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Investigation of self-generated magnetic ﬁeld and dynamics of a pulsed plasma ﬂow

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Plasma Science and Technology 2022年第5期24卷 146-153页

作者： Aigerim TAZHEN Merlan DOSBOLAYEV Tlekkabul ramazanov Institute of Experimental and Theoretical Physics Al-Farabi Kazakh National UniversityAlmaty 050040Kazakhstan

Due to the growing interest in studying the compression and disruption of the plasma filament in magnetic fusion devices and Z-pinches, this work may be important for new developments in the field of controlled thermonuclear fusion. recently, on a coaxial plasma accelerator, we managed to obtain the relatively long-lived(~300 μs) plasma filaments with its self-magnetic field. This was achieved after modification of the experimental setup by using high-capacitive and lowinductive energy storage capacitor banks, as well as electrical cables with low reactive impedance. furthermore, we were able to avoid the reverse reflection of the plasma flux from the end of the plasma accelerator by installing a special plasma-absorbing target. Thus, these constructive changes of the experimental setup allowed us to investigate the physical properties of the plasma filament by using the comprehensive diagnostics including rogowski coil,magnetic probes, and faraday cup. As a result, such important plasma parameters as density of ions and temperature of electrons in plasma flux, time dependent plasma filament’s azimuthal magnetic field were measured in discharge gap and at a distance of 23.5 cm from the tip of the cathode. In addition, the current oscillograms and Ⅰ–Ⅴ characteristics of the plasma accelerator were obtained. In the experiments, we also observed the charge separation during the acceleration of plasma flow via oscillograms of electron and ion beam currents.

关键词： coaxial plasma accelerator pulsed plasmaﬂow self magneticﬁeld electron density electron temperature faraday cup magnetic probe

Machine Learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic fZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

Computer Simulation of Two Component Dense Plasma by Molecular Dynamics Method

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Communications in Computational Physics 2014年第4期15卷 1159-1166页

作者： Zh.A.Moldabekov T.S.ramazanov IETP Al-Farabi Kazakh National University71 Al Farabi av.Almaty050040 Kazakhstan

In the present work two component dense semiclassical plasma of protons and electrons is *** and electrodynamic properties of the plasma by molecular dynamic simulation are *** these purposes semiclassical interparticle potential which takes into account quantum mechanical diffraction and symmetry effects is *** considered range of density of plasma is n=1022cm^(−3)to n=1024cm^(−3).fluctuations and dynamic dielectric functions were calculated using velocity autocorrelation functions.

关键词： Molecular dynamic simulation dense semiclassical plasma semiclassical interparticle potential

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural regeneration research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel refai Gerald r.rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew f.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAUrABH r.KIrAN D.SINGH r.VAISH V.S.CHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(fEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(Hr), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and fibonacci helicoidal(fH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural regeneration research 2025年第3期20卷 803-804页

作者： Glenn A.Harris Lauren r.Hirschfeld rainwater Charitable foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3r) or 4-repeat(4r) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

Deep Learning-Enabled Brain Stroke Classification on Computed Tomography Images

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Computers, Materials & Continua 2023年第4期75卷 1431-1446页

作者： Azhar Tursynova Batyrkhan Omarov Natalya Tukenova Indira Salgozha Onergul Khaaval rinat ramazanov Bagdat Ospanov Al-farabi Kazakh National University AlmatyKazakhstan International University of Tourism and Hospitality TurkistanKazakhstan Zhetisu University Named After I.Zhansugurov TaldykorganKazakhstan Abai Kazakh National Pedagogical University AlmatyKazakhstan Brunch Center of Excellence in Taldykorgan TaldykorganKazakhstan

In the field of stroke imaging, deep learning (DL) has enormousuntapped *** clinically significant symptoms of a cerebral strokeare detected, it is crucial to make an urgent diagnosis using available imagingtechniques such as computed tomography (CT) scans. The purpose of thiswork is to classify brain CT images as normal, surviving ischemia or cerebralhemorrhage based on the convolutional neural network (CNN) model. In thisstudy, we propose a computer-aided diagnostic system (CAD) for categorizingcerebral strokes using computed tomography images. Horizontal flip datamagnification techniques were used to obtain more accurate *** Data Generator to magnify the image in real time and apply anyrandom transformations to each training image. An early stopping method toavoid overtraining. As a result, the proposed methods improved several estimationparameters such as accuracy and recall, compared to other machinelearning methods. A python web application was created to demonstrate theresults of CNN model classification using cloud development techniques. Inour case, the model correctly identified the drawing class as normal with 79%accuracy. Based on the collected results, it was determined that the presentedautomated diagnostic system could be used to assist medical professionals indetecting and classifying brain strokes.

关键词： Ischemic stroke hemorrhage CNN deep learning classification

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.r.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis