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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural regeneration research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie d.de Schutter Lies de Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell rNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

development and characterization of stainless steel fiber-based copper-free brake liner formulation:A positive solution for steel fiber replacement

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Friction 2020年第2期8卷 396-420页

作者： Vijay r d.Lenin SINGArAVELU r.JAYAGANTHAN department of Production Engineering National Institute of TechnologyTiruchirappalli 620015Tamil NaduIndia department of Engineering design Indian Institute of Technology MadrasChennai 600036Tamil NaduIndia

This study deals with the development of drum brake liner for a multi-utility vehicle possessing a hydraulic brake system by varying 7 weight%of steel fiber and stainless steel fiber each,in friction composite *** developed friction composites were tested for physical,chemical,corrosion,mechanical,thermal properties,and tribological characteristics,under near-actual conditions using an inertia dynamometer as per industrial *** element analysis software(ANSYS)analysis was performed to show the thermal stress distribution of the developed friction composites at the maximum temperature rise due to heat generated during brake stops,and an extensive evaluation method was used to rank the *** study concludes that the brake factor of the stainless steel fiber-based friction composite produces stable performance in all conditions with a lower liner temperature rise of 340°C and lower thermal stress at 4.255294 ***,the steel fiber-based composites produced high performance at the beginning but deteriorated after a certain period due to higher levels of corrosion and a high temperature rise of 361°C resulting in a negative fade(-0.84%)and more thermal stress(5.619102 MPa).The primary plateau,secondary plateau,back transfer of drum wear debris,and the distribution of constituents on the worn surface of the developed composites in a resin matrix were identified and studied using a scanning electron microscope(SEM)equipped with energy-dispersive spectroscopy.

关键词： stainless steel fiber steel fiber brake liner friction composite

Mechanical and corrosion behaviour of hydroxyapatite reinforced Mg-Sn alloy composite by squeeze casting for biomedical applications

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Journal of Magnesium and Alloys 2020年第2期8卷 452-460页

作者： r radha d.Sreekanth School of Mechanical and Building Sciences Vellore Institute of TechnologyChennai 600127India

Magnesium alloys have gained increasing attention for biomedical applications due to their biocompatibility and the ***(HA)is known to be a highly bioactive because of its similar chemical and crystallographic structures to ***,HA is believed to be a potential ceramic material for the fabrication of Mg based composites,to combine the advantages of both Mg and ***,in general,the composites known to be more susceptible to corrosion attack than the matrix ***,in the present work,Sn is used as an alloying element to evaluate its effect on mechanical as well as corrosion properties of Mg/HA *** with 5 wt%HA and Mg-1 wt%Sn-5 wt%HA composites were prepared separately by stir assisted squeeze casting *** phase analysis and microstructure were characterized by X-ray diffraction(Xrd)and scanning electron microscope(SEM)coupled with energy dispersive spectroscopy(EdS)*** properties were evaluated by conducting the compression and micro hardness *** properties of as-cast composites were studied by linear polarization,Tafel and electrochemical impedance spectroscopy(EIS)*** results of both Xrd and SEM-EdS revealed that the main constitutional phases of as-cast Mg/HA composites were a-Mg and HA whereas,in Mg-Sn/HA composites,the phase Mg^Sn was observed along with fine distribution of HA *** both the cases,no interfacial reactions *** yield strength,ultimate compression strength and hardness were found to be increased with the addition of Sn in Mg/HA ***,the addition of Sn also played an important role in increasing the corrosion resistance of the Mg/HA composites which was attributed the refinement of grain size and the formation of Mg2Sn phase along the grain ***,it was concluded that the addition of Sn improves both mechanical and corrosion properties of Mg/HA composites.

关键词： Magnesium Composite Biomedical Corrosion Squeeze casting

Luminescence properties of Gd^(3+) containing glasses for ultra-violet(UV) light

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Journal of rare Earths 2014年第5期32卷 389-393页

作者： d.d.ramteke r.S.Gedam department of Applied Physics Visvesvaraya National Institute of Technology

Effect of Gd2O3 addition on optical properties of 27.5 Li2O-72.5 B2O3 glass systems was studied. density, differential thermal analysis （dTA）, optical absorption spectra and luminescence technique were used to characterize the prepared glasses. Emis- sion spectra showed two band 6p7/2→8S7/2 （311.5 nm） and 6p5/2→8S7/2 （305 nm） under the excitation of 274 nm. The intense emission at 311.5 nm suggested that these glasses could be useful as source of narrowband UV light.

关键词： glasses rare earths absorption band gap luminescence UV light

Electrical and optical properties of lithium borate glasses doped with Nd_2O_3

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Journal of rare Earths 2012年第8期30卷 785-789页

作者： r.S. Gedam d.d. ramteke department of Applied Physics Visvesvaraya National Institute of Technology

Glass series with general formula 25Li2O-（75-x）B2O3-xNd2O3 was prepared by conventional melt quench technique. Electrical and optical characterizations of these glasses were carried out. It was observed that conductivity of glasses decreased and activation energy in- creased with the addition of Nd2O3. The density and refractive index of the glasses increased while optical band gap and radiation length de- creased due to structural changes.

关键词： conductivity density refractive index optical absorption Tauc's plot rare earths

Effects of Nano-Y_2O_3 and Sintering Parameters on the Fabrication of PM duplex and Ferritic Stainless Steels

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Acta Metallurgica Sinica(English Letters) 2016年第1期29卷 58-71页

作者： r.Shashanka d.Chaira department of Metallurgical and Materials Engineering National Institute of Technology

Here we report the effects of nano-Y203 addition, sintering atmosphere and time during on the fabrication of PM duplex and ferritic stainless steels composites by dual-drive planetary milling of elemental Fe, Cr and Ni powders followed by conventional pressureless sintering. Yttria-free and yttria-dispersed duplex and ferritic stainless steels are fabricated by conventional sintering at 1000, 1200 and 1400 ℃ temperatures under argon atmosphere. In another set of experiment, yttria-free and yttria-dispersed duplex and ferritic stainless steels are consolidated at 1000 ℃ for l h under nitrogen atmosphere to study the effect of sintering atmosphere. It has been found that densities of duplex and yttria- dispersed duplex stainless steel increase from 71% to 91% and 78% to 94%, respectively, with the increase in sintering temperature. Similarly, hardness value increases from 257 to 567 HV25 in case of duplex, and from 332 to 576 HV25 in yttria-dispersed duplex stainless steel. X-ray diffraction analysis shows the domination of more intense austenite phase than ferrite at higher sintering temperature and also in nitrogen atmosphere. It is also evident that addition of yttria enhances phase transformation from a-Fe to 7-Fe. duplex and yttria-dispersed duplex stainless steels exhibit the maximum com- pressive yield strength of 360 and 312 MPa, respectively.

关键词： Nano-Y2O3 Composites Stainless steel Powder metallurgy (PM) Mechanical properties Microstructure Phase transitions

Magnetic susceptibility measurements on metakaolin admixtured cement hydrated with ground water and sea water

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International Journal of Minerals,Metallurgy and Materials 2009年第3期16卷 349-354页

作者： d. Govindarajan r. Gopalakrishnan department of Physics Annamalai University Annamalai Nagar608002 Tamilnadu India

The role of metakaolin in the properties of Portland cement hydrated with ground water and sea water was described by magnetic susceptibility study. Cement pastes containing 0wt%, 10wt%, 20wt% and 30wt% replacement of metakaolin and in a water/cement （W/C） ratio of 0.4 were prepared. The susceptibility at different hydration periods was determined by Faraday Curie balance and it was related to the changes in setting time and compressive strength of admixtured cement. Compared with sea water-treated cement paste, the magnetic susceptibility of ground water-treated cement paste is higher in value. The observed result shows that, irrespective of water, the magnetic susceptibility increases with increasing metakaolin percentage replacement level in cement.

关键词： magnetic susceptibility admixtured cement hydration pozzolanic activity sea water

Landslide inventory validation and susceptibility mapping in the Gerecse Hills, Hungary

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Geo-Spatial Information Science 2021年第3期24卷 498-508页

作者： dávid Gerzsenyi Gáspár Albert department of Cartography and Geoinformatics Eötvös Loránd UniversityBudapestHungary

Landslides pose a threat to property both in the populated and cultivated areas of the Gerecse Hills (Hungary). The currently available landslide inventory database holds the records from many sites in the area, but the database is out-of-date. Here we address the problem of revising the National Landslides Cadastre landslide inventory database by creating a landslide suscept-ibility map with a multivariate model based on likelihood ratio functions. The model is applied to the TandEM-X dEM (0.4″ res.), the current landslide inventory of the area, and data acquired from geological maps. By comparing the distributions of four variables in the landslide and non-landslide area with grid computation methods, the model yields landslide susceptibility estimates for the study area. The estimations show to what extent a certain area is similar to the sample areas, therefore, its likelihood to be affected by landslides in the future. The accuracy of the model predictions was checked in the field and compared to the results of our previous study using the SrTM-1 dEM for a similar analysis. The model gave accurate estimates when certain correction measures were applied to the input datasets. The limitations of the model, the input datasets, and the suggested correction measures are also discussed.

关键词： Landslide susceptibility landslide inventory TandEM-X Gerecse Hills landslides geomorphometry

Characterization of water-in-crude oil emulsions in oil spill response

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Journal of Environmental Sciences 2003年第4期15卷 506-509页

作者： MATHEr r.r. FOTHErINGHAM A.F. YANG r.d. HeriotWattUniversityScottishBordersCampus HeriotWattUniversityScottishBordersCampusHeriotWattUniversityScottishBordersCampus GalashielsUKGalashielsUKGalashielsUK

The formation of water in crude oil emulsions occurs when crude oils are spilled into sea. The water in crude oil emulsions significantly change the properties of the spilled crude oils and in turn influence the choices made relating to oil spill countermeasures. The water in crude oil emulsions were characterized using various techniques in this study. The environmental scanning electron microscopy observation of water droplets in the emulsions is also presented. It is a powerful tool in emulsion observations.

关键词： oil spill water in oil emulsions oil spill response dSC ESEM