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Biomaterials / bioinks and extrusion bioprinting

Bioactive Materials 2023年第10期28卷 511-536页

作者： X.B.Chen A.Fazel Anvari-Yazdi X.Duan A.Zimmerling r.gharraei N.K.Sharma S.Sweilem L.Ning Department of Mechanical Engineering University of Saskatchewan57 Campus DrS7K 5A9SaskatoonCanada b Division of Biomedical EngineeringUniversity of Saskatchewan57 Campus DrSaskatoonS7K 5A9Canada c Department of Mechanical EngineeringCleveland State UniversityClevelandOH44115USA

Bioinks are formulations of biomaterials and living cells, sometimes with growth factors or other biomolecules, while extrusion bioprinting is an emerging technique to apply or deposit these bioinks or biomaterial solutions to create three-dimensional (3D) constructs with architectures and mechanical/biological properties that mimic those of native human tissue or organs. Printed constructs have found wide applications in tissue engineering for repairing or treating tissue/organ injuries, as well as in vitro tissue modelling for testing or validating newly developed therapeutics and vaccines prior to their use in humans. Successful printing of constructs and their subsequent applications rely on the properties of the formulated bioinks, including the rheological, mechanical, and biological properties, as well as the printing process. This article critically reviews the latest developments in bioinks and biomaterial solutions for extrusion bioprinting, focusing on bioink synthesis and characterization, as well as the influence of bioink properties on the printing process. Key issues and challenges are also discussed along with recommendations for future research.

关键词： 3D bioprinting Extrusion Bioinks Biomaterials Tissue engineering

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