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Additively manufactured Ti–Ta–Cu alloys for the next-generation load-bearing implants

International Journal of Extreme Manufacturing 2024年第1期6卷 353-374页

作者： Amit bandyopadhyay Indranath Mitra Sushant Ciliveri Jose D Avila William Dernell Stuart b Goodman Susmita bose W.M.Keck biomedical Materials research Laboratory School of Mechanical and Materials EngineeringWashington State UniversityPullmanWA 99164United States of America Veterinary Clinical Sciences College of Veterinary MedicineWashington State UniversityPullmanWA 99164United States of America Department of Orthopedic Surgery Stanford University Medical CenterRedwood CityCA 94063United States of America

bacterial colonization of orthopedic implants is one of the leading causes of failure and clinical complexities for load-bearing metallic implants. Topical or systemic administration of antibiotics may not offer the most efficient defense against colonization, especially in the case of secondary infection, leading to surgical removal of implants and in some cases even limbs. In this study, laser powder bed fusion was implemented to fabricate Ti3Al2V alloy by a 1:1 weight mixture of CpTi and Ti6Al4V powders. Ti-Tantalum(Ta)–Copper(Cu) alloys were further analyzed by the addition of Ta and Cu into the Ti3Al2V custom alloy. The biological,mechanical, and tribo-biocorrosion properties of Ti3Al2V alloy were evaluated. A 10 wt.% Ta(10Ta) and 3 wt.% Cu(3Cu) were added to the Ti3Al2V alloy to enhance biocompatibility and impart inherent bacterial resistance. Additively manufactured implants were investigated for resistance against Pseudomonas aeruginosa and Staphylococcus aureus strains of bacteria for up to 48 h. A 3 wt.% Cu addition to Ti3Al2V displayed improved antibacterial efficacy, i.e.78%–86% with respect to CpTi. Mechanical properties for Ti3Al2V–10Ta–3Cu alloy were evaluated, demonstrating excellent fatigue resistance, exceptional shear strength, and improved tribological and tribo-biocorrosion characteristics when compared to Ti6Al4V. In vivo studies using a rat distal femur model revealed improved early-stage osseointegration for alloys with10 wt.% Ta addition compared to CpTi and Ti6Al4V. The 3 wt.% Cu-added compositions displayed biocompatibility and no adverse infammatory response in vivo. Our results establish the Ti3Al2V–10Ta–3Cu alloy’s synergistic effect on improving both in vivo biocompatibility and microbial resistance for the next generation of load-bearing metallic implants.

关键词： Ti6Al4V load-bearing implants additive manufacturing 3D printing antibacterial performance

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Clinical features of gastroesophageal reflux disease and erosive esophagitis:Insights from patients undergoing esophagogastroduodenoscopy in resource-limited Ethiopia

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World Journal of Gastroenterology 2024年第34期30卷 3883-3893页

作者： Firehiwot A Mengistie Abate b Shewaye Abel T Tasamma Zekarias S Ayalew Department of Internal Medicine Addis Ababa UniversityAddis Ababa 1176Addis AbabaEthiopia Department of Internal Medicine Rheum Rheumatology and Internal Medicine Specialty ClinicAddis Ababa 1000Addis AbabaEthiopia Division of Gastroenterology and hepatology Department of Internal MedicineAdera Medical and Surgical CenterAddis Ababa 1000Addis AbabaEthiopia

bACKGrOUND Gastroesophageal reflux disease(GErD)is a common disease worldwide with varying clinical presentations and risk *** data for Africa is lacking,but an increasing trend is expected due to demographic and epidemiological *** endoscopic studies for general gastrointestinal disorders have shown some patients with erosive esophagitis(EE),no studies in Ethiopia have investigated the clinical characteristics,risk factors,and severity of GErD using esophagogastroduodenoscopy(EGD).AIM To assess the clinical features of GErD in Ethiopian patients who underwent EGD and determine the severity and risk factors of *** We conducted a multicenter,retrospective cross-sectional study of 221 patients diagnosed with GErD and endoscopic findings of EE at Trauma Associated Severe hemorrhage and Amniotic Membrane Stem Cell between January 2019 and August *** were collected from electronic medical records and phone call *** used descriptive statistics and binary logistic regression analysis with SPSS version 26 to identify the association between variables with a statistical significance set at P valuehe mean±SD age of the patients was 44.8(±15.9)years,with a male-to-female ratio of 1.6:*** most commonly reported symptom was epigastric pain(80.5%),followed by heartburn(43%).Los Angeles(LA)-A EE was diagnosed in 71.1%of patients,followed by LA-b(14.9%),LA-C(7.7%),and LA-D(5.9%).Multivariate analysis showed that age 50 or above,presence of bleeding,and endoscopic findings of duodenitis/duodenopathy were significantly associated with severe EE(Pricture and barrett’s esophagus were observed in 4.5%and 1.36%of patients with EE,*** Most of the patients had milder EE with fewer ***,severe EE was more prevalent in older patients and those with duodenitis/duodenopathy.

关键词： Gastroesophageal reflux disease Erosive esophagitis hiatal hernia Esophagogastroduodenoscopy heart burn

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Net effect of air pollution controls on health risk in the beijing-Tianjin-hebei region during the 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： Changqing Lin Peter K.K.Louie Alexis K.h.Lau Jimmy C.h.Fung Zibing Yuan Minghui Tao Xuguo Zhang Md.Shakhaoat hossain Chengcai Li Xiang Qian Lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of Environment and Energy South China University of TechnologyGuangzhou 510006China hubei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public health and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jockey Club School of Public health and Primary Care The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reducing the emission of nitrogen oxides(NO_(x))may increase O_(3) *** the counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous when the assessments focus on the changes in pollutant *** this study,a risk-based method was used to gauge the net effect of air pollution controls on mortality risk in the beijing–Tianjin–hebei(bTh)region during the 2022 Winter Olympics and Paralympics(WOP).This mega-event presents a unique opportunity to investigate the efficacy of deep cuts in pollutant *** show that O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in the *** to the active photochemical formations,O_(3) became the dominant pollutant that affected human health during the *** the substantial O_(3) increases,the health benefits of NO_(2) reductions overwhelmed the adverse health effects of O_(3) increases in most regions of the bTh(at 81 out of 112 stations).After considering the impacts of particulate matter,the integrated health risk of air pollution mixtures declined almost everywhere in the *** results underscore the great necessity of changing the assessment paradigm of pollution control from using concentration-based methods to using risk-based *** with the carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to achieve synergistic control solutions for air pollution and climate change.

关键词： Ozone Nitrogen dioxide health risk Carbon neutrality Mega-events

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非线性扩散-对流反应中的行进波

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国外科技新书评介 2005年第2期 1-2页

作者： b．h．吉尔丁 r．克斯奈胡作玄不详中国科学院系统科学研究所

行进波可在许多自然过程中观察到(如：疾病传播、燃料燃烧等)，本书刻划了在非线性扩散-对流反应方程所描述的现象中这类波的特性。作者使用了一种新的积分方程方法，得出许多过去不可能得到的新结果，其中包括退化扩散和非线性对流的... 详细信息

行进波可在许多自然过程中观察到(如：疾病传播、燃料燃烧等)，本书刻划了在非线性扩散-对流反应方程所描述的现象中这类波的特性。作者使用了一种新的积分方程方法，得出许多过去不可能得到的新结果，其中包括退化扩散和非线性对流的效应，

关键词：非线性扩散行进波对流积分方程方法疾病传播自然过程燃料燃烧反应方程

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Long Term X-ray Spectral Variations of the Seyfert-1 Galaxy Mrk 279

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research in Astronomy and Astrophysics 2024年第6期24卷 307-314页

作者： K.Akhila ranjeev Misra Savithri h.Ezhikode K.Jeena Department of Physics Providence Women’s CollegeUniversity of CalicutKerala 673009India Inter-University Centre for Astronomy and Astrophysics(IUCAA) PB No.4GaneshkhindPune 411007India Department of Physics and Electronics CHRIST(Deemed to be University)Hosur Main RoadBangalore 560029India

We present the results from a long term X-ray analysis of Mrk 279 during the period 2018–*** use data from multiple missions–AstroSat,NuSTAr and XMM-Newton,for the *** X-ray spectrum can be modeled as a double Comptonization along with the presence of neutral Fe Kαline emission,at all *** determined the source’s X-ray flux and luminosity at these different *** find significant variations in the source’s flux *** also investigate the variations in the source’s spectral components during the observation *** find that the photon index and hence the spectral shape follow the variations only over longer time *** probe the correlations between fluxes of different bands and their photon indices,and found no significant correlations between the parameters.

关键词： galaxies:Seyfert galaxies:individual(Mrk 335) X-rays:galaxies

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替萘普酶治疗轻度急性缺血性卒中患者的临床研究

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中国临床药理学杂志 2024年第14期40卷 2027-2027页

作者： COUTTS S b 孟海峰

本研究为一项多中心、前瞻性、平行、开放、盲法结果评估、随机对照试验。多个国家共48家医院的成年患者被纳入研究。研究对象为轻度急性缺血性卒中(美国国立卫生研究院卒中量表评分0~5)和颅内闭塞或局灶性灌注异常患者,在卒中发作后12... 详细信息

本研究为一项多中心、前瞻性、平行、开放、盲法结果评估、随机对照试验。多个国家共48家医院的成年患者被纳入研究。研究对象为轻度急性缺血性卒中(美国国立卫生研究院卒中量表评分0~5)和颅内闭塞或局灶性灌注异常患者,在卒中发作后12h内入组。患者入组后按照1:1的比例被随机分为对照组与试验组,对照组接受常规的非溶栓治疗。

关键词：急性缺血性卒中卒中发作美国国立卫生研究院卒中量表评分成年患者灌注异常随机对照试验盲法结果评估

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英汉法德管道工程词汇第1版

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1982年

作者： h.勃克许等冯亮译

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ISBN: (数字)7362762506

ISBN: (纸本)15037·2235

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关键词：交通运输综合运输管道运输

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recent Ventures in Interdisciplinary Arctic research:The ArCPATh Project

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Advances in Atmospheric Sciences 2024年第8期41卷 1559-1568页

作者： Astrid E.J.OGILVIE Leslie A.KING Noel KEENLYSIDE François COUNILLON brynhildur DAVIÐSDÓTTIr Níels EINArSSON Sergey GULEV Ke FAN Torben KOENIGK James r.MCGOODWIN Marianne h.rASMUSSON Shuting YANG Institute of Arctic and Alpine research(INSTAAr) University of ColoradoBoulder CO 80303USA Stefansson Arctic Institute AkureyriÍS-600Iceland royal roads University BC V9B 5Y2Canada University of bergen Bergen N-5007Norway Nansen Environmental and remote Sensing Centre Bergen N-5007Norway University of Iceland Reykjavík 102Iceland Shirshov Institute of Oceanology Moscow 117218Russia Moscow State University Moscow 11991Russia Chinese Academy of Sciences Beijing 100045China Swedish Meteorological and hydrological Institute SE-60176 NorrköpingSweden Danish Meteorological Institute CopenhagenØ2100Denmark Obukhov Institute of Atmospheric Physics RAS119017MoscowRussia

This paper celebrates Professor Yongqi GAO's significant achievement in the field of interdisciplinary studies within the context of his final research project Arctic Climate Predictions: Pathways to resilient Sustainable Societies-ArCPATh(https://***/en/projects/finished-projects/arcpath). The disciplines represented in the project are related to climatology, anthropology, marine biology, economics, and the broad spectrum of social-ecological studies. Team members were drawn from the Nordic countries, russia, China, the United States, and Canada. The project was transdisciplinary as well as interdisciplinary as it included collaboration with local knowledge holders. ArCPATh made significant contributions to Arctic research through an improved understanding of the mechanisms that drive climate variability in the Arctic. In tandem with this research, a combination of historical investigations and social, economic, and marine biological fieldwork was carried out for the project study areas of Iceland, Greenland, Norway, and the surrounding seas, with a focus on the joint use of ocean and sea-ice data as well as social-ecological drivers. ArCPATh was able to provide an improved framework for predicting the near-term variation of Arctic climate on spatial scales relevant to society, as well as evaluating possible related changes in socioeconomic realms. In summary, through the integration of information from several different disciplines and research approaches, ArCPATh served to create new and valuable knowledge on crucial issues, thus providing new pathways to action for Arctic communities.

关键词： recent Ventures in Interdisciplinary Arctic research:The ArCPATh Project

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哈佛商学院不会教你的商业策略

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2019年

作者： (美) 马克·h.麦考梅克

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Assessment of bisphenols in children's toy and baby products in the Middle East

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Emerging Contaminants 2024年第3期10卷 336-342页

作者： K.Martínez-Guijarro b.Gevao M.Porcelli S.Al-Salem Saif Uddin M.bahloul h.Taqi M.hajeyah D.Krishnan S.rajagopalan A.boota Environment Pollution and Climate Program Kuwait Institute for Scientific ResearchP.O.Box 23884SafatKuwait EPA Sierra Leone

A major concern from the scientific community has been raised since evidence of bisphenol A(bP-A)can leach out from the products where they are incorporated as well as its endocrine disrupting effects observed in animals and ***-A and several related chemicals such as bisphenol AP(bP-AP),bisphenol b(bPeb),bisphenol S(bPeS),bisphenol AF(bP-AF),bisphenol(bPeP),bisphenol Z(bP-Z)were analyzed in this ***-A and bP-S were the only bisphenols detected in the samples analyzed in this *** median(range;mean)concentrations of bP-A found in this study was 321 ng/g(11-200932;4893 ng/g).The analysis was carried out by sonicating 0.1 g of a cryo-milled sample aliquot in methanol followed by UPLC-MS/MS *** concentrations of bP-A were found in several products labeled as bP-A free such as nursing bottles which are particularly problematic from the children's exposure point of *** study presents the first reliable bisphenols in children's toys and baby products commercialized in the Middle *** is,however,a need to continue monitoring these compounds,especially in low-cost toys,and the so-called bP-A-free products,which appear to have high levels of target contaminants and can pose an exposure risk for infants and children in the region.

关键词： bisphenols bisphenol A(bP-A) bisphenol S(bPeS) Children Toys

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