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It's all about timing, early treatment with hyperbaric oxygen therapy and corticosteroids is essential in acute acoustic trauma

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Journal of Otology 2021年第4期16卷 237-241页

作者： A.B.Bayoumy r.P.Weenink E.Lvan der Veen F.S.Besseling-Hansen A.D.M.Hoedemaeker F.J.Mde Jong M.Hvan der Laan r.Swenker r.avan hulst J.Ade ru Department of Otolaryngology Central Military HospitalMinistry of DefenseUtrechtthe Netherlands Department of Anesthesiology and Department of Hyperbaric Medicine Amsterdam University Medical CentersLocation AMCAmsterdamthe Netherlands Department of Otolaryngology-Head and Neck Surgery University Medical Centre UtrechtUtrechtthe Netherlands Diving Medical Centre Royal Netherlands NavyMinistry of DefenseDen Helderthe Netherlands

Background: Acute acoustic trauma (AAT) is an acute hearing impairment caused by intense noiseimpact. The current management strategy for AAT with substantial hearing loss in the Dutch militaryis the combination therapy with corticosteroids and hyperbaric oxygen therapy (HBOT). In a previousstudy, early initiation of the combination therapy was associated with better outcomes. Therefore, weperformed a new analysis to assess the difference in hearing outcome between patients in whomcombination therapy was started within two days, versus after more than two ***: A retrospective analysis was performed on military patients diagnosed with AAT with substantial hearing loss who presented between February 2018 and March 2020. Absolute and relativehearing improvement between first and last audiograms were calculated for all affected frequencies(defined as loss of 20 dB on initial audiogram). We also determined the amount of patients whorecovered to the level of Dutch military requirement, and performed speech discrimination ***: In this analysis, 30 male patients (49 ears) with AAT were included. The median age was 24.5years (IQr 23e29). The median time to initiation of therapy with corticosteroids and HBOT were one andtwo days, respectively. HBOT was started within two days in 31 ears, and after more than two days in 18ears. The mean absolute and relative hearing gains were 18.8 dB (SD 14.6) and 46.8% (SD 31.3) on allaffected frequencies. The 100% discrimination/speech perception level improved from 64.0 dB to 51.7 dB(gain 12.3 dB ± 14.1). There was significantly more improvement in absolute and relative hearingimprovement when HBOT was started in 2 days, compared to >2 ***: Our analysis shows results in favor of early initiation ( 2 days) of the combination treatmentof HBOT and corticosteroids in patients with AAT.

关键词： Hyperbaric oxygen therapy Acute acoustic trauma Hearing loss Corticosteroids Blast injury Noise-induced hearing loss

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rapid and robust control of single quantum dots

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Light(Science & Applications) 2016年第1期5卷 143-149页

作者： Nicolò Accanto Pablo M de roque Marcial Galvan-Sosa Sotirios Christodoulou Iwan Moreels Niek F van hulst ICFO-Institut de Ciencies Fotoniques The Barcelona Institute of Science and Technology08860 Castelldefels(Barcelona)Spain Instituto deÓptica-CSIC 28006 MadridSpain Istituto Italiano di Tecnologia 16163 GenovaItaly Department of Physics University of Genova16146 GenovaItaly ICrEA-InstitucióCatalana de recerca i Estudis avançats 08010 BarcelonaSpain

The combination of single particle detection and ultrafast laser pulses is an instrumental method to track dynamics at the femtosecond time scale in single molecules,quantum dots and plasmonic *** control of the extremely short-lived coherences of these individual systems has so far remained elusive,yet its successful implementation would enable arbitrary external manipulation of otherwise inaccessible nanoscale *** ensemble measurements,such control is often achieved by resorting to a closed-loop optimization strategy,where the spectral phase of a broadband laser field is iteratively *** scheme needs long measurement times and strong signals to converge to the optimal *** requirement is in conflict with the nature of single emitters whose signals are weak and *** we demonstrate an effective closed-loop optimization strategy capable of addressing single quantum dots at room temperature,using as feedback observable the two-photon photoluminescence induced by a phase-controlled broadband femtosecond *** to the optimization loop is the use of a deterministic and robust-against-noise search algorithm converging to the theoretically predicted solution in a reduced amount of steps,even when operating at the few-photon *** optimization of the single dot luminescence is obtained within~100 trials,with a typical integration time of 100 ms per *** times are faster than the typical photobleaching times in single molecules at room *** results show the suitability of the novel approach to perform closed-loop optimizations on single molecules,thus extending the available experimental toolbox to the active control of nanoscale coherences.

关键词： closed-loop control coherent control single quantum dot two-photon luminescence ultrafast

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Phase control of femtosecond pulses on the nanoscale using second harmonic nanoparticles

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Light(Science & Applications) 2014年第1期3卷 335-341页

作者： Nicolo Accanto Jana B Nieder Lukasz Piatkowski Marta Castro-Lopez Francesco Pastorelli Daan Brinks Niek F van hulst ICFO—Institut de Ciencies Fotoniques 08860 Castelldefels(Barcelona)Spain Institut Fresnel CNRS UMR7249Aix-Marseille University13397 MarseilleFrance ICrEA—Institucio Catalana de recerca i Estudis avanc¸ats(ICrEA) 08010 BarcelonaSpain

Investigations of ultrafast processes occurring on the nanoscale require a combination of femtosecond pulses and nanometer spatial ***,controlling femtosecond pulses with nanometer accuracy is very challenging,as the limitations imposed both by dispersive optics on the time duration of a pulse and by the spatial diffraction limit on the focusing of light must be overcome *** this paper,we provide a universal method that allows full femtosecond pulse control in subdiffraction-limited *** achieve this aim by exploiting the intrinsic coherence of the second harmonic emission from a single nonlinear nanoparticle of deep subwavelength *** method is proven to be highly sensitive,easy to use,quick,robust and *** approach allows measurements of minimal phase distortions and the delivery of tunable higher harmonic light in a nanometric ***,the method is shown to be compatible with a wide range of particle sizes,shapes and materials,allowing easy optimization for any given *** method will facilitate the investigation of light–matter interactions on the femtosecond–nanometer level in various areas of scientific study.

关键词： diffraction limit Fourier limit multiphoton intrapulse interference phase scan nanoparticle nanophotonics phase control second harmonic generation ultrafast

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《词重音:理论和类型议题》述评

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当代语言学 2021年第3期23卷 466-474页

作者：江荻 Harry van der hulst 江苏师范大学汉语和汉藏语研究中心中国社会科学院民族学与人类学研究所不详

1.引言词重音在跨语言视角下呈现出复杂的多样性类型,寻找统一的理论阐释和描述一直是国际语音韵律研究领域追求的方向。Harry van der hulst与同行近年来尝试以构建数据库的方式揭示词重音的分布模式、形成方式,并设计有效模型来解释... 详细信息

1.引言词重音在跨语言视角下呈现出复杂的多样性类型,寻找统一的理论阐释和描述一直是国际语音韵律研究领域追求的方向。Harry van der hulst与同行近年来尝试以构建数据库的方式揭示词重音的分布模式、形成方式,并设计有效模型来解释其行为和形式表征。围绕数据库项目StressTyp2,hulst组织了两次专题讨论会,国际语音韵律学术界一批顶级专家参与讨论,就广泛的数据样本提出一系列关键性新方法和新理论,引起学界极大的兴趣。

关键词：语音韵律专题讨论会形式表征词重音参与讨论跨语言视角分布模式顶级专家

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《元音和谐中的不对称性: 表达层面的解释》述介

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当代语言学 2020年第2期22卷 295-302页

作者： Harry van der hulst 顾笙韵张吉生不详华东师范大学外语学院上海闵行区200241

元音和谐指在特定的语法范畴内,所有元音具有某个或某些共同的特征,比如腭位、唇状、舌位高低或舌根位置等(van der hulst 2016)。元音和谐是在阿尔泰语系、乌拉尔语系以及非洲诸语言中普遍存在的音系过程。元音和谐可以贯穿整个语素,... 详细信息

元音和谐指在特定的语法范畴内,所有元音具有某个或某些共同的特征,比如腭位、唇状、舌位高低或舌根位置等(van der hulst 2016)。元音和谐是在阿尔泰语系、乌拉尔语系以及非洲诸语言中普遍存在的音系过程。元音和谐可以贯穿整个语素,也可以跨越语素界,绝大多数语言的元音和谐域是韵律词。根据和谐的方向,元音和谐可分为单向和谐和双向和谐。根据触发元音的特征,元音和谐可分为词根控制型和词缀控制型。元音和谐的复杂性主要体现在中性元音上。所谓中性元音,是指那些不参与和谐的元音。一直以来,中性元音被分为两大类:不透明性和透明性。不透明性中性元音会阻断和谐过程,而透明性中性元音允许和谐特征通过并进一步扩散(Archangeli and Pulleyblank 2007)。几十年以来,对中性元音的形式特征的描述一直是音系学研究中的难题。目前已有对中性元音作出有效而经济的解释的多种尝试,但无论是历时音变说、特征不充分赋值说,还是特征漂浮说等.

关键词：中性元音元音和谐语法范畴音系学不透明性阿尔泰语系不对称性韵律词

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幽门螺杆菌感染的治疗：1994年休士敦第七届胃十二指肠病理学和幽门螺杆菌

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中华消化杂志 1995年第3期15卷 164-166页

作者：莫剑忠荷兰阿姆斯特丹医学学术中心胃肠病肝科

幽门螺杆菌感染的治疗：１９９４年休士敦第七届胃十二指肠病理学和幽门螺杆菌研讨会和洛杉矶世界胃肠病学大会ｖａｎｄｅｒＨｕｌｓｔＲＷＭ，ＴｙｔｇａｔＧＮＪ幽门螺杆菌（Ｈｐ）的根治使胃十二指肠溃疡的复发显著减少。今年，对于... 详细信息

幽门螺杆菌感染的治疗：１９９４年休士敦第七届胃十二指肠病理学和幽门螺杆菌研讨会和洛杉矶世界胃肠病学大会ｖａｎｄｅｒＨｕｌｓｔＲＷＭ，ＴｙｔｇａｔＧＮＪ幽门螺杆菌（Ｈｐ）的根治使胃十二指肠溃疡的复发显著减少。今年，对于溃疡病中的Ｈｐ，美国ＮＩＨ统一意见...

关键词：幽门螺杆菌胃十二指肠溃疡病理

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Innervated full thickness grafts in distal finger amputations

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Chinese Journal of Traumatology 2017年第6期20卷 355-358页

作者： Anouk J.M. Cornelissen Martijn A. van Onna Xavier H.A. Keuter rene rWJ. van der hulst Maastricht University Medical Center Department of Plastic and Reconstructive Surgery R Debyelaan 25 Maastricht 6229 HX The Netherlands

Innervated full thickness graft will be presented as an option to reconstruct a fingertip defect which might result in better sensibility than standard reconstruction using a full thickness graft without innervation. ... 详细信息

关键词： Finger joint Amputation Surgical flaps Innervation Neuroma

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乌干达花卉业前景喜人

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中国花卉园艺 2005年第13期 48-49页

作者： Jeroen van der hulst 钟云芳

乌干达是非洲东部的内陆国家,横跨赤道,东邻肯尼亚,南接坦桑尼亚和卢旺达,西接刚果(金),北连苏丹,自然条件优越,加上政府的大力支持,鲜切花产品生产潜力巨大。

关键词：乌干达花卉业前景种植面积发展速度花卉种植出口商品花卉市场肯尼亚种植业出口量年平均出口额邻国经营公司

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Colonoscopic yield of colorectal neoplasia in daily clinical practice

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World Journal of Gastroenterology 2009年第9期15卷 1085-1092页

作者： Jochim S Terhaar sive Droste Mike E Craanen rene WM van der hulst Joep F Bartelsman Dick P Bezemer Kim r Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ArE Tuynman roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder Department of Gastroenterology and Hepatology VU University Medical CentrePO Box 70571007 MBAmsterdamThe Netherlands Gastroenterology and Hepatology Kennemer Gasthuis2000 AKHaarlemThe Netherlands Gastroenterology and Hepatology Academic Medical Centre1100 DDAmsterdamThe Netherlands Epidemiology and Biostatistics VU University Medical Centre1007 MBAmsterdamThe Netherlands Pathology VU University Medical Centre1007 MBAmsterdamThe Netherlands Gastroenterology and Hepatology Slotervaart Hospital1006 BKAmsterdamThe Netherlands Gastroenterology and Hepatology Medical Centre Alkmaar1800 AMAlkmaarThe Netherlands Gastroenterology and Hepatology Sint Lucas Andreas Hospital1061 AEAmsterdamThe Netherlands

AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per ***:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or ***:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients.

关键词： Colorectal cancer Screening Advanced neoplasia Colonoscopy Adenoma

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中国上消化道疾病患者幽门螺杆菌感染根除前后胃粘膜病理改变与空泡毒素活性的关系

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胃肠病学 2001年第3期6卷 131-134页

作者：陈晓宇 rWM van der hulst A van der Ende 萧树东 GNJ Tytgat FJW Ten Kate 上海第二医科大学附属仁济医院上海市消化疾病研究所‘200001 荷兰阿姆斯特丹大学医学中心

目的：观察幽门螺杆菌（Ｈ．ｐｙｌｏｎ）阳性消化性溃疡病和慢性胃炎患者Ｈ．ｐｙｌｏｒｉ根除前后胃粘膜病理改变与空泡毒素（ＶａｃＡ）活性的关系。方法：功能性消化不良伴Ｈ．ｐｙｌｏｒｉ感染的中国患者７４例，于Ｈ．ｐｙｌｏ... 详细信息

目的：观察幽门螺杆菌（Ｈ．ｐｙｌｏｎ）阳性消化性溃疡病和慢性胃炎患者Ｈ．ｐｙｌｏｒｉ根除前后胃粘膜病理改变与空泡毒素（ＶａｃＡ）活性的关系。方法：功能性消化不良伴Ｈ．ｐｙｌｏｒｉ感染的中国患者７４例，于Ｈ．ｐｙｌｏｎ根除前和４～６周后作胃镜检查，根据新悉尼病理分级法按半定量记分对治疗前后的胃粘膜病理变化程度进行分级。结果：ＶａｃＡ菌检出率为８０％（５９７４），消化性溃疡病患音的检出率与慢性胃炎患者无明显差别；ＶａｃＡ＋和ＶａｃＡ－组患者的Ｈ．ｐｙｌｏｒｉ根除率亦无明显差别。根除治疗前，Ｖａｃａ和ＶａｃＡ－组患者的胃粘膜慢性炎症、活动性、表面上皮损伤、萎缩、肠化和淋巴滤泡数显无著著差别；治疗后４－６周，两组患者的胃窦粘膜炎症活动性、表面上皮损伤和慢性炎症程度均明显减轻，尤以前者为著（Ｐ＜０．０００１），ＶａｃＡ组患者的胃窦部淋巴滤泡数量减少亦梢较ＶａｃＡ组明显（Ｐ＝００５１），两组患者的胃粘膜萎缩和肠化程度均无明显好转。结论：中国上消化道疾病患者Ｈ．ｐｙｌｏｎ感染根除前后的胃粘膜病理改变与ＶａｃＡ活性无明显关系。成功根除Ｈ．ｐｙｌｏｒｉ感染并不引起萎缩和肠化的逆转。

关键词：螺杆菌感染细菌毒素类病理学上消化道溃疡胃炎

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