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A Peptide Containing T-Cell Epitopes of <i>Chlamydia trachomatis</i>recombinant MOMP Induces Systemic and Mucosal Antibody responses in Mice

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World Journal of Vaccines 2011年第4期1卷 138-147页

作者： Murtada A. Taha Shree r. Singh Kara Hulett Shreekumar r. pillai ronald Agee Vida A. Dennis 不详

We reported that intranasal immunization of mice with recombinant major outer membrane protein (MOMP) of Chlamydia trachomatis genetically fused with modified cholera toxin elicited mucosal and systemic antibody responses, but with inefficient protective mechanisms for complete protection of mice against a homologous C. trachomtis challenged infection. To begin to identify specific immunogenic MOMP regions to pursue as vaccine candidates, herein we selected small gene fragments of the MOMP gene containing T-cell epitopes (278-370 aa) and generated a rMOMP peptide (rMOMP-278). rMOMP and rMOMP-278 proteins were cloned, expressed, and their purities and specificities confirmed by SDS-PAGE and Western blot, respectively. We tested the immunogenicity of rMOMP-278 as compared to the parent rMOMP in mice. Mice were immunized intramuscularly with purified rMOMP proteins;total- and isotype- (IgA, IgG1, IgG2a, and IgG2b) specific antibodies in sera and vaginal washes were measured by ELISA. Immunized mice developed antigen-specific total antibodies in a kinetic fashion, with responses being higher to rMOMP than rMOMP- 278. However, antigen-specific isotype antibodies were detected in the order of IgG2b > IgG2a > IgG1 for rMOMP- 278, indicating more of a mixed Th1/Th2 response. Contrastingly, antibody responses to rMOMP was more of a predominant Th2 response in the order of IgG1 > IgG2b > IgG2a. Our data are evidence to suggest that rMOMP-278 is immunogenic by its ability to evoke systemic and mucosal immune responses with a Th1 bias in mice, and therefore may be an attractive peptide alternative to full MOMP as a vaccine candidate against C. trachomatis genital tract infection.

关键词： Bacteria rMOMP Mucosal Vaccine Antibody

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为新轮胎应用设计的粉末轮胎碎屑的再生

橡塑资源利用 2003年第3期 42-45页

作者： Hari Chandro Chandrasekaran r.pillai 陈静天津市橡胶工业研究所

一种基于橡胶再生的专门用于新轮胎配方中的新型回用轮胎碎屑被研制出并通过了测试。与市场上其它的再生橡胶和脱硫轮胎橡胶的硫化产品相比,在不影响最终产品性能的前提下能加入更大的量。与市场中现有的回用,脱硫橡胶不同的是,用聚合... 详细信息

一种基于橡胶再生的专门用于新轮胎配方中的新型回用轮胎碎屑被研制出并通过了测试。与市场上其它的再生橡胶和脱硫轮胎橡胶的硫化产品相比,在不影响最终产品性能的前提下能加入更大的量。与市场中现有的回用,脱硫橡胶不同的是,用聚合物取代要远胜于添加或填充。其成本与优级轮胎碎屑相差不多,从经济方面来看也是十分吸引人的。

关键词：轮胎胎面轮胎应用脱硫配方聚合物轮胎橡胶混炼胶拉伸性能再生橡胶硫化产品

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胶园化学除草综述

世界热带农业信息 1981年第1期 26-29+43页

作者： K. r. pillai 凌育凡

本文综述了胶园化学除草的最新进展,简述如下。一、化学除草剂朝高效的方向发展过去使用亚砷酸钠防除杂草很少考虑杂草种群的种类组成。因为亚砷酸钠是一种没有什么选择性的灭生性触杀剂。然而较新颖

关键词：除草剂作用方式防效混合剂除莠剂复配剂茅草枯杂草种群胶园化学除草

用于水下电子声学换能器技术透声材料的橡胶配件的研究及其老化特性(二)

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橡塑资源利用 2017年第3期 34-40页

作者： velayudhan balakrishna pillai 孙新(编译) 不详天津市橡胶工业研究所有限公司 300384

对于有效的消除回声参数，r和T都必须接近于0。术语称之为反声衰减（Er）和传导损耗（TL）。

关键词：声学换能器老化特性橡胶配件材料技术电子水下传导损耗

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磷酸化槚如坚果壳液对天然橡胶硫化胶物理机械性能的影响

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橡胶参考资料 1993年第3期23卷 36-41页

作者： A. r. r. Menon C. K. S. pillai G. B. Nando 王进文

1 前言在为改善橡胶制品性能,从而满足特殊使用要求的不懈研究中,橡胶工艺人员一直在胶料中使用各种专用填加剂。它们包括起交联剂、增粘剂或增塑剂作用的某些酚醛树脂。然而。

关键词：天然橡胶硫化胺填加剂

Human galectin-9 potently enhances SArS-CoV-2 replication and inflammation in airway epithelial cells

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Journal of Molecular Cell Biology 2023年第4期15卷 46-59页

作者： Li Du Mohamed S.Bouzidi Akshay Gala Fred Deiter Jean-Noël Billaud Stephen T.Yeung Prerna Dabral Jing Jin Graham Simmons Zain Y.Dossani Toshiro Niki Lishomwa C.Ndhlovu John r.Greenland Satish K.pillai Vitalant research Institute San FranciscoCA 94105USA Department of Laboratory Medicine University of CaliforniaSan FranciscoCA 94143-0134USA Department of Medicine University of CaliforniaSan FranciscoCA 94143-0410USA Veterans Affairs Health Care System San FranciscoCA 94121USA QIAGEN Digital Insights Redwood CityCA 94063USA Division of Infectious Diseases Department of MedicineWeill Cornell MedicineNew YorkNY 10021USA Department of Immunology Kagawa UniversityKagawa 760-0016Japan

The severe acute respiratory syndrome coronavirus 2 (SArS-CoV-2) pandemic has caused a global economic and health crisis. recently, plasma levels of galectin-9 (Gal-9), a β-galactoside-binding lectin involved in immune regulation and viral immunopathogenesis, were reported to be elevated in the setting of severe COVID-19 disease. However, the impact of Gal-9 on SArS-CoV-2 infection and immunopathology remained to be elucidated. In this study, we demonstrate that Gal-9 treatment potently enhances SArS-CoV-2 replication in human airway epithelial cells (AECs), including immortalized AECs and primary AECs cultured at the air–liquid interface. Gal-9–glycan interactions promote SArS-CoV-2 attachment and entry into AECs in an angiotensin-converting enzyme 2 (ACE2)-dependent manner, enhancing the binding of the viral spike protein to ACE2. Transcriptomic analysis revealed that Gal-9 and SArS-CoV-2 infection synergistically induced the expression of key pro-inflammatory programs in AECs, including the IL-6, IL-8, IL-17, EIF2, and TNFα signaling pathways. Our findings suggest that manipulation of Gal-9 should be explored as a therapeutic strategy for SArS-CoV-2 infection.

关键词： SArS-CoV-2 galectin-9 inflammation airway epithelial cells

Baseline neutrophil-lymphocyte ratio and platelet-lymphocyte ratio appear predictive of immune treatment related toxicity in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1900-1912页

作者： Sirish Dharmapuri UmutÖzbek Hiren Jethra Tomi Jun Thomas U Marron Anwaar Saeed Yi-Hsiang Huang Mahvish Muzaffar Matthias Pinter Lorenz Balcar Claudia Fulgenzi Suneetha Amara Arndt Weinmann Nicola Personeni Bernhard Scheiner Tiziana Pressiani Musharraf Navaid Bertram Bengsch Sonal Paul Uqba Khan Dominik Bettinger Naoshi Nishida Yehia Ibrahim Mohamed Arndt Vogel Anuhya Gampa James Korolewicz Antonella Cammarota Ahmed Kaseb Peter r Galle Anjana pillai Ying-Hong Wan Alessio Cortellini Masatoshi Kudo Antonio D’Alessio Lorenza rimassa David James Pinato Celina Ang Tisch Cancer Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Population Health Science and Policy Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Data Analytics Harrisburg Harrisburg University of Science and TechnologyHarrisburdPA 17101United States SEMA4 StamfordCT 06902United States Division of Medical Oncology Kansas University of Kansas Cancer CenterKansasMO 66160United States Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipei 11217Taiwan Department of Internal Medicine Brody School of MedicineEast Carolina UniversityGreenvilleNC 27858United States Department of Internal Medicine III Division of Gastroenterology and HepatologyMedical University of ViennaVienna 1090Austria Department of Surgery and Cancer Imperial College LondonHammersmith Hospital LondonLondon W120HSUnited Kingdom Department of Hepatology Johannes Gutenberg-University Medical CentreNiedersachsen 30625Germany Medical Oncology Unit ASST GardaVia Lungomella ValsecchiBresciaManerbio 25025Italy Medical Oncology and Hematology Unit Humanitas Cancer CenterIRCCS Humanitas Research HospitalMilanRozzano 20089Italy Department of Medicine II Univ Med Ctr FreiburgHugstetter Str 55University Hospital FreiburgFreiburg D-79106Germany Department of Oncology Baltimore LifeBridge HealthBaltimoreMD 21215United States Division of Hematology and Oncology Weill Cornell Medical CollegeNY 10065United States Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka 577-8502Japan Department of Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Gastroenterology Hepatology and Endocrinology HannoverArndt VogelMedical School HannoverCarl-Neubergstr.Hannover 30659Germany Department of Hepatology Rush University Medical Group 1725 W Harrison St Ste 158ChicagoIL 60612United States Department of Biomedica

BACKGrOUND A well-recognized class effect of immune checkpoint inhibitors(ICI)is immune-related adverse events(IrAEs)ranging from low grade toxicities to life-threatening end organ damage requiring permanent discontinuation of *** are reported inreated with *** are,however,no reliable markers to predict the onset and severity of *** tested the association between neutrophil-lymphocyte ratio(NLr)and platelet-lymphocyte ratio(PLr)at baseline with development of clinically significant IrAEs(grade≥2)in hepatocellular carcinoma(HCC)patients treated with *** To test the association between NLr and PLr at baseline with development of clinically significant IrAEs(grade≥2)in HCC patients treated with *** Data was extracted from an international database from a consortium of 11 tertiary-care referral ***=absolute neutrophil count/absolute lymphocyte count(ALC)and PLr=platelet count/*** of 5 was used for NLr and 300 for PLr based on *** also tested the association between rESULTS Data was collected from 361 patients treated between 2016-2020 across the United States(67%),Asia(14%)and Europe(19%).Most patients received Nivolumab(n=255,71%).One hundred sixty-seven(46%)patients developed at least one IrAE,highest grade 1 in 80(48%),grade≥2 in 87(52%)*** a univariable regression model PLr>300 was significantly associated with a lower incidence of grade≥2 IrAEs(Or=0.40;P=0.044).Similarly,a trend was observed between NLr>5 and lower incidence of grade≥2 IrAEs(Or=0.58;P=0.097).Multivariate analyses confirmed PLr>300 as an independent predictive marker of grade≥2 IrAEs(Or=0.26;P=0.011),in addition to treatment with programmed cell death ligand 1(PD-1)/cytotoxic T lymphocyte-associated protein-4(Or=2.57;P=0.037)and PD-1/tyrosine kinase inhibitor(Or=3.39;P=0.01)*** use was not associated with IrAE incidence(Or=1.02;P=0.954).Patients treated with steroids had a>2-fold higher incidence of gr

关键词： Neutrophil-lymphocyte ratio Platelet-lymphocyte ratio Inflammatory biomarkers Immunotherapy Immune toxicity

The association between body composition and self-reported co-morbidity in subjects with chronic obstructive pulmonary disease

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Open Journal of Internal Medicine 2012年第2期2卷 100-106页

作者： Erica P. A. rutten Per S. Bakke Sreekumar G. pillai Scott Wagers Thomas B. Grydeland Amund Gulsvik Emiel F. M. Wouters Center of Expertise for Chronic Organ Failure (Ciro) Horn The Netherlands Genetics GlaxoSmithKline R&D Raleigh USA Section of Thoracic Medicine Institute of Medicine University of Bergen Bergen Norway

Background: Differences in body composition are extensively investigated in subjects with COPD as low muscle mass was independently associated with increased morbidity and mortality. Also cardio-vascular co-morbidity is often reported in COPD and the contribution of fat mass in COPD related co-morbidity is gaining interest. We hypothesized that the prevalence of low muscle mass and high fat mass is higher in subjects with COPD compared to a group of current and former smokers without COPD, which result in higher reported cardiovascular co-morbidity in the COPD group. Methods: In 954 subjects with COPD and 955 subjects without COPD, body composition was assessed by bio-electrical impedance analysis and information on self-reported co-morbidity was collected. Participants were stratified for low fat free mass index and high fat mass index (resp. fat free mass index 50th percentile of the subjects without COPD). results: Subjects with COPD were more likely to have low fat free mass index than current and former smokers without COPD. The prevalence of high fat mass index was comparable between the groups. The percentage of self-reported co-morbidity was higher in subjects with COPD, but only reports of myocardial infarction were disease specific. Conclusion: Low fat free mass index was more common in COPD, but the prevalence of high fat mass index was comparable between subjects with and without COPD. Nevertheless, subjects with COPD reported more myocardial infarction, implying that other factors than the amount of fat mass are involved in the increased co-morbidity in COPD.

关键词： Co-Morbidity Fat Free Mass Fat Mass

A Peptide Containing T-Cell Epitopes of Chlamydia trachomatis recombinant MOMP Induces Systemic and Mucosal Antibody responses in Mice

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