检索结果-南通市图书馆

dynamic glial response and crosstalk in demyelination-remyelination and neurodegeneration processes

Neural regeneration research 2021年第7期16卷 1359-1368页

作者： Tianci Chu Lisa B.E.Shields Wenxin Zeng Yi Ping Zhang Yuanyi Wang gregory N.barnes Christopher B.Shields Jun Cai Pediatric research Institute Department of PediatricsUniversity of Louisville School of MedicineLouisvilleKYUSA Norton Neuroscience Institute Norton HealthcareLouisvilleKYUSA department of Spine Surgery The First Hospital of Jilin UniversityChangchunJilin ProvinceChina department of Neurology University of Louisville School of MedicineLouisvilleKYUSA department of Pharmacology and Toxicology University of LouisvilleLouisvilleKYUSA department of Neurological Surgery University of Louisville School of MedicineLouisvilleKYUSA

Multiple sclerosis is an autoimmune disease in which the immune system attacks the myelin sheath in the central nervous *** is characterized by blood-brain barrier dysfunction throughout the course of multiple sclerosis, followed by the entry of immune cells and activation of local microglia and *** cells(microglia, astrocytes, and oligodendrocyte lineage cells) are known as the important mediators of neuroinflammation, all of which play major roles in the pathogenesis of multiple *** communications between glial cells affect the activities of oligodendrocyte lineage cells and influence the demyelination-remyelination process.A finely balanced glial response may create a favorable lesion environment for efficient remyelination and *** review focuses on glial response and neurodegeneration based on the findings from multiple sclerosis and major rodent demyelination *** particular, glial interaction and molecular crosstalk are discussed to provide insights into the potential cell-and molecule-specific therapeutic targets to improve remyelination and neuroregeneration.

关键词： astrocyte crosstalk demyelination glial response microglia/macrophage multiple sclerosis neurodegeneration neuroinflammation oligodendrocyte lineage cells remyelination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Occupational Noise Levels in Two Fish rearing Buildings at an Aquaculture Facility

引用

Occupational diseases and Environmental Medicine 2017年第2期5卷 58-66页

作者： Jill Voorhees Michael E. barnes South dakota department of game Fish and Parks Cleghorn Springs State Fish Hatchery Rapid City USA South dakota department of game Fish and Parks McNenny State Fish Hatchery Spearfish USA

Occupational noise is commonly encountered during aquaculture. This study documented noise levels in two buildings at a production fish hatchery, a tank room with 32, 1.8-m diameter tanks, and a rearing pavilion with 32, 6.1-m diameter tanks. With water flowing to all of the tanks in the tank room, mean noise levels were 68.4 dB, and significantly increased to 73.0 dB during tank cleaning and 73.2 dB when intermittent automatic feeders were running. The highest tank room values of 77.1 dB were recorded directly next to individual tanks during cleaning. With water flowing to all of the tanks in the rearing pavilion, mean noise levels were 70.2 dB. A significant increase to 76.1 dB was observed when the pavilion tanks were being power washed, with the highest value of 83.2 dB recorded immediately adjacent to the power washer. Although none of the noise levels exceeded regulatory limits, the use of techniques to reduce occupational noise in aquaculture environments is recommended.

关键词： Noise Aquaculture Fish Hatchery Tanks Water Flow

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

垃圾渗滤液的物化预处理研究

垃圾渗滤液的物化预处理研究

引用

作者： dolores barnes 江南大学

学位级别：硕士

中后期垃圾填埋场渗滤液,由于氨氮（NH+4-N）浓度高、BOd/COd（B/C）比较低,很难直接进行生物处理。本文就磷酸镁铵沉淀法（Magnesium ammonium Phosphate, MAP）和Fenton氧化法两种预处理工艺对中后期垃圾渗滤液的处理效果进行了比较... 详细信息

中后期垃圾填埋场渗滤液,由于氨氮（NH+4-N）浓度高、BOd/COd（B/C）比较低,很难直接进行生物处理。本文就磷酸镁铵沉淀法（Magnesium ammonium Phosphate, MAP）和Fenton氧化法两种预处理工艺对中后期垃圾渗滤液的处理效果进行了比较和分析,并以好氧膜生物反应器为后续处理工艺,对预处理效果进行了验证。结果发现,对于MAP沉淀法,pH值为9、Mg2+:PO3-4:NH+4比例为1:1:1时,NH+4-N和COd的去除率分别在97.0%和50.0%以上,浓度分别从2132 mg l-1和4113 mg l-1降低到46 mg l-1和2057 mg l-1。对于Fenton氧化法,在最佳反应条件（H2O2浓度为3500 mg l-1,Fe2+浓度为437.5 mg l-1,pH值为4,H2O2与Fe2+质量比为8,反应时间为30min）下,NH+4-N和COd的去除率分别为76%和6.3%,浓度分别降为987 mg l-1和1997 mg l-1。在上述条件下,MAP沉淀法和Fenton氧化法处理后的垃圾渗滤液B/C比从原来的0.35分别提高到0.66和0.71,可生化性显著提高。研究还发现,MAP沉淀法不受温度影响,而Fenton氧化法的处理效率与反应温度呈正相关。MAP沉淀法对于垃圾渗滤液中的NH+4-N和COd均有良好的去除效果,因此是一种较理想的预处理工艺。MAP沉淀法结合好氧膜生物反应器（Membrane Bio-reactor, MBr）的组合工艺对垃圾渗滤液的处理效果较好,MBr水力停留时间12h,渗滤液中的NH+4-N几乎完全被去除,COd去除率在80%以上。

关键词：中后期垃圾渗滤液磷酸镁铵沉淀法 Fenton氧化法物化法预处理工艺可生化性膜生物反应器

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

An initial investigation replacing fish meal with a commercial fermented soybean meal product in the diets of juvenile rainbow trout

引用

Open Journal of Animal Sciences 2012年第4期2卷 234-243页

作者： Michael E. barnes Michael L. Brown Kurt A. rosentrater Jason r. Sewell department of Agricultural and Biosystems Engineering Iowa State University Ames USA department of Wildlife and Fisheries Sciences South Dakota State University Brookings USA Nutraferma Inc. North Sioux City USA South dakota department of game Fish and Parks McNenny State Fish Hatchery Spearfish USA

The inclusion of PepSoygen (PSg), a commercially-available fermented soybean meal product, was evaluated with juvenile rainbow trout, Oncorhynchus mykiss in an initial 70-day feeding trial, with a supplemental trial involving a subset of the experimental diets continuing for an additional 40 d. Six diets containing 0%, 10%, 20%, 30%, 40%, or 50% PSg, with the PSg directly replacing fish meal, were used in the first trial. There were no significant differences in weight gain or feed conversion ratio between the fish meal-based control diet and diets containing up to 30% PSg. However, weight gain was significantly reduced and feed conversion ratio significantly increased with the 40% and 50% PSg diets. No health assessment differences were observed in fish receiving any of the diets, and no evidence of gross gut inflammation was evident. There were no significant differences in weight gain or feed conversion ratio among the four dietary treatments ranging from 0% to 30% PSg which were fed for an additional 40 d after the initial 70-d trial (110 days total). Based on these results, juvenile rainbow trout diets can contain up to 30% PSg without any loss of rearing performance, thereby replacing at least 60% of the fish meal.

关键词： rainbow Trout Fermented Soybean Meal PepSoygen Oncorhynchus mykiss diet Alternative Proteins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

在改进的等离子体源质谱仪中加入电光离子检测器(英文)

引用

光谱学与光谱分析 2002年第5期22卷 828-837页

作者： david A.Solyom James H.barnes Ole A.grn gary M.Hieftje 美国印第安纳大学化学系

从整个质谱学的历史来看 ,阵列检测器一直用来进行同时和连续的质谱测量研究。利用阵列检测器获取多道数据的好处已为人们所熟知 ,这包括较大的占空因素、借助比值和内标技术改善的精度以及对快信号瞬变过程较好的定量分析。由于有这些... 详细信息

从整个质谱学的历史来看 ,阵列检测器一直用来进行同时和连续的质谱测量研究。利用阵列检测器获取多道数据的好处已为人们所熟知 ,这包括较大的占空因素、借助比值和内标技术改善的精度以及对快信号瞬变过程较好的定量分析。由于有这些好处 ,多种基于阵列检测器的测量仪器得到开发 ,包括光学的和质谱仪。本文描述配备多道电光离子检测器的等离子体源Mattauch Herzog质谱仪改善了的性能。所有的实验均采用一个辉光放电源。过去报道的这台质谱仪的基于阵列检测器的数据在质量方面受到严重的局限 ,谱峰形状和分辨率都极差。本文将介绍与阵列检测器有关的几个性能指数 ,这包括灵敏度、分辨率、谱峰形状以及同位素灵敏度。所有这些性能指数都得到明显的改善。

关键词：等离子体源质谱仪电光离子检测器 Mattauch-Herzog质谱仪阵列检测器

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Statistical Analysis for Engineers and Scientists：A Computer-Based Approach 工程师和科学家实用统计分析——基于计算机的方法

引用

丛书名：国外大学优秀教材--工业工程系列

2002年

作者： J. Wesley barnes

本书是第一本从现代计算机观点出发的工程统计学教材。通过集成教材中内容宽广的软件程序，结合在工程和科研中的应用，为学生讲授概率和统计学的概念。本书包含独特、全面及用户友好的软件包（用于PC机或苹果机），其特色是以应用为取... 详细信息

ISBN: (纸本)9787900641977

本书是第一本从现代计算机观点出发的工程统计学教材。通过集成教材中内容宽广的软件程序，结合在工程和科研中的应用，为学生讲授概率和统计学的概念。本书包含独特、全面及用户友好的软件包（用于PC机或苹果机），其特色是以应用为取向，而对大多数理论问题的探讨较为直观。通过精心设计的章节式学习方式和各种练习，帮助学生在充分学习使用软件的过程中掌握各章的内容，并对所有出现的假设检验中的有效样本进行了完全和详细的统计处理。本书的主要内容包括：多元回归分析、离散随机变量的卷积和变换、双变量概率分布、假设检验的操作特性曲线、统计过程控制和非参数统计分析等。

关键词： Engineering

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Landlocked Fall Chinook Salmon Egg Storage for delayed Fertilization

引用

Advances in Bioscience and Biotechnology 2020年第5期11卷 160-165页

作者： Hunter Eide Michael E. barnes South dakota department of game Fish and Parks McNenny State Fish Hatchery Spearfish South Dakota USA

delayed fertilization of salmonid eggs can be a useful option to enhance the efficiency of artificial spawning operations. This experiment examined the fertility of landlocked fall Chinook salmon (Oncorhynchus tshawytscha) eggs stored for various times after removal from female broodstock. Fertilization occurred either immediately after spawning or the eggs were stored with oxygen at 11°C and fertilized at 4, 6, 8, 12, or 20 hours post-spawn. Survival to the eyed stage of egg development was significantly greater in the eggs fertilized immediately or after four, six, or eight hours of storage compared to those eggs stored for 12 or 20 hours prior to fertilization (P = 0.024). Survival to hatch was also significantly different (P = 0.018) and followed the same pattern. This study is the first to document the successful fertilization of landlocked fall Chinook salmon eggs after eight hours of storage.

关键词： delayed Fertilization Chinook Salmon Egg Storage Oncorhynchus tshawytscha

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The PI3K/AKT Pathway and renal Cell Carcinoma

引用

Journal of genetics and genomics 2015年第7期42卷 343-353页

作者： Huifang guo Peter german Shanshan Bai Sean barnes Wei guo Xiangjie Qi Hongxiang Lou Jiyong Liang Eric Jonasch gordon B.Mills Zhiyong ding department of Systems Biology The University of Texas MD Anderson Cancer Center department of genitourinary Medical Oncology The University of Texas MD Anderson Cancer Center department of radiation Oncology People's Hospital of Linzi District department of Natural Products Chemistry Key Laboratory of Chemical Biology of Ministry of EducationSchool of Pharmaceutical SciencesShandong University

The phosphatidylinositol 3 kinase （PI3K）/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway, and thus is frequently activated as a cancer driver. More importantly, the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades, providing many potential targets for cancer therapy. renal cell carcinoma （rCC） is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies. The PI3K/AKT pathway is modestly mutated but highly activated in rCC, representing a promising drug target. Indeed, PI3K pathway inhibitors of the rapalog family are approved for use in rCC. recent large-scale integrated analyses of a large number of patients have provided a molecular basis for rCC, reiterating the critical role of the PI3K/AKT pathway in this cancer. In this review, we summarize the genetic alterations of the PI3K/AKT pathway in rCC as indicated in the latest large-scale genome sequencing data, as well as treatments for rCC that target the aberrant activated PI3K/AKT pathway.

关键词： PI3K AKT mTOr renal cell carcinoma Targeted therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A slow-growth high-mortality meta-analysis for insects： A comment on Chen and Chen

引用

Insect Science 2018年第2期25卷 352-354页

作者： Shannon M. Murphy Mayra C. Vidal Claudia J. Hallagan Elizabeth E. barnes E. dale Broder department of Biological Sciences University of Denver Denver CO US

dear Editor, Insect Science recently published a meta-analysis that tried to test support for the slow-growth high-mortality （hereafter Sg-HM） hypothesis （Chen＆ Chen, 2018）. Meta-analysis is a powerful statistical tool used to quantitatively compare and summarize multiple studies （Arnqvist ＆ Wooster, 1995）. However, results from a meta-analysis must be carefully interpreted when only limited sample sizes are available. Many conclusions made by Chen and Chen （2018） are based on low sam- rile sizes and/or have small fail-safe numbers,

关键词： FILE-drAWEr PrOBLEM LEAF QUALITY HYPOTHESIS PrEdATION

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

金属元素比值在镁铁质-超镁铁质侵入岩的铂族元素矿床勘探中的应用

引用

地质地球化学 1991年第4期19卷 17-20页

作者： S.J.barnes 李松辽宁有色勘查大队

即使岩浆中可能含有足够在侵入体中形成矿床的铂族元素,然而由于硫化物起到了铂族元素集聚体的作用,因此岩浆在它现在的位置定位以前就不应该经历硫化物的分凝作用。先期硫化物的分凝作用将把铀族元素从岩浆中提取出来并在别的位置(可... 详细信息

即使岩浆中可能含有足够在侵入体中形成矿床的铂族元素,然而由于硫化物起到了铂族元素集聚体的作用,因此岩浆在它现在的位置定位以前就不应该经历硫化物的分凝作用。先期硫化物的分凝作用将把铀族元素从岩浆中提取出来并在别的位置(可能在深部)淀积下来。假如先期硫化物的分凝作用没有把铂族元素从岩浆中提取出来,那么它们就有可能在侵入体中早期硫化物形成的位置富集。由于铂族元素在硫化物中具有此Ni和Cu高得多的分配系数,所以硫化物的分凝作用会强烈地影响Ni和Cu与铂族元素的比值。因此,为了判断某一侵入体中是否有可能赋存有铂族元素矿床,应该对冷凝边上Ni和Cu与铂族元素的比值加以研究。如果冷凝岩中铂族元素相对于Ni和Cu而言没有被贫化,那么该侵入体中就可能赋存铂族元素矿床。为了对侵入体中富集的铂族元素进行定位,可以利用横穿地层剖面岩石的Ni和Cu与铂族元素的比值,来寻找硫化物最初达到饱和的位置。然而,由于Ni和Cu与铂族元素的比值还受橄榄石和铬铁矿结晶作用的影响而使情况变得复杂化。为了消除橄榄石和铬铁矿对铂族元素和Ni迁移的影响,有必要考虑Pd/Ir或Pd/rh或Pd/Pt与Ni/Cu的比值关系。

关键词：铂矿床勘探金属元素比值侵入岩

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：