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Bridging the Gap:Integration of Artificial Intelligence with Organ-on-Chip(AI-OoC)

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IJLAI Transactions on Science and Engineering

IJLAI Transactions on Science and Engineering 2024年第1期2卷 17-23页

作者： mirza Abdul Aleem Baig Center for Biomedical Engineering School of Electronic Engineering and Information ScienceUniversity of Science and Technology of China(USTC)HefeiAnhuiP.R.China

.Organ-on-Chip(OoC)has emerged as a revolutionary approach to emulate human organ function-ality in vitro,offering unparalleled insights into physiological processes and disease *** integration of artiﬁcial intelligence(AI)with OoC platforms presents a transformative synergy,combining the precision of microscale organ replication with the analytical prowess of intelligent algorithms,is emerging as a transforma-tive force in harnessing the full potential of *** perspective investigates the multifaceted implications of integrating AI with OoC,examining its impact on biomedical research,acknowledging the synergistic po-tential that arises from combining the precision of microscale organ replication with the analytical capabilities of intelligent algorithms,and fostering a future where the intricate workings of the technology and biology.

关键词： Organ-on-Chip(OoC) Artiﬁcial Intelligence(AI) Biomedical research Technology&Biology.

Exploring Bioinspired AI for Advanced Cell Labeling:Advancements and Applications in Biomedical research

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IJLAI Transactions on Science and Engineering

IJLAI Transactions on Science and Engineering 2024年第3期2卷 66-71页

作者： mirza Abdul Aleem Baig Center for Biomedical Engineering School of Information Science and Technology University of Science and Technology of China

Context:Bioinspired Artificial Intelligence(Bio-AI)has emerged as a transformative tool in biomedical research,addressing challenges in cell labeling essential for understanding cellular behavior and *** cell labeling methods often struggle with accuracy,scalability,and adaptability in complex ***:This paper theoretically explores the integration of Bio-AI models into cell labeling *** aims to assess how these models C encompassing neural networks,swarm intelligence,evolutionary algorithms,and self-organizing maps C can enhance cell identification and ***:The paper examines various Bio-AI models that mimic biological processes such as neural functioning,swarm behavior,and evolutionary *** also evaluates the application of multimodal AI systems that combine imaging data with molecular and genetic *** addition,the potential of dynamic cell labeling,inspired by neural plasticity,is ***:The integration of Bio-AI models has demonstrated significant improvements in accuracy,adaptability,and scalability for cell *** labeling systems minimize human error and enhance *** advancements in multimodal AI systems have shown promise in combining imaging with genetic and molecular data,providing more comprehensive insights into cellular *** labeling models inspired by neural plasticity offer enhanced tracking of cellular transitions over ***:Bio-AI holds transformative potential in biomedical research via enabling real-time,dynamic labeling,essential for tracking cellular changes over time in processes like cancer progression,stem cell differentiation,and immune *** continued evolution of these AI-driven approaches is expected to accelerate breakthroughs in understanding diseases,tissue engineering,and regenerative medicine.

关键词： Bioinspired Artificial Intelligence Biomedical research Cell Labeling Bio-AI Models

Navigating Biomedical Ethical Challenges of Artificial Intelligence in Healthcare

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IJLAI Transactions on Science and Engineering

IJLAI Transactions on Science and Engineering 2024年第2期2卷 29-35页

作者： mirza Abdul Aleem Baig Center for Biomedical Engineering School of Electronic Engineering and Information Science University of Science and Technology of China(USTC) HefeiAnhuiP.R.China

Biomedical ethics,commonly known as bioethics,constitutes a dynamic and interdisciplinary field that confronts the intricate ethical challenges and moral quandaries inherent at the convergence of medicine,healthcare,and the life *** foundation lies in the core principles of respect for autonomy,beneficence,non-maleficence,and justice,which collectively establish a robust framework for guiding ethical decisionmaking in the realm of clinical practice,research endeavors,and the formulation of healthcare *** principle of autonomy underscores the importance of respecting individuals’rights to make informed decisions about their own healthcare,while beneficence and non-maleficence emphasize the ethical obligation to promote well-being and prevent ***,in the context of biomedical ethics,demands the equitable distribution of resources and fair treatment for all *** ethics serves as an indispensable compass for healthcare professionals,researchers,policymakers,and society at large,providing ethical guidance to navigate the intricate landscape of advancements in medicine and the life sciences.

关键词： Biomedical ethics Autonomy underscores Non-maleficence

Deep Learning Based Signal Detection for Quadrature Spatial Modulation System

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China Communications 2024年第10期 78-85页

作者： Shu Dingyun Peng Yuyang Yue Ming Fawaz AL-Hazemi Mohammad Meraj mirza School of Computer Science and Engineering Macau University of Science and Technology Department of Computer and Network Engineering University of Jeddah Department of Computer Science College of Computers and Information Technology Taif University

With the development of communication systems, modulation methods are becoming more and more diverse. Among them, quadrature spatial modulation(QSM) is considered as one method with less capacity and high efficiency. In QSM, the traditional signal detection methods sometimes are unable to meet the actual requirement of low complexity of the system. Therefore, this paper proposes a signal detection scheme for QSM systems using deep learning to solve the complexity problem. results from the simulations show that the bit error rate performance of the proposed deep learning-based detector is better than that of the zero-forcing(ZF) and minimum mean square error(MMSE) detectors, and similar to the maximum likelihood(ML) detector. Moreover, the proposed method requires less processing time than ZF, MMSE,and ML.

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Optimized protoplast isolation and transfection with a breakpoint:accelerating Cas9/sgrNA cleavage efficiency validation in monocot and dicot

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aBIOTECH 2024年第2期5卷 151-168页

作者： Debasmita Panda Subhasis Karmakar Manaswini Dash Swagat Kumar Tripathy Priya Das Sagar Banerjee Yiping Qi Sanghamitra Samantaray Pradipta Kumar Mohapatra mirza J.Baig Kutubuddin A.Molla ICAr National rice research Institute CuttackOdisha 753006India Department of Botany Ravenshaw UniversityCuttackOdisha 753003India Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA

The CrISPr-Cas genome editing tools are revolutionizing agriculture and basic biology with their simplicity and precision ability to modify target genomic ***-predicted guide rNAs(grNAs)often fail to induce efficient cleavage at target *** target loci are inaccessible due to complex chromatin ***,there is no suitable tool available to predict the architecture of genomic target sites and their ***,significant time and resources are spent on performing editing experiments with inefficient *** in vitro-cleavage assay could provide a rough assessment of grNA efficiency,it largely excludes the interference of native genomic *** in-vivo testing gives a proper assessment of the cleavage ability of editing reagents in a native genomic ***,we developed a modified protocol that offers highly efficient protoplast isolation from rice,Arabidopsis,and chickpea,using a sucrose gradient,transfection using PEG(polyethylene glycol),and validation of single guide rNAs(sgrNAs)cleavage efficiency of *** have optimized various parameters for PEG-mediated protoplast transfection and achieved high transfection efficiency using our protocol in both monocots and *** introduced plasmid vectors containing Cas9 and sgrNAs targeting genes in rice,Arabidopsis,and chickpea *** dual sgrNAs,our CrISPrdeletion strategy offers straightforward detection of genome editing success by simple agarose gel *** sequencing of PCr products confirmed the editing efficiency of specific ***,we demonstrated that isolated protoplasts can be stored for up to 24/48 h with little loss of viability,allowing a pause between isolation and *** high-efficiency protocol for protoplast isolation and transfection enables rapid(less than 7 days)validation of sgrNA cleavage efficiency before proceeding with stable *** isolation and transfection method can als

关键词： Protoplast Genome editing Transgene-free edited plants rice Chickpea

FlowBreakdown of Hybrid Nanofluid on a rigid Surface with Power Law Fluid as Lubricated Layers

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1485-1499页

作者： mirza Naveed Jahangeer Baig NadeemSalamat Sohail Nadeem NaeemUllah Mohamed Bechir Ben Hamida Hassan Ali Ghazwani Sayed M.Eldin A.S.Al-Shafay Instituite of Mathematics Khwaja Fareed University of Engineering and Information TechnologyRahim yar Khan64200Pakistan Department of Mathematics Quaid-I-Azam UniversityIslamabad44000Pakistan Department of Mathematics Wenzhou UniversityWenzhou325035China College of Engineering Department of Mechanical EngineeringImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11564Saudi Arabia research Laboratory of Ionized Backgrounds and reagents Studies(EMIr) Preparatory Institute for Engineering Studies of Monastir(IPEIM)University of MonastirMonastir5060Tunisia Higher School of Sciences and Technology of Hammam Sousse Department of PhysicsJazan82511Kingdom of Saudia Arabia Department of Mechanical Engineering Faculty of engineeringJazan UniversityP.O.Box 45124JazanKingdom of Saudia Arabia Center of research Faculty of EngineeringFuture University in EgyptNew Cairo11835Egypt Department of Mechanical Engineering College of EngineeringPrince Sattam bin Abdulaziz UniversityAlkharj16436Saudi Arabia

Thiswork investigates an oblique stagnation point flowof hybrid nanofluid over a rigid surface with power lawfluidas lubricated layers. Copper (Cu) and Silver (Ag) solid particles are used as hybrid particles acting in water H2O asa base fluid. The mathematical formulation of flow configuration is presented in terms of differential systemthat isnonlinear in nature. The thermal aspects of the flow field are also investigated by assuming the surface is a heatedsurface with a constant temperature T. Numerical solutions to the governing mathematical model are calculatedby the rK45 algorithm. The results based on the numerical solution against various flow and thermal controllingparameters are presented in terms of line graphs. The specific results depict that the heat flux increases over thelubricated-indexed parameter.

关键词： Oblique stagnation point flow hybrid nanofluid lubricated layer magnetohydrodynamics

Low T3 vs low T3T4 euthyroid sick syndrome in septic shock patients:A prospective observational cohort study

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World Journal of Critical Care Medicine 2024年第3期13卷 53-62页

作者： mirza Kovacevic Visnja Nesek-Adam Semir Klokic Ekrema Mujaric Department of Anesthesiology Resuscitation and Intensive CareCantonal HospitalZenica 72000Bosnia and Herzegovina Department of Anesthesiology Resuscitation and Intensive CareClinical Hospital Sveti DuhZagreb 10000Croatia Gruppenpraxis General Practitioner's OfficeLaufen 4242Switzerland Department of Internal Diseases Cantonal HospitalZenica 72000Bosnia and Herzegovina

BACKGrOUND Both phases of euthyroid sick syndrome(ESS)are associated with worse prognosis in septic shock *** there are still no indications for supplementation therapy,there is no evidence that both phases(initial and prolonged)are adaptive or that only prolonged is maladaptive and requires *** To analyze clinical,hemodynamic and laboratory differences in two groups of septic shock patients with *** A total of 47 septic shock patients with ESS were divided according to values of their thyroid hormones into low T3 and low T3T4 *** analysis included demographic data,mortality scores,intensive care unit stay,mechanical ventilation length and 28-day survival and laboratory with *** The Simplified Acute Physiology Score II score(P=0.029),dobutamine(P=0.003)and epinephrine requirement(P=0.000)and the incidence of renal failure and multiple organ failure(MOF)(P=0.000)were significantly higher for the low ***(P=0.047),neutrophilia(P=0.038),lymphopenia(P=0.013)and lactatemia(P=0.013)were more pronounced on T2 for the low T3T4 group compared to the low T3 *** blood pressure at T0(P=0.017)and T1(P=0.007),as well as mean arterial pressure at T0(P=0.037)and T2(P=0.033)was higher for the low T3 *** The low T3T4 population is associated with higher frequency of renal insufficiency and MOF,with worse laboratory and hemodynamic *** findings suggest potentially maladaptive changes in the chronic phase of septic shock.

关键词： Septic shock Euthyroid sick syndrome Low T3 Low T3T4 Intensive care unit

Hepatic vein reconstruction during hepatectomy:A feasible and underused technique

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 421-427页

作者： Manish Ahuja Kunal Joshi Chris Coldham Paulo Muiesan Bobby Dasari Manuel Abradelo ravi Marudanayagam Darius mirza John Isaac David Bartlett Nikolaos A Chatzizacharias robert P Sutcliffe Keith J roberts Department of HPB and Liver Transplant Surgery University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Immunology and Immunotherapy University of BirminghamBirminghamUK

Complete surgical resection(r0)of liver tumors,primary or metastatic,remains the main objective in management of primary and metastatic liver tumors[1].Tumors invading to the proximity of the hepatic venous outflow pose a peculiar challenge to achieve r0 resections,because this location may render a tumor *** median survival of patients with liver tumor without surgery is less than 12 months[2].Even with surgery,post-hepatectomy liver failure and subsequently increased mortality are the main problems associated with complex resection[3].Moreover,when the vein is affected,vein resection and subsequent reconstruction are *** resection is a standard practice in liver resection and transplantation[4],for example,hepatic vein reconstruction during a living-donor liver transplant,porto-mesenteric axis reconstruction during resection of advanced pancreatic cancer and caval reconstruction during resection of retroperitoneal ***,novel techniques like total hepatic vascular exclusion(HVE)[5],veno-venous bypass[6]and ex vivo hepatic resection[7,8]have facilitated curative resections of tumors close to one or more major hepatic veins.

关键词： hepatectomy surgery mortality

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心脏双源多层CT评估仿人类心脏运动模具的血管钙化斑块标本

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国际医学放射学杂志 2008年第A6期31卷 498-498页

作者： D.T.Boll E.M.Merkle E.K.Paulson r.a.mirza T.r.Fleiter 李芳 Department of radiology Duke University Medical Center DUMC 3808 Durham NC27710.

目的评估心脏双源多层CT及其图像后处理技术是否可以比单源多层CT能更准确地对钙化斑块进行定量评估,以光学相干断层成像(optical coherence tomography,OCT)

关键词：心脏运动钙化斑块图像后处理技术单源 coherence 参照标准双能探测器阵列数据集计

维普期刊数据库