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Machine Learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAUrABH r.KIrAN D.SINGH r.VAISH V.S.CHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(Hr), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural regeneration research 2025年第3期20卷 803-804页

作者： Glenn A.Harris Lauren r.Hirschfeld rainwater Charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3r) or 4-repeat(4r) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

Applied Fault Detection and Diagnosis for Industrial Gas Turbine Systems

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International Journal of Automation and computing 2017年第4期14卷 463-473页

作者： Yu Zhang Chris bingham Mike Garlick Michael Gallimore School of Engineering University of Lincoln Lincoln LN6 7TS UK Siemens Industrial Turbomachinery Lincoln LN6 3AD UK

The paper presents readily implementable approaches for fault detection and diagnosis （FDD） based on measurements from multiple sensor groups, for industrial systems. Specifically, the use of hierarchical clustering （HC） and self-organizing map neural networks （SOMNNs） are shown to provide robust and user-friendly tools for application to industrial gas turbine （IGT） systems. HC fingerprints are found for normal operation, and FDD is achieved by monitoring cluster changes occurring in the resulting dendrograms. Similarly, fingerprints of operational behaviour are also obtained using SOMNN based classification maps （CMs） that are initially determined during normal operation, and FDD is performed by detecting changes in their CMs. The proposed methods are shown to be capable of FDD from a large group of sensors that measure a variety of physical quantities. A key feature of the paper is the development of techniques to accommodate transient system operation, which can often lead to false-alarms being triggered when using traditional techniques if the monitoring algorithms are not first desensitized. Case studies showing the efficacy of the techniques for detecting sensor faults, bearing tilt pad wear and early stage pre-chamber burnout, are included. The presented techniques are now being applied operationally and monitoring IGTs in various regions of the world.

关键词： Fault detection and diagnosis hierarchical clustering, self-organizing map neural network.

The role of cell free DNA and liquid biopsies in haematological conditions

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Cancer Drug resistance 2020年第3期3卷 521-531页

作者： Nicholas bingham Andrew Spencer Australian Centre for Blood Diseases Monash UniversityVictoria 3181Australia.

Cell free nucleic acids(CFNAs)are nucleic acids released from cells that circulate within bodily *** advances in molecular techniques have led to the ability to interrogate CFNAs in a clinically meaningful way,for example the identification and assessment of foetal CFNAs in maternal blood,allowing minimally invasive testing for foetal genetic *** majority of CFNAs arise from haemopoietic cells,making it a particularly rich source of genetic information in haematological ***,the innate genetic heterogeneity of haematological malignancies,as epitomised by multiple myeloma,lend itself well to“liquid biopsies”.This approach promises to provide a more wholistic assessment of whole disease genetics,especially when contrasted against the current gold-standard of single site tissue *** review briefly summarises the definitions and physiology of CFNAs,both cell free DNA(cfDNA)and extracellular rNA(exrNA),before exploring the literature surrounding the current and future roles of cfDNA in the haematological malignancies and patient care.

关键词： cfDNA liquid biopsy haematology myeloma lymphoma leukaemia

A robust WENO scheme for nonlinear waves in a moving reference frame

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Journal of Hydrodynamics 2016年第3期28卷 482-488页

作者： Stavros KONTOS Harry B.bingham Ole LINDBErG Allan P.ENGSIG-KArUP Department of Mechanical Engineering Technical University of DenmarkDenmark Department of Applied Mathematics and Computer Science Technical University of DenmarkDenmark

For robust nonlinear wave simulation in a moving reference frame, we recast the free surface problem in Hamilton-Jacobi form and propose a Weighted Essentially Non-Oscillatory （WENO） scheme to automatically handle the upwinding of the convective term. A new automatic procedure for deriving the linear WENO weights based on a Taylor series expansion is introduced. A simplified smoothness indicator is proposed and is shown to perform well. The scheme is combined with high-order explicit runge-Kutta time integration and a dissipative Lax-Friedrichs-type flux to solve for nonlinear wave propagation in a moving frame of reference. The WENO scheme is robust and less dissipative than the equivalent order upwind-biased finite difference scheme for all ratios of frame of reference to wave propagation speed tested. This provides the basis for solving general nonlinear wave-structure interaction problems at forward speed.

关键词： nonlinear waves Weighted Essentially Non-Oscillatory (WENO) finite difference

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.r.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural regeneration research 2025年第3期20卷 725-739页

作者： Benjamin r.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin