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Silicon-based metal-organic frameworks(SiMOFs)for immunogenic cell death in cancer therapy

Nano research 2025年第1期18卷 628-641页

作者： Min han Zishan Chen Shiying Zhou Zunde Liao Xiangting Yi Yao he Yiling Zhong Kam w.Leong College of Pharmacy State Key Laboratory of Bioactive Molecules and Druggability AssessmentJinan UniversityGuangzhou 511443China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA Institute of Functional Nano and Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China

Silicon-based nanomaterials,known for their unique properties and favorable biocompatibility,significantly impact sectors like energy,electronics,and ***,metalorganic frameworks(MOFs)have emerged as promising candidates for biomedicine,characterized by adjustable chemical composition,high porosity,and ***,the combination of silicon with MOFs to create silicon-based MOF nanostructures(SiMOFs)remains ***,we establish a diverse library of SiMOFs with various nanostructures,including flower-like,capsule-like,hexagonal snowflake-like,and necklace-like morphologies via microwave-assisted *** SiMOFs,with their spacious interiors,are ideal for drug *** are used to load drugs and create drug-loaded SiMOFs(e.g.,SiFeO).SiFeO exhibits excellent photothermal effects and high reactive oxygen species(rOS)generation capacity,enabling synergistic treatments involving chemochemodynamic-photothermal *** approach efficiently triggers immunogenic cell death(ICD)and demonstrates excellent antitumor efficacy in *** staining reveals that the synergistic therapy can modulate the tumor microenvironment(TME)by reducing M2-phenotype macrophages,increasing the activation of antigen-presenting cells(APCs),enhancing the infiltration of CD4^(+)and CD8^(+)T cells,elevating Granzyme B production,and decreasing the presence of immunosuppressive regulatory T cells(Tregs).Consequently,drug-loaded SiMOFs-mediated combination therapy effectively reverses the immunosuppressive TME and activates robust antitumor immune responses by inducing ICD in tumor cells,ultimately achieving superior anticancer efficacy.

关键词： silicon-based nanomaterials nanocarriers immunogenic cell death antitumor immune responses

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Improving the hard magnetic properties by intragrain pinning for Ta doped nanocrystalline Ce-Fe-B alloys

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Journal of Materials Science & Technology 2019年第9期35卷 1877-1885页

作者： J.S.Zhang w. Li X.F. Liao h.Y. Yu L.Z. Zhao h.X. Zeng D.r. Peng Z.w. Liu School of Materials Science and Engineering South China University of TechnologyGuangzhou510640China Innovative Center for Advanced Materials (ICAM) Hangzhou Dianzi UniversityHangzhou310012China

To develop Ce based permanent magnets with high performance/cost ratio, Ta doping is was employed to enhance the magnetic performance of Ce-Fe-B alloys. For melt spun Cei7Fe78-xTaxB6 (x = 0-1) alloys, the coercivity hc increases from 439 to 553 kA/m with increasing x value from 0 to 0.75. Microstructure characterizations indicate that Ta doping is helpful for grain refinement. A second phase of TaB2 is observed in Ce17Fe77.25Tao.75B6 alloy, which acts as the pinning center of the magnetic domains, resulting in the change of coercivity mechanism from nucleation type to nucleation +pinning type. The micromagnetic simulation confirms that non-magnetic particles within hard magnetic phase can increase the demagnetization field around them and it is crucial for preventing the further magnetization reverse by pinning effect. Take the advantage of Ta doping for enhancing the coercivity, Ce content of Ce-Fe-B alloy can be further cut down to increase the remanence Jr due to the reduced volume fraction of CeFe2 phase and increased Fe/Ce ratio. As a result, a good combination of magnetic properties with hc = 514 kA/m, Jr = 0.49 T, and the maximum energy product (Bh)max = 36 kJ/m^3 have been obtained in Ce15Fe79.25Tao.75B6 alloy. It is expected that the present work can serve as a useful reference for designing new permanent magnetic materials with low-cost.

关键词： Melt-spinning Permanent magnets Second phase Coercivity mechanism Thermal stability

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Brillouin Lasing with a reduced Self-Pulsing Characteristic Using a Short-Length Erbium-Doped Fiber as the Nonlinear Gain Medium

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Chinese Physics Letters 2014年第5期31卷 61-64页

作者： A. Zarei r. Z. r. r. rosdin N. M. All h. Ahmad S. w. harun Department of Electrical Engineering University of Malaya Kuala Lumpur 50603 Malaysia Photonics research Centre University of Malaya Kuala Lumpur 50603 Malaysia

A single-wavelength Brillouin laser is demonstrated by using a 3-m-long erbium doped fiber （EDF） in a ring cavity. The EDF is used to provide both nonlinear and linear gains to generate a stimulated Brillouin scattering （SBS） and to amplify the generated SBS, respectively. The Brillouin erbium fiber laser （BEFL） operates at 1561.5 nm, where the operating wavelength is up-shifted by 0.08nm from the Brillouin pump. The operation wavelength is also tunable within 1560.6-1562.6nm. The BEFL Mso shows a self-pulsing characteristic with repetition of 66. 7khz when the BP is set around the threshold pump power of 13row. Compared to the conventional Brillouin fiber laser with a long cavity length, the proposed BEFL exhibits a significantly lower amplitude of pulse. This laser has many potential applications, such as in optical communication and sensors.

关键词： Stimulated Brillouin scattering

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Assessment of predatory ability of native and non-native freshwater gammaridean species： A rapid test with water fleas as prey

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Current Zoology 2011年第6期57卷 836-843页

作者： B.E.M.w. STOFFELS J.S. TUMMErS G. VAN DEr VELDE D. PLATVOET h.w.M. hENDrIKS r.S.E.w. LEUVEN radboud University Nijmegen Institute for Water and Wetland Research Department of Animal Ecology and Ecophysiology Heyendaalseweg 135 NL-6525 AJ Nijmegen The Netherlands Netherlands Centre for Biodiversity Naturalis P.O. Box 9517 NL-2300 RA Leiden The Netherlands Netherlands Centre for Biodiversity Naturalis Mauritskade 57 NL-1092 AD Amsterdam The Netherlands radboud University Nijmegen Faculty of Science Department of Mathematics Heyendaalseweg 135 NL-6525 AJ Nijmegen The Netherlands radboud University Nijmegen Institute for Water and Wetland Research Department of Environmental Science Heyendaal seweg 135 NL-6525 AJ Nijrnegen The Netherlands

Predation rate with relation to species, sex and water temperature was tested among four different gammaridean spe- cies： Dikerogammarus villosus, Gammarus roeselii, Gammarus pulex and Gammarus fossarum. Tests were performed in micro- cosms in climate-controlled rooms at five different temperatures. Daphnia magna, a common water flea, served as prey. On ave- rage D. villosus showed the highest consumption rate of Daphnia magna over the entire temperature range, followed in decreas- ing order by G pulex, G roeselii and G fossarum. The predation rate of all species showed a distinct peak at 20~C. Correction of predation rates for body size gave somewhat different results. D. villosus is then still the most predatory of all gammaridean spe- cies tested followed by G. pulex, G. fossarum and G roeselii. The outcome of the Daphnia tests is consistent with results of other studies with different prey. This supports that the Daphnia test is a good and quick indicator of the predatory abilities in gam- maridean species at varying temperatures, and allows the prediction of how changing temperature regimes influence invasion impacts

关键词： Daphnia Temperature Predation rate Amphipods Invasions

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A Passively Mode-Locked Erbium-Doped Fiber Laser Based on a Single-wall Carbon Nanotube Polymer

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Chinese Physics Letters 2013年第5期30卷 85-88页

作者： F.Ahmad S.w.harun r.M.Nor N.r.Zulkepely h.Ahmad P.Shum Department of Electrical Engineering Faculty of EngineeringUniversity of Malaya50603Kuala LumpurMalaysia Department of Electrical Engineering Universiti Teknologi MalaysiaKuala 54100 LumpurMalaysia Photonics research Centre University of MalayaKuala Lumpur 50603Malaysia Department of Physics University of MalayaKuala Lumpur 50603Malaysia OPTIMUS School of Electrical and Electronics EngineeringNanyang Technological UniversitySingapore 639798Singapore

we demonstrate a simple,compact and low-cost mode-locked erbium-doped fiber laser(EDFL)using a single-wall carbon nanotube(SwCNT)poly-ethylene oxide(PEO)composite as a passive saturable absorber(SA).The composite with an SwCNT concentration of 18wt%is prepared by mixing the SwCNT homogeneous solution with a diluted PEO polymer solution.A droplet of the polymer composite is applied on the fiber ferrule end,which is then mated to another clean ferrule connector to construct an *** SA is then integrated into the laser system to self-start stable mode locking at 1557 nm without employing a polarization *** EDFL generates a stable soliton pulse train with a duration of 0.81 ps,repetition rate of 44 Mhz and average output power of 92.4μw at a 980 nm pump power of 26.8 *** soliton laser starts to lase at a pump power threshold of 14.6 mw.

关键词： pump fiber polarization

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The Unified Coordinate System in Computational Fluid Dynamics

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Communications in Computational Physics 2007年第4期2卷 577-610页

作者： w.h.hui Division of Mechanics Research Centre for Applied SciencesAcademia SinicaNankangTaipei 115Taiwan.

A fundamental issue in CFD is the role of coordinates and,in particular,the search for“optimal”*** paper reviews and generalizes the recently developed unified coordinate system(UC).For one-dimensional flow,UC uses a material coordinate and thus coincides with Lagrangian *** two-dimensional flow it uses a material coordinate,with the other coordinate determined so as to preserve mesh othorgonality(or the Jacobian),whereas for three-dimensional flow it uses two material coordinates,with the third one determined so as to preserve mesh skewness(or the Jacobian).The unified coordinate system combines the advantages of both Eulerian and the Lagrangian system and ***,the followings are shown in this paper.(a)For 1-D flow,Lagrangian system plus shock-adaptive Godunov scheme is superior to Eulerian system.(b)The governing equations in any moving multi-dimensional coordinates can be written as a system of closed conservation partial differential equations(PDE)by appending the time evolution equations–called geometric conservation laws–of the coefficients of the transformation(from Cartesian to the moving coordinates)to the physical conservation laws;consequently,effects of coordinate movement on the flow are fully accounted for.(c)The system of Lagrangian gas dynamics equations is written in conservation PDE form,thus providing a foundation for developing Lagrangian schemes as moving mesh schemes.(d)The Lagrangian system of gas dynamics equations in two-and three-dimension are shown to be only weakly hyperbolic,in direct contrast to the Eulerian system which is fully hyperbolic;hence the two systems are not equivalent to each other.(e)The unified coordinate system possesses the advantages of the Lagrangian system in that contact discontinuities(including material interfaces and free surfaces)are resolved sharply.(f)In using the UC,there is no need to generate a body-fitted mesh prior to computing flow past a body;the mesh is automatically

关键词： Unified coordinates Eulerian coordinates Lagrangian coordinates contact discontinuities automatic mesh generation moving mesh conservation form.

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Effect of substrate temperature on the morphological,structural,and optical properties of rF sputtered Ge(1-x)Snx films on Si substrate

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Chinese Physics B 2017年第5期26卷 313-318页

作者： h Mahmodi M r hashim Nano-Optoelectronics research Laboratory School of Physics Universiti Sains Malaysia 11800 USM Pulau Penang Malaysia Institute of Nano Optoelectronics research and Technology (INOr) Universiti Sains Malaysia 11800 USM Pulau Penang Malaysia

In this study, Ge（1-x）Snx alloy films are co-sputtered on Si（100） substrates using rF magnetron sputtering at different substrate temperatures. Scanning electron micrographs, atomic force microscopy（AFM）, raman spectroscopy, and x-ray photoemission spectroscopy（XPS） are conducted to investigate the effect of substrate temperature on the structural and optical properties of grown Ge Sn alloy films. AFM results show that rMS surface roughness of the films increases from 1.02 to 2.30 nm when raising the substrate temperature. This increase could be due to Sn surface segregation that occurs when raising the substrate temperature. raman spectra exhibits the lowest FwhM value and highest phonon intensity for a film sputtered at 140℃. The spectra show that decreasing the deposition temperature to 140℃ improves the crystalline quality of the alloy films and increases nanocrystalline phase formation. The results of raman spectra and XPS confirm Ge–Sn bond formation. The optoelectronic characteristics of fabricated metal-semiconductor-metal photodetectors on sputtered samples at room temperature（rT） and 140℃ are studied in the dark and under illumination. The sample sputtered at 140℃ performs better than the rT sputtered sample.

关键词： sputtering magnetron illumination crystalline raising roughness optoelectronic phonon segregation FwhM

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Grain size and temperature effect on the tensile behavior and deformation mechanisms of non-equiatomic Fe(41)Mn(25)Ni(24)Co8Cr2high entropy alloy

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Journal of Materials Science & Technology 2020年第7期42卷 190-202页

作者： h.T.Jeong w.J.Kim Department of Materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul121-791Republic of Korea

The effect of the grain size on the tensile properties and deformation mechanisms of a nonequiatomic Fe(41)Mn(25)Ni(24)Co8 Cr2 high-entropy alloy was studied in the temperature range between 298 and 1173 K by preparing the samples with three different grain sizes through severe plastic deformation and subsequent annealing:ultrafine(sub)grain size(≤0.5μm),8.1μm and 590.2μ*** the temperature between 298 and773 K,the material with the large grain size of 590.2μm exhibited the largest tensile ductility(57%-82%)due to its high strain hardening associated with mechanical twinning,but it exhibited the lowest strength due to its large grain *** material with the ultrafine(sub)grain size exhibited the lowest tensile ductility(3%-7%)due to a greatly reduced strain hardening ability after severe plastic deformation,but it exhibited the highest strength due to the dislocation strengthening and grain refinement *** tensile testing at temperatures above 973 K,recrystallization occurred in the material with the ultrafine(sub)grains during the sample heating and holding stage,leading to the formation of fine and equiaxed grains with the sizes of 6.8-13.5μ*** deformation behavior of the Fe(41)Mn(25)Ni(24)Co8 Cr2 with different grain sizes in the high temperature range between 973 and 1173 K,where pseudosteady-state flow was attained in the stress-strain curves,could be explained by considering the simultaneous contribution of grain boundary sliding and dislocation-climb creep to total plastic *** activation energies for plastic flow for the materials with different grain sizes were similar as^199 kJ/*** predicting the deformation mechanism,it was important to consider the change in grain size by rapid grain growth or recrystallization during the sample heating and holding stage because grain boundary sliding is a grain-size-dependent deformation *** sample with the ultrafine(sub)grains exhibited the large tensile elongations of 30%-85%due to it

关键词： high entropy alloys Grain size high temperature deformation mechanism Tensile behavior Grain boundary sliding

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Effect of roll speed ratio on the texture and microstructural evolution of an FCC high-entropy alloy during differential speed rolling

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Journal of Materials Science & Technology 2022年第16期111卷 152-166页

作者： h.T.Jeong w.J.Kim Department of Materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

A very coarse-grained(335μm)Fe_(41)Mn_(25)Ni_(24)Co_(8)Cr_(2)high-entropy alloy with a single FCC phase was cold rolling to a 80%reduction in thickness using the differential speed rolling technique with various speed ratios(Srs)ranging between 1 and *** the Sr was increased,the volume fraction of the region of high-density micro-shear bands increased to accommodate the higher shear *** Sr=4,the entire thickness of the sheet was covered with micro-shear bands,and ultrafine(sub)grains with a size of1.4μm were uniformly formed along the shear bands.A continuous dynamic recrystallization(CDrX)mechanism occurred during rolling,and a higher Sr accelerated the CDrX *** conventional rolling(at Sr=1),a brassrorientation texture with minor components of Shand Curorientations *** higher Srs,shear texture developed as the main type,while the development of rolling texture was *** microstructure at Sr=4 obtained after annealing at973 K showed a fully recrystallized microstructure composed of a five times smaller grain size(4μm)with a higher intensity ofγfiber texture compared with that prepared by conventional *** samples processed with high Srs exhibited better tensile properties compared with the conventionally rolled sample in terms of strength and ductility after *** current results demonstrate that by using differential speed rolling with a high Sr,one can achieve a significantly finer and more homogeneous microstructure,stronger shear texture,and superior tensile mechanical properties for an FCC high-entropy alloy compared to that obtained by conventional *** strength of the as-rolled and annealed samples was quantitatively explained by considering the contribution of grain size and dislocation density to strengthening.

关键词： high entropy alloys Differential speed rolling Texture Grain refinement Strength Severe plastic deformation

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BioMinE:An integrated project for developing biohydrometallurgy in Europe——Executive summary of its activities and outputs after three years

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中国有色金属学会会刊：英文版 2008年第6期18卷 1328-1335页

作者： Dominique h.r.MOrIN BrGM-EPI/Eco 3Avenue C.Guillemin-BP 600945060 Orléans Cedex 2France

Biohydrometallurgy 是生物工学和冶金学的意外联合的后代。从某极端 biotopes 的特定的性质，在微生物引起的新陈代谢和矿物质之间的相互作用的活跃原则被提取了被用作有效冶金过程。许多有利工业操作基于这些 bioprocesses 一直在跑... 详细信息

Biohydrometallurgy 是生物工学和冶金学的意外联合的后代。从某极端 biotopes 的特定的性质，在微生物引起的新陈代谢和矿物质之间的相互作用的活跃原则被提取了被用作有效冶金过程。许多有利工业操作基于这些 bioprocesses 一直在跑例如恢复铜，黄金，铀或钴，许多另外的应用程序被设计了。欧洲在这个区域在是相当活跃的过去，但是当前领导在南非，美洲和澳大利亚。BioMinE (在欧洲的忍受金属的材料的生物工学) 是与欧洲 Commision 的支持发射的一个大综合工程。它针对刺激在在这个技术领域里开发新概念的最相关的大学，研究和工业组织之间的协同作用以后允许矿物质资源的更好的利用。当他们识别了需要从今天并且明天的资源为金属抽取发现新过程，欧洲非铁的金属采矿工业开始了并且发展 BioMinE 工程。

关键词：生物显微冶金术生物技术欧洲活性

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