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乳腺X线筛检异常后随访的时间分布:不同机构间的差异

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国际医学放射学杂志 2012年第1期 70-70页

作者： r.D.rosenberg S.j.Haneuse B.M.Geller D.S.Buist D.L.Miglioretti r.j.brenner 夏艺 Department of radiology University of New Mexico-HSC1 University of New Mexico HSC 10 5530AlbuquerqueNM 87131-0001

目的描述接受乳腺X线筛查后、推荐立即随访的社区妇女进行随访的时间分布,以及不同机构类型和机构级别间随访时间有无差异。材料与方法本研究由伦理委员会

关键词：乳腺筛查乳房时间分布机构级别差异

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确定可接受的最低的乳腺筛查阅片标准

国际医学放射学杂志 2010年第4期 369-369页

作者： P.A.Carney E.A.Sickles B.S.Monsees L.W.Bassett r.j.brenner S.A.Feig 李宁 Department of Family Medicine and Department of Public Health and Preventive Medicine Oregon Health & Science University3181 SW Sam Jackson Park RdPortland

目的本研究旨在确立乳腺筛查中医师可接受的最低阅片标准并剖析在美国放射实践中实施该标准的影响。材料与方法经机构伦理委员会批准,符合HIPAA要求。应用双期设置的Angoff方法,以敏感度、

关键词：乳腺筛查医师召回率检出率癌肿敏感度特异度阳性预测值 PPV

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向病人说明乳腺钼靶片的误诊

国际医学放射学杂志 2010年第1期 73-73页

作者： T.H.Gallagher A.j.Cook r.j.brenner P.A.Carney D.L.Miglioretti B.M.Geller 姜卫香 Department of Medicine and Division of General Internal MedicineUniversity of Washington

目的通过问卷调查评估放射科医生对因乳腺钼靶片误诊而延误了乳腺癌诊断时对病人进行解释的态度。材料与方法本研究获得伦理委员会批准,调查了来自7个不同乳腺癌监督协会的364名放射科医生2005—2006年间的乳腺钼靶

关键词：乳腺钼靶病人放射科

1996年—2004年放射学家在基于社区乳腺癌监测联盟的乳腺X线摄影筛查中解释性能随时间变化趋势

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国际医学放射学杂志 2010年第5期 470-470页

作者： L.E.Ichikawa W.E.Barlow M.L.Anderson S.H.Taplin B.M.Geller r.j.brenner 杨卉 Group Health research Institute 1730 Minor Ave

关键词：乳腺癌乳腺肿瘤筛查时间变化摄影美术

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.j. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.j. Addison j. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras j. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi j. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.j. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke j.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.r. Amos V. Ananiev C. Anastopoulos T. Andeen j.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki j.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.j. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena j-F. Arguin S. Argyropoulos j.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah j. Assahsah K. Assamagan r. Astalos S. Atashi r.j. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.j. Bailey V.r. Bailey j.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan r. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas j. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS jET QUArK GLUON TAGGING

Artificial intelligence using advanced imaging techniques and cholangiocarcinoma: recent advances and future direction

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Artificial Intelligence in Gastroenterology 2022年第3期3卷 88-95页

作者： Aaron r brenner Passisd Laoveeravat Patrick j Carey Danielle joiner Samuel H Mardini Manol jovani Department of Internal Medicine University of Kentucky College of MedicineLexingtonKY 40536United States Division of Digestive Diseases and Nutrition University of Kentucky College of MedicineLexingtonKY 40536United States Division of Digestive Diseases and Nutrition University of Kentucky College of MedicineLexingtonKENTUCKY 40536United States Digestive Diseases and Nutrition University of Kentucky Albert B.Chandler HospitalLexingtonKY 40536United States

While cholangiocarcinoma represents only about 3%of all gastrointestinal tumors,it has a dismal survival rate,usually because it is diagnosed at a late *** utilization of Artificial Intelligence(AI)in medicine in general,and in gastroenterology has made gigantic ***,the application of AI for biliary disease,in particular for cholangiocarcinoma,has been *** use of AI in combination with clinical data,cross-sectional imaging(computed tomography,magnetic resonance imaging)and endoscopy(endoscopic ultrasound and cholangioscopy)has the potential to significantly improve early diagnosis and the choice of optimal therapeutic options,leading to a transformation in the prognosis of this feared *** this review we summarize the current knowledge on the use of AI for the diagnosis and management of cholangiocarcinoma and point to future directions in the field.

关键词： Cholangiocarcinoma Artificial intelligence Cholangioscopy Artificial neural network Machine learning Therapeutic endoscopy Endoscopic ultrasound

Current landscape in motoneuron regeneration and reconstruction for motor cranial nerve injuries

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Neural regeneration research 2020年第9期15卷 1639-1649页

作者： Yanjun Xie Kevin j.Schneider Syed A.Ali Norman D.Hogikyan Eva L.Feldman Michael j.brenner Department of Otolaryngology-Head and Neck Surgery University of Michigan Medical SchoolAnn ArborMIUSA Department of Neurology University of Michigan Medical SchoolAnn ArborMIUSA

The intricate anatomy and physiology of cranial nerves have inspired clinicians and scientists to study their roles in the nervous system. Damage to motor cranial nerves may result from a variety of organic or iatrogenic insults and causes devastating functional impairment and disfigurement. Surgical innovations directed towards restoring function to injured motor cranial nerves and their associated organs have evolved to include nerve repair, grafting, substitution, and muscle transposition. In parallel with this progress, research on tissue-engineered constructs, development of bioelectrical interfaces, and modulation of the regenerative milieu through cellular, immunomodulatory, or neurotrophic mechanisms has proliferated to enhance the available repertoire of clinically applicable reconstructive options. Despite these advances, patients continue to suffer from functional limitations relating to inadequate cranial nerve regeneration, aberrant reinnervation, or incomplete recovery of neuromuscular function. These shortfalls have profound quality of life ramifications and provide an impetus to further elucidate mechanisms underlying cranial nerve denervation and to improve repair. In this review, we summarize the literature on reconstruction and regeneration of motor cranial nerves following various injury patterns. We focus on seven cranial nerves with predominantly efferent functions and highlight shared patterns of injuries and clinical manifestations. We also present an overview of the existing reconstructive approaches, from facial reanimation, laryngeal reinnervation, to variations of interposition nerve grafts for reconstruction. We discuss ongoing endeavors to promote nerve regeneration and to suppress aberrant reinnervation and the development of synkinesis. Insights from these studies will shed light on recent progress and new horizons in understanding the biomechanics of peripheral nerve neurobiology, with emphasis on promising strategies for optimizing

关键词： axon degeneration cranial neuropathy facial nerve facial paralysis motoneuron nerve regeneration peripheral nerve recurrent laryngeal nerve synkinesis vocal fold paralysis

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Changing the paradigm：the potential for targeted therapy in laryngeal squamous cell carcinoma

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Cancer Biology & Medicine 2016年第1期13卷 87-100页

作者： Megan L.Ludwig Andrew C.Birkeland rebecca Hoesli Paul Swiecicki Matthew E.Spector j.Chad brenner Department of Otolaryngology Head and Neck SurgeryUniversity of Michigan Medical SchoolAnn ArborMI 48109USA Cellular and Molecular Biology Program University of MichiqanAnn ArborMI 48109USA Department of Hematology Oncology University of Michigan Medical SchoolAnn ArborMI 48109USA Comprehensive Cancer Center University of Michigan Medical SchoolAnn ArborMI 48109USA

Laryngeal squamous cell carcinoma(LSCC) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past few decades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LSCC may be an ideal disease for consideration of further treatment stratification and personalization. Here, we will discuss the important history of LSCC as a model system for organ preservation, unique and potentially targetable genetic signatures of LSCC, and methods for bringing stratified, personalized treatment strategies to the 21^(st) century.

关键词：鳞状细胞癌靶向治疗个性化癌症治疗模型系统疾病历史保存

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Survival trends of patients with non-metastatic gastric adenocarcinoma in the US and European countries:the impact of decreasing resection rates

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Cancer Communications 2022年第7期42卷 648-662页

作者： Lei Huang Lina jansen rob H.A.Verhoeven jelle P.ruurda Liesbet Van Eycken Harlinde De Schutter jan johansson Mats Lindblad Tom B.johannesen Vesna Zadnik Tina Zagar Sjoerd M.Lagarde Cornelis j.Hvan de Velde Petra Schrotz-King Hermann brenner Division of Clinical Epidemiology and Aging research German Cancer Research Center(DKFZ)Heidelberg 69120Germany Medical Faculty Heidelberg of Heidelberg University Heidelberg 69120Germany German Cancer Consortium German Cancer Research CenterHeidelberg 69120Germany Department of research&Development Netherlands Comprehensive Cancer OrganizationUtrecht 3501 DBThe Netherlands Department of Medical Oncology Amsterdam University Medical CentersAmsterdam 1105 AZThe Netherlands Department of Surgery University Medical Center UtrechtUtrecht 3508 GAThe Netherlands Belgian Cancer registry Brussels B-1210Belgium Department of Esophageal and Gastric Surgery Lund University HospitalLund 22185Sweden Department of Clinical Science Interventionand TechnologyDivision of SurgeryKarolinska University HospitalStockholm 17176Sweden registry Department The Cancer Registry of NorwayOslo 0379Norway Epidemiology and Cancer registry Institute of Oncology LjubljanaLjubljana 1000Slovenia Department of Surgery Erasmus Medical Centre-University Medical Centre RotterdamRotterdam 3015 CEThe Netherlands Department of Surgical Oncology Leiden University Medical CenterLeiden 2300 RCThe Netherlands Division of Preventive Oncology German Cancer Research Center and National Center for Tumor DiseasesHeidelberg 69120Germany

Background:We previously observed decreasing resection rates of nonmetastatic gastric adenocarcinoma(GaC)in the US and some European *** and to what extent these trends affect the trends in overall survival(OS)of patients with non-metastatic GaC at the population level remain *** large international population-based cohort study aimed to assess the impact of the previously observed decreasing resection rates on multivariable-adjusted trends in the long-term OS of patients with non-metastatic ***:Individual-level data of patients with non-metastatic GaC were obtained from the national cancer registries of the Netherlands,Belgium,Sweden,Norway,and Slovenia,and the US Surveillance,Epidemiology,and End results *** analyzed data for each country *** between year of diagnosis and OS were assessed using Cox proportional hazards regression model with adjustment for multiple prognostic variables,with and without including resection and chemotherapy as potential explanatory ***:A total of 66,398 non-metastatic GaC patients diagnosed in 2003-2016 were analyzed,with an accumulated follow-up of 172,357 *** adjustment for resection,OS was improved only slightly in the US[hazard ratio(Hr)_(per year)=0.99;Hr_(≥vs.rovement was observed in the investigated European countries,with OS even worsening in Sweden(Hr_(per year)=1.03;Hr_(≥vs.r adjusting for resection,the increasing OS trend became stronger in the US(Hr_(per year)=0.98;Hr_(≥vs.ral trend became insignificant in *** Slovenia(Hr_(per year)=0.99;Hr_(≥vs.rway(Hr_(per year)=0.97;Hr_(≥vs.roved OS over time emerged after resection *** OS in patients undergoing resection was observed in the US,the Netherlands,and *** for chemotherapy did not alter the observed *** analyses by tumor location showedm

关键词： gastric adenocarcinoma resection rate adjusted overall survival temporal trend prognostic factors international population-based cohort study