效地完成相关操作;我们知道相关的成本情况,也知道目前成本正在不断降低,而且未来会继续降低。同时,我们也知道,只要各个国家、公司、团体继续将化石燃料用作能源及用于各种工业过程,则世界就会一直需要碳捕集和封存技术。我们缺少的是必要的政策驱动和技术上呈中性(不会增加二氧化碳排放)的方法,以达到及时、低成本地降低CO_2排放,并维持稳定的、安全的电力供应以保证能源密集型工业产品的生产和使用。我们以澳大利亚为例来说明过去20年内人们对碳捕集和封存技术所做的各种努力,尤其是在碳捕集和封存技术研究和示范工程以及国际合作方面所做的各种努力。在澳大利亚国内,碳捕集和封存技术的大规模推广进展非常慢。但全球最大的碳捕集和封存项目将作为Gorgon液化天然气项目的一部分,很快在澳大利亚国内投入运营,另外还有数个大规模的碳捕集和封存的旗舰级项目正在考察中。CO2CrC Otway项目是澳大利亚国内目前唯一一个运行中的二氧化碳封存项目。该项目目前正在进行一些细节方面的组织和推进工作。需要指出的是,如果要推广Otway项目,还需对地下岩石对封存CO_2的影响开展大量研究。如果要在全球范围广泛使用碳捕集和封存技术,国际能源机构和国际气候变化委员会等机构都认为我们面临很大的挑战,还有很多重大问题需要解决。要解决这些问题,全球各方必须紧密协作。

关键词：二氧化碳碳捕集和封存技术 Otway 澳大利亚

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Detecting subtle yet fast skeletal muscle contractions with ultrasoft and durable graphene-based cellular materials

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National Science review 2022年第4期9卷 105-115页

作者： Zijun He Zheng Qi Huichao Liu Kangyan Wang Leslie roberts jefferson Z.Liu Yilun Liu Stephen j.Wang Mark j.cook George P.Simon Ling Qiu Dan Li Department of Chemical Engineering The University of Melbourne Department of Materials Science and Engineering Monash University Department of Chemical Engineering Monash University State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi'an Jiaotong University Neurophysiology Department Department of Neurology and Neurological ResearchSt Vincent's Hospital Department of Medicine St.Vincent's HospitalUniversity of Melbourne Department of Mechanical Engineering University of Melbourne Department of Design Monash University School of Design The Hong Kong Polytechnic University Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen InstituteTsinghua University

Human bodily movements are primarily controlled by the contractions of skeletal muscles. Unlike joint or skeletal movements that are generally performed in the large displacement range, the contractions of the skeletal muscles that underpin these movements are subtle in intensity yet high in frequency. This subtlety of movement makes it a formidable challenge to develop wearable and durable so?t materials to electrically monitor such motions with high fidelity for the purpose of, for example, muscle/neuromuscular disease diagnosis. Here we report that an intrinsically fragile ultralow-density graphene-based cellular monolith sandwiched between silicone rubbers can exhibit a highly effective stress and strain transfer mechanism at its interface with the rubber, with a remarkable improvement in stretchability(>100%). In particular, this hybrid also exhibits a highly sensitive, broadband-frequency electrical response(up to 180 Hz) for a wide range of strains. By correlating the mechanical signal of muscle movements obtained from this hybrid material with electromyography, we demonstrate that the strain sensor based on this hybrid material may provide a new, so?t and wearable mechanomyography approach for real-time monitoring of complex neuromuscular–skeletal interactions in a broad range of healthcare and human–machine interface applications. This work also provides a new architecture-enabled functional so?t material platform for wearable electronics.

关键词： cellular graphene strain sensors high-frequency electromechanical property surface mechanomyography skeletal muscle activity

rates, predictors, and causes of readmission after transcatheter aortic valve replacement in patients with chronic kidney disease

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World journal of Cardiology 2024年第7期16卷 402-411页

作者： Taha Teaima Gianfranco Bittar Carlini rohan A Gajjar Imran Aziz Sami j Shoura Abdul-rahim Shilbayeh Naim Battikh Tareq Alyousef Division of Cardiology Department of MedicineJohn H.StrogerJr.Hospital of Cook CountyChicagoIL 60612United States

BACKGrOUND Transcatheter aortic valve replacement(TAVr)is a revolutionary procedure for severe aortic *** coexistence of chronic kidney disease(CKD)and TAVr introduces a challenge that significantly impacts patient *** To define readmission rates,predictors,and causes after TAVr procedure in CKD stage 1-4 *** We used the national readmission database 2018 and 2020 to look into readmission rates,causes and predictors after TAVr procedure in patients with CKD stage *** Out of 24758 who underwent TAVr and had CKD,7892(32.4%)patients were readmitted within 90 days,and had higher adjusted odds of being females(adjusted odds ratio:1.17,95%CI:1.02-1.31,P=0.02)with longer length of hospital stay>6 days,and more comorbidities including but not limited to diabetes mellitus,anemia,and congestive heart failure(CHF).CONCLUSION Most common causes of readmission included CHF(18.0%),sepsis,and complete atrioventricular *** readmission predictors with very close followup is warranted to prevent such high rate of readmission.

关键词： Chronic kidney disease Transcatheter aortic valve replacement readmission Predictors rates