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Field-resolved high-order sub-cycle nonlinearities in a terahertz semiconductor laser

Light(Science & Applications) 2021年第12期10卷 2531-2540页

作者： J.riepl J.raab P.Abajyan H.Nong J.r.Freeman L.H.Li E.H.Linfield A.G.Davies A.Wacker T.Albes C.Jirauschek C.Lange S.S.Dhillon r.huber Department of Physics University of RegensburgRegensburgGermany Laboratoire de Physique de l’Ecole Normale Supérieure ENSUniversitéPSLCNRSSorbonne UniversitéUniversitéde ParisParisFrance School of Electronic and Electrical Engineering University of LeedsWoodhouse LaneLeedsUK Mathematical Physics and NanoLund Lund UniversityLundSweden Department of Electrical and Computer Engineering Technical University of MunichMunichGermany Department of Physics TU Dortmund UniversityDortmundGermany

The exploitation of ultrafast electron dynamics in quantum cascade lasers(QCLs)holds enormous potential for intense,compact mode-locked terahertz(THz)sources,squeezed THz light,frequency mixers,and comb-based metrology *** the important sub-cycle dynamics have been notoriously difficult to access in operational THz ***,we employ high-field THz pulses to perform the first ultrafast two-dimensional spectroscopy of a free-running THz *** incoherent and coherent nonlinearities up to eight-wave mixing are detected below and above the laser *** data not only reveal extremely short gain recovery times of 2 ps at the laser threshold,they also reflect the nonlinear polarization dynamics of the QCL laser transition for the first time,where we quantify the corresponding dephasing times between 0.9 and 1.5 ps with increasing bias currents.A density-matrix approach reproducing the emergence of all nonlinearities and their ultrafast evolution,simultaneously,allows us to map the coherently induced trajectory of the Bloch *** observed high-order multi-wave mixing nonlinearities benefit from resonant enhancement in the absence of absorption losses and bear potential for a number of future applications,ranging from efficient intracavity frequency conversion,mode proliferation to passive mode locking.

关键词： polarization mixer cycle

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Indicators of global sustainable sourcing as a set covering problem:an integrated approach to sustainability

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Ecosystem Health and Sustainability 2015年第2期1卷 12-20页

作者： Patrick r.huber Nathaniel P.Springer Allan D.Hollander V.ryan Haden Sonja Brodt Thomas P.Tomich James F.Quinn Information Center for the Environment University of CaliforniaDavisCalifornia 95616 USA Agricultural Sustainability Institute University of CaliforniaDavisCalifornia 95616 USA

Sustainability describes a broad set of themes centered on current human uses of the planet’s *** multiple uses and users of the term have led to a proliferation of salient issues and associated *** present a new method to systematically link these issues and indicators under two conceptual frameworks of sustainability in order to enable quantitative *** demonstrate this approach with a specific use case focused on the global sourcing of agricultural *** use the optimization software Marxan in a novel way to develop minimum sets of indicators that provide maximum coverage of sustainability *** covering sets were identified and accumulation curves were developed to measure the contribution of each indicator in each set to overall issues *** greater detail in the assessment of each indicator would likely provide more effective sets of indicators,those that were generated provide optimism that this approach can bring better focus to sustainability assessments.

关键词： global sourcing indicators Marxan software minimum covering set optimization sustainability

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以热喷涂为例阐述标准对工业的益处

以热喷涂为例阐述标准对工业的益处

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中国表面工程协会热喷涂专业委员会热喷涂技术交流会

作者： B.Schambch D.Bhme r.huber 张艳玲 (德国)德国标准化学会 (德国)SLV慕尼黑NL GSI 公司

1.前言随着社会变得越来越复杂化、学术化,影响社会的规则也越来越复杂。由于一些特殊规则变得更加具体,对这些规则的要求也更高。近来受全球化影响,标准化变得越来越重要,标准化成为这条路上的一个重要组成部分。2.标准对今天有那些影...

1.前言随着社会变得越来越复杂化、学术化,影响社会的规则也越来越复杂。由于一些特殊规则变得更加具体,对这些规则的要求也更高。近来受全球化影响,标准化变得越来越重要,标准化成为这条路上的一个重要组成部分。2.标准对今天有那些影响?标准辅助全球化这意味着:全球化是全世界的进步。

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Machine Learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

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Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

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A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAUrABH r.KIrAN D.SINGH r.VAISH V.S.CHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(Hr), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural regeneration research 2025年第3期20卷 803-804页

作者： Glenn A.Harris Lauren r.Hirschfeld rainwater Charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3r) or 4-repeat(4r) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

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In situ characterization of particle formation in spray flame synthesis using wide-angle light scattering

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Particuology 2024年第3期86卷 304-312页

作者： Simon Aβmann Franz J.T.huber Stefan Will Lehrstuhl für Technische Thermodynamik(LTT) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91058Germany Erlangen Graduate Schoolin Advanced Optical Technologies(SAOT) Friedrich-Alexander-Universitat Erlangen-Nurnberg(FAU)Erlangen91052Germany Competence Unit Engineering of Advanced Materials(EAM) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91052Germany

Wide-angle light scattering(WALS)was used for in situ measurements of droplet and nanoparticle size distributions during the synthesis of titania and iron oxide particles from liquid precursor solutions in the standardized SpraySyn burner for spray flame *** was synthesized from titanium tetraisopropoxide(TTIP)and iron oxide from iron(II)nitrate nonahydrate(INN)using ethanol(EtOH)as *** images were taken at heights up to 120 mm above the burner surface and classified into droplet and particle *** size distributions were derived from a sequential analysis of scattering data containing the oscillating Mie pattern,the lognormal size distribution parameters for spherical and fractal particle fractions from a multivariate approach on averaged particle scattering *** results show that the precursor addition leads to altered evaporation behavior and even droplet disruption probably induced by puffing or micro-explosions compared to pure *** the case of TTIP(a hygroscopic alkoxide),the synthesis of a large fraction of spheres was observed,while the nitrate INN leads to the formation of mostly fractal aggregates.

关键词： Spray flame synthesis Metal oxide particles Elastic light scattering Droplet size distribution Nanoparticle morphology Particle size distribution

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Methyltransferase-like 3(METTL3)inhibition potentiates anti-tumor immunity:a novel strategy for improving anti-PD1 therapy

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Signal Transduction and Targeted Therapy 2024年第1期9卷 10-11页

作者： Anna Brichkina roman Suezov Magdalena huber Institute of Systems Immunology Member of the German Center for Lung Research(DZL)Philipps University of Marburg35043 MarburgGermany

In a recent article published in Cancer Discovery,Guirguis et *** that enzymatic inhibitors of the m6 A methyltransferase METTL3 induced a formation of immunostimulatory doublestranded mrNAs(dsrNAs)in cancer cells,which triggered a profound tumor-cell-intrinsic interferon response leading to an enhanced antigen presentation and thereby increased killing of tumor cells by cytotoxic CD8+*** inhibition of METTL3 synergized with anti-PD1 immunotherapy,highlighting its potential for improving cancer treatment.

关键词： PD1 immunity

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No evidence of contagious yawning in the red-footed tortoise Geochelone carbonaria

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Current Zoology 2011年第4期57卷 477-484页

作者： Anna WILKINSON Natalie SEBANZ Isabella MANDL Ludwig huber Department of Cognitive Biology University of Vienna Althanstrasse 14 Vienna 1090 Austria Department of Biological Sciences University of Lincoln Lincoln LN2 2LG UK Donders Institute for Brain Cognition and Behavior Centre for Cognition Radboud University Nijmegen P.O. Box 9104 6500 HE Nijmegen The Netherlands

Three hypotheses have attempted to explain the phenomenon of contagious yawning. It has been hypothesized that it is a fixed action pattern for which the releasing stimulus is the observation of another yawn, that it is the result of non-conscious mimicry emerging through close links between perception and action or that it is the result of empathy, involving the ability to engage in mental state attribution. This set of experiments sought to distinguish between these hypotheses by examining contagious yawning in a species that is unlikely to show nonconscious mimicry and empathy but does respond to social stimuli： the red-footed tortoise Geochelone carbonaria. A demonstrator tortoise was conditioned to yawn when presented with a red square-shaped stimulus. Observer tortoises were exposed to three conditions： observation of conditioned yawn, non demonstration control, and stimulus only control. We measured the number of yawns for each observer animal in each condition. There was no difference between conditions. Experiment 2 therefore increased the number of conditioned yawns presented. Again, there was no significant difference between conditions. It seemed plausible that the tortoises did not view the conditioned yawn as a real yawn and therefore a final experiment was run using video recorded stimuli. The observer tortoises were presented with three conditions： real yawn, conditioned yawns and empty background. Again there was no significant difference between conditions. We therefore conclude that the red-footed tortoise does not yawn in response to observing a conspecific yawn. This suggests that contagious yawning is not the result of a fixed action pattern but may involve more complex social processes [Current Zoology 57 （4）： 477-484, 2011].

关键词： reptile Contagious yawn Empathy Nonconscious mimicry Fixed action pattern

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