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光谱学与光谱分析 1992年第1期12卷 16-21页

作者：刘文清夏宇兴刘颂豪 r.ramponi r.cubeddu 中国科学院安徽光机所合肥230031 意大利米兰工业大学物理系

采用微微秒激光作激发源的时间相关单光子计数系统测量了血卟啉衍生物的肿瘤定位组分(TLF)在缓冲液中不同阳离子表面活性剂浓度下的荧光衰减波形I(t)和时间分辨光谱I(λ,t).

关键词：血卟啉荧光寿命时间分辨光谱

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血卟啉衍生物激光3号时间分辨荧光光谱学

科学通报 1989年第9期34卷 700-703页

作者：刘文清 r.ramponi r.cubeddu 刘颂豪中国科学院安徽光学精密机械研究所意大利米兰工业大学物理研究所

用血卟啉衍生物(HpD)作为光敏药物的光动力学疗法(PDT)已愈来愈多地用于恶性肿瘤的局部治疗中。这种技术的成功是由于HpD在肿瘤细胞中的积聚程度大于正常细胞,当肿瘤细胞中的HpD用红光敏化时,吸收足够的能量引起肿瘤细胞被杀死的结果。

关键词：血卟啉衍生物激光3号荧光光谱学

血卟啉衍生物HpD激光3号不同浓度下的时间窗荧光光谱学

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量子电子学 1989年第3期6卷 255-259页

作者：刘文清 r.cubeddu r.ramponi 中国科学院安徽光学精密机械研究所意大利米兰工业大学物理研究所国家研究委员会量子电子学中心

采用改进后的时间相关单光子计数系统研究了血卟啉衍生物HpD激光3号在磷酸盐缓冲液中浓度0.625μg/ml至10μg/ml的时间窗荧光谱,这是在不同延迟时间测量的一种光谱。根据测量的光谱积分荧光寿命分别为2ns和15ns,选择两个不同宽度的时间... 详细信息

采用改进后的时间相关单光子计数系统研究了血卟啉衍生物HpD激光3号在磷酸盐缓冲液中浓度0.625μg/ml至10μg/ml的时间窗荧光谱,这是在不同延迟时间测量的一种光谱。根据测量的光谱积分荧光寿命分别为2ns和15ns,选择两个不同宽度的时间窗,分别延迟0和18ns,来分析样品中各个荧光组份对整个光谱的贡献。峰值波长615am的荧光主要是HpD中单体的贡献,具有较长的荧光寿命(～15ns),而波长630～660nm区的荧光则是荧光寿命约0.7ns的聚合物和荧光寿命约2.3ns的多聚物剩余部份与“自由生色团”相互作用的结果。所得结果还与国外类似样品DHE作了比较。

关键词：血卟啉衍生物荧光谱时间窗 HpD

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微微秒时间分辨激光荧光光谱的测量

量子电子学 1988年第4期 317-325页

作者：刘文清 r.cubeddu F.Docchio r.ramponi P.Taroni 中国科学院安徽光学精密机械研究所 Centro di Elettronica Quantistica e Strumentazione Elettronica del CNr. Istituto di Fisica del Politecnico P. za L. da Vinci Milano Italy Dipatimento di Automazione Industriale Facolta di Ingegneria Universita degli Studi Via Valotti 25060 Mompiano Brescia Italy

本文描述了一台用于测量时间分辨荧光光谱Ⅰ(λ,t)的时间相关单光子计数系统,使用微微秒激光脉冲作激发光源。系统的响应时间不大于50ps。可同步测量荧光寿命、时间积分光谱Ⅰ(λ)和两个时间门光谱Ⅰ(λ,t)。给出了从化合物的时间门光... 详细信息

本文描述了一台用于测量时间分辨荧光光谱Ⅰ(λ,t)的时间相关单光子计数系统,使用微微秒激光脉冲作激发光源。系统的响应时间不大于50ps。可同步测量荧光寿命、时间积分光谱Ⅰ(λ)和两个时间门光谱Ⅰ(λ,t)。给出了从化合物的时间门光谱中获得各个荧光组份的光谱的方法。测量了激光染料溶液的上述参量,借助于这些溶液表证了该系统的特点。

关键词：光谱带激光荧光光谱单光子计数系统染料溶液激光脉冲激发光源组份波长范围离子激光器单色仪

TIME-rESOLVED FLUOrESCENCE SPECTrOSCOPY OF HEMATOPOrPHYrIN DErIVATIVE LASEr No. 3

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Chinese Science Bulletin 1990年第4期35卷 321-325页

作者：刘文清 r. rAMPONI r. cubeddu 刘颂豪 Anhui Institute of Optics and Fine Mechanics Academia Sinica Hefei 230031 PRC Centro di Electtronica Quantistica Strumentazione Electtronica del-CNr Istituto di Fisica del PolitecnicoMilano Italy.

Ⅰ. INTrODUCTIONPhotodynamic therapy (PDT) which utilizes hematoporphyrin derivative (HpD) as a photosensitizing drug has increasingly being used for the local treatment of malignant tumors. The success of this method... 详细信息

关键词： hematoporphyrin-derivative (HpD) absorption spectra fluorescence spectra time-resolved fluorescence decay curve.

Machine Learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAUrABH r.KIrAN D.SINGH r.VAISH V.S.CHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(Hr), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural regeneration research 2025年第3期20卷 803-804页

作者： Glenn A.Harris Lauren r.Hirschfeld rainwater Charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3r) or 4-repeat(4r) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.r.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis