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巨大垂体泌乳素腺瘤溴隐停治疗停止后泌乳素持续抑制(病例报告及文献复习)

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德国医学 1999年第6期16卷 328-329页

作者：雷霆 r.fahlbusch P.Nomicos M.Buchfelder J.Honegger 同济医科大学附属同济医院神经外科 Neurochirurgische Klinik Kopfklinikum der Universitt Erlangen-Nuemberg Neurochirurgische Klinik Kopfklinikum der Universitt Erlangen-Nuemberg D-91054 Erlangen Germany

垂体腺瘤的治疗方法目前尚不统一,虽然大多学者倾向以手术切除为主,且仍以影像学来评价治疗效果,而对内分泌治疗及其治愈标准尚未足够重视。本文通过对1例巨大垂体泌乳素腺瘤手术前、后溴隐停的系统治疗的长期随访,提出一种巨大垂体泌... 详细信息

垂体腺瘤的治疗方法目前尚不统一,虽然大多学者倾向以手术切除为主,且仍以影像学来评价治疗效果,而对内分泌治疗及其治愈标准尚未足够重视。本文通过对1例巨大垂体泌乳素腺瘤手术前、后溴隐停的系统治疗的长期随访,提出一种巨大垂体泌乳素腺瘤综合治疗的模式,供临床参考。

关键词：垂体泌乳素肿瘤腺瘤溴隐停泌乳素治疗

人垂体生长激素腺瘤的分子生物学生化改变及潜在临床意义

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德国医学 1996年第4期13卷 240-241页

作者： E.F.Adams M.Buchfelder T.Lei B.Petersen r.fahlbusch 方俊敏雷霆 NEUrOCHIrUrGISCHE KLINIK UNIVErSITAT ErLANGEN-NUrNBErG SCHWABACHANLAGE ERLANGENGERMANY 同济医科大学附属同济医院

分子生物学检测证实,30%～40%的人肢端肥大症生长激素(GH)垂体腺瘤有 Gsα基因单个碱基的误义突变,产生的基因称为 gsp 癌基因。此外,大部分 GH 腺瘤异常表达 GH 释放因子(GrF)基因。gsp 癌基因使腺苷酸环化酶活性增强,导致细胞内cAMP ... 详细信息

分子生物学检测证实,30%～40%的人肢端肥大症生长激素(GH)垂体腺瘤有 Gsα基因单个碱基的误义突变,产生的基因称为 gsp 癌基因。此外,大部分 GH 腺瘤异常表达 GH 释放因子(GrF)基因。gsp 癌基因使腺苷酸环化酶活性增强,导致细胞内cAMP 水平过度升高。

关键词：垂体肿瘤腺瘤分子生物学

Analysis and Optimization of Operational and Pollutant Attributes of Diesel Engine with CNT-Infused Orange Peel Biodiesel-Diesel Blend Fuel

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Journal of Thermal Science 2024年第2期33卷 761-778页

作者： ranjeet rAI r.r.SAHOO Mechanical Engineering Department GLA UniversityMathura281406India Mechanical Engineering Department IIT(BHU)Varanasi221005India

The current study is performed to find sustainable solutions for the future of transportation and environmental *** conventional methods and experimental design table(L16 Orthogonal Array)techniques have been employed to examine and optimize a diesel-powered engine's operational and pollutant *** L16 Orthogonal Array is obtained through Taguchi's experimental design approach using Minitab 16 *** experimental design incorporated three control variables,namely engine speed,fuel type,and engine load,each with four *** operational parameters,namely brake thermal efficiency(BTE)and brake specific fuel consumption(BSFC),as well as the emission characteristics,including hydrocarbon(HC),carbon monoxide(CO),nitrogen oxide(NO),and smoke emissions,were acquired using the L16 orthogonal array(OA) and subsequently *** utilization of methodologies such as signal-to-noise(S/N) ratio and grey analysis was employed to determine the optimal operational state of the engine to achieve maximum performance while minimizing *** engine's ideal state of operation,in terms of BTE and BSFC,was determined to be at 75% engine load,1000 r/min engine speed,and using 10^(-4)(in vol) carbon nanotube incorporated 20% orange peel biodiesel(OPB20CNT100) blended fuel(A3-B1-C4).The study indicated that engine load significantly influenced BTE and BSFC,with 84.05% and 87.79% contribution factors,*** 25% engine load,1000 r/min,and OPB20CNT100 fuel(A1-B1-C4) CO,smoke,NO,and HC emissions were the *** load affects emissions the *** BSFC increased 3.10% and NO emissions 1.77%.BTE,CO,smoke,and HC emissions decreased by 1.9%,12.29%,47.05%,and 47.22%,respectively,at optimal operating conditions concerning diesel *** study shows that Taguchi-Grey's experimental design optimizes diesel engine operational and pollutant *** outcomes revealed that orange peel biodiesel infused with CNT can replace diesel fuel in a

关键词： Taguchi-Grey method OPB20CNT100 transesterification S/N ratio GrG HC CO and NO

脑磁图支持下的功能性磁共振成像在功能性神经元导航中的应用

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Oncology and Translational Medicine 2000年第1期17卷 34-34页

作者： Ch.Nimsky O.Ganslandt H.Kober M.Mller S.Ulmer B.Tomandl r.fahlbusch 郭东生李杰 Department of Neurosurgery Division of Neuroradiology(BT) University Erlangen-Nürnberg Erlangen Germany 同济医科大学附属同济医院

目的本研究通过将脑磁图(MEG)和功能性磁共振(fMrI)获取的功能性数据传输到神经导航系统来达到在术中证实运动区及附近病变的目的。材料与方法本组7例,女6例,男1例,年龄31～37岁。均为中央沟运动皮层及附近的病变。使用西门子1.5T 功能... 详细信息

目的本研究通过将脑磁图(MEG)和功能性磁共振(fMrI)获取的功能性数据传输到神经导航系统来达到在术中证实运动区及附近病变的目的。材料与方法本组7例,女6例,男1例,年龄31～37岁。均为中央沟运动皮层及附近的病变。使用西门子1.5T 功能性磁共振仪,采用轴位平面回波成

关键词：功能性脑磁图体感诱发电位

Kinematic analysis of flexible bipedal robotic systems

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 795-818页

作者： r.FAZEL A.M.SHAFEI S.r.NEKOO Department of Mechanical Engineering Shahid Bahonar University of KermanKerman ***Iran Departamento de Ingenieria de Sistemas y Automatica Escuela Técnica Superior de IngenieriaUniversidad de SevillaSeville 41092Spain

In spite of its intrinsic complexities,the passive gait of bipedal robots on a sloping ramp is a subject of interest for numerous *** distinguishes the present research from similar works is the consideration of flexibility in the constituent links of this type of robotic *** is not a far-fetched assumption because in the transient(impact)phase,due to the impulsive forces which are applied to the system,the likelihood of exciting the vibration modes increases ***,the human leg bones that are involved in walking are supported by viscoelastic muscles and ***,for achieving more exact results,it is essential to model the robot links with viscoelastic *** this end,the Gibbs-Appell formulation and Newton's kinematic impact law are used to derive the most general form of the system's dynamic equations in the swing and transient phases of *** most important issue in the passive walking motion of bipedal robots is the determination of the initial robot configuration with which the system could accomplish a periodic and stable gait solely under the effect of gravitational *** extremely unstable nature of the system studied in this paper and the vibrations caused by the impulsive forces induced by the impact of robot feet with the inclined surface are some of the very serious challenges encountered for achieving the above-mentioned *** overcome such challenges,an innovative method that uses a combination of the linearized equations of motion in the swing phase and the algebraic motion equations in the transition phase is presented in this paper to obtain an eigenvalue *** solving this problem,the suitable initial conditions that are necessary for the passive gait of this bipedal robot on a sloping surface are *** effects of the characteristic parameters of elastic links including the modulus of elasticity and the Kelvin-Voigt coefficient on the walking stability of this type of

关键词： bipedal robot flexible link swing phase transient phase eigenvalue problem Kelvin-Voigt coefficient

Holographic dark energy in non-conserved gravity theory

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Communications in Theoretical Physics 2024年第4期76卷 126-133页

作者： H r Fazlollahi Institute of Gravitation and Cosmology Peoples Friendship University of Russia(RUDN University)6 Miklukho-Maklaya StMoscow117198Russia

recently, reconsidering the rastall idea T_(μ;νν)^(v)=α_(,μ) through relativistic thermodynamics gives a new form for the scalar field α which led us to construct modern modified theory of gravity debugged ‘non-conserved gravity theory’ Fazlollahi 2023 Euro. Phys. J. C 83 923. This theory unlike other modified theories of gravity cannot directly explain the current acceleration expansion in the absence of the cosmological constant and or existence of other forms of dark energy. Hence, in this study we have reinvestigated holographic dark energy Ρ_(X)~H^(2) in the non-conserved theory of gravity. In this context, the density and pressure of dark energy depend on the non-conserved term and density of the dust matter field. As shown, due to non-conservation effects on large-scale structures, unlike the original holographic model, our model onsets an acceleration epoch for the current Universe satisfies observations. Moreover, the interaction and viscous scenarios are studied for this model.

关键词： non-conserved gravity covariant form of thermodynamics holographic dark energy

Pile foundation in alternate layered liquefiable and non-liquefiable soil deposits subjected to earthquake loading

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 359-376页

作者： Praveen Huded M Suresh r Dash LEA Associates South East Asia Pvt.Ltd. New Delhi 110044India Indian Institute of Technology Bhubaneswar Khurda 752050India

Pile foundations are still the preferred foundation system for high-rise structures in earthquake-prone *** foundations have experienced failures in past earthquakes due to *** on pile foundations in liquefiable soils has primarily focused on the pile foundation behavior in two or three-layered soil ***,in natural occurrence,it may occur in alternative layers of liquefiable and non-liquefiable ***,the experimental and/or numerical studies on the layered effect on pile foundations have not been widely addressed in the *** of the design codes across the world do not explicitly mention the effect of sandwiched non-liquefiable soil layers on the pile *** the present study,the behavior of an end-bearing pile in layered liquefiable and non-liquefiable soil deposit is studied *** study found that the kinematic bending moment is higher and governs the design when the effect of the sandwiched non-liquefied layer is considered in the analysis as opposed to when its effect is ***,ignoring the effect of the sandwiched non-liquefied layer in a liquefiable soil deposit might be a nonconservative design approach.

关键词： pile foundation liquefaction alternately layered soil fixity effect layered effect

Effect of cylinder wall parameters on the final packing density of mono-disperse spheres subject to three-dimensional vibrations Author links open overlay panel

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Particuology 2024年第8期91卷 211-225页

作者： Jack r.Grogan Andrei L.Nicuşan Christopher r.K.Windows-Yule School of Chemical Engineering The University of BirminghamEdgbastonBirminghamB152TTUK

Achieving densely packed particles is desirable within the industries of ceramics,pharmaceuticals,defence and additive *** this work,we use the discrete element method(DEM)to determine the effect of wall parameters on the final packing density of mono-disperse spheres subject to 4 varying three-dimensional vibration and fill *** focus specifically on the impact of the container wall parameters on the particles'final packing *** on from the validation of the DEM simulation the particle-wall coefficient of restitution,the particle-wall coefficient of rolling friction and the particle-wall coefficient of sliding friction were varied individually and the effect on the final packing density *** relatively low particle-particle friction glass beads,the effect of these wall properties had no discernible effect on the final packing density *** on from these findings the particle-wall properties were varied at the extreme values of particle-particle coefficient of rolling friction and particle-particle coefficient of sliding *** a particle-particle coefficient of sliding friction=1,increases in particle-wall coefficient of restitution resulted in a minor increase in the final packing density of particles though this was not statistically *** a particle-particle coefficient of sliding friction=1,increases in particle-wall coefficient of rolling friction resulted in a minor decrease in the final packing density of the particles though again not to a degree where the trend can,with complete certainty,be distinguished from the random error across the ***,when the particle-particle coefficient of sliding friction=1,increases in particle-wall coefficient of sliding friction resulted in a significant decrease in the final packing density of *** decrease was attributed to the propagation of force chains throughout the *** significant decrease in final packing density with

关键词： Vibropacking Packing Densification Vibration Discrete element method Friction Wall friction restitution

Conservation laws,Lie symmetries,self adjointness,and soliton solutions for the Selkov–Schnakenberg system

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Communications in Theoretical Physics 2024年第2期76卷 29-44页

作者： Kashif Ali Aly r Seadawy Syed T r rizvi Noor Aziz Department of Mathematics COMSATS University IslamabadLahore CampusPakistan Mathematics Department Faculty of ScienceTaibah UniversityAl-Madinah Al-Munawarah41411Saudi Arabia

In this article,we explore the famous Selkov–Schnakenberg(SS)system of coupled nonlinear partial differential equations(PDEs)for Lie symmetry analysis,self-adjointness,and conservation ***,miscellaneous soliton solutions like dark,bright,periodic,rational,Jacobian elliptic function,Weierstrass elliptic function,and hyperbolic solutions of the SS system will be achieved by a well-known technique called sub-ordinary differential *** these results are displayed graphically by 3D,2D,and contour plots.

关键词： Selkov-Schnakenberg system Lie symmetry analysis conservation laws adjointness integrability