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Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease(GCKD)cohort

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bone research 2023年第4期11卷 764-771页

作者： Katharina Charlotte reimer Jennifer Nadal Heike Meiselbach Matthias Schmid Ulla T.Schultheiss Fruzsina Kotsis Helena Stockmann Nele Friedrich Matthias Nauck Vera Krane Kai-Uwe Eckardt Markus P.Schneider rafael Kramann Jürgen Floege Turgay Saritas Department of Nephrology Rheumatologyand Clinical ImmunologyUniversity Hospital RWTH AachenAachenGermany Institute of Experimental Medicine and Systems biology RWTH Aachen UniversityAachenGermany Institute for Cell and Tumor biology RWTH Aachen UniversityAachenGermany Institute of Medical biometry Informatics and EpidemiologyUniversity Hospital of BonnBonnGermany Department of Nephrology and Hypertension University of Erlangen-NürnbergErlangenGermany Institute of Genetic Epidemiology Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Medicine IV-Nephrology and Primary Care Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Nephrology and Medical Intensive Care Charité-Universitätsmedizin BerlinBerlinGermany Department of Nephrology University Medical Center RegensburgRegensburgGermany Institute of Clinical Chemistry and Laboratory Medicine University Medicine GreifswaldGreifswaldGermany DZHK(German Centre for Cardiovascular research) Partner Site GreifswaldUniversity MedicineGreifswaldGermany Department of Medicine I Division of NephrologyUniversity Hospital WürzburgWürzburgGermany

Mineral and bone disorder(MbD)in chronic kidney disease(CKD)is tightly linked to cardiovascular disease(CVD).In this study,we aimed to compare the prognostic value of nine MbD biomarkers to determine those associated best with adverse cardiovascular(CV)outcomes and *** 5217 participants of the German CKD(GCKD)study enrolled with an estimated glomerular filtration rate(eG Fr)between 30–60 mL·min-1 per 1.73 m2 or overt proteinuria,serum osteoprotegerin(OPG),C-terminal fibroblast growth factor-23(FGF23),intact parathyroid hormone(iP TH),bone alkaline phosphatase(bAP),cross-linked C-telopeptide of type 1 collagen(CTX1),procollagen 1intact N-terminal propeptide(P1NP),phosphate,calcium,and 25-OH vitamin D were measured at *** with missing values among these parameters(n=971)were excluded,leaving a total of 4246 participants for *** a median follow-up of6.5 years,387 non-CV deaths,173 CV deaths,645 nonfatal major adverse CV events(MACEs)and 368 hospitalizations for congestive heart failure(CHF)were *** and FGF23 were associated with all outcomes,with the highest hazard ratios(Hrs)for *** the final Cox regression model,adjusted for CV risk factors,including kidney function and all other investigated biomarkers,each standard deviation increase in OPG was associated with non-CV death(Hr 1.76,95%CI:1.35–2.30),CV death(Hr 2.18,95%CI:1.50–3.16),MACE(Hr 1.38,95%CI:1.12–1.71)and hospitalization for CHF(Hr 2.05,95%CI:1.56–2.69).Out of the nine biomarkers examined,stratification based on serum OPG best identified the CKD patients who were at the highest risk for any adverse CV outcome and mortality.

关键词： Kidney cardiovascular vitamin

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Aerobic bacteria associated with chronic suppurative otitis media in Angola

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Infectious Diseases of Poverty 2018年第1期7卷 404-413页

作者： Fabian Udden Matuba Filipe Ake reimer Maria Paul Erika Matuschek John Thegerstrom Sven Hammerschmidt Tuula Pelkonen Kristian riesbeck Clinical Microbiology Department of Translational MedicineFaculty of MedicineLund UniversityMalmoSweden OrL-department Hospital Josina Machel Faculty of MedicineAgostinho Neto UniversityLuandaAngola Nashalsan Höllviken Ab HollvikenSweden EUCAST Development Laboratory c/o Clinical MicrobiologyCentral HospitalVaxjoSweden Department of Molecular Genetics and Infection biology University of GreifswaldGreifswaldGermany Children’s Hospital Helsinki University HospitalHelsinkiFinland and University of HelsinkiHelsinkiFinland

background:Chronic suppurative otitis media(CSOM)is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living *** antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some *** goal of this study was to define aerobic pathogens associated with CSOM in Angola with the overall aim to provide a background for local treatment ***:Samples from ear discharge and the nasopharynx were collected and cultured from 152 patients with ear discharge and perforation of the tympanic *** of bacterial species was performed with matrix-assisted laser desorption/ionization-time of flight mass spectrometry and pneumococci were serotyped using multiplex polymerase chain *** susceptibility testing was done according to ***:One hundred eighty-four samples from ear discharge and 151 nasopharyngeal swabs were collected and yielded 534 and 289 individual isolates,*** all patients,correspondence rate of isolates from 2 ears in patients with bilateral disease was 27.3%and 9.3%comparing isolates from the nasopharynx and ear discharge,*** spp.(14.7%),Pseudomonas aeruginosa(13.2%)and Enterococcus spp.(8.8%)were dominating pathogens isolated from ear discharge.A large part of the remaining species belonged to Enterobacteriaceae(23.5%).Pneumococci and Staphylococcus aureus were detected in approximately 10%of nasopharyngeal *** rates to quinolones exceeded 10%among Enterobacteriaceae and was 30.8%in ***,whereas 6.3%of *** were ***:The infection of the middle ear in CSOM is highly polymicrobial,and isolates found in nasopharynx do not correspond well with those found in ear *** associated with CSOM in Angola are dominated b

关键词： Chronic suppurative otitis media Enterobacteria Infection Otitis media Proteus Pseudomonas aeruginosa

静息心率对冠状动脉病伴高血压患者预后的影响

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心血管病学进展 2009年第2期30卷 348-348页

作者： Averza Mr reimer WS Lenzen M 袁志敏（摘译）刘运德（校）不详四川省第五人民医院成都市第三人民医院

通常而言心率快慢与人均寿命长短逆相关;且静息心率(rHr)增快往往反映副交感张力降低和交感张力增强,并与血压和死亡风险强相关;相反,在急性心肌梗死和心力衰竭患者,使用b阻滞剂用以降低rHr,皆与其预后改善有关。现就冠状动脉疾病(CAD)... 详细信息

通常而言心率快慢与人均寿命长短逆相关;且静息心率(rHr)增快往往反映副交感张力降低和交感张力增强,并与血压和死亡风险强相关;相反,在急性心肌梗死和心力衰竭患者,使用b阻滞剂用以降低rHr,皆与其预后改善有关。现就冠状动脉疾病(CAD)伴接受治疗的高血压患者,rHr与其不良预后问关系进行分析。[第一段]

关键词：高血压患者静息心率不良预后冠状动脉病心力衰竭患者急性心肌梗死冠状动脉疾病人均寿命

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乐高之家

城市环境设计 2019年第2期118卷 62-73页

作者： Snorre Nash Andreas Klok Pedersen Agne Tamasauskaite Annette birthe Jensen Ariel Joy Norback Wallner Ask Hvas birgitte Villadsen Chris Falla Christoffer Gotfredsen Daruisz Duong Vu Hong David Zahle Esben Christoffersen Franck Fdida Ioana Fartadi Scurtu Jakob Andreassen Jakob Ohm Laursen Jakob Sand Jakub Matheus Wlodarczyk Jesper bo Jensen Jesper boye Andersen Julia boromissza Kasper reimer Hansen Katarzyna Krystyna Siedlecka Katarzyna Stachura Kekoa Charlot Leszek Czaja Lone Fenger Albrechtsen Louise b?geskov Hou Mads Enggaard Stidsen Magnus Algreen Suhr Manon Otto Marta Christensen Mathias bank Stigsen Michael Kepke Ole Dau Mortensen ryohei Koike Sergiu Calacean S?ren Askehave Stefan Plugaru Stefan Wolf Thomas Jakobsen randb?ll Tobias Hjortdal Tommy bj?rnstrup Iwan baan Kim Christensen 陈思瑾

"乐高之屋展现了乐高积木的无限可能性。通过系统的创造力,让所有年龄段的孩子都能够使用这些工具来创造他们自己的世界,并通过游戏的方式生活其中。最棒的是,建筑和乐高游戏都是这样的:使人们能够想象比现状更令人兴奋和更具表现力的... 详细信息

"乐高之屋展现了乐高积木的无限可能性。通过系统的创造力,让所有年龄段的孩子都能够使用这些工具来创造他们自己的世界,并通过游戏的方式生活其中。最棒的是,建筑和乐高游戏都是这样的:使人们能够想象比现状更令人兴奋和更具表现力的新世界,并为他们提供使之成为现实的技能。这就是孩子们每天用乐高积木来做的事情,这也是我们今天用真实的砖石在乐高之屋里完成的事情,使比伦德向真

关键词：乐高积木展览空间