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The PI3K/AKT Pathway and renal Cell Carcinoma

1998年

作者： John barnes

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Journal of Genetics and Genomics 2015年第7期42卷 343-353页

作者： Huifang Guo Peter German Shanshan Bai Sean barnes Wei Guo Xiangjie Qi Hongxiang Lou Jiyong Liang Eric Jonasch Gordon B.Mills Zhiyong ding department of Systems Biology The University of Texas MD Anderson Cancer Center department of Genitourinary Medical Oncology The University of Texas MD Anderson Cancer Center department of radiation Oncology People's Hospital of Linzi District department of Natural Products Chemistry Key Laboratory of Chemical Biology of Ministry of EducationSchool of Pharmaceutical SciencesShandong University

The phosphatidylinositol 3 kinase （PI3K）/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway, and thus is frequently activated as a cancer driver. More importantly, the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades, providing many potential targets for cancer therapy. renal cell carcinoma （rCC） is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies. The PI3K/AKT pathway is modestly mutated but highly activated in rCC, representing a promising drug target. Indeed, PI3K pathway inhibitors of the rapalog family are approved for use in rCC. recent large-scale integrated analyses of a large number of patients have provided a molecular basis for rCC, reiterating the critical role of the PI3K/AKT pathway in this cancer. In this review, we summarize the genetic alterations of the PI3K/AKT pathway in rCC as indicated in the latest large-scale genome sequencing data, as well as treatments for rCC that target the aberrant activated PI3K/AKT pathway.

关键词： PI3K AKT mTOr renal cell carcinoma Targeted therapy

Landlocked Fall Chinook Salmon Egg Storage for delayed Fertilization

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Advances in Bioscience and Biotechnology 2020年第5期11卷 160-165页

作者： Hunter Eide Michael E. barnes South dakota department of Game Fish and Parks McNenny State Fish Hatchery Spearfish South Dakota USA

delayed fertilization of salmonid eggs can be a useful option to enhance the efficiency of artificial spawning operations. This experiment examined the fertility of landlocked fall Chinook salmon (Oncorhynchus tshawytscha) eggs stored for various times after removal from female broodstock. Fertilization occurred either immediately after spawning or the eggs were stored with oxygen at 11°C and fertilized at 4, 6, 8, 12, or 20 hours post-spawn. Survival to the eyed stage of egg development was significantly greater in the eggs fertilized immediately or after four, six, or eight hours of storage compared to those eggs stored for 12 or 20 hours prior to fertilization (P = 0.024). Survival to hatch was also significantly different (P = 0.018) and followed the same pattern. This study is the first to document the successful fertilization of landlocked fall Chinook salmon eggs after eight hours of storage.

关键词： delayed Fertilization Chinook Salmon Egg Storage Oncorhynchus tshawytscha

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垃圾渗滤液的物化预处理研究

垃圾渗滤液的物化预处理研究

作者： dolores barnes 江南大学

学位级别：硕士

中后期垃圾填埋场渗滤液,由于氨氮（NH+4-N）浓度高、BOd/COd（B/C）比较低,很难直接进行生物处理。本文就磷酸镁铵沉淀法（Magnesium Ammonium Phosphate, MAP）和Fenton氧化法两种预处理工艺对中后期垃圾渗滤液的处理效果进行了比较... 详细信息

中后期垃圾填埋场渗滤液,由于氨氮（NH+4-N）浓度高、BOd/COd（B/C）比较低,很难直接进行生物处理。本文就磷酸镁铵沉淀法（Magnesium Ammonium Phosphate, MAP）和Fenton氧化法两种预处理工艺对中后期垃圾渗滤液的处理效果进行了比较和分析,并以好氧膜生物反应器为后续处理工艺,对预处理效果进行了验证。结果发现,对于MAP沉淀法,pH值为9、Mg2+:PO3-4:NH+4比例为1:1:1时,NH+4-N和COd的去除率分别在97.0%和50.0%以上,浓度分别从2132 mg l-1和4113 mg l-1降低到46 mg l-1和2057 mg l-1。对于Fenton氧化法,在最佳反应条件（H2O2浓度为3500 mg l-1,Fe2+浓度为437.5 mg l-1,pH值为4,H2O2与Fe2+质量比为8,反应时间为30min）下,NH+4-N和COd的去除率分别为76%和6.3%,浓度分别降为987 mg l-1和1997 mg l-1。在上述条件下,MAP沉淀法和Fenton氧化法处理后的垃圾渗滤液B/C比从原来的0.35分别提高到0.66和0.71,可生化性显著提高。研究还发现,MAP沉淀法不受温度影响,而Fenton氧化法的处理效率与反应温度呈正相关。MAP沉淀法对于垃圾渗滤液中的NH+4-N和COd均有良好的去除效果,因此是一种较理想的预处理工艺。MAP沉淀法结合好氧膜生物反应器（Membrane Bio-reactor, MBr）的组合工艺对垃圾渗滤液的处理效果较好,MBr水力停留时间12h,渗滤液中的NH+4-N几乎完全被去除,COd去除率在80%以上。

关键词：中后期垃圾渗滤液磷酸镁铵沉淀法 Fenton氧化法物化法预处理工艺可生化性膜生物反应器

Statistical Analysis for Engineers and Scientists：A Computer-Based Approach 工程师和科学家实用统计分析——基于计算机的方法

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A slow-growth high-mortality meta-analysis for insects： A comment on Chen and Chen

丛书名：国外大学优秀教材--工业工程系列

2002年

作者： J. Wesley barnes

本书是第一本从现代计算机观点出发的工程统计学教材。通过集成教材中内容宽广的软件程序，结合在工程和科研中的应用，为学生讲授概率和统计学的概念。本书包含独特、全面及用户友好的软件包（用于PC机或苹果机），其特色是以应用为取... 详细信息

ISBN: (纸本)9787900641977

本书是第一本从现代计算机观点出发的工程统计学教材。通过集成教材中内容宽广的软件程序，结合在工程和科研中的应用，为学生讲授概率和统计学的概念。本书包含独特、全面及用户友好的软件包（用于PC机或苹果机），其特色是以应用为取向，而对大多数理论问题的探讨较为直观。通过精心设计的章节式学习方式和各种练习，帮助学生在充分学习使用软件的过程中掌握各章的内容，并对所有出现的假设检验中的有效样本进行了完全和详细的统计处理。本书的主要内容包括：多元回归分析、离散随机变量的卷积和变换、双变量概率分布、假设检验的操作特性曲线、统计过程控制和非参数统计分析等。

关键词： Engineering

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Insect Science 2018年第2期25卷 352-354页

作者： Shannon M. Murphy Mayra C. Vidal Claudia J. Hallagan Elizabeth E. barnes E. dale Broder department of Biological Sciences University of Denver Denver CO US

dear Editor, Insect Science recently published a meta-analysis that tried to test support for the slow-growth high-mortality （hereafter SG-HM） hypothesis （Chen＆ Chen, 2018）. Meta-analysis is a powerful statistical tool used to quantitatively compare and summarize multiple studies （Arnqvist ＆ Wooster, 1995）. However, results from a meta-analysis must be carefully interpreted when only limited sample sizes are available. Many conclusions made by Chen and Chen （2018） are based on low sam- rile sizes and/or have small fail-safe numbers,

关键词： FILE-drAWEr PrOBLEM LEAF QUALITY HYPOTHESIS PrEdATION

金属元素比值在镁铁质-超镁铁质侵入岩的铂族元素矿床勘探中的应用

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地质地球化学 1991年第4期19卷 17-20页

作者： S.J.barnes 李松辽宁有色勘查大队

即使岩浆中可能含有足够在侵入体中形成矿床的铂族元素,然而由于硫化物起到了铂族元素集聚体的作用,因此岩浆在它现在的位置定位以前就不应该经历硫化物的分凝作用。先期硫化物的分凝作用将把铀族元素从岩浆中提取出来并在别的位置(可... 详细信息

即使岩浆中可能含有足够在侵入体中形成矿床的铂族元素,然而由于硫化物起到了铂族元素集聚体的作用,因此岩浆在它现在的位置定位以前就不应该经历硫化物的分凝作用。先期硫化物的分凝作用将把铀族元素从岩浆中提取出来并在别的位置(可能在深部)淀积下来。假如先期硫化物的分凝作用没有把铂族元素从岩浆中提取出来,那么它们就有可能在侵入体中早期硫化物形成的位置富集。由于铂族元素在硫化物中具有此Ni和Cu高得多的分配系数,所以硫化物的分凝作用会强烈地影响Ni和Cu与铂族元素的比值。因此,为了判断某一侵入体中是否有可能赋存有铂族元素矿床,应该对冷凝边上Ni和Cu与铂族元素的比值加以研究。如果冷凝岩中铂族元素相对于Ni和Cu而言没有被贫化,那么该侵入体中就可能赋存铂族元素矿床。为了对侵入体中富集的铂族元素进行定位,可以利用横穿地层剖面岩石的Ni和Cu与铂族元素的比值,来寻找硫化物最初达到饱和的位置。然而,由于Ni和Cu与铂族元素的比值还受橄榄石和铬铁矿结晶作用的影响而使情况变得复杂化。为了消除橄榄石和铬铁矿对铂族元素和Ni迁移的影响,有必要考虑Pd/Ir或Pd/rh或Pd/Pt与Ni/Cu的比值关系。

关键词：铂矿床勘探金属元素比值侵入岩

rearing Performance of Juvenile Brown Trout (<i>Salmo trutta</i>) Subjected to Exercise and dietary Bioprocessed Soybean Meal

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Open Journal of Animal Sciences 2018年第3期8卷 303-328页

作者： Jill M. Voorhees Michael E. barnes Steven r. Chipps Michael L. Brown South dakota department of Game Fish and Parks McNenny State Fish Hatchery Spearfish USA Unites States Geological Survey South Dakota Cooperative Fish and Wildlife Research Unit Department of Natural Resource Management Brookings USA department of Natural resource Management South Dakota State University Brookings USA

This 121-day experiment evaluated the rearing performance of brown trout Salmo trutta fed one of two isonitrogenous and isocaloric diets and reared at velocities of either 2.8 or 16.1 cm/s. Fishmeal was the primary protein source for the reference diet, and bioprocessed soybean meal replaced approximately 67% of the fishmeal in the experimental diet. At the end of the experiment, there were no significant differences in gain, percent gain, feed conversion rates, or specific growth rates between the dietary treatments. There were also no significant differences in intestinal morphology, splenosomatic, hepatosomatic, and viscerosomatic indices related to diet composition. However, gain, percent gain, feed fed, and specific growth rate were all significantly greater in brown trout reared at the higher velocity. No significant differences in any of the other variables measured were observed between the velocity treatments. There were no significant interactions between diet and velocity in any of the variables. Based on the results of this study, bioprocessed soybean meal can replace at least 67% of the fishmeal in brown trout diets, regardless of the rearing velocities used in this study. However, higher rearing velocities are recommended to maximize juvenile brown trout growth rates.

关键词： Brown Trout Salmo trutta Bioprocessed Soybean Meal Exercise diet

Free Care Is Not Enough: Barriers to Attending Free Clinic Visits in a Sample of Uninsured Individuals with diabetes

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Open Journal of Nursing 2014年第13期4卷 912-919页

作者： Jennifer A. Mallow Laurie A. Theeke Emily r. barnes Tara Whetsel Brian K. Mallow School of Nursing West Virginia University Morgantown West Virginia USA Sovern run LLC Albright West Virginia USA

Free care does not always lead to improved outcomes. Attendance at free clinic appointments is unpredictable. Understanding barriers to care could identify innovative interventions. The purpose of this study was to examine patient characteristics, biophysical outcomes, and health care utilization in uninsured persons with diabetes at a free clinic. A sample of 3139 patients with at least one chronic condition was identified and comparisons were made between two groups: those who attended all scheduled appointments and those who did not. Geographic distance to clinic and multiple chronic conditions were identified as barriers to attendance. After one year, missing more than one visit had a positive correlation with increased weight, A1C, and lipids. Additionally, patients who missed visits had higher blood pressure, depression scores, and numbers of medications. Future research should further enhance understanding of barriers to care, build knowledge of how social and behavioral determinants contribute to negative outcomes in the context of rurality. Innovative methods to deliver more frequent and intensive interventions will not be successful if they are not accessible to patients.

关键词： diabetes rural Health Poor Uninsured Free Clinic Chronic Conditions Health disparities

Additive Manufacturing:Incremental Improvements to a disruptive Technology

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Accounts of Materials research 2021年第8期2卷 574-576页

作者： John E.barnes Kevin Slattery The barnes Global Advisors PittsburghPennsylvaniaUnited States The barnes Global Advisors St.LouisMissouriUnited States

Additive Manufacturing(AM)is disruptive and complex not only in its nature but also in what it can *** have always had difficulty absorbing complexity and disruption due to our skeptical nature and need to *** being a 3-dimensional solution is simply an example of how AM is disruptive because people are adept at thinking in two *** a technology as transformative as AM to progress,some assumptions have to be made and certain approximations have to be asserted and held to be true until they can be revisited *** we weigh the societal benefit that AM can and will bring,efficiency comes to the *** could be efficiency of energy use,efficiency of materials utilization,or efficiency in designs that are lighter and then use less *** matter what form efficiency takes,it impacts *** achieve a greater impact,AM must become more pervasive,and for it to become more pervasive,it must become more *** additional source of complexity in AM is the sheer number of process variables,such as feedstock,energy source,part geometry,and postprocessing,with more than 100 identified,1 not including the interrelationships between these *** similar numbers are present in other manufacturing processes,such as forging and casting,civilization has had between 200 and 5000 years to understand the variables in these processes,which is longer than society wants to wait in the case of AM.

关键词： casting Additive absorbing