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地震预报假说的检验

地壳构造与地壳应力 2002年第3期 1-7页

作者： r.console 王福江

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地震区的应力降和断层的统计分布

地震地质译丛 1982年第1期 30-33页

作者： M.Caputo r.console 陈树岩

Caputo(1976,1977)提出了解释地震学中至今用于地震统计的经验定律的统一模型,这些模型适用于单个地震区的震级和地震矩统计。最初用世界平均值对模型所做的验证虽然可靠,但由于该模型仅适用于单个地震区,所以不是完全令人满意的。用另... 详细信息

Caputo(1976,1977)提出了解释地震学中至今用于地震统计的经验定律的统一模型,这些模型适用于单个地震区的震级和地震矩统计。最初用世界平均值对模型所做的验证虽然可靠,但由于该模型仅适用于单个地震区,所以不是完全令人满意的。用另外一些数据对模型进行了更加可靠的检验(Caputo和console,1977)。他们还

关键词：应力降应变阶跃震源参数统计分布震级地震矩震源矩地震区

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地震丛集模型的改进

世界地震译丛 2004年第5期35卷 1-9页

作者： r.console M.Murru A.M.Lombardi 刘素英张天中不详河北省地震局

假定地震是随机点过程的实现,并且全部地震的震级分布都遵从6为常数的古登堡一里克特定律,通过传染性模型,我们对地震的时空发生率密度进行了模拟。发生率密度是通过两项求和计算的,一项代表独立或者说自发的活动性,另一项代表由先前地... 详细信息

假定地震是随机点过程的实现,并且全部地震的震级分布都遵从6为常数的古登堡一里克特定律,通过传染性模型,我们对地震的时空发生率密度进行了模拟。发生率密度是通过两项求和计算的,一项代表独立或者说自发的活动性,另一项代表由先前地震诱发的活动性。第一项只与空间有关,而第二项依赖于三个因素,包括已发生地震的震级、时间和位置。本文中,对时间项我们使用修正后的大森定律,重点研究震级和空间项。对于每一项,我们形成了两种不同的假设,并且根据1987年到2000年意大利仪器记录地震的目录,分别找出了各自的最大似然参数。对2001年纪录的地震活动性计算了各自的可能性并进行了比较,这为找到最佳模型提供了一个途径。对各种假设进行蒙特卡罗模拟,由此来评估我们选择的假设的可信度。我们的研究表明,对于空间分布,反向幂密度函数比正态密度函数更可靠,而余震发生对于震级的尺度不变性假设可以在高可信水平上被拒绝。最终的模型适宜于在真实环境中计算地震发生概率。

关键词：地震丛集震级时间项余震地震活动性发生概率空间分布发生率诱发传染性

由人工目录检验平静以后的前震导致的地震概率增益

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世界地震译丛 1998年第2期29卷 38-40页

作者： r. console M. Murru 董旭光林怀存山东省地震局

分析了由意大利地震监测台网15a的观测所取得的资料,通过简单算法来确定前兆——前震发生之后主震发生的比率。前兆是在一段平静期之后的中等地震。观测到的前震数依赖于平静的空间范围r_1和时间范围T_1。对给定的一组数据,通过优化这... 详细信息

分析了由意大利地震监测台网15a的观测所取得的资料,通过简单算法来确定前兆——前震发生之后主震发生的比率。前兆是在一段平静期之后的中等地震。观测到的前震数依赖于平静的空间范围r_1和时间范围T_1。对给定的一组数据,通过优化这些参数,可以得出前兆(前震)发生之后对应地震的比率的最高值。我们通过最优化处理,得出的概率增益(G)大于100。为了评价影响G值的有关因子,使用人工目录检验了我们的方法。该目录是通过对实际目录的地震发生时间、空间坐标或两者一起随机化处理得到的。分析表明:从优化参数r_1和T_1得到的概率增益的表观高值是因为:(a)目录的短缺。(b)地震活动的非均匀空间分布。(c)地震发生率随时间的实际变化。

关键词：地震前兆地震概率增益人工地震目录检验

Glutamine transporters as pharmacological targets: From function to drug design

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Asian Journal of Pharmaceutical Sciences 2020年第2期15卷 207-219页

作者： Mariafrancesca Scalise Lorena Pochini Michele Galluccio Lara console Cesare Indiveri Department of DiBEST(Biologia Ecologia e Scienze della Terra)University of CalabriaArcavacata di Rende(CS)87036Italy

Among the different targets of administered drugs,there are membrane transporters that play also a role in drug delivery and disposition.Moreover,drug-transporter interactions are responsible for off-target effects of drugs underlying their toxicity.The improvement of the drug design process is subjected to the identification of those membrane transporters mostly relevant for drug absorption,delivery and side effect production.A peculiar group of proteins with great relevance to pharmacology is constituted by the membrane transporters responsible for managing glutamine traffic in different body districts.The interest around glutamine metabolism lies in its physio-pathological role;glutamine is considered a conditionally essential amino acid because highly proliferative cells have an increased request of glutamine that cannot be satisfied only by endogenous synthesis.Then,glutamine transporters provide cells with this special nutrient.Among the glutamine transporters,SLC1A5,SLC6A14,SLC6A19,SLC7A5,SLC7A8 and some members of SLC38 family are the best characterized,so far,in both physiological and pathological conditions.Few 3D structures have been solved by CryoEM;other structural data on these transporters have been obtained by computational analysis.Interactions with drugs have been described for several transporters of this group.For some of them,the studies are at an advanced stage,for others,the studies are still in nuce and novel biochemical findings open intriguing perspectives.

关键词： Glutamine transporters Drug delivery Pharmacokinetics Screening Proteoliposome

用合成地震目录模拟希腊科林斯湾断层系的地震活动

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世界地震译丛 2016年第4期47卷 309-328页

作者： rodolfo console roberto Carluccio Elefhteria Papadimitriou Vassilis Karakostas 李红(译) 陈连旺(校) 赵仲和(复校) 不详北京市地震局中国地震局地壳应力研究所中国地震台网中心

特征地震假设是模拟大断层上随时间变化的地震复发过程的基础。但是,特征地震假设并没有有力的观测证据。鲜有断层段具有单个已破裂事件的悠长历史记录或古地震记录,加上资料与参数的不确定性,很难获取复发的分布特征。例如,科林斯湾断... 详细信息

特征地震假设是模拟大断层上随时间变化的地震复发过程的基础。但是,特征地震假设并没有有力的观测证据。鲜有断层段具有单个已破裂事件的悠长历史记录或古地震记录,加上资料与参数的不确定性,很难获取复发的分布特征。例如,科林斯湾断层系(CGFS)的强震记载超过2 000年,虽然最近300年M≥6.0地震的目录是完整的,但其中记录的独立断层段上发生的特征地震则凤毛麟角。采用基于物理的地震模拟算法可以产出长达10万年且包含超过50万个4级以上事件的地震目录。此模拟算法的主要特征是:(1)对断层系中每个断层段都采用平均的地震滑动速率;(2)采用探索式程序实现破裂生长和停止,从而得到自组织的震级分布;(3)地震震源间具有相互作用;(4)应力再分布过程中微小地震的影响。用此算法模拟科林斯湾断层系可以给出较为真实的地震时空强特征。这些特征包括强震的长期周期性、强震与小震事件的短期丛集性以及在较高震级区间偏离古登堡—里克特分布的较真实的震级分布。

关键词：采用原创的地震模拟算法合成目录包含10万年时长中的50万个地震模拟器可再现真实的地震活动

Single-port technique evolution and current practice in urologic procedures

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Asian Journal of Urology 2021年第1期8卷 100-104页

作者： Marcio Covas Moschovas Kulthe ramesh Seetharam Bhat Fikret Fatih Onol Travis rogers Gabriel Ogaya-Pinies Shannon roof Vipul r.Patel Department of robotic Surgery Advent Health Global Robotics InstituteCelebrationFLUSA Hospital Universitario rey Juan Carlos MadridSpain

Different groups described the single-port surgery since its first report in laparoscopic procedures.However,the acceptance of this technique among urologists,even after the robotic approach,was reduced in the past years.Therefore,to overcome the challenges related to the single-port surgery,a new robotic platform named da Vinci SP was created with exclusive single port technology.We performed a non-systematic literature review regarding the single port technique in urologic surgeries since the first laparoscopic report until the da Vinci SP robotic platform.Three different periods were described(laparoscopy,robotic,and da Vinci SP),and we focused in our experience with this new single port robot.We selected different articles and summarized the information regarding the use of single-site surgery in laparoscopic procedures and the challenges of this approach.We also reported the experience of different groups using the single port robotic technique and some recent reports of the da Vinci SP approach.In our experience with this new console,we described some critical points related to our radical prostatectomy technique and the lessons learned during the introduction of this novel platform.Previous single-site procedures described some common challenges that limited the technique expansion.However,our experience with the da Vinci SP described feasible and safe procedures with acceptable intraoperative outcomes.The introduction of this platform is recent in the market,and the literature still lacks a high level of evidence describing the long-term outcomes of this new technology.

关键词： da Vinci SP Single-port surgery robotic surgery

Extraperitoneal robot-assisted radical prostatectomy: Comparison with transperitoneal technique

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World Journal of Clinical Urology 2013年第2期2卷 3-9页

作者： Chris Anderson Ben Ayres rami Issa Matthew Perry Evangelos Liatsikos Jens-Uwe Stolzenburg Khurshid r Ghani Department of Urology St George’s HospitalSt George’s Healthcare NHS TrustLondon SW17 0JTUnited Kingdom Department of Urology University of Patras School of Medicine26500 RIO PatrasGreece Department of Urology University of Leipzig04103 LeipzigGermany Vattikuti Urology Institute Henry Ford HospitalDetroitMI 48202United States

AIM: To determine peri-operative, oncological, functional and safety profiles of extraperitoneal robot-assisted radical prostatectomy(e rArP) vs transperitoneal robot-assisted radical prostatectomy(t rArP) in a single centre.METHODS: A total of 120 consecutive patients underwent 50 e rArP and 70 e rArP operations respectively by the same surgical team. Peri-operative and post-operative outcomes including blood loss, hospitalization, complications(Clavien grade), positive surgical margin(PSM) rates, continence and erectile function were compared. The performance of e rArP required several technical modifications. These included developmentof retzius' space by balloon insufflation, laparoscopic dissection of lateral extensions of this area; caudal port positioning; cranial digital stripping of peritoneum for sucker port and lodging the bagged prostate specimen adjacent to the lateral assistant port to permit space for urethro-vesical anastomosis.rESULTS: robotic console times were shorter with e rArP vs t rArP(145.1 min vs 198.3 min, P re were no significant differences in blood loss, PSM rates(e rArP 17.7% vs t rArP 22%) or complications(e rArP 8.5% vs t rArP 8%). A drain was used in all patients after t rArP and in 25/70 e rArP cases. Length of hospital stay was shorter after e rArP(mean 1.94 d vs 3.6 d, P re were no differences between techniques in continence or potency at 6 mo. e rArP required several technical modifications: development of retzius' space by balloon insufflation, laparoscopic dissection of lateral extensions of this area; caudal port positioning; and lodging the bagged prostate specimen adjacent to the lateral assistant port to permit space for urethro-vesical anastomosis.CONCLUSION: e rArP demonstrated advantages in surgical times, hospital stay and equivalence in PSM rates, complications and functional outcomes. e rArP is a useful alternative to t rArP especially in patients with adhesions, pre-existing inguinal hernias, or those unable to withstand steep Trendele

关键词： Prostatic neoplasms robotics Laparoscopy Prostatectomy Complications

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MrI测量诊断橄榄-桥脑-小脑萎缩的价值

福州总医院学报 2001年第1期8卷 41-43页

作者：肖慧胡万鹏孙实香郑春雨李铭山福州总医院CT科佳木斯大学临床医学院附属医院放射科

目的:通过MrI测量正常成人及OPCA患者的脑干及周围间隙探讨其在诊断OPCA中的价值。方法:正常成人106例和OPCA患者21例,采用正中矢状面T1W图象直接光标测量计算。结果:以绝对值测量时OPCA患者脑干各径线值均小于正常组;桥脑与桥前池比值(... 详细信息

目的:通过MrI测量正常成人及OPCA患者的脑干及周围间隙探讨其在诊断OPCA中的价值。方法:正常成人106例和OPCA患者21例,采用正中矢状面T1W图象直接光标测量计算。结果:以绝对值测量时OPCA患者脑干各径线值均小于正常组;桥脑与桥前池比值(B/F)、延髓与延髓前池比值(C/G)在判断脑干的正常形态及异常改变中意义较大。结论:MrI测量可以为诊断OPCA提供较客观、较准确的参考价值。

关键词：诊断 OPCA MrI 脑干患者正常成人橄榄-桥脑-小脑萎缩比值矢状面异常改变